Download or read book The Manufacture of Chemicals by Batch or Continuous Processing written by V. L. Gonzalez and published by Wiley. This book was released on 2015-12-21 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a very detailed study of the choice between batch and continuous processing operations in the chemical and allied industries. It shows what the conventional approach has been since the first continuous processes developed into the market that continuous processing is use to produce volume chemicals and batched is for producing smaller quantities and why this approach is not necessarily valid now in light of present new circumstances such as the changes in energy costs, new automation devices, inflation, and new health and safety regulations, etc. The study is carried out by a literature review of the common points between technology selection related to batch and continuous processes, then by case studies and mathematical models developed to validate the choice. Finally the conventional approach is redefined in light of present circumstances.

Download or read book Handbook of Batch Process Design written by P.N. Sharratt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Batch processes are used to manufacture many fine organic chemicals, and as such they can be considered to underpin much of the modern chemical industry. Despite widespread use and a consequent huge contribution to wealth creation, batch processes have attracted limited attention outside the user industries. Batch chemicals processing uses a number of core techniques and technologies, such as scheduling and sequence control, agitation and batch filtration. The combination of these technologies with often complex chemistry, the multi-purpose nature of much of this type of plant, the distinctive safety and environmental issues, and a fast moving commercial environment makes the development of a successful batch process a considerable challenge for the chemist or engineer. The literature on the topics covered in this book is fragmented and often not easily accessible, so this handbook has been written to address this problem and to bring together design and process analysis methods in the core areas of batch process design. By combining the science and pragmatism required in the development of successful batch processes this new book provides answers to real problems in an accessible and concise way. Written by an international team of authors drawn from industry, consulting and academe, this book is an essential part of the library of any chemist, technologist or engineer working on the development of new or existing batch processes.

Download or read book Practical Batch Process Management written by Mike Barker and published by Elsevier. This book was released on 2004-11-18 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically batch control systems were designed individually to match a specific arrangement of plant equipment. They lacked the ability to convert to new products without having to modify the control systems, and did not lend themselves to integration with manufacturing management systems. Practical Batch Management Systems explains how to utilize the building blocks and arrange the structures of modern batch management systems to produce flexible schemes suitable for automated batch management, with the capability to be reconfigured to use the same plant equipment in different combinations. It introduces current best practice in the automation of batch processes, including the drive for integration with MES (Manufacturing Execution System) and ERP (Enterprise Resource Planning) products from major IT vendors. References and examples are drawn from DCS / PLC batch control products currently on the market. - Implement modern batch management systems that are flexible and easily reconfigured - Integrate batch management with other manufacturing systems including MES and ERP - Increase productivity through industry best practice

Download or read book Chemical Production Scheduling written by Christos T. Maravelias and published by Cambridge University Press. This book was released on 2021-05-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand common scheduling as well as other advanced operational problems with this valuable reference from a recognized leader in the field. Beginning with basic principles and an overview of linear and mixed-integer programming, this unified treatment introduces the fundamental ideas underpinning most modeling approaches, and will allow you to easily develop your own models. With more than 150 figures, the basic concepts and ideas behind the development of different approaches are clearly illustrated. Addresses a wide range of problems arising in diverse industrial sectors, from oil and gas to fine chemicals, and from commodity chemicals to food manufacturing. A perfect resource for engineering and computer science students, researchers working in the area, and industrial practitioners.

Download or read book Industrialization of Biology written by National Research Council and published by National Academies Press. This book was released on 2015-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.

Download or read book Semicontinuous Reactive Distillation for Specialty Chemicals Production written by Thomas A. Adams (II.) and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Continuous Pharmaceutical Processing written by Zoltan K Nagy and published by Springer Nature. This book was released on 2020-06-10 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PAT) for continuous processing, process control strategies including new concepts of quality-by-control (QbC), real-time process management and plant optimization, business and supply chain considerations related to continuous manufacturing as well as safety guidelines related to continuous chemistry. A separate chapter is dedicated to discussing regulatory aspects of continuous manufacturing, with description of current regulatory environment quality/GMP aspects, as well as regulatory gaps and challenges. Our aim from publishing this book is to make it a valuable reference for readers interested in this topic, with a desire to gain a fundamental understanding of engineering principles and mechanistic studies utilized in understanding and developing continuous processes. In addition, our advanced readers and practitioners in this field will find that the technical content of Continuous Pharmaceutical Processing is at the forefront of recent technological advances, with coverage of future prospects and challenges for this technology.

Download or read book Introduction to Chemical Engineering written by S. PUSHPAVANAM and published by PHI Learning Pvt. Ltd.. This book was released on 2012-05-09 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an outgrowth of the author’s teaching experience of a course on Introduction to Chemical Engineering to the first-year chemical engineering students of the Indian Institute of Technology Madras. The book serves to introduce the students to the role of a chemical engineer in society. In addition to the classical industries, the role of chemical engineers in several esoteric areas such as semiconductor processing and biomedical engineering is discussed. Besides highlighting the principles and processes of chemical engineering, the book shows how chemical engineering concepts from the basic sciences and economics are used to seek solutions to engineering problems. The book is rich in examples of innovative solutions found to problems faced in chemical industry. It includes a wide spectrum of topics, selected from the industrial interactions of the author. It encourages the student to see the similarities in the concepts which govern apparently dissimilar examples. It introduces various concepts, using both physical and mathematical bases, to facilitate the understanding of difficult processes such as the scale-up process. The book contains several case studies on safety, ethics and environ-mental issues in chemical process industries.

