Download or read book The Maudsley Family Study of Psychosis written by Colm McDonald and published by Psychology Press. This book was released on 2008-07-25 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Maudsley Family Study of Psychosis investigates the genetically produced markers of abnormal brain structure and function (‘intermediate phenotypes’) which underlie the clinical syndrome of schizophrenia, and more recently bipolar disorder

Download or read book Bipolar Disorder Vulnerability written by Jair Soares and published by Academic Press. This book was released on 2018-06-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior

Download or read book The Maudsley Guidelines on Advanced Prescribing in Psychosis written by Paul Morrison and published by John Wiley & Sons. This book was released on 2020-01-21 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to treating psychosis that provides information on drug options and side-effects in order to allow for weighing treatment options knowledgably The Maudsley Guidelines on Advanced Prescribing in Psychosis offers a resource that puts the focus on the need to treat the individual needs of a patient. The authors – noted experts on the topic – offer an alternative to the one-size-fits-all treatment of psychosis and shows how to build psychiatrist and patient relationships that will lead to effective individual treatment plans. The book provides up-to-date data and information about commonly used anti-psychotic drugs and drugs used in bipolar disorder. The text weighs both the upsides and downsides of each pharmaceutical presented, and helps prescribers and patients weigh the costs and benefits of various options to reach an appropriate treatment plan. The authors highlight the treatment at a population level and the systems in which individual treatments take places. This important resource: Facilitates the tailoring of an appropriate treatment plan for clients manifesting signs of psychosis Offers a comparative strategy that helps gauge the suitability of one treatment plan over another Provides at-hand data and information about commonly used anti-psychotic drugs Includes an understanding of the origins and side-effects of each drug presented The Maudsley Guidelines on Advanced Prescribing in Psychosis offers psychiatrists and other mental health practitioners an essential guide for treating psychosis on an individualized level.

Download or read book Schizophrenia Bulletin written by and published by . This book was released on 2013 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Maudsley Reader in Phenomenological Psychiatry written by Matthew R. Broome and published by Cambridge University Press. This book was released on 2012 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book brings together and interprets previously hard-to-find texts, new translations and passages detailing the interplay between philosophy and psychopathology, making them accessible to a new generation of mental health researchers, practitioners and policy makers.

Download or read book Advances in Physiology Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physiology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Physiology. The editors have built Advances in Physiology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Physiology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Physiology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Assessing Rare Variation in Complex Traits written by Eleftheria Zeggini and published by Springer. This book was released on 2015-08-13 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of rare variants, such as the impact of fine-scale population structure, and with combining information on rare variants across studies in a meta-analysis framework. Genetic association studies have in the last few years substantially enhanced our understanding of factors underlying traits of high medical importance, such as body mass index, lipid levels, blood pressure and many others. There is growing empirical evidence that low-frequency and rare variants play an important role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of genomic research, including complex trait association studies, technology is in danger of outstripping our capacity to analyse and interpret the vast amounts of data generated. The field of statistical genetics in the whole-genome sequencing era is still in its infancy, but powerful methods to analyse the aggregation of low-frequency and rare variants are now starting to emerge. The chapter Functional Annotation of Rare Genetic Variants is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Vulnerability to Psychosis written by Paolo Fusar-Poli and published by Psychology Press. This book was released on 2013-06-17 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early clinical intervention in psychosis is now a major objective of mental health services and the development of specialist intervention services has greatly facilitated research on the early phases of this disorder. In this book, contributors provide a review of the neurobiological research in people at high risk of psychosis, focusing on the transition from being at a high risk state to their first episode. Contributors consider unaffected family members and twin studies as well as the individual’s data before and after the onset of the illness. The environmental factors that contribute to a psychotic episode are also examined. Vulnerability to Psychosis presents neurobiological findings in the context of what is now known about the psychopathology and cognitive impairments that are evident in people at high risk of psychosis. It will be essential reading for clinicians working with this client group, and will interest academics looking for state of the art information in this field.

