Download or read book The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults written by Dominik Wolf and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Cognition emerges from coordinated processing among distributed cortical brain regions, enabled through interconnected white matter networks. Cortical disconnection caused by age-related decline in white matter integrity (WMI) is likely to contribute to age-related cognitive decline. Physical activity (PA) has been suggested to have beneficial effects on white matter structure. However, its potential to counteract age-related decline in WMI is not yet well established. The present explorative study analyzed if PA was associated with WMI in cognitively healthy older adults and if this association was modulated by age. Forty-four cognitively healthy older individuals (aged 60-88 years) with diffusion-tensor imaging (DTI) and PA measurements were included from the AgeGain study. Voxelwise analysis using Tract-Based Spatial Statistics (TBSS) demonstrated that PA was associated with WMI in older adults. However, results emphasized that this association was restricted to high age. The association between PA and WMI was found in widespread white matter regions suggesting a global rather than a regional effect. Supplementary analyses demonstrated an association between the integrity of these regions and the performance in memory [verbal learning and memory test (VLMT)] and executive functioning (Tower of London).Results of the present explorative study support the assumption that PA is associated with WMI in older adults. However, results emphasize that this association is restricted to high age. Since cognitive decline in the elderly is typically most pronounced in later stages of aging, PA qualifies as a promising tool to foster resilience against age-related cognitive decline, via the preservation of the integrity of the brains WM

Download or read book The Relations Between Physical Activity Executive Function and White Matter Integrity in Older Adults written by Marissa Ann Gogniat and published by . This book was released on 2019 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world's population of older adults is steadily increasing as people begin to live longer (Murman, 2015). There is a need to examine lifestyle changes that may prevent or slow down age-related cognitive decline. Physical activity is associated with better cognitive function in older adults (Colcombe & Kramer, 2003), particularly better executive function (Angeveran et al., 2008; Smith et al., 2010; Sherder et al., 2014). There is reason to believe that white matter integrity may mediate these changes (Grieve et al., 2007; Daselaar et al., 2015). In the current study, level of physical activity and steps in healthy older adults was measured. Diffusion tensor imaging (DTI) was utilized to examine white matter integrity, and neuropsychological testing was used to examine level of executive functioning. Results indicated that average steps were significantly related to executive function (t=2.829, p=.007), while moderate to vigorous physical activity (MVPA) was not (t=1.772, p=.08). White matter integrity, measured globally and in regions-of-interest (ROIs) did not mediate the associations between MVPA or average steps and executive function. These results suggest that white matter integrity alone may not be the mechanism by which physical activity impacts executive function in healthy older adults, and future research should examine additional health risk factors that may contribute.

Download or read book White Matter Dementia written by Christopher M. Filley and published by Cambridge University Press. This book was released on 2016-04-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.

Download or read book Effect of Age Vascular Parameters Physical Activity and Cardiorespiratory Fitness on Executive Performances written by Roman Goenarjo and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many studies have reported that regular physical activity and cardiorespiratory fitness were associated with cognitive performance and more selectively with executive functions. Among numerous physiological mechanisms that may underlie the association between them, prefrontal cortex oxygenation seems to play a major role. However, the specific impact of prefrontal oxygenation on the link between physical activity and cognition is influenced by several factors, such as gender, age, or cardiovascular health. Therefore, the aim of this thesis was to investigate the impact of physical activity and cardiorespiratory fitness on executive functions across the adults' age span in healthy males, as well as the influence of prefrontal cortex oxygenation and cardiovascular health. To obtain those objectives, we conducted a review of the effect of physical activity on the brain in older adults and four cross-sectional studies. From our review, we highlighted that: • In older adults, higher fitness level is associated with better performance in several executive function tests. Even though the limited number of studies available makes it difficult to draw definitive conclusions.• Better cardiovascular fitness in older adults is associated with improve arterial stiffness, higher vascular reactivity, and greater amplitude of cerebral oxygenation during exercise or cognitive tasks.• Greater gray matter volume and white matter integrity were related to the cardiorespiratory fitness but less consistently related to physical activity.• At least 12 weeks of an aerobic exercise program are required to give advantageous effects to the brainAnd our experimental works show that:In young males:• The active individuals performed better in executive tasks than their inactive counterparts and had a larger change in prefrontal cortex oxygenation during the most complex conditions of Stroop task.• High cardiorespiratory fitness was related to a better performance in dual-task and greater oxygenation on both sides of the prefrontal cortex.In older males:• Cardiorespiratory fitness is not related to Stroop task performance nor prefrontal cortex oxygenation in overall older males.• Higher cardiorespiratory fitness was related to a better performance and greater right prefrontal cortex oxygenation during a Stroop task in 61+ years old group but not in 55-60 years old group, suggesting the importance of age-group classification to evaluate the effect of cardiorespiratory fitness on executive function in older male subjects.• Older males have stronger relationships between several vascular parameters and Stroop task performance than young malesThis work shows the relationship between physical activity and cardiorespiratory fitness on executive functions in young and older males. The potential neurophysiological mechanisms that underlie that relationship, especially prefrontal oxygenation and vascular health, are presented.

Download or read book Diffusion MRI written by Heidi Johansen-Berg and published by Academic Press. This book was released on 2013-11-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain Provides practical advice on running an experiment Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience Full color throughout

Download or read book The Influence of Aerobic Fitness on Cerebral White Matter Integrity and Cognitive Function in Older Adults Results of a One year Exercise Intervention written by Susie Heo and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral white matter degeneration occurs with increasing age and is associated with declining cognitive function. Given the expected rise in the number and proportion of older adults in the United States, it is imperative to identify lifestyle factors that can counteract the deleterious effects of aging. Research has shown that cardiovascular fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to white matter integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the biological mechanisms underlying the observed differences. Finally, we tested whether white matter integrity mediated the fitness-associated improvements in cognitive performance. Using a region-of-interest approach on diffusion tensor images in 70 older adults, we examined longitudinal differences in fractional anisotropy, radial diffusivity and axial diffusivity within the prefrontal, parietal, occipital and temporal lobes. Our results indicate that improved cardiovascular fitness is associated with superior white matter integrity particularly in prefrontal and parietal brain regions, and that fractional anisotropy and radial diffusivity exhibit an overlapping pattern of distribution. In addition, we found a trend towards increased parietal white matter integrity partially mediating the relationship between improved aerobic fitness and enhanced short-term memory performance. We provide the first evidence for cerebral white matter integrity as one neurobiological mechanism explaining the beneficial influence of aerobic fitness on cognitive performance in older adults.

Download or read book APA Handbook of Dementia written by Glenn E. Smith and published by APA Handbooks in Psychology(r). This book was released on 2018 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: The APA Handbook of Dementia addresses assessment, comorbidity, evaluation, and treatment of various forms of dementia. The handbook reviews common dementias including Alzheimer's disease, Lewy body disease, vascular dementia, frontotemporal dementia, and other less common dementias. It is organized into sections discussing diagnosis, epidemiology, and neurobiology (including neuropathology and neuroimaging); assessment, including cultural issues, methodology, and neuropsychology; and primary, secondary, and tertiary intervention strategies. The handbook is intended as a resource for all psychologists and other health professionals that serve persons and families impacted by neurodegenerative disease.

Download or read book Diffusion Tensor Imaging written by Wim Van Hecke and published by Springer. This book was released on 2015-12-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field of DTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians and clinicians.

Download or read book Active Living Cognitive Functioning and Aging written by Leonard W. Poon and published by Human Kinetics. This book was released on 2006 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first title in a new series, this is an essential resource designed to introduce key issues and to raise consciousness among researchers, students and policy makers of the importance of an active lifestyle for the mind as a person ages.

Download or read book Physical Activity and the Aging Brain written by Ronald Ross Watson and published by Academic Press. This book was released on 2016-12-15 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning. This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer’s disease and age-related cognitive decline. The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process. Presents research scientists with a complete understanding of the role of exercise in healthy brain aging Considers the roles of nutrition, the mind-body connection, and other lifestyle factors Presents a major resource for exercise and physical activity in the neurological health of older adults Provides a synopsis of key ideas associated with the many aspects of physical activity, along with lifestyle factors that can modify neurological diseases and age-related neurological decline

Download or read book Cognitive Aging written by Denise Park and published by Psychology Press. This book was released on 2012-12-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our society ages, the topic of cognitive aging is becoming increasingly important. This volume provides an accessible overview of how the cognitive system changes as a function of normal aging. Building on the successful first edition, this volume provide an even more comprehensive coverage of the major issues affecting memory, attention, language, speech and other aspects of cognitive functioning. The essential chapters from the first edition have been thoroughly revised and updated and new chapters have been introduced which draw in neuroscience studies and more applied topics. In addition, contributors were encouraged to ensure their chapters are accessible to students studying the topic for the first time. This therefore makes the volume appealing as a textbook on senior undergraduate and graduate courses.

Download or read book Educating the Student Body written by Committee on Physical Activity and Physical Education in the School Environment and published by National Academies Press. This book was released on 2013-11-13 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical inactivity is a key determinant of health across the lifespan. A lack of activity increases the risk of heart disease, colon and breast cancer, diabetes mellitus, hypertension, osteoporosis, anxiety and depression and others diseases. Emerging literature has suggested that in terms of mortality, the global population health burden of physical inactivity approaches that of cigarette smoking. The prevalence and substantial disease risk associated with physical inactivity has been described as a pandemic. The prevalence, health impact, and evidence of changeability all have resulted in calls for action to increase physical activity across the lifespan. In response to the need to find ways to make physical activity a health priority for youth, the Institute of Medicine's Committee on Physical Activity and Physical Education in the School Environment was formed. Its purpose was to review the current status of physical activity and physical education in the school environment, including before, during, and after school, and examine the influences of physical activity and physical education on the short and long term physical, cognitive and brain, and psychosocial health and development of children and adolescents. Educating the Student Body makes recommendations about approaches for strengthening and improving programs and policies for physical activity and physical education in the school environment. This report lays out a set of guiding principles to guide its work on these tasks. These included: recognizing the benefits of instilling life-long physical activity habits in children; the value of using systems thinking in improving physical activity and physical education in the school environment; the recognition of current disparities in opportunities and the need to achieve equity in physical activity and physical education; the importance of considering all types of school environments; the need to take into consideration the diversity of students as recommendations are developed. This report will be of interest to local and national policymakers, school officials, teachers, and the education community, researchers, professional organizations, and parents interested in physical activity, physical education, and health for school-aged children and adolescents.

Download or read book Physical Activity and Health in the Elderly written by Alexandrina Lobo and published by Bentham Science Publishers. This book was released on 2010-12-30 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Physical inactivity is not only an individual's personal problem but is identified as a serious public health issue. Prolonged inactivity that occurs among many elderly persons tends to lead into a gradual decrease in all components of physical fitness, t"

Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

Download or read book Exercise and Its Mediating Effects on Cognition written by Waneen Wyrick Spirduso and published by Human Kinetics. This book was released on 2007 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title seeks to expand on reader's understanding by examining whether and how physical activity could indirectly affect cognitive function by influencing mediators that provide physical and mental resources for cognition.

Download or read book The Effects of Physical Activity and Exercise on Cerebral White Matter Integrity in Health and Chronic Pain written by Stephanie Marie Van Riper and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: To examine the interactions among physical activity, pain, and white matter integrity in both healthy women and Gulf War Veterans (GVs) with chronic musculoskeletal pain (CMP). Methods: Two studies were conducted. Study one involved healthy women (ages 25-40) who reported either greater than 300 minutes per week of moderate-vigorous physical activity (MVPA) - designated as high active (HA)) or less than 30 minutes of MVPA, designated as low active (LA). Physical activity was further measured using a self-report interview and accelerometry. Pain modulation was tested using exercise-induced hypoalgesia (EIH) and cardiorespiratory fitness was measured using maximal cycle ergometry. White matter integrity was measured using diffusion tensor imaging (DTI). Study two was a randomized controlled trial of 16-weeks of resistance exercise training (RET) or wait-list control in GVs with CMP. RET involved 10 exercises for whole-body training, was individually tailored, and progressed slowly to avoid symptom exacerbation. Strength, symptoms of pain and fatigue, physical activity (accelerometer), and white matter integrity (DTI) were measured at baseline and weeks 6, 11, and 17 of the trial. Data for both studies were analyzed using effect sizes (Hedges g) and linear mixed effects models (repeated measures and regressions). Results: For study one, HA women showed higher (p≤0.05) white matter integrity in the corpus callosum. Negative associations (p≤0.05) between white matter integrity and sedentary behavior occurred for the entire sample. In addition, differential relationships (Group-by-pain modulation interaction, p≤0.05) between pain modulation and white matter integrity were found for the HA and LA group - characterized by stronger relationships between white matter integrity and pain modulation in the LA group. For study two, 16-weeks of RET was found to be safe (no adverse events), improved strength (19%-46%), and did not worsen symptoms or decrease extra-intervention physical activity (p≥0.05). No effects (p≥0.05) of RET on white matter integrity were found. Conclusions: These studies suggest that physical activity is more strongly associated with white matter health than acute changes in strength (i.e., 16-weeks of RET), and that low levels of physical activity may be a risk factor for poor pain regulation (i.e., EIH) and thus chronic pain.

Download or read book Physical Activity Self Regulation and Executive Control Across the Lifespan written by Sean P. Mullen and published by Frontiers Media SA. This book was released on 2016-02-05 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is overwhelming evidence linking increased physical activity with positive changes in cognitive functioning and brain health. Much of what we know about these interrelationships comes from aerobic exercise training studies with older adults and children. This literature has paved the way for the neuroscientific investigation of mechanisms responsible for exercise-induced cognitive and brain health enhancement, a list that ranges from molecular changes to systemic changes in executive control and neural connectivity. A new perspective has also emerged that aims to understand executive control processes that may underlie the regulation of health behavior. In accordance with this view, physical activity falls under the umbrella of health behaviors that require a substantial amount of executive control. Executive control is a limited resource, and the aging process depletes this resource. People who regularly exercise are said to have higher “self-regulatory control”—planning, goal-shielding and impulse control—than irregular exercisers. The successful maintenance of physical activity participation in lieu of daily cognitive stressors likely reflects an adaptive resistance to control failures. Indeed, a handful of studies have shown the relationship between greater executive control and subsequently higher levels of physical activity. However, little is known about the neural correlates of physical activity adherence or sedentary behavior, with the view that neurocognitive factors have an antecedent and reciprocal influence on these behaviors. No research has focused on the brain networks responsible for the self-regulation of physical activity, which likely overlaps with structures and functions playing critical roles in the regulation of other health behaviors. Interdisciplinary investigations are needed to explain the extent to which physical activity self-regulation and self-regulatory failure is dependent upon, or under the influence of executive control processes and brain networks. Understanding the degree to which self-regulatory resources may be enhanced, restored, and trained will have enormous implications for basic science and applied fields. It is also of great import to understand whether or not physical activity self-regulation is a domain-specific behavior associated with specific brain networks, or to determine the extent to which regulatory network-sharing occurs. The aim of this Frontiers Research Topic is to curate contributions from researchers in social and cognitive neurosciences and related fields, whose work involves the study of physical activity behavior, self-regulation and executive control. For this Research Topic, we, therefore, solicit reviews, original research articles, and opinion papers, which draw theoretical or empirical connections related to sustained physical activity behavior, self-regulatory strategies, cognitive performance, and brain structure and function. While focusing on work in the neurosciences, this Research Topic also welcomes contributions in the form of behavioral studies, psychophysiological investigations, and methodological innovations. This Frontiers Research Topic will carve out new directions for the fields of exercise, cognitive, and social neurosciences. We hope you will consider submitting your work.