Download or read book Analysis Synthesis and Design of Chemical Processes written by Richard Turton and published by Pearson Education. This book was released on 2008-12-24 with total page 1562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leading Integrated Chemical Process Design Guide: Now with New Problems, New Projects, and More More than ever, effective design is the focal point of sound chemical engineering. Analysis, Synthesis, and Design of Chemical Processes, Third Edition, presents design as a creative process that integrates both the big picture and the small details–and knows which to stress when, and why. Realistic from start to finish, this book moves readers beyond classroom exercises into open-ended, real-world process problem solving. The authors introduce integrated techniques for every facet of the discipline, from finance to operations, new plant design to existing process optimization. This fully updated Third Edition presents entirely new problems at the end of every chapter. It also adds extensive coverage of batch process design, including realistic examples of equipment sizing for batch sequencing; batch scheduling for multi-product plants; improving production via intermediate storage and parallel equipment; and new optimization techniques specifically for batch processes. Coverage includes Conceptualizing and analyzing chemical processes: flow diagrams, tracing, process conditions, and more Chemical process economics: analyzing capital and manufacturing costs, and predicting or assessing profitability Synthesizing and optimizing chemical processing: experience-based principles, BFD/PFD, simulations, and more Analyzing process performance via I/O models, performance curves, and other tools Process troubleshooting and “debottlenecking” Chemical engineering design and society: ethics, professionalism, health, safety, and new “green engineering” techniques Participating successfully in chemical engineering design teams Analysis, Synthesis, and Design of Chemical Processes, Third Edition, draws on nearly 35 years of innovative chemical engineering instruction at West Virginia University. It includes suggested curricula for both single-semester and year-long design courses; case studies and design projects with practical applications; and appendixes with current equipment cost data and preliminary design information for eleven chemical processes–including seven brand new to this edition.

Download or read book Continuous Manufacturing of Pharmaceuticals written by Peter Kleinebudde and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Download or read book Chemical Process written by Robin Smith and published by John Wiley & Sons. This book was released on 2005-06-10 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the design and integration of chemical processes, emphasizing the conceptual issues that are fundamental to the creation of the process. Chemical process design requires the selection of a series of processing steps and their integration to form a complete manufacturing system. The text emphasizes both the design and selection of the steps as individual operations and their integration. Also, the process will normally operate as part of an integrated manufacturing site consisting of a number of processes serviced by a common utility system. The design of utility systems has been dealt with in the text so that the interactions between processes and the utility system and interactions between different processes through the utility system can be exploited to maximize the performance of the site as a whole. Chemical processing should form part of a sustainable industrial activity. For chemical processing, this means that processes should use raw materials as efficiently as is economic and practicable, both to prevent the production of waste that can be environmentally harmful and to preserve the reserves of raw materials as much as possible. Processes should use as little energy as economic and practicable, both to prevent the build-up of carbon dioxide in the atmosphere from burning fossil fuels and to preserve reserves of fossil fuels. Water must also be consumed in sustainable quantities that do not cause deterioration in the quality of the water source and the long-term quantity of the reserves. Aqueous and atmospheric emissions must not be environmentally harmful, and solid waste to landfill must be avoided. Finally, all aspects of chemical processing must feature good health and safety practice. It is important for the designer to understand the limitations of the methods used in chemical process design. The best way to understand the limitations is to understand the derivations of the equations used and the assumptions on which the equations are based. Where practical, the derivation of the design equations has been included in the text. The book is intended to provide a practical guide to chemical process design and integration for undergraduate and postgraduate students of chemical engineering, practicing process designers and chemical engineers and applied chemists working in process development. Examples have been included throughout the text. Most of these examples do not require specialist software and can be performed on spreadsheet software. Finally, a number of exercises have been added at the end of each chapter to allow the reader to practice the calculation procedures.

Download or read book Organometallic Flow Chemistry written by Timothy Noël and published by Springer. This book was released on 2016-04-22 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal

Download or read book Product and Process Design Principles written by Warren D. Seider and published by John Wiley & Sons. This book was released on 2017 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The new 4th edition of Seider’s 'Product and Process Design Principles : Synthesis, Analysis and Design' covers content for process design courses in the chemical engineering curriculum, showing how process design and product design are inter-linked and why studying the two is important for modern applications. A principal objective of this new edition is to describe modern strategies for the design of chemical products and processes, with an emphasis on a systematic approach. This fourth edition presents two parallel tracks : (1) product design ("what to make"), and (2) process design ("how to make"), with an emphasis on process design. Process design instructors can show easily how product designs lead to new chemical processes. Alternatively, product design can be taught in a separate course subsequent to the process design course."--adapted from description on publisher web site.

Download or read book Chemical Process Design and Integration written by Robin Smith and published by John Wiley & Sons. This book was released on 2016-08-02 with total page 923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a highly regarded author with industrial and academic experience, this new edition of an established bestselling book provides practical guidance for students, researchers, and those in chemical engineering. The book includes a new section on sustainable energy, with sections on carbon capture and sequestration, as a result of increasing environmental awareness; and a companion website that includes problems, worked solutions, and Excel spreadsheets to enable students to carry out complex calculations.

Download or read book Chemical Engineering in the Pharmaceutical Industry written by David J. am Ende and published by John Wiley & Sons. This book was released on 2011-03-10 with total page 1431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.

Download or read book Chemical Engineering in the Pharmaceutical Industry Active Pharmaceutical Ingredients written by David J. am Ende and published by John Wiley & Sons. This book was released on 2019-03-28 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: • Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety • Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying • Presents updated and expanded example calculations • Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industry focuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Download or read book EPA 440 1 written by and published by . This book was released on 1974-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: