Download or read book The Extracellular Environment in Controlling Neuronal Migration During Neocortical Development written by Yuki Hirota and published by Frontiers Media SA. This book was released on 2021-06-30 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Neuronal Migration during Corticogenesis written by Chiaki Ohtaka-Maruyama and published by Frontiers Media SA. This book was released on 2016-07-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Download or read book Mouse Brain Development written by Andre M. Goffinet and published by Springer Science & Business Media. This book was released on 2012-08-10 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Download or read book The Reeler Mouse as a Model of Brain Development written by Catherine Lambert de Rouvroit and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.
Download or read book Hippocampal Development written by S. J. Pleasure and published by S. Karger AG (Switzerland). This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampal formation plays a critical role in navigation and memory under normal conditions. In pathologies such as Alzheimer's disease and epilepsy, the hippocampus represents one of the first brain regions to suffer damage. When hippocampal development is abnormal, pathological conditions featuring cognitive dysfunction and seizures are common, particularly in children. This publication summarizes new data and relevant findings to a critical understanding of hippocampal development - from anatomy to physiology and from rodents to human. It provides original articles on developmental pathology and on the ongoing role of developmental signaling systems in adults. Broadly, the topics include processes involved in the development of normal or abnormal hippocampus and pathological implications associated with normal or abnormal development, and neurogenesis in an immature or adult hippocampus. Presenting a wide-ranging collection of contributions on hippocampal development, this issue will be of great value for neurobiologists, neurologists, psychiatrists and pediatricians.
Download or read book Macromolecular Protein Complexes II Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-01-14 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book The Neocortex written by Wolf Singer and published by MIT Press. This book was released on 2019-10-29 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts review the latest research on the neocortex and consider potential directions for future research. Over the past decade, technological advances have dramatically increased information on the structural and functional organization of the brain, especially the cerebral cortex. This explosion of data has radically expanded our ability to characterize neural circuits and intervene at increasingly higher resolutions, but it is unclear how this has informed our understanding of underlying mechanisms and processes. In search of a conceptual framework to guide future research, leading researchers address in this volume the evolution and ontogenetic development of cortical structures, the cortical connectome, and functional properties of neuronal circuits and populations. They explore what constitutes “uniquely human” mental capacities and whether neural solutions and computations can be shared across species or repurposed for potentially uniquely human capacities. Contributors Danielle S. Bassett, Randy M. Bruno, Elizabeth A. Buffalo, Michael E. Coulter, Hermann Cuntz, Stanislas Dehaene, James J. DiCarlo, Pascal Fries, Karl J. Friston, Asif A. Ghazanfar, Anne-Lise Giraud, Joshua I. Gold, Scott T. Grafton, Jennifer M. Groh, Elizabeth A. Grove, Saskia Haegens, Kenneth D. Harris, Kristen M. Harris, Nicholas G. Hatsopoulos, Tarik F. Haydar, Takao K. Hensch, Wieland B. Huttner, Matthias Kaschube, Gilles Laurent, David A. Leopold, Johannes Leugering, Belen Lorente-Galdos, Jason N. MacLean, David A. McCormick, Lucia Melloni, Anish Mitra, Zoltán Molnár, Sydney K. Muchnik, Pascal Nieters, Marcel Oberlaender, Bijan Pesaran, Christopher I. Petkov, Gordon Pipa, David Poeppel, Marcus E. Raichle, Pasko Rakic, John H. Reynolds, Ryan V. Raut, John L. Rubenstein, Andrew B. Schwartz, Terrence J. Sejnowski, Nenad Sestan, Debra L. Silver, Wolf Singer, Peter L. Strick, Michael P. Stryker, Mriganka Sur, Mary Elizabeth Sutherland, Maria Antonietta Tosches, William A. Tyler, Martin Vinck, Christopher A. Walsh, Perry Zurn
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Download or read book Reelin Glycoprotein written by S.H. Fatemi and published by Springer Science & Business Media. This book was released on 2008-06-04 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Download or read book Adult Neurogenesis written by Gerd Kempermann and published by Oxford University Press, USA. This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience-the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Download or read book Neural Transplantation CNS Neuronal Injury and Regeneration written by Joe Marwah and published by CRC Press. This book was released on 1994-02-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Download or read book Basic Electrophysiological Methods written by Ellen Covey and published by Oxford University Press. This book was released on 2015-02-25 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Electrophysiological Methods provides a concise and easy-to-read guide on a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with neuroscientific techniques. Intended for students, postdocs, and faculty with a basic neuroscience background, this text will not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Instead, each chapter provides a conscientious overview of the underlying theory -- a comprehensive description of equipment, materials, methods, data management, and analysis -- a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as strictly a DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.
Download or read book Developmental Psychopathology Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.
Download or read book Comparative Vertebrate Neuroanatomy written by Ann B. Butler and published by John Wiley & Sons. This book was released on 2005-09-02 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative Vertebrate Neuroanatomy Evolution and Adaptation Second Edition Ann B. Butler and William Hodos The Second Edition of this landmark text presents a broad survey of comparative vertebrate neuroanatomy at the introductory level, representing a unique contribution to the field of evolutionary neurobiology. It has been extensively revised and updated, with substantially improved figures and diagrams that are used generously throughout the text. Through analysis of the variation in brain structure and function between major groups of vertebrates, readers can gain insight into the evolutionary history of the nervous system. The text is divided into three sections: * Introduction to evolution and variation, including a survey of cell structure, embryological development, and anatomical organization of the central nervous system; phylogeny and diversity of brain structures; and an overview of various theories of brain evolution * Systematic, comprehensive survey of comparative neuroanatomy across all major groups of vertebrates * Overview of vertebrate brain evolution, which integrates the complete text, highlights diversity and common themes, broadens perspective by a comparison with brain structure and evolution of invertebrate brains, and considers recent data and theories of the evolutionary origin of the brain in the earliest vertebrates, including a recently proposed model of the origin of the brain in the earliest vertebrates that has received strong support from newly discovered fossil evidence Ample material drawn from the latest research has been integrated into the text and highlighted in special feature boxes, including recent views on homology, cranial nerve organization and evolution, the relatively large and elaborate brains of birds in correlation with their complex cognitive abilities, and the current debate on forebrain evolution across reptiles, birds, and mammals. Comparative Vertebrate Neuroanatomy is geared to upper-level undergraduate and graduate students in neuroanatomy, but anyone interested in the anatomy of the nervous system and how it corresponds to the way that animals function in the world will find this text fascinating.