Download or read book The metamorphosis of autism written by Bonnie Evans and published by Manchester University Press. This book was released on 2017-03-28 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. This book is available as an open access ebook under a CC-BY-NC-ND licence. What is autism and where has it come from? Increased diagnostic rates, the rise of the 'neurodiversity' movement, and growing autism journalism, have recently fuelled autism's fame and controversy. The metamorphosis of autism is the first book to explain our current fascination with autism by linking it to a longer history of childhood development. Drawing from a staggering array of primary sources, Bonnie Evans traces autism back to its origins in the early twentieth century and explains why the idea of autism has always been controversial and why it experienced a 'metamorphosis' in the 1960s and 1970s. Evans takes the reader on a journey of discovery from the ill-managed wards of 'mental deficiency' hospitals, to high-powered debates in the houses of parliament, and beyond. The book will appeal to a wide market of scholars and others interested in autism.

Download or read book Schizophrenia written by Anthony S. David and published by Psychology Press. This book was released on 2012-05-04 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is a unique project reflecting the contribution that Robin M. Murray has made to the field of psychiatry over the past 35 years, with a particular focus on the advances that have been made to the understanding and treatment of schizophrenia. International contributors have been brought together to pay tribute to Robin Murray’s work and explore the latest findings in the area. Sections cover: neurodevelopment neuroscience and pharmacology neuroimaging genetics cognition social psychiatry treatment. This book will be essential reading for psychiatrists, clinical psychologists, social and basic scientists whose work is related to major mental illness, as well as admirers of the work of Robin Murray.

Download or read book Search for the Causes of Schizophrenia written by W.F. Gattaz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: - The topics covered in the six sections of the book are Epidemiology and Environment, Precursors, Pathophysiological Mechanisms, Genetics, Controversies in Schizophrenia, and Treatment. - Reflects the progress made on Schizophrenia since 1986.

Download or read book The Epidemiology of Schizophrenia written by Robin M. Murray and published by Cambridge University Press. This book was released on 2002-11-28 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: An international team of leading researchers and clinicians here provide a comprehensive, epidemiological overview of this multi-faceted and still perplexing disorder, and address some of the key questions it raises. How important in the genetic contribution to schizophrenia? Do pregnancy and birth complications increase the risk for schizophrenia? Is the incidence of schizophrenia changing? Why is the rate higher among immigrants and in those born in cities? Controversial issues such as the validity of discrete or dimensional classifications of schizophrenia and the continuum between psychosis and 'normality' are explored in depth, and separate chapters are devoted to topics of particular relevance to schizophrenia such as suicide, violence and substance abuse. Finally, new prospects for treatment and prevention are considered. Drawing together the findings from social, genetic, developmental and classical epidemiology of schizophrenia, this text will prove an invaluable resource for clinicians and researchers.

Download or read book Recognition and Prevention of Major Mental and Substance Use Disorders written by American Psychopathological Association and published by American Psychiatric Pub. This book was released on 2007-05-03 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing that favorable clinical outcomes are associated with earlier initiation of treatment -- and even more ideally with prevention -- this volume addresses the current status of early intervention in, and prevention of, major mental and substance use disorders. A team of distinguished participants addresses this problem at many levels -- from the DNA molecule to public policy -- in order to show how prevention efforts should be informed by a better understanding of etiology and by a knowledge of indicators of vulnerability. In considering the current standing of etiological knowledge, Recognition and Prevention of Major Mental and Substance Use Disorders addresses issues that are critical precursors to the prevention of mental disorders and offers an understanding of factors that contribute to the disorders' development. The contributors review genetic methodologies and current findings in mental disorders, with an emphasis on schizophrenia, and then show how biological and psychosocial environmental variables may affect vulnerability. Chapters devoted specifically to lessons in prevention drawn from recent research into schizophrenia discuss the implications of prodromal studies and relationships between stress, critical periods, and the development of the disorder. The book includes contributions from NIH representatives on how basic scientific understanding of mental disorders can be translated into public policy. It also features chapters that describe cutting-edge projects in prevention research for Alzheimer's disease, drug dependence, antisocial behavior, and posttraumatic stress disorder -- each providing compelling accounts of how existing knowledge can be adapted to promising prevention efforts. Among the volume's contributions: New data on the role of substance abuse -- particularly marijuana and psychostimulants -- in increasing vulnerability to schizophrenia Review of vulnerability factors for several relevant disorders, examining stress and its concomitant psychobiological responses and the contribution of cognitive factors to vulnerability to depression Intriguing approach for translating successful treatment methods for schizophrenia into efforts to prevent the transition from the prodrome of the disorder to the full-blown illness Program for prevention of antisocial behavior that can be implemented as early as the first grade Secondary prevention efforts for posttraumatic stress disorder, with a focus on pharmacological interventions Each chapter reviews clinical implications of the research presented, contributing to a volume that will benefit clinicians and researchers who share the goal of preventing these debilitating conditions. This multidimensional, interdisciplinary work represents a major step toward cutting the social costs of these disorders -- and, more important, their untold cost in human suffering.

Download or read book Neurodevelopment and Schizophrenia written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 2004-11-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Download or read book Schizophrenia written by Steven R. Hirsch and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is one of the most complex and puzzling diseases toaffect mankind. It is the most common of the severe mentalillnesses (psychoses) with an estimated prevalence of 0.5 - 1% inthe general population and accounts for a very large portion of theday to day workload of the average psychiatrist. 50% of long-termpsychiatric patients in mental hospitals are schizophrenic. There is a great deal of controversy about the causes, diagnosisand treatment of schizophrenia with the consequence that a hugeamount of research is carried out in the field by psychiatrists,psychologists, neuroscientists and pharmacologists. For the averagepractising psychiatrist seeing schizophrenics on a regular basis,making sense of the vast body of information on the subject andfiltering out what is of clinical relevance can be very difficult.There is a constant stream of new drugs emerging and the newergeneration of drugs (the so-called atypicals) is very effective,but often expensive. The Editors (one American and one British) are both highlyrespected clinical psychiatrists who are probably the leadingexperts on schizophrenia from their respective countries andjointly have published almost 150 papers on the subject. They have brought together a strong group of contributors from theUSA, UK and Europe to produce what will be an essential referencefor the trainee and practising psychiatrist. The book consists of four sections; descriptive aspects,causative aspects, physical treatments andpsychological/behavioural/social treatments. There will bediscussion of the theoretical controversies over symptomatology,classification and aetiology, the relationship of schizophrenia tothe other psychoses, the significance of positive and negativesymptoms and pre-morbid personality. There will be chapters onorganic models of schiziophrenia, neurodevelopmental, genetic andstructural studies and the role of high-expressed emotion. Thefinal section will cover social and environmental treatment, therole of the families of schizophrenics and the psychoanalyticaltherapies. There is a new chapter on the patient's perspectivewritten by a former patient.

Download or read book Childhood Onset of Adult Psychopathology written by Judith L. Rapoport and published by American Psychiatric Pub. This book was released on 2008-11-01 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Age at onset studies have been an important approach to understanding disease across all medical specialties. Over the last few decades, genetic research has led to the identification of unique genes and, in some cases, physiologically different disorders. These advances bring us closer to identifying genetic vulnerability and implementing prevention programs for psychopathology. Childhood Onset of "Adult" Psychopathology: Clinical and Research Advances provides an understanding of the childhood onsets of adult psychiatric disorders, including when and in what sequence psychiatric disorders begin in childhood, and how these disorders evolve over the life span. This book examines Studies on the growing volume of data on very early forms of depression, criminality, alcoholism, schizophrenia, and anxiety Genetics, evolution, and the significance of age at onset in terms of individual variability and the course of disease The biological manner in which early-onset disorders progress New insights into the disease etiology of schizophrenia and the neurodevelopmental hypothesis The long-debated subject of whether depressive disorder in preadolescent children is the same as depressive disorder in adults and studies of individuals at risk for disorders of anxiety and depression The implications for prevention of adult psychiatric disorders, alcoholism, and antisocial personality disorder Complete with extensive references and tables, this text provides practitioners with a better understanding of adult psychopathology and insight into early detection and prevention methods.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt: