Download or read book The Evolution of Metalloenzymes Metalloproteins and Related Materials written by G. J. Leigh and published by . This book was released on 1977 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evolution of Metalloenzymes Metalloproteins and Related Materials written by G. J. Leigh and published by . This book was released on 1977 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Evolution of Metalloenzymes Metalloproteins and Related Materials written by G. J. Leigh and published by . This book was released on 1977* with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Future Directions in Metalloprotein and Metalloenzyme Research written by Graeme Hanson and published by Springer. This book was released on 2017-08-11 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest developments in metalloenzymes, including characterizing metal bridging in proteins and peptides, copper(II) complexes of marine peptides, high-spin Co(II) in model and metalloprotein systems to enzymes such as the molybdenum-containing enzymes, CW and pulse EPR of cytochrome P450 enzymes and the radical S-adenosylmethionine FeS family. In the previous two related volumes in the Biological Magnetic Resonance series, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine and Metals in Biology:Applications of High-Resolution EPR to Metalloenzymes, topics covered included high-resolution EPR methods, iron proteins, nickel and copper enzymes, metals in medicine, iron–sulfur cluster-containing proteins, and molybdenum enzymes. In this volume, new developments in these areas are covered in detail and new areas that have emerged are also detailed. This is an ideal book for graduate students and researchers working in the fie lds of high-resolution EPR, metalloenzymes, and metals in biology.
Download or read book Metalloproteins written by P.M. Harrison and published by Springer. This book was released on 1985-06-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology Bulletin of the Academy of Sciences of the USSR written by Akademii͡a nauk SSSR. and published by . This book was released on 1981 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developments and Interactions of the Precambrian Atmosphere Lithosphere and Biosphere written by B. Nagy and published by Elsevier. This book was released on 2000-04-01 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selection of papers from the IGCP Project 157 and 160 meeting at the Univ. Nacional Autonoma de Mexico, 11-14 Jan. 1982
Download or read book Design and Evolution of Metalloenzymes Through Multi scale Approaches written by Crystal Edie Valdez and published by . This book was released on 2015 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural metalloenzymes are often the most proficient catalysts in terms of their activity, selectivity, and ability to operate at mild conditions. However, metalloenzymes are occasionally surprising in their choice of catalytic metals, and in their responses to metal substitution. Indeed, from the isolated standpoint of producing the best catalyst, a chemist designing from first principles would likely choose a different metal. Due to competing evolutionary pressures, many natural enzymes may not have evolved to be ideal catalysts and can be improved for the isolated purpose of catalysis in vitro when the competing factors are removed. To improve and, in due course, design metalloenzymes, extensive sampling and proper treatment of the electronic structure of the bound metal(s), is required, while seamlessly merging the required techniques to assess energies and entropies, or their changes, for the entire system. Approaching these challenges with a multi-scale approach, the Alexandrova group has developed an accurate and efficient quantum mechanical/molecular mechanics (QM/MM) hybrid dynamics method to model metalloproteins called quantum mechanics/discrete molecular mechanics (QM/DMD). QM/DMD operates through an iterative scheme between QM and MM machineries. DMD is a flavor of molecular dynamics (MD) that approximates the continuous interaction potentials in classical MD with square-well potentials, course-graining the potentials and overall reducing the number of calculations needed. Due to these discretized potentials, DMD is driven by collision events rather than physical forces as in traditional MM and MD. Therefore, the user saves a tremendous amount of time with DMD by solving ballistic equations of motions rather than Newtonian equations of motions. This fast and efficient hybrid dynamics tools has allowed us to investigate various metal-dependent phenomena in natural metalloenzymes such as: 1) exploring Nature's curious choices for specific metals using two amide hydrolases that contain different metals as a case study, 2) examining protein conformational responses to substrate binding and metal replacement as showcased by the role of a flexible loop [beta]-lactamase in binding antibiotic substrates and 3) investigating how the species of the metal dictates the reaction mechanism in a pair acireductone dioxygenases (ARD/ARD'). Extending outside the realm of naturally occurring enzymes, our tools have the ability to span across formidable challenges such as metalloenzyme design, where stabilization of a transition state of the catalyzed reaction in the specific binding pocket around the metal needs to be achieved. QM/DMD was used in the redesign of a well-studied Zn2+ peptidase, carboxypeptidase A (CPA), an enzyme involved in the breakdown of proteins, with a slight preference for bulky hydrophobic groups. More specifically, the enzyme and substrate system were modified to create specific-specific binding and subsequent experiments proved the mutant to be catalytically active. Additionally, another tool called Eris-QM/DMD was formulated to better gauge the effect of mutation on protein structure during the design process. Eris is a stand-alone package that evaluates protein stability upon mutagenesis. Coupling the software to QM/DMD gives us the distinct advantage of accounting for the effect of the metal during protein alternations. With this diverse set of tools, our future ambitious goals are to install catalytically potent non-physiological metals into proteins. While nature is limited to operating with bio-available elements, some metals such as Ir, Pd, Sc, and Rh, which have been shown to be excellent catalysts, even surpassing physiological metals. If the catalytic activity of these non-physiological metals can be combined with the superb selectivity and mild operational conditions characteristic of proteins, new proficient enzymes may emerge. Another advantage to enzymatic catalysis, done either in vitro, or in vivo, is that it can be cheaper, "greener", and more efficient than synthetic catalysis. An early endeavor in this frontier of metalloenzyme design involves installing Pd2+ into an existing protein scaffold, specifically for intramolecular hydroarylation of C-C triple bonds to form coumarins.
Download or read book Amino Acids Peptides and Proteins written by R. C. Sheppard and published by Royal Society of Chemistry. This book was released on 1981 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Download or read book Comprehensive Asymmetric Catalysis written by Eric N. Jacobsen and published by Springer Science & Business Media. This book was released on 2003-09-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first supplement to the three volume reference work "Comprehensive Asymmetric Catalysis" critically reviews new developments to the hottest topics in the field written by recognised experts. Eleven chapters which are already in the major reference work have been supplemented and additionally five new chapters have been included. Thus the state-of-the art in this area is now re-established. Together with the basic three volume book set this supplement is not only the principal reference source for synthetic organic chemists, but also for all scientific researchers who use chiral compounds in their work (for example, in biochemical investigations and molecular medicine) as well as for pharmaceutical chemists and other industrial researchers who prepare chiral compounds.
Download or read book Origin of Life written by Y. Wolman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a record of the 6th International Conference on the Origins of Life and the 3rd Meeting of the International Society for the Study of the Origins of Life. The conference was held under the auspices of the Israel Academy of Sciences and Humanities at Jerusalem from June 22nd to June 27th 1980. A few weeks prior to the conference, Academician Aleksander Ivanovich Oparin passed away. Oparin, the father and founder of the study of the origins of life, proposed over 50 years ago that modern biological molecules had abidogical origins in the past, thus the beginning of life on Earth was preceded by a long period of abiogenic molecular evolution. Oparin was planning to report on his latest work in the opening session of the meeting - "Natural Selection: A Leading Factor in Transition from the Non-Living Matter to Life". This lecture will never be delivered. In Hebrew we say of those who have died "may their memory be bound with the bonds of eternal life". For Aleksander Ivanovich Oparin those words have particular significance, for surely his pioneering work will endure as long as the spirit of scientific enquiry prevails. This meeting was dedicated to the memory of Aleksander Ivanovich Oparin.
Download or read book Advances in Protein Chemistry written by and published by Academic Press. This book was released on 1983-01-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Chemistry
Download or read book Metabolism of Trace Metals in Man Vol I 1984 written by Owen M. Rennert and published by CRC Press. This book was released on 2017-11-22 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: A vast literature exists dealing with trace metals and a number of outstanding monographs deal with the biological, biochemical, or clinical effects of a specific trace metal or trace metals in general. However, newer aspects of trace metal research, i.e. the developmental aspects and generic implications, have not been systematically discussed in any existing texts. The present two volumes will summarize the present status of research in these areas and serve as milestones for future development in these areas of trace metal research.
Download or read book Inorganic Biochemistry written by H A O Hill and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Download or read book Metalloproteins written by Juan C. Fontecilla-Camps and published by Humana Press. This book was released on 2014-03-18 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins are involved in many key biological processes such as gas transport and metabolism, photosynthesis, cell respiration, the Krebs cycle and many other vital redox reactions. Metalloproteins: Methods and Protocols addresses multiple aspects of metalloenzyme research from the production and purification of metalloproteins using both standard recombinant techniques and a cell-free system, to the electrochemical analysis of metalloproteins, as well as IR techniques, Mössbauer spectroscopy and the theoretical interpretation of metalloenzyme catalytic and redox processes, to name a few topics. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Metalloproteins: Methods and Protocols seeks to serve both professionals and novices interested in the metalloprotein field.
Download or read book Chemical Recognition in Biology written by F. Chapeville and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of chemical recognition in biology were initiated about half a century ago with the flrst kinetic data obtained on enzyme catalysis and inhibition. They led to a rather static representation of the recognition process illustrated by the lock and key model that still continues to influence our overall image of recognition and its specificity. In several cases, crystallographic studies of enzyme-substrate complexes have supported this model. Indeed, in a crystallized ligand-enzyme complex, a close fltting is observed between the active center of the enzyme and the functional groups of the ligand. How ever, this does not necessarily result from a direct recognition process between rigid structures, but may result from a progressive adaptation during which the initial struc tures of the enzyme and the ligand are modified (induced-flt mechanism). Recently, a great deal of work has been devoted to the study of recognition in more complex systems such as the replication or the translation machin~ries; clearly, the extraordinary precision of such systems cannot be explained solely in terms of physical matching between enzymes and their substrates. This has led to a noticeable change of perspective in these areas. As a result of the new kinetic viewpoint, one rather focuses on the time-course of the processes, on the kinetic balance between steps of the reaction, on the energy-accuracy relationships and on the strategies which permit the achievement of high precision using relatively error-prone components in an appropriate dynamic interplay.
Download or read book Copper Proteins and Copper Enzymes written by Rene Lontie and published by CRC Press. This book was released on 2018-01-18 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.
