Download or read book The Effects of Environmental Chemicals on the Immune System written by S. G. Winslow and published by . This book was released on 1981 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effects of Environmental Chemicals on the Immune System written by S. G. Winslow and published by . This book was released on 1981 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Influences on the Immune System written by Charlotte Esser and published by Springer. This book was released on 2016-02-04 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together articles on the overarching theme of how the environment shapes the immune system. The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system. Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet. There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.
Download or read book The Secret Life of Chemicals written by Alfred Poulos and published by Springer Nature. This book was released on 2022-01-01 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides extensive information on the chemicals that inhabit our environment, our food, our water and our air and the impact that they may be having on human health. The author is a medical scientist, with training in the law. The book documents current understanding about pesticides in food, the plastics revolution, toxic metals, air, water and electronic waste pollutants, chemical exposure in the workplace, radiation pollutants, chemical exposure and hearing loss, how our bodies deal with chemicals, genetic variability and the risk of disease, the effect of chemicals on genes, mitochondria and the immune system and what we can do about it all. Industrialisation has resulted in many thousands of chemicals, which are being continuously developed and often escaping from where they are used into our human environment, without us really knowing enough about them. In high dosages or with continuous small dosage, the evidence suggests, that many of them could interfere with human health and some of them are known to be doing so. But for the vast majority, we are left wondering whether some could be responsible for some diseases the causes of which are inadequately understood. Every chapter is thoroughly reinforced with several pages of references from the peer-reviewed literature.
Download or read book Environmental Chemical Exposures and Immune System Integrity written by Edward J. Burger and published by . This book was released on 1987 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Sensitivity written by Stephen J. Barrett and published by Prometheus Books. This book was released on 2010-12-31 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical sensitivity (or "multiple chemical sensitivity") describes people with numerous troubling symptoms attributed to environmental factors, from simple housepaint to complex building structures and materials in offices and schools. Many such people are seeking special accommodations, applying for disability benefits, and filing lawsuits claiming that exposure to common foods and chemicals has made them ill. Their efforts are supported by some physicians who refer themselves as clinical ecologists. They use questionable diagnoses and treatment methods, while critics charge that these approaches are bogus and that "chemical sensitivity" is not a valid diagnosis. The complaints associated with chemical sensitivity include depression, irritability, poor memory, fatigue, drowsiness, constipation, sneezing, wheezing, skin rashes, headache, chest pain, pounding heart, swelling, upset stomach, paralysis, AIDS-like illnesses, psychotic experiences, and just about every other symptom noted in medical textbooks. One prominent clinical ecologist even claimed that chemical sensitivity patients may well be human "canaries" on an increasingly poisoned planet, and others have actually labeled chemical sensitivity as a disease. While some people are adversely affected by exposure to some chemicals, there is an overwhelming increase in false claims and reports from misled obsessive patients and opportunistic doctors. Chemical Sensitivity examines this phenomenon in depth and the scientific, legal, ethical, and political issues that surround it. The authors explore the speculations about environmental exposure in the light of scientific knowledge of human physiology, allergy and immunology, pathology, toxicology, and clinical medicine. They evaluate cases of chemical sensitivity relative to controlled tests, and reveal that symptoms were brought on by psychological factors rather than physical ones. Chemical Sensitivity also critically assesses claims related to "sick building syndrome," "mercury-amalgam toxicity," "yeast allergy," and Gulf War syndrome.
Download or read book Environmental Chemicals the Human Microbiome and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-29 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Download or read book Waste Incineration and Public Health written by National Research Council and published by National Academies Press. This book was released on 2000-10-21 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incineration has been used widely for waste disposal, including household, hazardous, and medical wasteâ€"but there is increasing public concern over the benefits of combusting the waste versus the health risk from pollutants emitted during combustion. Waste Incineration and Public Health informs the emerging debate with the most up-to-date information available on incineration, pollution, and human healthâ€"along with expert conclusions and recommendations for further research and improvement of such areas as risk communication. The committee provides details on: Processes involved in incineration and how contaminants are released. Environmental dynamics of contaminants and routes of human exposure. Tools and approaches for assessing possible human health effects. Scientific concerns pertinent to future regulatory actions. The book also examines some of the social, psychological, and economic factors that affect the communities where incineration takes place and addresses the problem of uncertainty and variation in predicting the health effects of incineration processes.
Download or read book Monitoring Human Tissues for Toxic Substances written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Download or read book Immune Dysfunctions and Abrogation of the Inflammatory Response by Environmental Chemicals written by Richard G. Olsen and published by . This book was released on 1982 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past year we have further characterized the immunotoxic effects of 1,1-dimethylhydrazine (UDMH). Evidence has been accumulated which indicates that UDMAH interferes with the regulatory arm of the immune system at low dose or concentration levels. Results from earlier experiments which supported this conclusion included: increased Jerne plaque response in UDMH-treated mice; abrogation of concanabalin A-induced suppressor activity following in vivo or in vitro UDMH exposure; and enhancement of lymphocyte blast transformation (LBT) by UDMH-treated lymphocytes. During the past year we have shown that at least one type of regulatory cell which UDMH appears to inhibit is in the adherent cell population of splenocytes. This is demonstrated by the fact that exposure of adherent cells to UDMH enhanced the mixed lymphocyte reaction (MLR). Preliminary experiments now in progress indicate that the UDMH suppresses prostaglandin E (PGE) production by the adherent splenocyte population, which would explain the effects seen in the MLR, as PGE has been shown by others to inhibit various immune responses, including the MLR. Experiments are currently underway which will evaluate the effects of UDMH on PGE synthesis by various subpopulations of lymphocytes and macrophages, as well as on cyclic nucleotide levels and Ia antigen expression (Ia antigen is a product of the immune responder genes). (Author).
Download or read book Toxicology of the Immune System written by Robert Burrell and published by Wiley. This book was released on 1992-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to increased awareness of the AIDS crisis as well as concern about environmental chemicals, immunotoxicology has quickly become one of the most important and controversial topics in occupational medicine and toxicology. This insightful reference/text clarifies the subject by exploring the basic environmental, occupational, and therapeutic agents that can suppress or strengthen the immune system. The authors provide a necessary bridge between immunology and toxicology to explain the various products and processes that may change immune parameters, affect host resistance to infections and tumors, and alter a system's future reaction to exposure. They assess the damage done not only to the immune system, but also damage by the immune system as a result of altered functioning. Throughout the book, emphasis is placed on the relevance to existing clinical health and possible future adverse effects. Even the more common immunotoxic conditions, such as food and drug intolerance, cigarette smoking, and occupational asthma, are put into perspective, with straightforward information on possible genetic, environmental, and pharmacological risk factors. Detailed sections are included on: Organ systems and target cells most often affected Types of damage and injury resulting from immunotoxic reactions Clinical populations in which immune system damage occurs Methods for investigating the etiology of agents and risk assessment Relevance of laboratory data to human risk Strategies for achieving standard practices to prevent the disparity in results that characterizes many immune system studies Regulatory affairs related to immunotoxicology Laboratory and experimental findings are probed to determine how and to what degree different immunotoxicants have induced clinical disease. Citations of animal research are restricted to those studies that point the way for future human studies, or have direct relevance to human situations. To further the reader’s understanding of xenobiotics, the authors treat the subject of purposeful immunomodulation, achieved by administering immunosuppressive or immunopotentiating drugs. Despite increasing public awareness, there remains an inaccurate perception of what chemicals can and cannot do. This important reference sets the record straight, making it an essential source for toxicologists, immunologists, industrial hygienists, microbiologists, allergists, as well as all professionals in the agricultural and cosmetic industries, and those involved in chemical and biological regulation.
Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.
Download or read book Early life Environmental Exposure and Disease written by Yankai Xia and published by Springer Nature. This book was released on 2020-07-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health.
Download or read book Review of the Environmental Protection Agency s Draft IRIS Assessment of Formaldehyde written by National Research Council and published by National Academies Press. This book was released on 2011-05-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Download or read book Immunotoxicity of Metals and Immunotoxicology written by Anthony Dayan and published by Springer. This book was released on 2012-12-02 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable scientific and political interest has been expressed, parallelling public concern about the effects of chemicals on the immune system and the implications of those effects for health. Coupled with speculation about the magnitude and extent of the problem is discussion of needs for predictive testing and regulatory control measures. The first international seminar on the immunological system as a target for toxic damage was held in Luxembourg in 1984. It was organized by the International Programme on Chemical Safety (United Nations Environment Programme-International Labour Office World Health Organization) and the Commission of the European Communities with the support of the US Environmental Protection Agency and the National Institute of Environmental Health Sciences (USA) and the participation of the International Society of Immunopharmacology. In view of the perceived importance of imrnunotoxicity, it was considered necessary to organize a follow-up meeting. Thus, an international workshop on the immunotoxicity of metals and immuno toxicology was held in Hanover, Federal Republic of Germany, on 6-10 November 1989.
