Download or read book The Development of Temperature and PH Responsive Hydrogels and Membranes for Selective Sorption of Perfluoroorganics and Nanoparticle Integrated Catalytic Degradation of PCB written by Anthony Saad and published by . This book was released on 2020 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Temperature Responsive Hydrogels and Nanoparticles for Advanced Drug Delivery written by Brandon Vaughn Slaughter and published by . This book was released on 2013 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many important therapeutic agents are associated with significant undesired side effects which often limit treatment duration and dosing. Specifically, most major classes of antitumor chemotherapeutics have deleterious effects on cell division and DNA synthesis throughout the body due to systemic biodistribution. Engineering systems for controlled drug delivery allows for improved quality of life during treatment; as well as higher localized therapeutic concentrations by isolating toxic drugs used in many diseases to specific physiological compartments. An important drug delivery strategy for controlled release of therapeutics is based on responsive polymer matrices, which undergo swelling transitions in response to environmental stimuli. Biologically relevant factors which may trigger the release of therapeutics from responsive polymers include pH, ionic strength, and temperature. Temperature responsive polymers integrated into a composite system with metal nanoparticles allow for on demand drug release via an externally-applied optical or magnetic energy source. The intent of this work was to develop a temperature-responsive drug delivery platform for controlled therapeutic release, as well to expand the toolbox for rational design of responsive hydrogel nanoparticles intended for therapeutic delivery. Temperature-responsive hydrogels were synthesized and examined in the form of nanoparticles and bulk polymer networks. These materials are based on interpenetrating polymer networks (IPNs) of polyacrylamide (PAAm) and poly(acrylic acid) (PAA), which exhibit a positive volume swelling response with respect to temperature. Since this system responds to pH, ionic strength, and temperature, these IPNs were characterized over a wide range of solution conditions. Critical synthesis parameters needed to optimize thermal responses for specific solution conditions were identified, as were the specific effects of pH and ionic strength on network swelling and stability. The reverse emulsion process used to synthesize IPN nanoparticles was characterized to determine how particle growth proceeds during preparation. To enhance biocompatibility, IPN nanoparticles were surface-modified with a corona of poly(ethylene glycol) to reduce protein adsorption, a common strategy to improve in vivo performance. Due to the large amounts of surfactants employed in the preparation of IPN nanoparticles, purification methods needed to improve safety of IPN nanoparticles were optimized, and studied in vitro to ensure cellular compatibility.
Download or read book Stimuli responsive and Self healing Nanocomposite Hydrogels Based on Reversible and Dynamic Crosslinks written by Meng Wu and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels, due to their soft and water abundant natures, highly resemble human skins and tissues and thereby have attracted extensive attention in recent years. Functional hydrogels showing responsiveness to various stimuli such as pH, temperature, strain and pressure are promising for a wide range of biomedical and electrical applications. However, traditional hydrogels crosslinked via permanent covalent bonds are generally weak, brittle and lack of functionalities. Incorporation of reversible and dynamic crosslinks into hydrogel networks can effectively improve their mechanical performances, introduce multiple responsiveness, and endow the hydrogels with self-healing capability. On the other hand, introduction of stiff nanomaterials into hydrogel matrix is an effective approach towards strong and functional gel materials. The combination of the nanofillers and appropriate interfacial reversible and dynamic interactions provides a promising method for the fabrication of high-performance multifunctional hydrogels to meet the increasing needs of modern materials. In this thesis, a review on hydrogels based on reversible and dynamic crosslinks, stimuli-responsive and self-healing functions, and nanocomposite hydrogels was presented first followed by three original research projects on developing nanocomposite hydrogels with stimuli sensitivity and self-healing property based on reversible interactions for biomedical and electrical applications. Injectable, self-healing and pH-responsive hydrogels are great intelligent drug delivery vehicles for controlled and localized therapeutic release. Hydrogels that show pH-sensitive behaviors in mildly acidic range are ideal to be used for the treatment of regions showing local acidosis like tumors, wounds and infections. In the first project, we present a facile preparation of an injectable, self-healing and super-sensitive pH-responsive nanocomposite hydrogel based on Schiff base reactions between aldehyde-functionalized polymers and amine-modified silica nanoparticles. The hydrogel shows fast gelation, injectability and rapid self-healing capability. Moreover, the hydrogel demonstrates excellent stability under neutral physiological conditions while a sharp gel-sol transition induced by faintly acidic environment. The pH-responsiveness of the hydrogel is ultra-sensitive, where the mechanical properties, hydrolytic degradation and drug release behaviors can alter significantly when subjected to a slight pH change of 0.2. The novel injectable, self-healing and sensitive pH-responsive hydrogel serves as a promising candidate as localized drug carriers with controlled delivery capability triggered by acidosis, holding great promise for cancer therapy, wound healing and infection treatment. Conductive hydrogels are of great significance for soft electronic devices. In the second project, we have developed a novel hydrogel ionic conductor by integrating nanofiller reinforcement with micelle cross-linking. The hydrogel was facilely prepared via one-pot polymerization of acrylamide and an amino-functionalized monomer in the presence of carbon nanotubes, aldehyde-modified F127 and LiCl. The dynamic chemical and physical interactions of the cross-linked network offers the hydrogel with a wide spectrum of properties, including excellent stretchability, toughness, exceptional elasticity, resistance to damage by sharp materials, self-healing property and high conductivity. In addition, the hydrogel demonstrated cooling-induced whitening optical behavior. When exploited as a strain and pressure sensor to monitor diverse human motions, the prepared hydrogel sensor showed excellent sensitivity and reliability. The hydrogel was further integrated with an eye mask to monitor human sleep and showed high reliability for the detection of rapid eye movement (REM) sleep. This work provides new insights into the fabrication of multifunctional, smart and conductive materials, holding great promise for a broad range of applications like wearable sensors, artificial skins, and soft robotics. In the third project, we have developed an ionic conductive nanocomposite hydrogel with ultra-stretchability and intelligent sensing functions. By leveraging the dynamic feature of multiple intermolecular interactions, polymer/carbon nanotube networks with excellent mechanical performances (i.e., tensile strength, stretchability and toughness up to 1.09 MPa, 4075% and 12.8 MJ/m3, respectively) were achieved. Additionally, the hydrogel is soft, elastic, transparent and self-healing. The rational combination of the mechanical and electrical properties renders the as-prepared hydrogel with excellent sensing performances and cycling stability, and therefore enables it to perform as a sensory unit of a complete platform for the recognition of some complicated human behaviors. Specifically, with the integration of machine learning module, the hydrogel-based platform exhibits great recognition accuracies to human handwriting motions from single letters to words and phrases after proper training. The combination of superior mechanical performances and intelligent sensing functions within this hydrogel-based ionic skin unlocks its potential as the intelligent human-device interface, which promotes the application of artificial intelligence in customized electronic devices.
Download or read book Responsive Membranes and Materials written by D. Bhattacharyya and published by John Wiley & Sons. This book was released on 2013-02-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new multifunctional membranes and materials which respond to external stimuli, such as pH, temperature, light, biochemicals or magnetic or electrical signals, represents new approaches to separations, reactions, or recognitions. With multiple cooperative functions, responsive membranes and materials have applications which range from biopharmaceutical, to drug delivery systems to water treatment. This book covers recent advances in the generation and application of responsive materials and includes: Development and design of responsive membranes and materials Carbon nanotube membranes Tunable separations, reactions and nanoparticle synthesis Responsive membranes for water treatment Pore-filled membranes for drug release Biologically-inspired responsive materials and hydrogels Biomimetic polymer gels Responsive Membranes and Materials provides a cutting-edge resource for researchers and scientists in membrane science and technology, as well as specialists in separations, biomaterials, bionanotechnology, drug delivery, polymers, and functional materials.
Download or read book Rangeland Monitoring written by and published by . This book was released on 1984 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanostructured Materials for Environmental Applications written by Subramanian Balakumar and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses how nanostructured materials play a key role in helping address environmental challenges. Employing nanostructured materials in catalysis can increase the efficient decomposition of toxic pollutants in air, water, and soil. This multidisciplinary book discusses the most promising nanostructured materials made-up of metals, metal oxides, metal chalcogenides, multi-metal oxides, carbon nanostructures, and hybrid materials that can address environmental remediation. It provides a well-referenced introduction to newcomers from allied disciplines and will be valuable to researchers in academia, industry, and government working on solutions to environmental problems. Provides a state-of-the-art review of key concepts of nanostructured materials in environmental science Discusses the most promising nanostructured materials that can assist with environmental remediation Illustrates challenges and opportunities for development, experimental design, methodology, and interpretation of results .
Download or read book Operation of Smart Homes written by Mehdi Rahmani-Andebili and published by Springer Nature. This book was released on 2021-06-15 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest research advancements in the operation of smart homes. It comprises new operation techniques including cooperative distributed energy scheduling, framework to react to malicious cyberattacks, framework for demand-side management, and framework for the design of smart homes to support residents’ wellness as well as new optimization techniques such as stochastic model predictive control and multi-time scale optimization. In addition, the book analyzes 11,000 studies that have been indexed in scientific databases and categorizes them based on various data points, including the field and the subject of the research, the name of the institutions, and the nationality of the authors. Presents new operation techniques of smart homes; Introduces new optimization techniques for operation of smart homes; Analyses 11,000 studies and categorizes them based on different data points.
