Download or read book The Micro Vasculature of the Cochlea written by Mattia Carraro and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis concerns the role of cochlear microvasculature in normal hearing function and in pathological conditions that result in hearing loss. In animal models we have investigated two major types of sensorineural hearing loss where degeneration of the stria vascularis has been implicated, namely presbyacusis and hearing loss associated with cytomegalovirus (CMV) infection. The former eventual affects all aging humans; the latter is a common etiology for congenital hearing loss in infants. The focus of experimental work is on the capillary networks of the cochlea. We chose to use corrosion cast techniques to visualize and quantify capillary vessel parameters. For the small and delicate cochleas of our mouse models, this required extensive technical improvements to corrosion casting methodology. These innovations proved successful. Three experimental animal model studies were made. The first involved analysis, and modeling of strial feeding arterioles in normal subject. The hypothesis posed was that the highly convoluted structure of these vessels acts to dampen cardiovascular pulsations within the cochlea and thereby prevent self-stimulation by such biological noise. The results from this study support the hypothesis. In our murine models of presbyacusis and of CMV infection we correlated loss of auditory thresholds measured with ABR methods, with degenerative changes to cochlear microvasculature. In mice with age-related, high frequency hearing loss, we report significant vascular degeneration of stria vascularis in basal (high frequency) cochlear areas compared to more apical regions. After CMV infection in newborn mice, we observed at 6 weeks a wide range of auditory threshold changes. At 8 weeks post-infection, the cochleas had suffered a wide range of vascular damage. The most vulnerable structure was stria vascularis in the mid-apical cochlear turn. Our novel finding that vascular damage is the primary lesion after CMV infection is consistent with some clinical characteristics of this hearing loss type in infants.
Download or read book The Cochlear Blood Flow written by Elisabeth Hultcrantz and published by . This book was released on 1978 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cochlea written by Peter Dallos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge about the structure and function of the inner ear is vital to an understanding of vertebrate hearing. This volume presents a detailed overview of the mammalian cochlea from its anatomy and physiology to its biophysics and biochemistry. The nine review chapters, written by internationally distinguished auditory researchers, provide a detailed and unified introduction to sound processing in the cochlea and the steps by which the ensuing signals are prepared for the central nervous system.
Download or read book Gray s Anatomy E Book written by and published by Elsevier Health Sciences. This book was released on 2015-09-25 with total page 2256 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1858, Drs. Henry Gray and Henry Vandyke Carter created a book for their surgical colleagues that established an enduring standard among anatomical texts. After more than 150 years of continuous publication, Gray’s Anatomy remains the definitive, comprehensive reference on the subject, offering ready access to the information you need to ensure safe, effective practice. This 41st edition has been meticulously revised and updated throughout, reflecting the very latest understanding of clinical anatomy from field leaders around the world. The book’s traditional lavish art programme and clear text have been further honed and enhanced, while major advances in imaging techniques and the new insights they bring are fully captured in new state-of-the-art X-ray, CT, MR, and ultrasonic images. Presents the most detailed and dependable coverage of anatomy available anywhere. Regional organization collects all relevant material on each body area together in one place, making access to core information easier for clinical readers. Anatomical information is matched with key clinical information where relevant. Numerous clinical discussions emphasize considerations that may affect medical care. Each chapter has been edited by experts in their field, ensuring access to the very latest evidence-based information on that topic. More than 1,000 completely new photographs, including an extensive electronic collection of the latest X-ray, CT, MR, and histological images. The downloadable Expert Consult eBook version included with your purchase allows you to search all of the text, figures, references and videos from the book on a variety of devices. Carefully selected electronic enhancements include additional text, tables, illustrations, labelled imaging and videos – as well as 24 specially invited ‘Commentaries’ on new and emerging topics related to anatomy.
Download or read book The Vasculature of the Rat Cochlea written by Michael Gerard Sneary and published by . This book was released on 1980 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inner Ear Partition written by B. Ars and published by Kugler Publications. This book was released on 1998 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: PrefaceUp to now, it was generally believed that the destruction of any part of the membranous labyrinth invariably led to complete hearing loss. This concept is no longer accurate!It became apparent that the inner ear was compartmentalized into a cochlea and a vestibule, separated from each other by two valves. Each compartment with its own morphology, physiology, particular biochemistry, and specific pathology. Today, surgery of either of these compartments can be performed without fear for the integrity of the other. This constitutes a revolution in surgery of the inner ear and leads to per.
Download or read book Microvascular Decompression Surgery written by Shi-Ting Li and published by Springer. This book was released on 2015-12-11 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an essential update on microvascular decompression (MVD) surgery, which has been widely accepted as an effective remedy for cranial nerve hyperexcitability disorders such as hemifacial spasm, trigeminal neuralgia, glossopharyngeal neuralgia, etc. The authors describe in detail those steps of the process that need the most attention in order to achieve an excellent postoperative outcome, including positioning, craniectomy, approach and identification of the culprit, etc. Though it primarily focuses on surgical principles and technical nuances, the book also addresses the intraoperative electrophysiologic monitoring and pathogeneses of hemifacial spasm and trigeminal neuralgia.
Download or read book Basic and Applied Aspects of Noise Induced Hearing Loss written by Richard J. Salvi and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September 1985, NATO sponsored an Advanced Study WOl'kshop entitled, "Noise-Induced Hearing Loss: Basic and Applied Aspects." Tne meeting was held in a mountain retreat near Lucca, Italy and was attended by scientists, clinicians, and public officials from 12 countries. This was the third in a series of such conferences organized by the authors. The first two were supported by the United States National Institute of Occupational Safety and Health; their proceedings were published as "The Effects of Noise on Hearing" in 1976 and "New Perspectives on Noise-Induced Hearing Loss" in 1982. The Organizing Committee approached NATO because it was felt that the problem of noise was common to all industrialized countries and was an especially serious problem for the military. Thus, the NATO sponsorship and the Italian site of the meeting were part of the Organizing Committee's plan to obtain an international and thorough repr'esentation on the problem of noise-induced hearing loss. The NATO meeting and proceedings followed the format of the previous two symposia with an initial focus on the anatomical and physiological disturbances resulting from noise-induced hearing loss. This was followed by sections devoted to studies of a more applied nature involving general auditory performance in noise, issues associated with the establishment of noise-exposure criteria, nonauditory effects of noise, and the interaction of noise with other agents.
Download or read book Delivering Therapeutics to the Inner Ear written by Peter S. Steyger and published by Frontiers Media SA. This book was released on 2021-08-17 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Benjamin Shapiro is President and co-founder of Otomagnetics. Topic Editor Sylvain Celanire is a co-Founder and Chief Executive Officer of PRAGMA Therapeutics. All other Topic Editors declare no competing commercial interests with regards to the Research Topic subject.
Download or read book COMPUTATIONAL OPTICAL SECTIONING MICROSCOPY USING CONVEX PROJECTION THEORY WITH APPLICATIONS MICROSCOPY COCHLEAR MICROVESSELS THREE DIMENSIONAL MICROSCOPY NOISE DAMAGE written by GOPAL B. AVINASH and published by . This book was released on 1992 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: issues which explore the effects of loud sound on hearing in mammals are considered.
Download or read book Gray s Anatomy E Book written by Susan Standring and published by Elsevier Health Sciences. This book was released on 2021-05-22 with total page 2602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Susan Standring, MBE, PhD, DSc, FKC, Hon FAS, Hon FRCS Trust Gray’s. Building on over 160 years of anatomical excellence In 1858, Drs Henry Gray and Henry Vandyke Carter created a book for their surgical colleagues that established an enduring standard among anatomical texts. After more than 160 years of continuous publication, Gray’s Anatomy remains the definitive, comprehensive reference on the subject, offering ready access to the information you need to ensure safe, effective practice. This 42nd edition has been meticulously revised and updated throughout, reflecting the very latest understanding of clinical anatomy from the world’s leading clinicians and biomedical scientists. The book’s acclaimed, lavish art programme and clear text has been further enhanced, while major advances in imaging techniques and the new insights they bring are fully captured in state of the art X-ray, CT, MR and ultrasonic images. The accompanying eBook version is richly enhanced with additional content and media, covering all the body regions, cell biology, development and embryogenesis – and now includes two new systems-orientated chapters. This combines to unlock a whole new level of related information and interactivity, in keeping with the spirit of innovation that has characterised Gray’s Anatomy since its inception. Each chapter has been edited by international leaders in their field, ensuring access to the very latest evidence-based information on topics Over 150 new radiology images, offering the very latest X-ray, multiplanar CT and MR perspectives, including state-of-the-art cinematic rendering The downloadable Expert Consult eBook version included with your (print) purchase allows you to easily search all of the text, figures, references and videos from the book on a variety of devices Electronic enhancements include additional text, tables, illustrations, labelled imaging and videos, as well as 21 specially commissioned ‘Commentaries’ on new and emerging topics related to anatomy Now featuring two extensive electronic chapters providing full coverage of the peripheral nervous system and the vascular and lymphatic systems. The result is a more complete, practical and engaging resource than ever before, which will prove invaluable to all clinicians who require an accurate, in-depth knowledge of anatomy.
Download or read book Inflammatory Mechanisms in Mediating Hearing Loss written by Vickram Ramkumar and published by Springer. This book was released on 2018-07-18 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.
Download or read book Morphological Aspects of Inner Ear Disease written by Yasuya Nomura and published by Springer Science & Business Media. This book was released on 2013-11-08 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book approaches inner ear diseases from a perspective that is as multifaceted as the diseases themselves. Common among these disorders are sudden deafness, Ménière’s disease, and perilymphatic fistula. With an awareness of the generally insufficient understanding of the causes and etiologies of these and other inner ear diseases, the author helps to fill those gaps in knowledge. Several factors have impeded a clearer understanding of inner ear diseases, chiefly the small size of the organ and its location in the hard temporal bone and, consequently, the inadequate resolution of CT and MRI images for pathophysiological analysis. This book provides morphological information about the inner ear, elucidating its fluids and blood vessels to help familiarize the reader with the complicated inner ear structures. Important information about how the inner ear responds to various stimuli is also given for a better understanding of the characteristics of the organ. Included are chapters describing specific diseases and animal models of the diseases. Examples and illustrations are presented for surgical applications. For instance, patients with intractable vertigo of inner-ear origin require surgical treatment and the application of a laser to the vestibular labyrinth, described in detail. With its generous use of color photographs, this book is an excellent reference text for all doctors and trainees in the field of otolaryngology.
Download or read book Textbook of Tinnitus written by Aage R. Møller and published by Springer Science & Business Media. This book was released on 2010-11-16 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Groundbreaking, comprehensive, and developed by a panel of leading international experts in the field, Textbook of Tinnitus provides a multidisciplinary overview of the diagnosis and management of this widespread and troubling disorder. Importantly, the book emphasizes that tinnitus is not one disease but a group of rather diverse disorders with different pathophysiology, different causes and, consequently, different treatments. This comprehensive title is written for clinicians and researchers by clinicians and researchers who are active in the field. It is logically organized in six sections and will be of interest to otolaryngologists, neurologists, psychiatrists, neurosurgeons, primary care clinicians, audiologists and psychologists. Textbook of Tinnitus describes both the theoretical background of the different forms of tinnitus and it provides detailed knowledge of the state-of-the-art of its treatment. Because of its organization and its extensive subject index, Textbook of Tinnitus can also serve as a reference for clinicians who do not treat tinnitus patients routinely.
Download or read book Translational Perspectives in Auditory Neuroscience written by Kelly L.Tremblay and published by Plural Publishing. This book was released on 2012-06-29 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scott Brown s Otorhinolaryngology and Head and Neck Surgery written by John C Watkinson and published by CRC Press. This book was released on 2018-06-12 with total page 3447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume in the Scott-Brown Otorhinolaryngology Head and Neck Surgery 8e three volume work is available either as in individual volume covering the sub specialties of Paediatrics, The Ear, and Skull Base Surgery, or as part of the classic three volume set. With over 100 chapters and numerous illustrations, this specialist volume contains authoritative and cutting edge information from some of the world's outstanding clinicians. It will be a constant companion through the specialty training years and beyond.
Download or read book Research Anthology on Pediatric and Adolescent Medicine written by Management Association, Information Resources and published by IGI Global. This book was released on 2022-02-25 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of pediatric and adolescent medicine is an essential part of medicine as children react to diseases differently than adults. As new viruses continue to emerge, and as procedures are updated and revised, there is a need for comprehensive resources on the new developments and emerging technologies in this field. As medical technologies and innovative practices spread in recent years, it is vital that medical professionals are knowledgeable on the developments in the pediatric field as well. The Research Anthology on Pediatric and Adolescent Medicine presents the developments, emerging technologies, and challenges in pediatric and adolescent medicine. It also explains adolescent health management and promotion as well as recent discoveries on childhood development. Covering topics such as media consumption, neuro-developmental disorders, and health promotion, this book is a critical resource for pediatricians, nurses, medical professionals, hospital administration, behavioral scientists, therapists, psychiatrists, medical students, researchers, and academicians.
