Download or read book The Intact and Sliced Brain written by Mircea Steriade and published by . This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connecting in vitro and in vivo studies of the mammalian brain. In this book Mircea Steriade cautions against the tendency of some neuroscientists to infer global brain functions such as arousal and sleep, epileptic events, and even conscious thinking from the properties of single cells. Based on his lifetime of research on intact brains, Steriade emphasizes the need to understand isolated networks within the context of the whole mammalian brain and to understand the brain of a behaving animal in terms of its fully dissected circuits. As much as knowledge of brain anatomy and function has progressed, Steriade is highly skeptical about the quest to relate consciousness to specific neuronal types. The book's sections are Changing Concepts of Localization of Brain Function, Evolution of Methods in Brain Studies, Similar and Contrasting Results from Studies in the Intact and Sliced Brain, Building Blocks of Synaptic Networks Underlying Normal and Paroxysmal States, and Of Neurons and Consciousness.
Download or read book The Intact and Sliced Brain written by Mircea Steriade and published by MIT Press. This book was released on 2001 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connecting in vitro and in vivo studies of the mammalian brain.
Download or read book Brain Slices written by Raymond Dingledine and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: In little less than a decade brain slices have gained prominence among neurobiologists as appropriate tools to study cellular electrophysiolog ical aspects of mammalian brain function. The purpose of this volume is to present in some detail several inquiries in the brain sciences that have benefited greatly by the use of brain slices. The book is directed primarily toward advanced students and researchers wishing to evaluate the impact these in vitro preparations of the mammalian brain are having on neurobiology. The term brain slice has come to refer to thin (100-700 j. Lm) sections of a brain region prepared from adult mammals and maintained for many hours in vitro, for either electrophysiological or biochemical stud ies. In addition to good accessibility, slices feature relatively intact syn aptic connections that allow a variety of experiments not feasible with standard in vivo or tissue culture preparations. Certain electrophysiol ogical studies once practical only with invertebrate models are becoming routine with mammalian brain slices. The ability to perform both bio chemical and electro physiological experiments on the same piece of CNS tissue provides additional bright prospects for future research. Although most of the electrophysiological studies have dealt with hippocampal slices, it should be evident from this book that slice methodology is not limited to the hippocampus. The Appendix, "Brain Slice Methods," is a multiauthored treatment of the technical aspects of brain slice work, collected into one document.
Download or read book Brain Slices written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Slices written by Avital Schurr and published by S. Karger AG (Switzerland). This book was released on 1987 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Slices in Basic and Clinical Research written by Avital Schurr and published by CRC Press. This book was released on 2020-02-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following: Mechanisms of synaptic plasticity as the basis of memory processes Chaos and synaptic variability Brain calcium currents Glutamate receptors Pathophysiology of excitotoxins Cerebral hypoxia-ischemia Neuronal injury Free radicals Optical methods of measuring brain metabolism Voltammetry in brain slices Calcium imaging Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices Intracellular double labeling of various neuronal populations Use of brain slices in teaching neurophysiological methods Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.
Download or read book Encyclopedia of Neuroscience written by Marc D. Binder and published by Springer. This book was released on 2008-10-13 with total page 4398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 5000-page masterwork is literally the last word on the topic and will be an essential resource for many. Unique in its breadth and detail, this encyclopedia offers a comprehensive and highly readable guide to a complex and fast-expanding field. The five-volume reference work gathers more than 10,000 entries, including in-depth essays by internationally known experts, and short keynotes explaining essential terms and phrases. In addition, expert editors contribute detailed introductory chapters to each of 43 topic fields ranging from the fundamentals of neuroscience to fascinating developments in the new, inter-disciplinary fields of Computational Neuroscience and Neurophilosophy. Some 1,000 multi-color illustrations enhance and expand the writings.
Download or read book Mind Wide Open written by Steven Johnson and published by Simon and Schuster. This book was released on 2004-02-27 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: BRILLIANTLY EXPLORING TODAY'S CUTTING-EDGE BRAIN RESEARCH, MIND WIDE OPEN IS AN UNPRECEDENTED JOURNEY INTO THE ESSENCE OF HUMAN PERSONALITY, ALLOWING READERS TO UNDERSTAND THEMSELVES AND THE PEOPLE IN THEIR LIVES AS NEVER BEFORE. Using a mix of experiential reportage, personal storytelling, and fresh scientific discovery, Steven Johnson describes how the brain works -- its chemicals, structures, and subroutines -- and how these systems connect to the day-to-day realities of individual lives. For a hundred years, he says, many of us have assumed that the most powerful route to self-knowledge took the form of lying on a couch, talking about our childhoods. The possibility entertained in this book is that you can follow another path, in which learning about the brain's mechanics can widen one's self-awareness as powerfully as any therapy or meditation or drug. In Mind Wide Open, Johnson embarks on this path as his own test subject, participating in a battery of attention tests, learning to control video games by altering his brain waves, scanning his own brain with a $2 million fMRI machine, all in search of a modern answer to the oldest of questions: who am I? Along the way, Johnson explores how we "read" other people, how the brain processes frightening events (and how we might rid ourselves of the scars those memories leave), what the neurochemistry is behind love and sex, what it means that our brains are teeming with powerful chemicals closely related to recreational drugs, why music moves us to tears, and where our breakthrough ideas come from. Johnson's clear, engaging explanation of the physical functions of the brain reveals not only the broad strokes of our aptitudes and fears, our skills and weaknesses and desires, but also the momentary brain phenomena that a whole human life comprises. Why, when hearing a tale of woe, do we sometimes smile inappropriately, even if we don't want to? Why are some of us so bad at remembering phone numbers but brilliant at recognizing faces? Why does depression make us feel stupid? To read Mind Wide Open is to rethink family histories, individual fates, and the very nature of the self, and to see that brain science is now personally transformative -- a valuable tool for better relationships and better living.
Download or read book The Human Advantage written by Suzana Herculano-Houzel and published by MIT Press. This book was released on 2016-03-18 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why our human brains are awesome, and how we left our cousins, the great apes, behind: a tale of neurons and calories, and cooking. Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25% of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals, but not because we are evolutionary outliers. The human brain was not singled out to become amazing in its own exclusive way, and it never stopped being a primate brain. If we are not an exception to the rules of evolution, then what is the source of the human advantage? Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex—the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture. Herculano-Houzel shows us how she came to these conclusions—making “brain soup” to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. The Human Advantage is an engaging and original look at how we became remarkable without ever being special.
Download or read book Brain Banking written by and published by Elsevier. This book was released on 2018-02-27 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. - Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more - Serves as a valuable resource for staff in existing brain banks by highlighting best practices - Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers - Authored by leaders from brain banks around the globe – the broadest, most expert coverage available
Download or read book Into the Gray Zone written by Adrian Owen and published by Simon and Schuster. This book was released on 2017-06-20 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "From renowned neuroscientist Adrian Owen comes a thrilling, heartbreaking tale of discovery in one of the least-understood scientific frontiers: the twilight region between full consciousness and brain death. People who inhabit this middle region called the 'gray zone' have sustained traumatic brain injuries or are the victims of stroke or degenerative diseases, such as Alzheimer's and Parkinson's. Many are oblivious to the outside world, and their doctors and families often believe they're incapable of thought. But a sizable number of patients--as many as twenty percent--are experiencing something different: intact minds adrift within damaged brains and bodies. In 2006, Adrian Owen led a team that discovered this lost population and made medical history, provoking an ongoing debate among scientists, physicians, and philosophers about the meaning, value, and purpose of life. In Into the Gray Zone, we follow Owen as he pushes forward the boundaries of science, using a variety of sophisticated brain scans, auditory prompts, and even Alfred Hitchcock film clips to not only 'find' patients who are trapped inside their heads but to actually communicate with them and elicit answers to moving questions, such as 'Are you in pain?' and 'Do you want to go on living?' and 'Are you happy?' (Many gray zone patients do, in fact, claim to be satisfied with their quality of life.) Into the Gray Zone shines a fascinating light on how we think, remember, and pay attention. And it shows us how the field of brain-computer interfaces is about to explode, radically changing prognoses for people with impaired brain function and creating, for all of us, the tantalizing possibility of telepathy and augmented intelligence. Ultimately; this is not just a spellbinding story of scientific discovery but a deeply human, affirming book that causes us to wonder anew at the indomitable bonds of love."--Jacket.
Download or read book Human Brain Anatomy in Computerized Images written by Hanna Damasio M.D. and published by Oxford University Press. This book was released on 2005-03-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: By using non-invasive tomographic scans, modern neuroimaging technologies are revealing the structure of the human brain in unprecedented detail. This spectacular progress, however, poses a critical problem for neuroscientists and for practitioners of brain-related professions: how to find their way in the current tomographic images so as to identify a particular brain site, be it normal or damaged by disease? Prepared by a leading expert in advanced brain-imaging techniques, this unique atlas is a guide to the localization of brain structures that illustrates the wide range of neuroanatomical variation. It is based on the analysis of 29 normal human brains obtained from three-dimensional reconstructions of magnetic resonance scans of living persons. The Second Edition of this atlas offers entirely new images, all from new brain specimens.
Download or read book Patch Clamp Analysis written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2008-02-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patch-Clamp Analysis: Advanced Techniques describes in reproducible detail all applications that involve patch pipet. Beginning with updated basic patch-clamp techniques, the book presents the newest developments, ranging from fast external solution switching and the switching of the pipet solution during recording, to the loose patch, the perforated patch, and the patch cram detection technique. The advanced techniques covered combine molecular biology and imaging to produce the patch pipet with RT-PCR and fluorometric techniques.
Download or read book Metastasis written by Ulrike S. Stein and published by Humana. This book was released on 2022-04-03 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most recent developments and methodologies on metastatic process, formation, and detection. Chapters guide readers through functional metastasis in vitro assays, non-mouse and mice metastasis models, methods for imaging metastasis, analyzing the tumor microenvironment, senescence and inflammation with respect to metastasis, methods to investgate the premetastatic/ metastatic, detecting biomarkers in patient, and bioinformatics to simulate the metastatic process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metastasis: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book Beyond Boundaries written by Miguel Nicolelis and published by Macmillan. This book was released on 2011-03-15 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering neuroscientist shows how the long-sought merger of brains with machines is about to become a paradigm-shifting reality Imagine living in a world where people use their computers, drive their cars, and communicate with one another simply by thinking. In this stunning and inspiring work, Duke University neuroscientist Miguel Nicolelis shares his revolutionary insights into how the brain creates thought and the human sense of self—and how this might be augmented by machines, so that the entire universe will be within our reach. Beyond Boundaries draws on Nicolelis's ground-breaking research with monkeys that he taught to control the movements of a robot located halfway around the globe by using brain signals alone. Nicolelis's work with primates has uncovered a new method for capturing brain function—by recording rich neuronal symphonies rather than the activity of single neurons. His lab is now paving the way for a new treatment for Parkinson's, silk-thin exoskeletons to grant mobility to the paralyzed, and breathtaking leaps in space exploration, global communication, manufacturing, and more. Beyond Boundaries promises to reshape our concept of the technological future, to a world filled with promise and hope.
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
