Download or read book Effects of Mycotoxins on the Intestine written by Isabelle P. Oswald and published by MDPI. This book was released on 2019-04-30 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.
Download or read book Effects of Mycotoxins on the Intestine written by Imourana Alassane-Kpembi and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota-now regarded as a fully-fledged organ associated with the gut-is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.
Download or read book The Intestinal Toxicity of Mycotoxins written by Imourana Alassane-Kpembi and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As for other food-born contaminants, the gastro-intestinal tract represents the first barrier against deoxynivalenol (DON). This mycotoxin frequently co-occurs with other type B trichothecenes (TCTs B) namely 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX). At the cellular level, DON binding to ribosomal RNA results in the inhibition of protein synthesis and triggers the mitogen-activated protein kinases (MAPKs) pathway that have been linked to immune response mechanisms. Thus, intestinal epithelial cell renewing is considered a putative target in DON toxicity. Moreover, based on the ability of DON to disturb the state of homeostasis of the inflammatory response in the intestine mimicking what is found in inflammatory bowel diseases (IBD), it is proposed that this mycotoxin may play a role in such diseases. However, very few is known about the intestinal toxicity of the other co-occuring TCT B, and their combined effects eventually. By means of in vitro human and porcine intestinal epithelial cells models and an ex vivo porcine jejunal explants model, we assessed the individual toxicity of five TCT B (DON, 3- and 15-ADON, NIV and FX) toward the intestine and we analyzed their combined toxicity in terms of additivity, synergy or antagonism. The tested TCT B significantly impaired the intestinal epithelial cell growth in the micromolar range, in increasing order of potency 3-ADON, DON, 15-ADON, NIV and FX. The toxicity of low doses of TCT B was synergistic. For mycotoxin concentrations corresponding to exposure levels reported for French and European consumers, the amplitude of this synergy ranged between 3 and 10. Benchmark dose analyses of the transcriptional data also showed that the exposure of the intestine to mycotoxin concentrations as low as 0.04μM for FX, 0.1μM for DON and 0.1μM for NIV could be associated to a significant activation of the inflammatory response mechanisms. Taken together, these results suggest that epithelial cell renewing and pro-inflammatory effects at the intestinal level may be consider very sensitive biomarkers for the assessment of the individual toxicity and interactions between the co-occurring TCTs B.
Download or read book Masked Mycotoxins in Food written by Chiara Dall'Asta and published by Royal Society of Chemistry. This book was released on 2015-11-05 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover this fast developing field, Masked Mycotoxins in Food will provide a full overview of the issues relating to the toxicology of masked mycotoxins present in food products. Mycotoxins are naturally occurring chemicals produced by moulds that can grow on crops and foodstuffs. Masked mycotoxins are modified mycotoxins, due to this modification many cannot be detected using standard analytical techniques, for example HPLC and ELISA, and further research is needed to understand the health risks and threats from these modified compounds.Masked mycotoxin research is an area of toxicological research that has gained significant interest and momentum in recent years. The aim of this book is to provide a full picture of the topic, from the masked mycotoxin formation in plants to their catabolic fate in humans. The book also provides new insights and will highlight possible gaps in the knowledge base of this relatively new area. Edited and written by World renowned experts working within the field, this book is of interest to toxicologists and biochemists, but also food scientists and agricultural researchers working in industry and academia.
Download or read book Fungal Toxins written by Solomon Kadis and published by Elsevier. This book was released on 2013-10-22 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Toxins: A Comprehensive Treatise, Volume VIII, Fungal Toxins is devoted to topics related to algal and fungal toxins and includes critically reviewed articles from different experts in related fields. The text is divided into three sections. Section A covers coumarins — its isolation, identification, biological action, natural occurrence, and uses. Section B deals with the epizootiology, clinical characteristics, and pathological findings of Stachybotryotoxicosis. Section C talks about phytopathogenic and helminthosporium toxins, toxic peptides found in Amanita species as well as other mushroom toxins, compounds accumulating in plants after an infection, and ergot. The book is recommended for microbiologists and toxicologists, especially those who would like to know more about the toxins produced by algae and fungi and their effects.
