Download or read book The EPA s IRIS Program written by United States. Congress. House. Committee on Science and Technology (2007). Subcommittee on Investigations and Oversight and published by . This book was released on 2008 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of EPA s Integrated Risk Information System IRIS Process written by National Research Council and published by National Academies Press. This book was released on 2014-06-25 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.
Download or read book Health Assessments of Chemicals and Contaminants written by Marcus Rowe and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Environmental Protection Agency (EPA) has not conducted a recent evaluation of demand for Integrated Risk Information System (IRIS) toxicity assessments with input from users inside and outside EPA. The health effects information in IRIS provides fundamental scientific information EPA needs to develop human health risk assessments. Specifically, EPA issued a needs assessment report in 2003, which estimated that 50 new or updated IRIS toxicity assessments were needed each year to meet users' needs. This book determines the extent to which EPA has evaluated demand for IRIS toxicity assessments from users inside and outside EPA; EPA's process for nominating and selecting chemicals for IRIS toxicity assessment and strategies for addressing any unmet agency needs when IRIS toxicity assessments are not available, applicable, or current.
Download or read book EPA s IRIS Program written by United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Investigations and Oversight and published by . This book was released on 2011 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress Toward Transforming the Integrated Risk Information System IRIS Program written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-04-11 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and doseâ€'response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA's National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA's progress toward addressing the past recommendations from the National Academies.
Download or read book Review of EPA s Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-10-31 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. The EPA has been working on its IRIS assessment of inorganic arsenic (iAs) for many years, and recently released its plans for completing it in the Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment. Much of the update was made in response to recommendations in a 2013 report made by the National Academies of Sciences, Engineering, and Medicine. The National Academies recently convened another evaluation of whether the various elements of the IRIS iAs assessment plan are appropriate to synthesize the scientific evidence and quantitate estimates of iAs toxicity. Review of EPA's IRIS Assessment Plan for Inorganic Arsenic explores the EPA's approach to prioritizing health outcomes, EPA's systematic review methods, EPA's consideration of potential health effects from early life exposures, mode-of-action information to inform dose-response analyses, and various approaches to investigate dose-response relationships.
Download or read book The EPA s IRIS Program written by United States and published by . This book was released on 2008-01-01 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of the Environmental Protection Agency s Draft IRIS Assessment of Formaldehyde written by National Research Council and published by National Academies Press. This book was released on 2011-05-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Download or read book Progress Toward Transforming the Integrated Risk Information System IRIS Program written by National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review Advances Made to the IRIS Process and published by . This book was released on 2018 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and dose‒response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report. Since 2014, new leadership of EPA’s National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. Progress Toward Transforming the Integrated Risk Information System Program: A 2018 Evaluation reviews the EPA’s progress toward addressing the past recommendations from the National Academies" -- Publisher's description
Download or read book EPA s IRIS Program written by United States. Congress. House. Committee on Science, Space, and Technology (2011- ). Subcommittee on Investigations and Oversight and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EPA s Iris Program written by United States. Congress and published by Createspace Independent Publishing Platform. This book was released on 2017-12-23 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: EPA's IRIS program : evaluating the science and process behind chemical risk assessment : hearing before the Subcommittee on Investigations and Oversight, Committee on Science, Space, and Technology, House of Representatives, One Hundred Twelfth Congress, first session, Thursday, July 14, 2011.
Download or read book Epa s Iris Program written by United States Congress and published by Createspace Independent Publishing Platform. This book was released on 2017-10-10 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: EPA's IRIS program: evaluating the science and process behind chemical risk assessment : hearing before the Subcommittee on Investigations and Oversight, Committee on Science, Space, and Technology, House of Representatives, One Hundred Twelfth Congress, first session, Thursday, July 14, 2011.
Download or read book The EPA s IRIS Program written by United States. Congress. House. Committee on Science and Technology (2007-2011). Subcommittee on Investigations and Oversight and published by . This book was released on 2008 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EPA s IRIS Program Evaluating the Science and Process Behind Chemical Risk Assessment Serial No 112 30 July 14 2011 112 1 Hearing written by and published by . This book was released on 2012* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of EPA s Integrated Risk Information System IRIS Process written by and published by . This book was released on 2014 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of U S EPA s ORD Staff Handbook for Developing IRIS Assessments written by National Academies of Sciences, Engineering, and Medicine and published by . This book was released on 2022-08-30 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.
Download or read book EPA Chemical Assessments Process Reforms Offer the Potential to Address Key Problems written by John B. Stephenson and published by DIANE Publishing. This book was released on 2009-12 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EPA Integrated Risk Info. System (IRIS) contains EPA's scientific position on the potential human health effects of exposure to more than 540 chemicals. Toxicity assessments in the IRIS database constitute the first two critical steps of the risk assessment process. Thus, IRIS is a critical component of EPA's capacity to support scientifically sound environmental decisions, policies, and regulations. This testimony discusses: (1) the findings from a March 2008 report ¿Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Info. System¿ and related testimonies; and (2) a preliminary evaluation of the revised IRIS assessment process EPA issued on May 21, 2009.
