Download or read book Epidermal Langerhans Cells written by Gerold Schuler and published by CRC Press. This book was released on 1990-12-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.

Download or read book Histiocytic Disorders written by Oussama Abla and published by Springer. This book was released on 2017-11-17 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Download or read book Imaging of Bone Tumors in Shoulder and Elbow written by Xiaoguang Cheng and published by Springer Nature. This book was released on 2021-03-11 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed description of typical imaging features of bone tumors and tumor-like lesions in the shoulder and elbow. Each chapter deals with one major bone tumor or tumor-like lesion, for example, giant cell tumor, bone cyst, osteochondroma, chondrosarcoma, Ewing sarcoma, bone metastases, lymphoma, etc. Typical cases are carefully selected from thousands of clinical cases accompanying with comprehensive imaging information of X-ray, CT and MRI. In-depth analysis and differential diagnostic tips from experienced bone tumor specialist are presented at the end of each case. This book will be useful and worthy to musculoskeletal radiologists, orthopaedic surgeons, general radiologists, and oncologists.

Download or read book Harper s Textbook of Pediatric Dermatology 2 Volume Set written by Peter H. Hoeger and published by John Wiley & Sons. This book was released on 2019-12-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Download or read book Histiocytic Disorders of Children and Adults written by Sheila Weitzman and published by Cambridge University Press. This book was released on 2011-02-17 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a comprehensive reference on all aspects of the histiocytic disorders, Histiocytic Disorders of Children and Adults stands out a seminal text on the genetics, pathophysiology and clinical management of this wide range of diseases. The chapters, written by acknowledged experts in the field, cover all aspects of hystiocytic disorders, from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are discussed in detail. Originally published in 2005, this book will be a valuable resource to clinicians and researchers who wish to learn more about histiocytic disorders.

Download or read book Tumors and Tumor Like Lesions of the Hepatobiliary Tract written by Arthur Zimmermann and published by Springer. This book was released on 2016-11-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

Download or read book The Langerhans Cell written by Jean Thivolet and published by . This book was released on 1988 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Unveiling Diabetes Historical Milestones in Diabetology written by V. Jörgens and published by Karger Medical and Scientific Publishers. This book was released on 2020-08-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: A history of diabetology told by renowned contributors, many have themselves already become a part of diabetes history. A must-have for every diabetologist! Diabetologists, diabetes educators, and many interested readers will appreciate this book. What is more, countless celebrations are planned for the 100th anniversary of the discovery of insulin: this book provides numerous illustrations, accounts of personal experiences, and critical remarks on the history of diabetology – in addition to the history of insulin. It spans an arc from antiquity to the work of Claude Bernard, Paul Langerhans, Josef von Mering, Apollinaire Bouchardat, Oskar Minkowski, E.P. Joslin, and F.M. Allen. The history of insulin is presented from the perspective of diabetologists from Scotland, Spain, Germany, and Poland. The history of oral antidiabetics is told by Harald Lebovitz, and the chapter about glitazones by Edwin Gale reads like a spy novel! Pierre Lefèbvre describes the work of the diabetologist Jean Pirart and the history of glucagon. Sir George Alberti has provided a chapter about the therapy of ketoacidosis, to which he himself made groundbreaking contributions. Nephropathy is presented by Hans-Henrik Parving, and Eva Kohner, Ronald Klein and Barbara E.K. Klein have contributed a chapter on retinopathy. Other contemporary topics such diabetes in pregnancy, diabetes technology, psychosocial aspects of diabetes, and the history of the EASD and ADA are also included in this book.

Download or read book Applied Oral Physiology written by Christopher L. B. Lavelle and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Oral Physiology is intended to provide undergraduate and graduate dental students with greater knowledge of oral physiology. It is aimed at bridging the gap between the basic sciences and clinical dentistry, in light of the changing patterns of dental practice. This book is organized into 23 chapters. The topics for this second edition were those that have a direct bearing upon oral diagnosis and treatment planning. The references, quoted at the end of each chapter, were also selected to provide a basis for future in-depth topic evaluation rather than as a comprehensive literature compendium. The coverage of the chapters includes blood supply of the oral tissue, anxiety and stress associated with dental treatment and mechanisms of tooth eruption. This book will be of interest to undergraduate and graduate dental students and practitioners.

Download or read book Diagnosis of Musculoskeletal Tumors and Tumor like Conditions written by Piero Picci and published by Springer Nature. This book was released on 2019-12-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a second revised edition, casts light on the often complex diagnosis of musculoskeletal tumors and tumor-like conditions by drawing on the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment and research in the field. The different entities are described from a multidisciplinary perspective, highlighting clinical, radiological, and histological correlations. Particular emphasis is placed on differential diagnosis, which often needs to take into account nontumoral conditions. The recent identification of further significant biological and genetic features, and the impact of these discoveries on the classification of round cell tumors, vascular lesions, and spindle/pleomorphic entities in bone, is also extensively discussed. The Rizzoli case archive dates back to September 1900 and contains the original material relating to more than 29,000 bone lesions and 11,000 soft tissue lesions. It is a fabulously rich resource, and this book will be invaluable for pathologists, radiologists, and clinicians at all levels of experience.