Download or read book Mycotoxin Control in Low and Middle Income Countries written by Christopher P. Wild and published by IARC Working Group Report. This book was released on 2016-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an evaluation of measures to reduce exposure to highly toxic and carcinogenic contaminants in staple diets in Africa as well as parts of Asia and Latin America. Many of the poorest people in these regions are exposed to the pervasive natural toxins, aflatoxins and fumonisins, on a daily basis by eating their staple diet of groundnuts, maize, and other cereals. Exposure to mycotoxins at these high levels substantially increases mortality and morbidity. Aflatoxins are a cause of human liver cancer, and fatalities from acute aflatoxin poisoning outbreaks occur in Africa and Asia. The International Agency for Research on Cancer convened a Working Group of world-leading experts to review the health effects of aflatoxins and fumonisins and to evaluate intervention measures. The panel concluded that these mycotoxins not only are a cause of acute poisoning and cancer but also are a likely contributor to the high levels of stunting in children in affected populations. The Working Group also identified effective measures to reduce exposure in developing countries. The panel evaluated 15 interventions, considering the strength of the evidence as well as its completeness and its transferability at an individual, community, or national level. Four of the interventions were judged to be ready for implementation: improvement of dietary diversity; crop sorting; post-harvest measures, including improved storage; and, in Latin America for maize, optimized nixtamalization. These recommendations would be relevant for investment of public, nongovernmental organization, and private funds at the scale of the subsistence farmer, the smallholder, and through to a more advanced value chain.
Download or read book Mycotoxin Contamination in Gastrointestinal Tract written by Javier Barkley and published by Foster Academics. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are toxic compounds that are produced naturally by certain types of molds such as fungi. These molds can grow on numerous foodstuffs such as cereals, nuts, spices, dried fruits, apples and coffee beans, often under warm and humid conditions. These toxins can cause adverse health effects that can range from acute poisoning to long-term effects such as immune deficiency and cancer. There are various types of mycotoxins such as Aflatoxins, Ochratoxin A, Patulin, and Fusarium fungi. Some negative effects of mycotoxins on intestinal health are decreased intestinal cell viability, reductions in short chain fatty acid (SCFA) concentrations, and elimination of beneficial bacteria. It also leads to an increased expression of genes involved in promoting inflammation and counteracting oxidative stress. The health risks of mycotoxins can be reduced by taking effective measures such as proper storage, inspection of whole grains, avoidance of foods kept for extended periods of time before being used, and consuming a balanced diet. This book traces the effects of mycotoxins on the gastrointestinal tract. Those with an interest in these toxic compounds would find it helpful.
Download or read book Mycotoxin Exposure and Related Diseases written by Susana Viegas and published by MDPI. This book was released on 2020-05-12 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins are considered the most frequently occurring natural contaminants in human and animal diets. Considering their potential toxic and carcinogenic effects, mycotoxin exposure assessment has particular importance in the context of health risk assessment. The magnitude of a given exposure allows the derivation of the associated risk and the potential for the establishment of a disease. Although food ingestion is considered a major route of human exposure to mycotoxins, other contexts may also result in exposure, such as specific occupational environments where exposure to organic dust also occurs due to the handling of organic materials. Animals could be exposed to mycotoxins through consumption of contaminated feed, subsequently entering in the food chain and thus constituting a source of exposure to humans. Human biomonitoring is considered a new frontier for the establishment of the human internal exposure to mycotoxins. Although several studies have summarized the potential outcomes associated with mycotoxin exposure, major gaps in data remain in recognizing the mycotoxins that are the cause of diseases. This book contributes provides research that supports the anticipation of potential consequences of the exposure of humans and animals to mycotoxins, future risk assessments, and the establishment of preventive measures.
Download or read book Damp Indoor Spaces and Health written by Institute of Medicine and published by National Academies Press. This book was released on 2004-10-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost all homes, apartments, and commercial buildings will experience leaks, flooding, or other forms of excessive indoor dampness at some point. Not only is excessive dampness a health problem by itself, it also contributes to several other potentially problematic types of situations. Molds and other microbial agents favor damp indoor environments, and excess moisture may initiate the release of chemical emissions from damaged building materials and furnishings. This new book from the Institute of Medicine examines the health impact of exposures resulting from damp indoor environments and offers recommendations for public health interventions. Damp Indoor Spaces and Health covers a broad range of topics. The book not only examines the relationship between damp or moldy indoor environments and adverse health outcomes but also discusses how and where buildings get wet, how dampness influences microbial growth and chemical emissions, ways to prevent and remediate dampness, and elements of a public health response to the issues. A comprehensive literature review finds sufficient evidence of an association between damp indoor environments and some upper respiratory tract symptoms, coughing, wheezing, and asthma symptoms in sensitized persons. This important book will be of interest to a wide-ranging audience of science, health, engineering, and building professionals, government officials, and members of the public.
Download or read book Masked Mycotoxins in Food written by Chiara Dall'Asta and published by Royal Society of Chemistry. This book was released on 2015-11-16 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover this fast developing field, Masked Mycotoxins in Food will provide a full overview of the issues relating to the toxicology of masked mycotoxins present in food products. Mycotoxins are naturally occurring chemicals produced by moulds that can grow on crops and foodstuffs. Masked mycotoxins are modified mycotoxins, due to this modification many cannot be detected using standard analytical techniques, for example HPLC and ELISA, and further research is needed to understand the health risks and threats from these modified compounds.Masked mycotoxin research is an area of toxicological research that has gained significant interest and momentum in recent years. The aim of this book is to provide a full picture of the topic, from the masked mycotoxin formation in plants to their catabolic fate in humans. The book also provides new insights and will highlight possible gaps in the knowledge base of this relatively new area. Edited and written by World renowned experts working within the field, this book is of interest to toxicologists and biochemists, but also food scientists and agricultural researchers working in industry and academia.
