Download or read book The Effects of Ischemia reperfusion Aging on the Inflammatory Response to Skeletal Muscle Injury in Rats written by Ahmed A. Ghaly and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ischemia reperfusion Injury of Skeletal Muscle written by Gary A. Fantini and published by R. G. Landes. This book was released on 1994 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication represents an up-to-date summary of the current understanding of reoxygenation injury in skeletal muscle and outlines future directions of those who will lead the way in this field. Skeletal muscle is generally more tolerant of ischemia reperfusion injury than other organ systems such as brain, heart, kidney, liver and bowel. Current knowledge regarding the pathophysiology of such injury has attracted correspondingly less attention and has been relatively slow to accumulate. This monograph brings together acknowledged leaders who have focused their research efforts on identifying mechanisms of reoxygenation injury in skeletal muscle; the virtual plethora of pathways and cytokines involved in the mediation of cellular injury is attested to by the number and diversity of chapters.
Download or read book Anti inflammatory Treatment Prevents Local and Systemic Effects of Skeletal Muscle Ischemia reperfusion Injury written by Claudia Dührkop-Sisewitsch and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Extracellular Matrix Remodeling and the Inflammatory Response During Skeletal Muscle Regeneration in Sarcopenic Obese Mice written by Lemuel Arthur Brown and published by . This book was released on 2016 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIM: Sarocpenic obesity is a national concern within the United States because this metabolic syndrome is tied with reduced mobility and quality of life. Both obesity and aging are associated with insulin-resistance, chronic low-grade inflammation and muscle weakness. Skeletal muscle regeneration is a process that involves the coordinated effort of myogenic regulatory factors (MRFs), inflammatory signaling, and extracellular matrix (ECM) remodeling for optimal regeneration. It has been demonstrated that obesity and aging have a reduction in muscle regeneration. It has not been examined if sarcopenic obesity will further reduce muscle mass and the regenerative process. The purpose of this study was to determine how sarcopenic obesity alters inflammatory signaling and extracellular remodeling in mouse skeletal muscle. METHODS: One hundred two male C57BL6/J mice (4 weeks old) were randomly assigned to either a high fat diet (HFD, 60% fat) or normal chow. Both young (3 months old) and aged mice (22-24 months old) were injected with either PBS or bupivacaine. Muscles were excised 3 or 21 days after injection. RESULTS: Mean cross-sectional area was reduced by 26% in aged HFD mice. The aged lean mice had 9% greater mean cross-sectional area 21 days following muscle damage but no changes were observed in aged HFD. Aged mice had nearly 2-fold collagen III content than young mice. P-STAT3/STAT3 was reduced by 82% in the aged HFD mice in the TA. NF-mB was 3-5 fold greater in the aged HFD mice compared to the aged lean mice in the gastrocnemius and the TA. There was a main effect of injury to reduce collagen I and III content in aged injured, and a main effect of diet with a decrease of collagen I, collagen III, and MMP-9 gene expression in aged HFD mice 3 days following muscle damage. CONCLUSION: Sarcopenic obese mice have reduced cross-sectional area than aged lean mice along with increased collagen III content and basal alterations in MyoD, ECM proteins, and inflammation gene expression. During skeletal muscle regeneration sarocopenic obese mice had dysregulated inflammatory signaling and reduced ECM gene expression. These data suggest further impairment in the regenerative process in sarcopenic obese mice.
Download or read book The Effect of Age on Skeletal Muscle Metabolism in the Aging Male Fischer 344 Rat written by Lisa Marie Larkin and published by . This book was released on 1992 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Ischemia and Ischemia reperfusion on Sarcoplasmic Reticulum Structure and Function in Rat Skeletal Muscle written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.
Download or read book Mavi s rg n written by and published by . This book was released on 1961 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Ageing and Physical Training on Rat Skeletal Muscle written by Vuokko Kovanen and published by . This book was released on 1989 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Fiber Type on Ischemia reperfusion Injury in Mouse Skeletal Muscle written by Melanie Dee Woitaske and published by . This book was released on 1996 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Aging and Nutrition on Skeletal Muscle Maintenance in Rats written by Jung Han Yoon Park and published by . This book was released on 1982 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Ischemia and Reperfusion on the Local Regulation of Oxygen Consumption Tissue Oxygenation and Blood Supply in Rat Skeletal Muscle written by Sami C. Dodhy and published by . This book was released on 2013 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In resting muscle, blood flow is regulated to meet the demand for O2 by the tissue. A modified ischemia (I)/reperfusion(R) investigation was systematically run and PISFO2, PaO2, Q and VO2 were observed. Twenty-nine spinotrapezius muscles from male Sprague-Dawley rats (284±20 grams) were surgically exteriorized for intravital microscopy to test a model relating blood flow, O2 supply and O2 demand. The model can aid in the understanding of the regulation of tissue PO2. The interstitial PO2 (PISFO2) and perivascular PO2 (PaO2) measurements were made using phosphorescence quenching microscopy (PQM). O2 consumption (VO2) values were obtained with a quasi-continuous, flash-synchronized, pressurized airbag to initiate ischemia and sample the rate of O¬2 change (dPO2/dt). Centerline red blood cell velocity was measured with an Optical Doppler Velocimeter and converted to flow using vessel diameter. 5-, 15-, 30-, 60-, 300- and 600-second ischemic durations were used to observe changes in PISFO2, Q, and VO2. A critical point was observed following 30 seconds of (I) where dPISFO2/dt during recovery was the fastest (4.25±0.72 mmHg/s) and was 1.00±0.16 mmHg/s following 600 seconds. Flow recovery, dQ/dt, peaked to 3.88±0.64 ([micro]l̇·min-1)/s after 60 seconds of (I) but significantly dropped to 2.83±0.55 ([micro]l·min-1)/s following 300 seconds of (I) but increased to 2.92±0.45 ([micro]l·min-1)/s following 600 seconds. This gives evidence to a no-reflow phenomenon occurring in the extended periods of ischemia. A peak in VO¬2 to 309.2±45.0 nl O2/cm3·s with a time course of 160 seconds occurred following 600 seconds of ischemia. As the ischemic duration decreased, the time course and peak VO2 also decreased. VO2 following 300 seconds of (I) was significantly higher than 5-60 seconds of (I) (p
Download or read book Advances in Blood Transfusion Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Blood Transfusion Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Blood Transfusion. The editors have built Advances in Blood Transfusion Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Blood Transfusion in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Blood Transfusion Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Mechanisms of Ischemia reperfusion Tolerance in Rat Skeletal Muscle written by Alison A. Dungey and published by . This book was released on 2003 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Insights into Estrogen Estrogen Receptor Effects in the Cardiac and Skeletal Muscle written by Georgios Kararigas and published by Frontiers Media SA. This book was released on 2020-05-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation in Heart Failure written by Matthijs Blankesteijn and published by Academic Press. This book was released on 2014-12-05 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure's breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. - Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment - Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure - Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure - Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases
