Download or read book The Genetics of Susceptibility to Johne s Disease in Dairy Cattle written by Michael G. Gonda and published by . This book was released on 2006 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Johne s Disease written by AR Milner and published by CSIRO PUBLISHING. This book was released on 1989 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Johne's disease (paratuberculosis) afflicts cattle worldwide and causes significant economic losses. It is also prevalent in goats and sheep and has been implicated in Johne's disease in humans. The book is divided into six sections covering all aspects of the prevalence, management, diagnosis, control and research on Johne's disease. ]ohne's disease is an international animal health problem, and is of particular importance in the southern States of Australia, especially in the major dairy areas of Victoria where approximately 10% of dairy herds are infected.
Download or read book Diversity and Evolution of the Bovine and Equine Toll Like Receptor Gene Family written by Colleen Ann Fisher and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes modulating innate immunity in mammals are generally considered the first line of defense with respect to invading pathogens and therefore it has become important to characterize naturally occurring genetic variation, and subsequently determine whether this variation is likely to be benign, beneficial, or detrimental to the host. Relevant to this study, the mammalian Toll-like receptor proteins (TLR), encoded by members of the TLR gene family, have the capacity to recognize a wide variety of pathogen ligands, and mutations within these genes have been shown to influence disease susceptibility or resistance within mammalian species. Two studies which sought to determine the frequency and distribution of naturally occurring genetic variation within the bovine and equine TLR genes revealed a large number of discrete point mutations, which were subsequently used to reconstruct haplotypes for each investigated gene across a large number of samples. Detailed analyses of haplotypes provided evidence for extensive haplotype sharing among specialized breeds, subspecies, and even divergent species. Classical and new tests of selection provided evidence for significant deviations from a strictly neutral model of molecular evolution for both cattle as well as equids, with some of the same TLR genes deviating from a strictly neutral model among divergent species. As a first step toward determining whether naturally occurring bovine TLR variation is likely to be benign, beneficial, or detrimental, we tested validated variation from bovine TLR genes capable of recognizing components of Mycobacteria for associations with Mycobacterium avium subspecies paratuberculosis (MAP) infection in dairy cattle, and found several SNPs that were nominally associated with disease status, thereby providing evidence for small-effect loci potentially influencing risk for differential susceptibility to Johne's disease. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/148065
Download or read book Unraveling the Genetics of Bovine Johne s Disease written by Chris P. Verschoor and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Johne's disease is a chronic, granulomatous enteritis of ruminants and some wild-type species that is caused by infection with Mycobacterium avium spp. paratuberculosis (MAP). This inflammatory bowel disease (IBD) is characterised by a lengthy yet variable asymptomatic subclinical phase in which infected animals can transmit MAP to their progeny and herd mates. This is followed by a clinical phase characterised by chronic diarrhoea, wasting, and eventually death. The impact of Johne's disease is particularly evident in the dairy and beef industries, where significant losses due to reduced productivity and fertility, mortality, and premature culling have been reported. This book addresses the genetics of this condition and its possible treatments.
Download or read book Control Strategies for Johne s Disease in Dairy Cattle written by Roxanne Bee Pillars and published by . This book was released on 2008 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Chromosomal Regions Associated with Infectious Diseases in Cattle written by Ricardo Zanella and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification of genetic markers involved with susceptibility or tolerance to infectious disease may offer a new approach to select for animals that are healthier and more productive animals.
Download or read book Johne s Disease in Dairy Cattle written by Sanjay Mallikarjunappa and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Johne's disease (JD) is a severe production limiting disease in cattle caused by Mycobacterium avium susbp. paratuberculosis (MAP) infection. Issues associated with currently available JD diagnostic methods have prompted evaluation of new diagnostic techniques. While the genetic basis of MAP infection status is supported via identification of various candidate genes and single nucleotide polymorphisms (SNPs), their validation prior to inclusion in a selective breeding program for JD resistance is essential. The purposes of this thesis was to evaluate salivary mRNA biomarkers as a potential MAP exposure diagnostic tool, identify new SNPs and also validate previously reported JD SNPs, and validate the functional relevance of the candidate gene IL10RA using a gene edited IL10RA knockout (KO) mammary epithelial cell line (MAC-T cells). RNA-seq transcriptome profile analysis of mandibular and parotid salivary glands revealed differences in expression of some immunoregulatory and anti-microbial genes between MAP-exposed and control unchallenged cattle. Subject to their validation, the identified expressed genes could serve as potential salivary biomarkers of MAP exposure. Fine mapping of previously identified JD quantitative trait loci by our lab, by imputation to high density (HD) SNP genotypes, enabled identification of new SNPs associated with MAP infection status. Follow-up validation of previously reported JD SNPs was also undertaken by testing their association with sire estimated breeding value (EBV) for milk ELISA test scores. A total of 498 sires grouped as high or low EBV group were genotyped using a custom SNP panel comprised of 155 JD SNPs, and 5 of these SNPs were confirmed for their association with JD. Functional relevance of a JD candidate gene was investigated by creation of IL10RA KO MAC-T cells using CRISPR/cas9 gene editing approach. Stimulation of IL10RA KO cells with immunostimulants like MAP lysate+/- IL10, revealed the regulatory role of IL10RA through its ligand IL-10 during MAP lysate stimulation. The findings of this thesis have addressed some of the knowledge-gaps specific to JD diagnosis and control. They provide a future framework for validation of salivary biomarkers, validation of JD SNPs using different JD phenotypes, and characterizing the functional importance of other JD candidate genes by gene editing approach.
Download or read book Johne s Disease paratuberculosis written by Leonard Russell Stephens and published by . This book was released on 1986 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Breeding for Disease Resistance in Farm Animals written by Stephen C. Bishop and published by CABI. This book was released on 2010 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing principles associated with breeding animals for enhanced health and resistance to specific diseases, this book provides a review of the field illustrated with examples covering many diseases of importance to livestock production, across all major livestock species. Authored by experts in the field, this updated edition covers techniques and approaches, viruses, TSEs, bacteria, parasites, vectors, and broader health issues seen in production systems, including metabolic diseases. The book will be an essential reference for professionals in the field, scientists and researchers, students, breeders, veterinarians, agricultural advisors and policy makers.
Download or read book Textbook of Rabbit Medicine E Book written by Molly Varga and published by Elsevier Health Sciences. This book was released on 2013-08-19 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Rabbit Medicine second edition is the completely revised and updated new edition of Frances Harcourt Brown’s acclaimed text covering all aspects of rabbit medicine. While the authoritative and evidence-based approach that made the original book so successful has been retained, in this new second edition well-known rabbit expert Molly Varga adds a stronger clinical focus that makes the Textbook invaluable as a point-of-care resource as well as a respected reference. With many additional features introduced for this update, the Textbook of Rabbit Medicine second edition remains the definitive and comprehensive reference of choice for all veterinary practitioners seeking information on the pet rabbit. Comprehensive, in-depth and authoritative coverage of the health and diseases of the domestic rabbit Detailed and explicit line artwork provides a clear understanding of physiological processes A practical, evidence-based resource for the effective treatment of pet rabbits. Entire text reviewed and updated by a leading expert, with major revision of therapeutics, anaesthesia, abscesses and neurology chapters. New clinical emphasis with clinical tips boxes throughout the text increase its practical focus Ancillary website presents clips of key procedures, an image library and podcasts Completely redesigned with more user-friendly text layout and full colour throughout. Many more illustrations specially commissioned for this edition
Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
Download or read book Paratuberculosis written by Marcel A. Behr and published by CABI. This book was released on 2020-09-24 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paratuberculosis, also referred to as Johne's disease, affects principally cattle, goats, sheep, buffalo, deer and other ruminants. It is common worldwide and responsible for significant economic losses in the ruminant livestock industries. A timely follow up to the first book on Paratuberculosis, this new edition is still the only comprehensive text providing both historical context and the latest developments in the field. Examining the epidemiology of paratuberculosis, the organism that causes the disease, and practical aspects of its diagnosis and control, it also addresses the link between paratuberculosis in the food chain and human health implications, including Crohn's disease.
Download or read book Diagnosis and Control of Johne s Disease written by National Research Council and published by National Academies Press. This book was released on 2003-08-13 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Johne's Disease is a chronic, progressive intestinal disease caused by infection with Mycobacterium avium subspecies paratuberculosis (Map) that affects primarily ruminant animals. In recent decades there has been growing concern over the lack of effective control of this disease and questions have arisen regarding the possibility that Map infection could be a cause of some cases of Crohn's disease in humans. This report presents a broad outline of the steps that should be taken to control Johne's disease, reduce the spread of Map, and minimize effects of the disease in animals. The report also describes the weaknesses of our current research agenda and provides recommendations for a new research strategy to resolve the question of whether there is a link between Johne's and Crohn's diseases.
Download or read book Bovine Medicine written by Anthony H. Andrews and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine Medicine provides practical and comprehensive information oncattle disease and production and is a key reference for all largeanimal vets. Since the first edition was published in 1991 therehave been significant improvements in disease control andmanagement of cattle. Almost all parts of the book have beenupdated and completely rewritten. There are new chapters onsurgery, embryo transfer, artificial insemination, ethno-veterinarymedicine and biosecurity, and a new consolidating chapter on theinteraction between the animal, environment, management anddisease. The previous edition has sold all over the world, and as aresult of this a greater emphasis has been placed on conditions andtheir treatment in areas other than temperate regions. A newsection entitled "Global Variation in Cattle Practice" has beenincluded with contributors discussing bovine medicine practice intheir part of the world. All in all this is an outstanding resource for any practisingvet and an excellent reference for veterinary students.
Download or read book Advances in the Diagnosis and Control of Johne s Disease written by Marta Alonso-Hearn and published by Frontiers Media SA. This book was released on 2021-12-01 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Llama and Alpaca Care E Book written by Chris Cebra and published by Elsevier Health Sciences. This book was released on 2014-02-15 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for the mixed practice large animal veterinarian, veterinary students, and camelid caretakers alike, Llama and Alpaca Care covers all major body systems, herd health, physical examination, nutrition, reproduction, surgery, anesthesia, and multisystem diseases of llamas and alpacas. Written by world-renowned camelid specialists and experts in the field, this comprehensive and uniquely global text offers quick access to the most current knowledge in this area. With coverage ranging from basic maintenance such as restraint and handling to more complex topics including anesthesia and surgery, this text provides the full range of knowledge required for the management of llamas and alpacas. "..an essential text for anyone working with South American camelids." Reviewed by Claire E. Whitehead on behalf of Veterinary Record, July 2015 Over 500 full-color images provide detailed, highly illustrated coverage of all major body systems, physical examination, nutrition, anesthesia, fluid therapy, multisystem diseases, and surgical disorders. World-renowned camelid experts and specialists in the field each bring a specific area of expertise for a uniquely global text. Comprehensive herd health content includes handling techniques, vaccinations, biosecurity, and protecting the herd from predators. Coverage of anesthesia and analgesia includes the latest information on pharmacokinetics of anesthetic drugs, chemical restraint, injectable and inhalation anesthesia, neuroanesthesia, and pain management. Reproduction section contains information on breeding management, lactation, infertility, and embryo transfer. Nutrition information offers detailed nutritional requirements and discusses feeding management systems and feeding behavior.
Download or read book Across borderlines written by Florence Brewer Boeckel and published by . This book was released on 1926 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
