Download or read book Hans Krebs The formation of a scientific life 1900 1933 written by Frederic Lawrence Holmes and published by Oxford University Press, USA. This book was released on 1991 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biography of one of the world's foremost biochemists, which traces his scientific career and his discoveries of the urea cycle and the citric acid cycle. The text makes use of five years of interviews with Hans Krebs, and a complete set of Krebs' key laboratory notebooks.

Download or read book The Formation of a Scientific Life 1900 1933 written by Frederic Lawrence Holmes and published by . This book was released on 1991 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hans Krebs written by Frederic Lawrence Holmes and published by . This book was released on 1991 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Molecular Vision of Life written by Lily E. Kay and published by Oxford University Press, USA. This book was released on 1993 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating study examines the rise of American molecular biology to disciplinary dominance, focusing on the period between 1930 and the elucidation of DNA structure in the mid 1950s. Research undertaken during this period, with its focus on genetic structure and function, endowed scientists with then unprecedented power over life. By viewing the new biology as both a scientific and cultural enterprise, Lily E. Kay shows that the growth of molecular biology was a result of systematic efforts by key scientists and their sponsors to direct the development of biological research toward a shared vision of science and society. She analyzes the motivations and mechanisms empowering this vision by focusing on two key institutions: Caltech and its sponsor, the Rockefeller Foundation. Her study explores a number of vital, sometimes controversial topics, among them the role of private power centers in shaping scientific agenda, and the political dimensions of "pure" research. It also advances a sobering argument: the cognitive and social groundwork for genetic engineering and human genome projects was laid by the American architects of molecular biology during these early decades of the project. This book will be of interest to molecular biologists, historians, sociologists, and the general reader alike.

Download or read book Investigative Pathways written by Frederic Lawrence Holmes and published by Yale University Press. This book was released on 2004-02-09 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.

Download or read book The First Miracle Drugs written by John E. Lesch and published by . This book was released on 2007 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.

Download or read book Geographies of City Science written by Tanya O'Sullivan and published by University of Pittsburgh Press. This book was released on 2019-10-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dublin at the turn of the twentieth century was both the second city of the British Empire and the soon-to-be capital of an emerging nation, presenting a unique space in which to examine the past relationship between science and the city. Drawing on both geography and biography, Geographies of City Science underscores the crucial role urban spaces played in the production of scientific knowledge. Each chapter explores the lives of two practitioners from one of the main religious and political traditions in Dublin (either Protestant and Unionist or Catholic and Nationalist). As Tanya O’Sullivan argues, any variation in their engagement with science had far less to do with their affiliations than with their “life spaces”—domains where human agency and social structures collide. Focusing on nineteenth-century debates on the origins of the universe as well as the origins of form, humans, and language, O’Sullivan explores the numerous ways in which scientific meaning relating to origin theories was established and mobilized in the city. By foregrounding Dublin, her book complements more recent attempts to enrich the historiography of metropolitan science by examining its provenance in less well-known urban centers.

Download or read book Hans Krebs written by Frederic Lawrence Holmes and published by Oxford University Press. This book was released on 1993-05-20 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.

Download or read book Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-19 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Download or read book Companion to Science in the Twentieth Century written by John Krige and published by Taylor & Francis. This book was released on 2003 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work on science in the 20th century represents work in America, Europe and Asia. It includes such topics as the countries that have made the most significant contributions, the relationship between science and industry and the importance of instrumentation.

Download or read book Companion Encyclopedia of Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-05 with total page 979 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Download or read book A History of Biology written by Michel Morange and published by Princeton University Press. This book was released on 2023-08-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive history of the biological sciences from antiquity to the modern era This book presents a global history of the biological sciences from ancient times to today, providing needed perspective on the development of biological thought while shedding light on the field's upheavals and key breakthroughs through the ages. Michel Morange brings to life the dynamic interplay of science, society, and biology’s many subdisciplines, enabling readers to better appreciate the interdisciplinary exchanges that have shaped the field over the centuries. Each chapter of this incisive book focuses on a specific period in the history of biology, describing the major transformations that occurred, the enduring scientific concerns behind these changes, and the implications of yesterday's science for today's. Morange covers everything from the first cell theory to the origins of the concept of ecosystems, and offers perspectives on areas that are often neglected by historians of biology, such as ecology, ethology, and plant biology. Along the way, he highlights the contributions of technology, the important role of hypothesis and experimentation, and the cultural contexts in which some of the most breathtaking discoveries in biology were made. Unrivaled in scope and written by a world-renowned historian of science, A History of Biology is an ideal introduction for students and experts alike, and essential reading for anyone seeking to understand the present state of biological knowledge.

Download or read book A Cognitive Historical Approach to Creativity written by Subrata Dasgupta and published by Routledge. This book was released on 2019-03-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the heart of creativity is the practice of bringing something new into existence, whether it be a material object or abstract idea, thereby making history and enriching the creative tradition. A Cognitive Historical Approach to Creativity explores the idea that creativity is both a cognitive phenomenon and a historical process. Blending insights and theories of cognitive science with the skills, mentality and investigative tools of the historian, this book considers diverse issues including: the role of the unconscious in creativity, the creative process, creating history with a new object or idea, and the relationship between creators and consumers. Drawing on a plethora of real-life examples from the eighteenth century through to the present day, and from distinct fields including the arts, literature, science and engineering, Subrata Dasgupta emphasizes historicity as a fundamental feature of creativity. Providing a unified, integrative, interdisciplinary treatment of cognitive history and its application to understanding and explaining creativity in its multiple domains, A Cognitive Historical Approach to Creativity is essential reading for all researchers of creativity.

Download or read book Explaining Photosynthesis written by Kärin Nickelsen and published by Springer. This book was released on 2015-06-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recounting the compelling story of a scientific discovery that took more than a century to complete, this trail-blazing monograph focuses on methodological issues and is the first to delve into this subject. This book charts how the biochemical and biophysical mechanisms of photosynthesis were teased out by succeeding generations of scientists, and the author highlights the reconstruction of the heuristics of modelling the mechanism—analyzed at both individual and collective levels. Photosynthesis makes for an instructive example. The first tentative ideas were developed by organic chemists around 1840, while by 1960 an elaborate proposal at a molecular level, for both light and dark reactions, was established. The latter is still assumed to be basically correct today. The author makes a persuasive case for a historically informed philosophy of science, especially regarding methodology, and advocates a history of science whose narrative deploys philosophical approaches and categories. She shows how scientists’ attempts to formulate, justify, modify, confirm or criticize their models are best interpreted as series of coordinated research actions, dependent on a network of super- and subordinated epistemic goals, and guided by recurrent heuristic strategies. With dedicated chapters on key figures such as Otto Warburg, who borrowed epistemic fundamentals from other disciplines to facilitate his own work on photosynthesis, and on more general topics relating to the development of the field after Warburg, this new work is both a philosophical reflection on the nature of scientific enquiry and a detailed history of the processes behind one of science’s most important discoveries.

Download or read book A Cultural History of Chemistry in the Modern Age written by Peter J. T. Morris and published by Bloomsbury Publishing. This book was released on 2023-12-14 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Cultural History of Chemistry in the Modern Age covers the period from 1914 to the present. The impact of chemistry and the chemical industry on science, war, society, and the economy has made this era the “Chemical Age”. Having prospered in the West, chemical science spread across the globe and slowly became more diversified in terms of its ethnic and gendered mix. After flourishing for sixty years, the chemical industry was impacted by the Oil Crisis of the 1970s and became almost invisible in the West. While the industry has clearly delivered many benefits to society-such as new materials and better drugs-it has been excoriated by critics for its impact on the environment. The 6 volume set of the Cultural History of Chemistry presents the first comprehensive history from the Bronze Age to today, covering all forms and aspects of chemistry and its ever-changing social context. The themes covered in each volume are theory and concepts; practice and experiment; laboratories and technology; culture and science; society and environment; trade and industry; learning and institutions; art and representation. Peter J. T. Morris is Honorary Research Associate at the Science Museum, London, and at University College London, UK Volume 6 in the Cultural History of Chemistry set. General Editors: Peter J. T. Morris, University College London, UK, and Alan Rocke, Case Western Reserve University, USA.

Download or read book Perspectives on Chemical Biography in the 21st Century written by Isabel Malaquias and published by Cambridge Scholars Publishing. This book was released on 2019-01-14 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overlooked, even despised by historians of chemistry for many years, the genre of biography has enjoyed a revival since the beginning of this century. The key to its renaissance is the use of the biographical form to provide a contextual analysis of important themes in contrast to the uncritical, almost hagiographic, lives of chemists written in the earlier part of the twentieth century. Bringing together the contributions of scholars active in several different countries, Perspectives on Chemical Biography in the 21st Century leads the reader through emerging questions around sources, and the generic problems faced by authors of biographies, before moving on to discuss aspects more related with physical, theoretical and inorganic chemistry, and facets of 19th century chemistry. In contrast to the letters and diaries of earlier chemists, we are now faced with scientists who communicate by telephone and email, and compose their documents on computers. Are we facing a modern equivalent of the destruction of the Library of Alexandria where all our sources are wiped out electronically?

Download or read book Chemical Structure Spatial Arrangement written by Peter J. Ramberg and published by Routledge. This book was released on 2017-05-15 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a comprehensive narrative of the early history of stereochemistry, Dr Ramberg explores the reasons for and the consequences of the fundamental change in the meaning of chemical formulas with the emergence of stereochemistry during the last quarter of the nineteenth century. As yet relatively unexplored by historians, the development of stereochemistry - the study of the three-dimensional properties of molecules - provides a superb case study for exploring the meaning and purpose of chemical formulas, as it entailed a significant change in the meaning of chemical formulas from the purely chemical conception of 'structure' to the physico-chemical conception of molecules provided by the tetrahedral carbon atom. This study is the first to treat the emergence of the unique visual language of organic chemistry between 1830 and 1874 to place in context the near simultaneous proposal of the tetrahedral carbon atom by J.H. van 't Hoff and J.A. Le Bel in 1874. Dr Ramberg then examines the research programs in stereochemistry by Johannes Wislicenus, Arthur Hantzsch, Victor Meyer, Carl Bischoff, Emil Fischer and Alfred Werner, showing how the emergence of stereochemistry was a logical continuation of established research traditions in chemistry. In so doing, he also illustrates the novel and controversial characteristics of stereochemical ideas, especially the unprecedented use of mechanistic and dynamic principles in chemical explanation.