Download or read book Mycotoxins in Food written by N Magan and published by Elsevier. This book was released on 2004-07-16 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotoxins, toxic compounds produced by fungi, pose a significant contamination risk in both animal feed and foods for human consumption. With its distinguished editors and international team of contributors, Mycotoxins in food summarises the wealth of recent research on how to assess the risks from mycotoxins, detect particular mycotoxins and control them at differing stages in the supply chain. Part one addresses risk assessment techniques, sampling methods, modelling and detection techniques used to measure the risk of mycotoxin contamination and the current regulations governing mycotoxin limits in food. Part two looks at how the risk of contamination may be controlled, with chapters on the use of HACCP systems and mycotoxin control at different stages in the supply chain. Two case studies demonstrate how these controls work for particular products. The final section details particular mycotoxins, from ochratoxin A and patulin to zearalenone and fumonisins. Mycotoxins in food is a standard reference for all those concerned with ensuring the safety of food. Discusses the wealth of recent research in this important area Covers risk assessment, detection of particular mycotoxins and how to control them throughout the supply chain Describes how the risk of contamination can be controlled, including the use of HACCP systems
Download or read book Industrial Enzyme Applications written by Andreas Vogel and published by John Wiley & Sons. This book was released on 2019-10-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a "must-read": It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.
Download or read book Sustainable Agriculture Reviews 40 written by Eric Lichtfouse and published by Springer Nature. This book was released on 2020-02-12 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent research advances in sustainable agriculture, with focus on crop production, biodiversity and biofuels in Africa and Asia.
Download or read book Mycotoxins in Grain written by J. David Miller and published by . This book was released on 1994 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biosynthetic diversity of secondary metabolites; Epidemiology of fusarium ear diseases of cereals; Breeding for resistance to fusarium wheat and maize; Spectral characteristic of secondary metabolites; Penicillium and aspergillus toxins; Ecological aspects of growth and mycotoxin production by storage fungi; Alternaria toxins; Immunotoxic effects of mycotoxins; Toxicology of mycotoxins; Residues in food products of animal origin; Decontamination of fusarium mycotoxins; Prevention of human mycotozicoses through risk assessment and risk management; Factors responsible for economic losses due to fusarium mycotoxin contamination of grains, foods, and feedstuffs; Diseases in humans with mycotoxins as possible causes.
Download or read book Diagnosis of Mycotoxicoses written by J.L. Richard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current problems associated with the mycotoxicoses include the recognition of an animal disease as being a mycotoxicosis and confirmation of diagnosis of the mycotoxicosis by satisfactory laboratory methods. By gathering a vast amount of scientific literature, diagnosticians can provide themselves with suitable informa tion for making such a diagnosis. However, the increased number of reported intoxications caused by fungi, the wide range in diversity of disease conditions and the chemical compounds causing the mycotoxicoses, and the ever-changing and rapid developments in the technology of mycotoxin analysis has made the gathering and assimilation of sufficient information by the diagnostician an insurmountable task. This is the reason for development of the symposium and the publication of this book; the first time that the subject of diagnosis of mycotoxicoses has been assembled in a single publication and as a compilation of topic papers by experts in this subject area. The UJNR panel on toxic microorganisms is interested in all aspects of intox ications by microorganisms as evidenced by its annual joint meetings in either the United States or Japan and its involvement in sponsoring numerous symposia and several publications in this broad scientific area. The overall mission of the National Animal Disease Center includes research efforts in the improvement or establishment of diagnostic methods for animal diseases. The UJNR panel and the NADC provided the funds and encouragement for the development of a symposium on the diagnosis of mycotoxicoses in the United States and . Tapan.
Download or read book Neuro Immuno Gastroenterology written by Cris S. Constantinescu and published by Springer. This book was released on 2016-05-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
Download or read book The Toxicology of Aflatoxins written by David L. Eaton and published by Elsevier. This book was released on 2013-10-22 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aflatoxins, natural fungal toxins found in foods and animal feeds, have great public health significance. This book presents the basic and applied toxicology of aflatoxins, including analytical identification, agricultural and veterinary implications, toxicology and carcinogenesis in humans, and economic and regulatory problems associated with aflatoxin contamination and control. Molecular mechanisms of aflatoxin toxicity Analytical issues in sampling and analysis Regulatory and economic issues associated with aflatoxin contamination of food and feed Presentation of human and animal toxicology, veterinary, and agricultural issues related to aflatoxin contamination