Download or read book Diabetes Insipidus in Children written by Craig A. Alter and published by Springer Nature. This book was released on 2021-09-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Utilizing clinical case material of children with diabetes insipidus (DI), this concise, practical pocket guide will provide clinicians with the best real-world strategies to properly diagnose and manage the various manifestations of the disorder they may encounter. It presents a detailed cross-section of pediatric patients, with different etiologies of the disease and possible complications, to provide sensible management scenarios to physicians treating patients with DI. The cases presented include diagnostic strategies and radiological findings for familial and nephrogenic DI as well as DI resulting from hypophysitis, germ cell tumors, Rathkes Cleft Cysts, Langerhans Cell Histiocytosis, craniopharyngiomas, genetic causes, and congenital malformations. Each case focuses on a specific learning objective with clinical pearls, and together these cases represent a comprehensive understanding of children with DI from many aspects. Managing pediatric patients with DI is a threefold challenge of determining the diagnosis, etiology and treatment. Pragmatic and reader-friendly, Diabetes Insipidus in Children is an excellent resource to assist endocrinologists and other clinicians caring for patients with this disease.

Download or read book Granulomatous diseases in Otorhinolaryngology Head and Neck written by Sanjana Vijay Nemade and published by Springer Nature. This book was released on 2021-09-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the ‘Essential features’ of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Download or read book Skin Tissue Engineering and Regenerative Medicine written by Mohammad Albanna and published by Academic Press. This book was released on 2016-01-14 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. Explores cellular and molecular processes of wound healing, scar formation, and dermal repair Includes examples of animal models for wound healing and translation to the clinical world Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

Download or read book Absolute Dermatology Review written by Hugh Morris Gloster, Jr. and published by Springer. This book was released on 2015-05-28 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​Each dermatologist that was board certified after 1992 is required by the American Board of Dermatology to take a recertification exam every ten years. One of the major components of the exam is to be able to identify clinical photographs of approximately 200 skin diseases, and while there are other components to the test, they vary according to subspecialty. However, everyone is required to identify the images, so several months before the exam, the American Board of Dermatology releases a list of the skin diseases that will be tested, but does not provide the images or reveal which ones will appear. Review of Clinical Conditions for the Dermatology Recertification Examination provides a thorough, concise review of clinical images of the specific conditions that the reader will be required to recognize during the American Board of Dermatology recertification test. In addition, concise key clinical features for each image will be provided that will assist the reader in recognizing the clinical images on the examination, enabling them a more efficient way to study for the test without having to look up images online or in a large text book. Written by a board certified dermatologic surgeon who recently took the recertification exam, this book proves indispensable to dermatologists taking the exam or residents who want a quick reference of the clinical appearances of the main conditions generally encountered by a dermatologist.​ ​​

Download or read book Skull Base Imaging written by F. Allan Midyett and published by Springer Nature. This book was released on 2020-07-13 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to skull base imaging. Skull base is often a “no man’s land” that requires treatment using a team approach between neurosurgeons, head and neck surgeons, vascular interventionalists, radiotherapists, chemotherapists, and other professionals. Imaging of the skull base can be challenging because of its intricate anatomy and the broad breadth of presenting pathology. Although considerably complex, the anatomy is comparatively constant, while presenting pathologic entities may be encountered at myriad stages. Many of the pathologic processes that involve the skull base are rare, causing the average clinician to require help with their diagnosis and treatment. But, before any treatment can begin, these patients must come to imaging and receive the best test to establish the correct diagnosis and make important decisions regarding management and treatment. This book provides a guide to neuoradiologists performing that imaging and as a reference for related physicians and surgeons. The book is divided into nine sections: Pituitary Region, Cerebellopontine Angle, Anterior Cranial Fossa, Middle Cranial Fossa, Craniovertebral Junction, Posterior Cranial Fossa, Inflammatory, Sarcomas, and Anatomy. Within each section, either common findings in those skull areas or different types of sarcomas or inflammatory conditions and their imaging are detailed. The anatomy section gives examples of normal anatomy from which to compare findings against. All current imaging techniques are covered, including: CT, MRI, US, angiography, CT cisternography, nuclear medicine and plain film radiography. Each chapter additionally includes key points, classic clues, incidence, differential diagnosis, recommended treatment, and prognosis. Skull Base Imaging provides a clear and concise reference for all physicians who encounter patients with these complex and relatively rare maladies.

Download or read book Bone Tumors written by Jaime Paulos and published by Springer Nature. This book was released on 2021-07-15 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest techniques for diagnostics and treatments specific to bone and soft tissue tumors. It focuses on imaging and classification of the bone and soft tissue tumors and how histology and cytogenetic aspects can be used to identify tumors. Each chapter focuses on a specific type of tumor, providing a concise overview of relevant information on their characteristics along with the latest surgical and medical treatments available. Bone Tumors: Diagnosis and Therapy Today is a concise guide to successfully identifying and treating bone and soft tissue tumors, making it a valuable resource for practicing medical professionals and trainees who encounter these patients in their day-to-day practice.

Download or read book Brain Imaging with MRI and CT written by Zoran Rumboldt and published by Cambridge University Press. This book was released on 2012-11-08 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most imaging books are ordered according to underlying etiology. However, in real life clinical practice, radiologists usually make their differential diagnoses according to the image patterns, as the etiology is often unknown. Brain Imaging with MRI and CT presents over 180 disease processes and normal variants, grouping entities by these basic patterns to accentuate differential diagnostic features. High quality CT and MRI scans show multiple typical and distinguishing images for each entity. Common and unusual clinical scenarios are described, including dilated perivascular spaces, capillary teleangiectasia, Susac's syndrome and desmoplastic infantile ganglioglioma. Both basic and advanced imaging techniques are used, reflecting the reality of clinical practice. This image-focused book emphasises the most pertinent clinical information relevant to the diagnostic process. Trainee and practising radiologists will find Brain Imaging with MRI and CT an invaluable and clinically relevant tool for learning and teaching.