Download or read book The Identification of Novel Variant Surface Antigens of Plasmodium Falciparum written by Amanda Kathleen Lukens and published by . This book was released on 2011 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Novel Proteins on the Surface of Plasmodium Falciparum Infected Erythrocytes written by Weidong Zhu and published by . This book was released on 2004 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterisation of Plasmodium Falciparum Variant Surface Antigens Expressed by Parasites Causing Severe Malaria in Children written by Pamela A. Magistrado and published by . This book was released on 2005 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterization of MB2 written by Thanh Viet Nguyen and published by . This book was released on 2001 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book The Malaria Genome Projects written by Irwin W. Sherman and published by World Scientific. This book was released on 2012 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Project came into being, the people who created it, and the cadre of scientists who are attempting to see the promise of the Project realized. The promise was: a more complete understanding of the genes of the parasite (and its vector) would provide a rational basis for the development of antimalarial drugs and vaccines, allow a better understanding of the regulation of the complex life cycle in the red blood and liver cells of the human, identify the genes the parasite uses to thwart the host immune response and the ways in which the parasite evades cure by drug treatments, as well as leading to more effective measures of control transmission. The hope was that cracking the genetic code of Plasmodium and Anopheles would reveal the biochemical Achilles heel of the parasite and its vector, leading to the development of novel drugs and better methods of control, and by finding the targets of protective immunity could result in the manufacture of effective vaccines. Through a historic approach, this book will allow for those new to the field, or those with insufficient background in the sciences, to have an easier entry point. Even scientists already working in the field may better appreciate how discoveries made in the past can impact the direction of future research.
Download or read book Antibodies to Variant Surface Antigens of Plasmodium Falciparum and Protection from Malaria in an Area of Low and Seasonal Transmission written by Trine Staalsø and published by . This book was released on 2001 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clonally Variant Non coding RNA Family and Its Role in Plasmodium Falciparum Antigenic Variation written by Anna Barcons Simon and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antigenic variation is an immune evasion mechanism used by the malaria parasite Plasmodium falciparum to establish prolonged infection. It prevents parasite clearance by switching the display of variant surface antigens encoded by the 60-member var gene family. Blood stage parasites express var genes in a mutually exclusive manner, with a single var active at a given time, ensuring that the immune system remains naive to a parasite sub-population. Despite multiple factors known to be involved in default var gene silencing, such as histone modifications and nuclear architecture, a specific activation factor has not been identified yet. In this thesis work, a polymerase III-transcribed family of GC-rich ncRNA was explored as a candidate regulatory factor of var gene activation. The GC-rich ncRNA family consists of 15 homologous members positioned adjacent to chromosome-central var genes. RNA FISH analysis revealed that the GC-rich ncRNA is targeted to the var expression site in trans. Overexpression of one GC-rich ncRNA member overrules singular var expression and induces transcription of a specific subset of var genes. We developed a dead Cas9 system aiming to target transcription of all GC-rich members. Strikingly, transcriptional blocking of all GC-rich members by CRISPR interference results in down-regulation of var transcription to background levels. Our data support a role of this ncRNA in the activation process of var genes. Moreover, we show that the GC-rich ncRNA gene family is clonally variant, indicating that this may determine switch rate and switch order of the var gene family. We developed a robust ChIRP (chromatin isolation by RNA purification) protocol that allowed us to identify potential chromatin binding regions and interacting partners of this ncRNA family. The validation of several promising candidate proteins obtained my mass spectrometry is ongoing. Furthermore, we investigated whether the gene loci of these ncRNAs display long-range interactions using a chromosome conformation capture technique. We obtained evidence that the gene loci of these ncRNAs display long-range interactions between them and can thus play a role in nuclear spatial foci organization. This study provides the first functional link between Pol III and Pol II transcription in the process of mutually exclusive expression of virulence genes. Moreover, exploring this ncRNA is a key step in unveiling the process of immune evasion and pathogenesis of P. falciparum.
Download or read book Novel Approaches for the Characterisation of Plasmodium Variant Surface Antigens written by Lisa Sharling and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Approaches for the Characterisation of Plasmodium Variant Surface Antigens written by Lisa Sharling and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Patterns of Antibody Acquisition to the Major Variant Surface Antigen of Plasmodium Falciparum written by Sofonias Kifle Tessema and published by . This book was released on 2016 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book World Malaria Report 2019 written by World Health Organization and published by . This book was released on 2019-08-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programs and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination, and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal infant and child health the "High Burden to High Impact" approach as well as biological threats to the fight against malaria. The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders
Download or read book Malaria written by Irwin W. Sherman and published by Amer Society for Microbiology. This book was released on 1998-01 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every 30 seconds a death is caused by Malaria. This book brings together recent advances in our understanding of the basic biology, genetics and pathogenesis of malaria, to facilitate the rapid generation of new insights and interventions. Each chapter is written by a leading expert(s), and serves as both a useful introduction to the area and a helpful set of references. Malaria: Parasite Biology, Pathogenesis and Protection is a useful entry point for graduate and medical students, scientists and individuals engaged in a subspecialty of Malaria research, as well as those who are simply interested in getting a grasp on the present status of this ever burgeoning public health problem.
Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.
