Download or read book The First Miracle Drugs written by John E. Lesch and published by . This book was released on 2007 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
Download or read book The Demon Under the Microscope written by Thomas Hager and published by Crown. This book was released on 2006-09-19 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.
Download or read book Miracle Medicines written by Robert L. Shook and published by Penguin. This book was released on 2007-03-01 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: It’s the business of saving lives. Miracle Medicines goes behind the scenes of the pharmaceutical industry and into the high-security laboratories to tell the stories of the men and women---chemists, physiologists, medical and clinical researchers, engineers---who have chosen to toil for years in the lab in order to transform scientific theories into new lifesaving medicines. You’ll witness the day-to-day labors, victories and defeats of the dedicated professionals who are waging a war against the diseases that still plague mankind. From the confines of their laboratories, these pharmaceutical adventurers explore unknown territories in health and science. Miracle Medicines reveals what really happens during the long and uncertain journey that each new drug and its creators must endure from theory, to research, to testing and, finally, FDA approval and delivery to the public. It’s a very human story within the context of fascinating scientific innovation. Through first hand interviews you’ll also meet the patients who benefit from these manmade miracles and learn how, within their bloodstreams, an ongoing battle is raging. The drugs profiled are: Advair: GlaxoSmithKline’s revolutionary asthma medication, the first packaged as both a control and emergency drug. Gleevec: The Novartis’ chronic myeloid leukemia treatment born from decades of medical research in a field of study that was once considered hopeless. Humalog: Eli Lilly’s reinvention of insulin to control diabetes has been described as being better than nature Lipitor: Pfizer’s miracle antidote for high cholesterol that was nearly lost to the pharmaceutical vaults and has since become the world’s top-selling medicine. Norvir: Abbott’s contribution to the fight against HIV that nearly erases all traces of the disease from the bloodstream and prolongs the life of patients. Remicade: Created for the treatment of Crohn’s disease, rheumatoid arthritis and other Immune Mediated Inflammatory Diseases, Johnson & Johnson’s revolutionary biomedicine was developed from technology that once was only found in science fiction. Seroquel: AstraZeneca’s treatment for both schizophrenia and bipolar mania that has given millions of psychiatrics a new lease on life. This compelling and truth-revealing book will forever change the way you view the medicines in your medicine cabinet, and the people who create them.
Download or read book Miracle Cure written by William Rosen and published by Penguin. This book was released on 2017-05-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.
Download or read book The Mold in Dr Florey s Coat written by Eric Lax and published by Macmillan. This book was released on 2005-02 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eric Lax's The Mold in Dr. Florey's Coat is the dramatic, untold story of the discovery of the first wonder drug, the men who led the way, and how it changed the modern world
Download or read book Aspirin written by Diarmuid Jeffreys and published by Chemical Heritage Foundation. This book was released on 2008-12 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fast-paced, medical-historical mystery, filled with twists and turns.-Chicago Tribune
Download or read book Ten Drugs written by Thomas Hager and published by Abrams. This book was released on 2019-03-05 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: “The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History
Download or read book Breakthrough written by Thea Cooper and published by Macmillan + ORM. This book was released on 2010-09-14 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: An “inspirational” account of how a young girl plight’s “launched a boon for diabetics the world over . . . A remarkable story . . . worthy reading” (Booklist). It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of America’s most-distinguished jurist and politician, Charles Evans HugheAs, has been diagnosed with juvenile diabetes. It is essentially a death sentence. The only accepted form of treatment—starvation—whittles her down to forty-five pounds of skin and bones. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases—a miracle soon marred by scientific jealousy, intense business competition and fistfights. In a race against time and a ravaging disease, Elizabeth becomes one of the first diabetics to receive insulin injections—all while its discoverers and a little known pharmaceutical company struggle to make it available to the rest of the world. Relive the heartwarming true story of the discovery of insulin as it’s never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others. “[A] fascinating tale of Nobel Prize–winning research. . . . This book is an important read for anyone with diabetes. It is an enjoyable read for those who love mystery and human drama.” —Kenneth T. Jackson, Barzun Professor of History, Columbia University
Download or read book Penicillin written by Robert Bud and published by OUP Oxford. This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author sets the discovery and use of penicillin in the broader context of social and cultural changes across the world. He examines the drug's contributions to medicine and agriculture, and investigates the global spread of resistant bacteria as antibiotic use continues to rise.
Download or read book The Antibiotic Paradox written by Stuart B. Levy and published by Springer. This book was released on 2013-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of antibiotics heralded medicine's triumph over previously fatal diseases that once destroyed entire civilizations - thus earning their reputation as miracle drugs. But today, the terrifying reality of antibiotic-resistant bacteria resulting from our widespread misuse of antibiotics forewarns us that the miracle may be coming to an end. The seemingly innocent consumer who demands antibiotics to treat nonbacterial diseases such as the common cold or plays doctor by saving old prescriptions for later use is paving the way for a future of antibiotic failure. "What harm can it do?" is a popular refrain of people worldwide as they pop another antibiotic pill. Dr. Stuart Levy - the leading international expert on hazards of antibiotic misuse - reveals how this cavalier and naive attitude about the power of antibiotics can have deadly consequences. He explains that we are presently witnessing a massive evolutionary change in bacteria. This build-up of new antibiotic-resistant bacteria in individuals and the environment worldwide is an insidious and silent process. Thus, unwittingly consumers encounter resistant bacteria in their meat, poultry, fish, and vegetables. Unregulated dispensing of antibiotics in poorer countries breeds countless more resistant strains. Since bacteria recognize no geographical boundaries, resistant forms can travel the globe. If this trend continues to grow unchecked, we may someday find that all of our antibiotics are obsolete. Today doctors can no longer expect that their first choice of antibiotic for women's urinary tract infections or children's ear infections will work. Similarly, cancer therapy is rendered useless if patients are unable to fight infections that are sometimes resistant to eight to ten different drugs. In developing countries, people are now dying of previously treatable diseases that are no longer responsive to traditional antibiotics. These problems are just a harbinger of what will come if we do not act now. Dr. Levy, recognized by The New Yorker for his superb contributions to this field, is sending out an urgent message that the world cannot afford to ignore any longer. The goal of this unprecedented investigation into the dangers of antibiotic misuse is to protect the world community from resistant infections and ensure the success of antibiotics for generations to come
Download or read book Magic Cancer Bullet written by Daniel Vasella, M.D. and published by Harper Collins. This book was released on 2003-06-03 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: History of the breakthrough of the cancer pill "Gleevec."
Download or read book Wonder Drug written by Stephen Trzeciak, M.D. and published by St. Martin's Essentials. This book was released on 2022-06-21 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pair of doctors team up to illuminate, through neuroscience and captivating stories from their clinical practice, how serving others—and pitching in to the world in general—is a secret superpower. If a doctor’s prescription could bring you: - Longer life - Better health - More energy and resilience - Less burnout, depression and anxiety - More happiness, fulfillment and well-being - More personal and professional success (including higher income) - And, no harmful side effects Would you take it? In Wonder Drug, physician scientists Stephen Trzeciak, M.D., and Anthony Mazzarelli, M.D., illuminate, through neuroscience and captivating stories from their clinical practices, how being a giving, other-focused person is a secret superpower. Serving others—and pitching in to the world in general—is the evidence-based way to live your life. Kinder people not only live longer, they also live better. Science shows that serving others is not just the right thing to do, it’s also the smart thing to do. Wonder Drug will make you rethink your notions of “self-care” and “me time,” and realize that focusing on others is a potent antidote to the weariness that so many of us feel in modern times. Getting outside of your own head, outside the swirl of self-concern that may dominate your mental chatter, is, ironically, one of the best things you can do for yourself. Building upon their earlier work showing that, in the context of healthcare, having more compassion for patients is a powerful way to not only achieve better patient outcomes, but also promote well-being, resilience and resistance to burnout among healthcare workers, Trzeciak and Mazzarelli now extend their research to uncover how the power of serving others reaches far beyond the medical world and can be a life-changing therapy for everyone. Wonder Drug relates to the varying meanings of giving in real people’s daily lives. The stories in this book will convince and inspire you to make simple prism changes. You don’t need a total life upheaval, just a purposeful shift in mindset. In fact, the crucial first piece of the evidence-based prescription is this: start small. Per science, the best way to well-being and finding your true fulfillment is this: scan your orbit for the people around you in need of help, and go fill that need, as often as you can.
Download or read book The Exercise Cure written by Jordan Metzl and published by Rodale. This book was released on 2013-12-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: What if there were a drug to treat every illness, across all body systems, proven potent against heart disease, depression, arthritis, PMS and erectile dysfunction—even in chronic diseases such as asthma, dementia, and certain types of cancer? What if it had no side effects, was completely free, readily available, and worked for everyone? Every single person who took it decreased her risk of premature death and raised his quality of life. Would you want it? In a healthcare system that spends 17% of GDP, roughly $2.7 trillion, mostly on disease treatment, how do we save money and prevent illness? By increasing the use of the world's most effective preventive medicine: exercise. Jordan D. Metzl, MD, explains how everyone can maximize their daily dose in his groundbreaking new book, The Exercise Cure. In The Exercise Cure, Dr. Metzl—nationally renowned sports medicine physician—offers malady-specific and well-researched exercise prescriptions to help readers stay healthy, heal disease, drop pounds, increase longevity, and transform their lives. Today's medical system is largely focused on fixing rather than preventing problems, and many treatments carry significant side effects. Cholesterol-lowering drugs are linked to frequent muscle and joint problems, anti-hypertensive drugs like Beta-blockers cause headaches and diminished energy, and Prozac and other popular anti-depressant medications carry multiple consequences including sexual dysfunction. Dr. Metzl knows that exercise is inexpensive, powerful medicine that has benefits in prevention and treatment of disease without disturbing side effects. Even in older adults, daily exercise has been found to prevent dementia by generating neuron development in the hippocampus, the memory center of the brain. Combining the latest data and his proven motivational skills, Dr. Metzl addresses the common maladies troubling millions. He discusses our cardiovascular, pulmonary, metabolic, musculoskeletal, neurologic, reproductive, and endocrinologic body systems, with special sections on sleep problems and cancer prevention, presenting the science behind the role of exercise as medicine. Then, he details fun, fat-torching, life-prolonging workouts that can be tailored easily to any fitness level, beginner to advanced, and provides nutritional information, including meal plans for healthy eating and disease prevention, as well.
Download or read book Your Own Perfect Medicine written by Martha Christy and published by Delivery Minds. This book was released on 2019-12-18 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's the most astounding proven natural cure that medical science has ever discovered - yet none of the incredible research findings on this incomparable natural medicine I've ever been revealed to the public! Now, for the first time ever, learn to use this simple method and read about the startling and amazing medical cures that prestigious researchers and doctors themselves have witnessed in clinical use of this inexpensive, incredibly effective, yet virtually unknown natural medicine.
Download or read book The Immortal Life of Henrietta Lacks written by Rebecca Skloot and published by Crown. This book was released on 2010-02-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.
Download or read book Studies in the History of Modern Pharmacology and Drug Therapy written by John Parascandola and published by Taylor & Francis. This book was released on 2023-04-21 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: An acknowledged expert on the history of modern pharmacology and drug therapy, John Parascandola here brings together 19 of his most important papers on these subjects. The book is divided into three topical sections. In the first group of articles, devoted to pharmacological theory, Dr. Parascandola sheds new light on our understanding of the history of such key pharmacological concepts as receptor theory, structure-activity relationships, and the role of stereochemistry in physiological action. The second section focuses on the discipline of pharmacology and offers insights into the pivotal role played by John J. Abel in the shaping of the field, the development of pharmacology in schools of pharmacy and in the Federal Government, and the national pharmacological society's membership ban on pharmacologists working in industry. The final section on drug therapy discusses various drugs from antibiotics to sulfones, and their use in the treatment of diseases such as leprosy and syphilis.
Download or read book Shooting Up written by Łukasz Kamieński and published by Oxford University Press. This book was released on 2016 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacologically enhanced militaries -- Alcohol -- From pre-modern times to the end of the Second World War -- Pre-modern times: opium, hashish, mushrooms and coca -- Napoleon in Egypt and the adventures of Europeans with hashish -- The Opium Wars -- The American Civil War, opium, morphine and the "soldiers' disease"--The colonial wars and the terrifying "barbarians"--coca to cocaine: the First World War -- The Second World War -- The Cold War -- From the Korean War to the war over mind control -- In search of wonderful new techniques and weapons -- Vietnam: the first true pharmacological war -- The Red Army in Afghanistan and the problem of drug addiction -- Towards the present -- Contemporary irregular armies empowered by drugs -- Intoxicated child soldiers -- Drugs in the contemporary American Armed Forces -- Conclusion -- Epilogue: war as a drug
