Download or read book The Isolation and Characterization of Genes Down regulated in a Rat Model System of Ovarian Cancer written by David Roberts and published by . This book was released on 2001 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LOT1 gene is composed of 6 exons and spans more than 65 kb. This gene was previously determined to be down regulated in a rat model system of ovarian cancer and in a high percentage of human ovarian cancer cell lines. Unlike traditional tumor suppressor genes, which follow Knudson's two-hit hypothesis, the LOT1 open reading frame (ORF) was determined to be devoid of any inactivating mutations. Since the 5' regulatory region of a gene may also regulate a gene's expression, we sought to clone and functionally characterize the LOT1 cis-acting region. A region upstream of the LOT1 5' end was cloned and was demonstrated to have transcriptional activity in luciferase reporter assays using human ovarian cancer cell line A2780.
Download or read book Characterization of Genetic Alterations in Ovarian Cancer written by and published by . This book was released on 2000 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer is a highly lethal malignancy specific to women. We have set up the infrastructure at Mayo for an Ovarian Cancer Research Program utilizing the rich resources of clinical material and linking work from molecular geneticists with that of dedicated clinicians. We are proposing to combine several powerful strategies to clone many of fie genes involved in ovarian cancer development. The first project focuses on identifying genes that are over-expressed or under-expressed during the development of ovarian cancer using subtraction suppression hybridization cDNA libraries and Gene Expression Array Analysis in collaboration with Millennium Predictive Medicine. The second project focuses on the role of gene amplification in familial versus sporadic ovarian cancer. The third project is to characterize two common fragile sites, FRA6F (6q21) and FRA6E (6q26) which are derived from chromosomal regions frequently deleted in ovarian cancer and that also contain genes involved in replication senescence. Thus we have three interactive projects whose overall focus is to identify key genetic targets in the development of ovarian cancer. This Program Project is centered within a larger institutional effort to better understand the biology of the development of ovarian cancer and to devise better strategies for prevention, early detection and treatment of this lethal disease.
Download or read book Analysis of Genes Differentially Expressed in a Human Ovarian Cancer Model written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objectives of this study were to (1) analyze gene expression in a model of human ovarian cancer from a benign to a malignant phenotype in cells grown in organotypic culture and (20 confirm gene expression patterns by RNA analysis. Two human cell lines were used, 96.9.18 and 1.24.96, and RNA extracted from cells at various stages of malignant change were queried on Affymetrix HU133A and B chips in triplicate (96.9.18) or HU133A plus chip in triplicate (1.24.96) . Data analysis has revealed a number of genes that are dysregulated in both 96.9.18 and 1.24.96. An analysis of the interaction of these genes showed that 5 genes are downregulated between the two cell lines and 183 genes are upregulated during malignant progression. Downregulated genes are too few to analyze but the upregulated genes are involved in apotosis, cytokine-cytokine receptor interactions, toll-like receptor signaling pathway, and the MAPK signaling pathway.
Download or read book Isolation and Characterization of Candidate Tumor Suppressor Genes written by Michele Genini and published by . This book was released on 1995 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2001 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Oncogenes and Growth Factors written by Ralph A. Bradshaw and published by Elsevier Science & Technology. This book was released on 1987 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Pathology and Genetics of Tumours of the Breast and Female Genital Organs written by World Health Organization and published by IARC. This book was released on 2003 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 5th volume in a WHO series on histological and genetic typing of human tumours. This edition focuses on cancers of the breast and female genital organs, and describes diagnostic criteria, pathological features, associated genetic alterations and gene expression patterns in a disease-oriented manner. Sections on all recognised neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors. It contains colour photographs, X-rays, computed tomography (CT) and magnetic resonance (MR) images, charts and over 3,200 references. The classifications presented reflect the views of WHO working group conferences held in France in January and March 2002, and the volume was produced in collaboration with the International Academy of Pathology.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Analysis of Cancer written by Jacqueline Boultwood and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years, technological advances in molecular biology have proven invaluable to the understanding of the pathogenesis of human cancer. The application of molecular technology to the study of cancer has not only led to advances in tumor diagnosis, but has also provided markers for the assessment of prognosis and disease progression. The aim of Molecular Ana- sis of Cancer is to provide a comprehensive collection of the most up-to-date techniques for the detection of molecular changes in human cancer. Leading researchers in the field have contributed chapters detailing practical pro- dures for a wide range of state-of-the-art techniques. Molecular Analysis of Cancer includes chapters describing techniques for the identification of chromosomal abnormalities and comprising: fluor- cent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), and microsatellite analysis. FISH has a pro- nent role in the molecular analysis of cancer and can be used for the detection of numerical and structural chromosomal abnormalities. The recently described SKY, in which all human metaphase chromosomes are visualized in specific colors, allows for the definition of all chromosomal rearrangements and marker chromosomes in a tumor cell. Protocols for the detection of chromosomal re- rangements by PCR and RT-PCR are described, as well as the technique of DNA fingerprinting, a powerful tool for studying somatic genetic alterations in tumorigenesis.
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bibliography of Agriculture written by and published by . This book was released on 1998 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
