Download or read book Medicinal Chemistry written by Thomas Nogrady and published by Oxford University Press. This book was released on 2005-08-11 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Download or read book Drug Abuse Handbook written by Jozef Bicerano and published by CRC Press. This book was released on 2006-12-21 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the

Download or read book Forensic and Clinical Applications of Solid Phase Extraction written by Michael J. Telepchak and published by Springer Science & Business Media. This book was released on 2004-04-28 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This complete laboratory reference manual explains the principles behind solid phase extraction (SPE) and provides readily reproducible protocols for solving extraction problems in forensic and clinical chemistry. Numerous actual chromatograms, based on original research and diverse applications, demonstrate the technique and the results that can be achieved. Extensive appendices allow fast access to frequently needed information on reagents, the preparation of solutions and buffers, milliequivalent and millimode calculations, buffers and pKa for SPE, and a complete RapidTrace® technical manual. Each proven protocol is described in step-by-step detail and contains an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and on avoiding known pitfalls.

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Download or read book The Chemistry and Biology of Isoquinoline Alkaloids written by J.D. Phillipson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isoquinolines form one of the largest groups of plant alkaloids and they in clude a number of valuable clinical agents such as codeine, morphine, eme tine and tubocurarine. Research into different aspects of isoquinolines con tinues in profusion, attracting the talents of botanists, chemists, bioche mists, analysts, pharmacists and pharmacologists. Many of these aspects are of an interdisciplinary nature, and in April 1984, The Phytochemical Society of Europe arranged a 3-day symposium on The Chemistry and Bi ology of Isoquinoline Alkaloids in order to provide a forum for scientists of differing disciplines who are united by a common interest in this one class of natural product. Each chapter in this volume is based on a lecture given at this symposium. Attempts have been made to make the aims and objectives, experimental findings and conclusions reached, intelligible to scientists of differing backgrounds. The introductory chapter, which is mainly based on a historical discus sion, stresses that plants containing isoquinolines have proved to be both a boon and a curse to mankind. The Opium Poppy, Papaver somniferum, produces the medicinally used alkaloids morphine, codeine, noscapine and papaverine whilst it also continues to provide drugs of abuse, particularly morphine and its readily prepared O,O-diacetyl derivative, heroin. Numer ous other alkaloids have been isolated from other members of the Papaver acea, and a knowledge of their presence and distribution within the various species has proved a useful adjunct to systematic botanical studies.

Download or read book Introduction to Pharmacology Third Edition written by Mannfred A. Hollinger and published by CRC Press. This book was released on 2002-11-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Introduction to Pharmacology has over recent years become a highly influential text among students wishing to acquire a knowledge of pharmacology without having to refer to the larger, more detailed, traditional pharmacology volumes. This revised and updated second edition contains significant new material to bring the reader up-to-date with the latest practices and principles in pharmacology. Exploring the basic principles in both the therapeutic and toxicological aspects of drug use, the book employs contemporary examples of medication, supplemented with an increased number of accurate and easy-to-interpret figures and diagrams. Additionally, Introduction to Pharmacology presents the important concept of understanding the limitations surrounding the drugs that cure, replace physiological inadequacies, or treat symptoms, and which have led to the system of drug classification. The broad scope of the book also encompasses the role of the FDA, drugs in sport, and the use of animals for drug experimentation. A clear and accessible book, Introduction to Pharmacology builds on the strengths of the first edition and is an invaluable reference for all students interested in this subject.

Download or read book Handbook of Chemical Synonyms and Trade Names written by William Gardner and published by CRC Press. This book was released on 2019-07-23 with total page 1599 pages. Available in PDF, EPUB and Kindle. Book excerpt: To this Eighth Edition of the late Mr William Gardner‘s Chemical Synonyms and trade Names there have been added some 3,300 new entries, principally in the field of plastics, alloys and pharmaceuticals. A number of entries describing products known to the Editors to be no longer commercially available have been deleted, with the principal object of keeping the bulk of the book within reasonable bounds; but it has been possible to add nearly 400 names to the Index of Manufacturers to be found at the end of the book. The sum of these additions and deletions represents a net increase of about 10 per cent, in the scope of this Eighth Edition as compared with its predecessor published in 1971.

Download or read book An Essay on the Effects of Opium Considered as a Poison written by John Awsiter and published by DigiCat. This book was released on 2022-09-16 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: DigiCat Publishing presents to you this special edition of "An Essay on the Effects of Opium. Considered as a Poison" by John Awsiter. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.

Download or read book Organic Chemistry written by Pierre Vogel and published by John Wiley & Sons. This book was released on 2019-10-07 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.

Download or read book Opioid Analgesics written by A.F. Casy and published by Springer Science & Business Media. This book was released on 1986-06-30 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

Download or read book Van Nostrand s Encyclopedia of Chemistry written by Glenn D. Considine and published by Wiley-Interscience. This book was released on 2005-02-03 with total page 1856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists, engineers, and technologists in many fields need a knowledge of chemistry because of the importance of chemistry in diverse technologies. In addition, to "classical" topics of chemistry, the new Encyclopedia covers nanotechnology, fuel cell technology, green chemistry, forensic chemistry, supramolecular chemistry, combinatorial chemistry, materials chemistry, and proteomics. This fifth print edition has been revised and updated, and includes over 200 new articles, as well as 1,300 updated articles.

Download or read book Treating Wood by the Cold soaking Method written by J. Oscar Blew and published by . This book was released on 1961 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book JAYPEE S NURSES DICTIONARY written by U.N. PANDA and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Remington written by Adeboye Adejare and published by Academic Press. This book was released on 2020-11-03 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PCP's Bicentennial Edition Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics. - Contains a comprehensive source of principles of drug discovery and development topics, especially for scientists that are new in the pharmaceutical industry such as those with trainings/degrees in chemistry and engineering - Provides a detailed source for formulation scientists and compounding pharmacists, from produg to excipient issues - Updates this excellent source with the latest information to verify facts and refresh on basics for professionals in the broadly defined pharmaceutical industry

Download or read book Medicine Takers Prescribers and Hoarders written by Karen Dunnell and published by Taylor & Francis. This book was released on 2024-04-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1970s, the consumption of both prescribed and non-prescribed medicines in Britain was increasing. Originally published in 1972, this book takes a look at the medicine takers and the types of medicine they take. It examines the relationship between self-medication and prescription, and describes the frequency and nature of repeat prescribing. The medicines kept in a random sample of households were counted and analysed, and data about the length of time people hoarded medicines is used as a basis for estimating the proportion of prescribed medicines that are wasted. By putting the views and habits of people as patients alongside information from their general practitioners the study illuminates the relationship between patients and doctors. In addition, variations between people in different social classes direct light on the distribution of care and the equity of services at the time

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by Ernst Jucker and published by Birkhäuser. This book was released on 2011-12-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 47 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with inotropic steroids, with chemokines and their involvement in a wide range of inflam matory diseases, with the subclassification and nomenclature of ul- and Uz-adrenoceptors, with Chinese traditional medicine, with drug targets in the molecular pathogenesis of asthma, with cytokines and their therapeutic application in immunosuppression and immunostimulation, with alter native medicine and with the potential use of calcium blockers in psy chiatry. These reviews and the quotations of original articles provide the reader with valuable information on several new developments in the world-wide search for new and better medicines. In 1959, when the Editor started this series of monographs, it was his intention to help disseminate informa tion on the vast and fast growing domain of drug research. Already at that time,it was not possible to follow the major individual publications in this field, and the reader was thereby provided with a tool to keep abreast of the latest developments and trends. This goal remained unchanged over the last 37 years, and I believe that the reviews in PDR are useful to the non-specialist who can obtain an overview of a particular field of drug research in a relatively short time.

Download or read book National Formulary written by and published by . This book was released on 1955 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: