Download or read book The Development and Application of Nanoparticles for Cell Tracking and Multimodal Imaging written by Jeanne Elizabeth Lemaster and published by . This book was released on 2019 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell therapy is an emerging tool to treat a variety of conditions from cancer to musculoskeletal disorders to cardiac disease. Current FDA-approved stem cell therapies utilize cells from peripheral blood or bone marrow to treat patients who have disorders of the hematopoietic system; however clinical trials for utilizing stem cells to treat muscular skeletal disorders and cardiac disease are underway. Because stem cells self-renew and differentiate in multiple lineage pathways, the general theory behind stem cell therapy is that damaged tissue can be repaired or regenerated and that trophic activity of stem cells can modulate other immune cells. While stem cell therapy has the potential to treat a variety of conditions due to its regenerative and proliferative activity, more study is needed to address ideal injection time, method of injection, distribution, and retention concerns. Imaging stem cells addresses these concerns and can provide more information overall about the fate of stem cells. Contrast agents are needed to increase the contrast and specificity of imaging stem cells. Nanoparticle-based contrast agents are important tools for imaging because they offer high contrast and stable signal. Chapter 1 of this thesis provides a background on cell therapy and various imaging modalities. Chapter 2 details the design and synthesis of gadolinium-doped synthetic melanin nanoparticles which were used to label stem cells for photoacoustics and magnetic resonance imaging (MRI). Chapter 3 explores the mechanism of ultraviolet (UV)-induced synthetic melanin nanoparticle generation. Chapter 4 describes the design, synthesis, and application of an iron oxide PLGA-based nanoparticle used for ultrasound, photoacoustics, and magnetic particle imaging (MPI). Finally, Chapter 5 describes the synthesis and application of a nanoparticle for cancer treatment that shows an increase in photoacoustic intensity as drug is released. This nanoparticle was then used to treat tumors in mice and luminescence was used to monitor treatment response. Chapter 6 concludes with a perspective on the future of imaging cell therapy with possible directions.

Download or read book Design and Applications of Nanoparticles in Biomedical Imaging written by Jeff W.M. Bulte and published by Springer. This book was released on 2016-11-25 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.

Download or read book Nanoplatform Based Molecular Imaging written by Xiaoyuan Chen and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.

Download or read book Magnetic Particle Imaging written by Tobias Knopp and published by Springer Science & Business Media. This book was released on 2012-05-04 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.

Download or read book Synthesis And Studies of Bimodal Imaging Probes written by V. Priya and published by . This book was released on 2023-03-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an in-depth exploration of the exciting field of bimodal imaging probes; the book covers a broad range of topics related to the synthesis and studies of bimodal imaging probes, including fluorescence, magnetic resonance, and contrast agents. It also delves into molecular imaging, nanotechnology, in vivo and in vitro imaging, optical imaging, PET imaging, CT imaging, MRI imaging, biocompatible nanoparticles, multimodal imaging, quantum dots, gold nanoparticles, surface-enhanced Raman spectroscopy, NIR fluorescence, bioimaging, drug delivery, theranostics, biosensors, cancer imaging, neuroimaging, molecular probes, cell tracking, photoacoustic imaging, ultrasensitive detection, multifunctional imaging agents, inorganic nanoparticles, organic dyes, optical coherence tomography, single photon emission computed tomography, nanoscale imaging, molecular targeting, inorganic-organic hybrid materials, biosignaling, superparamagnetic iron oxide nanoparticles, polymeric nanoparticles, nanorods, nanoshells, and nanocages. The book begins with an introduction to the field of bimodal imaging probes, providing a detailed overview of the various imaging techniques used in this field. It then delves into the synthesis of bimodal imaging probes, discussing the different types of nanoparticles and dyes used, as well as the different strategies for their synthesis. The book also covers the various studies conducted in this field, highlighting the progress made in the development of bimodal imaging probes for different applications, including cancer imaging, drug delivery, and molecular targeting. The book is an essential resource for researchers and students interested in the field of bimodal imaging probes, providing a comprehensive overview of the latest research and techniques. It is written in an accessible style and is suitable for both beginners and experts in the field.

Download or read book Nanomaterials for Regulating Cancer and Stem Cell Fate written by Birju P. Shah and published by . This book was released on 2014 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: The realm of nanomedicine, defined as the applications of nanotechnology for medical purposes such as diagnosis, monitoring and treatment of diseases, has grown exponentially over the past few decades; with several research efforts translating into commercial success stories. Such applications requires the amalgamation of research efforts from different disciplines such as chemistry, biology, physics, engineering and clinical medicine. While the earlier efforts in nanomedicine were focused mainly on improving the properties of the available therapeutics, current research efforts are more geared towards developing novel therapeutics or imaging modalities based on the supramolecular assembly of nanoscale building blocks. There is a plethora of nanoscale platforms that are being developed for clinical uses, including, polymeric nanoparticles, liposomes and micelles, metallic nanostructures, semiconductor quantum dots and silicon oxide nanoparticles. However, there are several obstacles that need to be overcome, prior to the wide-spread clinical applications of these nanoparticles, such as (i) developing well-defined nanoparticles of varying size, morphology and composition to enable various clinical applications; (ii) optimization of the biopharmaceutical properties such as physiological stability, solubility and systemic circulation of the nanoparticle-based therapeutics; (iii) delivery of different kinds of therapeutics without altering their pharmacological effects; (iv) overcome various physiological barriers encountered in order to deliver the therapeutics to the target location; and (v) real-time monitoring of the nano-therapeutics within the human body for tracking their uptake, localization and effect. Hence, this dissertation focuses on developing multimodal nanotechnology-based approaches to overcome the above-mentioned challenges by combining either different nanoparticle compositions or different therapeutic moieties, towards a singular purpose of regulating cancer and stem cell fate, such as proliferation, differentiation and cell death. The initial part of this dissertation describes the synthesis and characterization of well-defined and monodisperse multimodal magnetic core-shell nanoparticles (MCNPs), comprised of a highly magnetic core surrounded by a thin gold shell. As a result of combining two different elements (Fe and Au) within a single nanoplatform, these multimodal core-shell nanoparticles possessed both magnetic and plasmonic properties, which allowed for enhanced therapy and imaging. These nanoparticles were utilized for mainly two applications: (i) Magnetically-facilitated delivery of siRNA and plasmid DNA to neural stem cells for inducing neuronal differentiation and non-invasive imaging and (ii) Combined hyperthermia and targeted delivery of a mitochondria-targeting peptide for enhancing apoptosis in brain and breast cancer cells. The following part of this dissertation presents the synthesis and applications of a multi-functional polymeric delivery platform (known as DexAMs), composed of a dendritic cationic polyamine conjugated to a single beta-cyclodextrin moiety. The DexAM molecule was utilized as a single vehicle to simultaneously deliver two orthogonal therapeutics - anticancer drugs and siRNAs against oncogenes, in a target-specific manner to brain tumor cells. This combined delivery of chemotherapeutics and siRNA targeted the multiple dysregulated pathways in cancer cells and this resulted in a synergistic effect on the apoptosis of brain tumor cells, as compared to the individual treatments. The final part of this thesis presents synthesis of stimuli-responsive fluorescence resonance energy transfer (FRET)-based mesoporous silica nanoparticles for real-time monitoring of drug release in cells. These MSNs were composed of a porous silica support which allowed for drug loading, a stimuli-responsive valve composed of disulfide bonds, and a FRET donor-acceptor pair of coumarin and fluorescein integrated within the disulfide bond. The stimuli-responsive valve was cleaved only in the presence of increased glutathione concentrations found within cancer cells, resulting in change in the FRET signal, thus allowing for real time monitoring of drug release. Taken together, these nanomaterial-based approaches combine therapeutic and imaging modalities within a single nanoplatform and as a result have the potential for regulating cancer and stem cell fate such as proliferation, differentiation and apoptosis as well as allowing for real-time monitoring of these events in a non-invasive manner.

Download or read book The Textbook of Nanoneuroscience and Nanoneurosurgery written by Babak Kateb and published by CRC Press. This book was released on 2013-07-25 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about n

Download or read book Multifunctional Nanoparticles for Drug Delivery Applications written by Sonke Svenson and published by Springer Science & Business Media. This book was released on 2012-02-22 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Download or read book Advances in Nanotechnology Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 8760 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nanotechnology. The editors have built Advances in Nanotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nanotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nanotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Near Infrared Emitting Nanoparticles for Biomedical Applications written by Antonio Benayas and published by Springer Nature. This book was released on 2020-04-13 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for in vivo imaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the “nano” level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes. Assembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications; Explains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications; Presents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.

Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-09-08 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Download or read book Korean Journal of Radiology written by and published by . This book was released on 2009 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fluorescence Methods for Investigation of Living Cells and Microorganisms written by Natalia Grigoryeva and published by BoD – Books on Demand. This book was released on 2020-09 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence methods play a leading role in the investigation of biological objects. They are the only non-destructive methods for investigating living cells and microorganisms in vivo. Using intrinsic and artificial fluorescence methods provides deep insight into mechanisms underlying physiological and biochemical processes. This book covers a wide range of modern methods involved in experimental biology. It illustrates the use of fluorescence microscopy and spectroscopy, confocal laser scanning microscopy, flow cytometry, delayed fluorescence, pulse-amplitude-modulation fluorometry, and fluorescent dye staining protocols. This book provides an overview of practical and theoretical aspects of fluorescence methods and their successful application in the investigation of static and dynamic processes in living cells and microorganisms.

Download or read book Nanoscale Magnetic Materials and Applications written by J. Ping Liu and published by Springer Science & Business Media. This book was released on 2010-04-05 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscale Magnetic Materials and Applications covers exciting new developments in the field of advanced magnetic materials. Readers will find valuable reviews of the current experimental and theoretical work on novel magnetic structures, nanocomposite magnets, spintronic materials, domain structure and domain-wall motion, in addition to nanoparticles and patterned magnetic recording media. Cutting-edge applications in the field are described by leading experts from academic and industrial communities. These include new devices based on domain wall motion, magnetic sensors derived from both giant and tunneling magnetoresistance, thin film devices in micro-electromechanical systems, and nanoparticle applications in biomedicine. In addition to providing an introduction to the advances in magnetic materials and applications at the nanoscale, this volume also presents emerging materials and phenomena, such as magnetocaloric and ferromagnetic shape memory materials, which motivate future development in this exciting field. Nanoscale Magnetic Materials and Applications also features a foreword written by Peter Grünberg, recipient of the 2007 Nobel Prize in Physics.

Download or read book Nanoparticles in Biomedical Imaging written by Jeff W.M. Bulte and published by Springer Science & Business Media. This book was released on 2007-11-22 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.