Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Membrane Protein Assembly written by Gunnar von Heijne and published by R. G. Landes. This book was released on 1997 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book American Doctoral Dissertations written by and published by . This book was released on 1998 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Membrane Permeability 100 Years Since Ernest Overton written by and published by Academic Press. This book was released on 1999-05-21 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia. This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations. - Provides an historical perspective of Overton's contributions to the theory of narcosis - Presents an overview of each permeability mechanism, including active transport, endocytosis, exocytosis, and passive diffusion

Download or read book The Structure of Biological Membranes Third Edition written by Philip L. Yeagle and published by CRC Press. This book was released on 2011-07-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition provides readers with an understanding of membrane structure and function that is rooted in the history of the field and brought to the forefront of current knowledge. The first part of the book focuses on the fundamentals of lipid bilayers and membrane proteins. Three introductory chapters supply those new to the field with the tools and conceptual framework with which to approach the state-of-the-art chapters that follow. The second part of the book presents in-depth analyses of focused subjects within the study of membranes, covering topics that include: Phase behavior of lipid bilayers Lipid bilayers as an isolated structure Cholesterol’s role in cell biology Lateral organization of membranes The role of membrane lipids in initial membrane protein folding Membrane protein synthesis and assembly of oligomeric membrane proteins Membrane protein stability with relationships to function and protein turnover Membrane protein function using a transport protein Interactions between membrane proteins and membrane lipids A final chapter pulls together many of the topics, examining in detail the complexity inherent in the synthesis and assembly of lipids and proteins in mitochondrial membranes. With contributions from leading researchers, this completely revised and updated third edition reflects recent advances in the field of biological membranes. It offers a valuable resource for students, as well as structural biologists, biophysicists, cell biologists, biochemists, and researchers in the pharmaceutical and biotechnology industries. What’s New in This Edition: Three accessible chapters introduce students to the field of biological membranes Completely revised and updated chapters present current topics in membrane research

Download or read book Membrane Structural Biology written by Mary Luckey and published by Cambridge University Press. This book was released on 2014-02-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.

Download or read book Lipid Polymorphism and Membrane Properties written by and published by Academic Press. This book was released on 1997-10-02 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major lipid components of biological membranes can undergo many diverse and fascinating morphological rearrangements. Studies of these diverse phases and the manner in which they are formed tends to alter the properties of ordinary bilayer membranes. This book examines the structural and biological roles of lipids forming non-lamellar structures.Key Features* Characterization of non-lamellar structures * Protein activity and membrane properties* Analysis of membrane fusion* Affect of non-lamellar forming lipids on biological systems

Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2668 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource

Download or read book Octanol Water Partition Coefficients written by James M. Sangster and published by John Wiley & Sons. This book was released on 1997-05-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Verhalten gelöster Stoffe in Octanol-Wasser-Gemischen ähnelt sehr dem im lebenden Gewebe; daher zieht man den Octanol-Wasser-Verteilungskoeffizienten logK(OW) beispielsweise zur Untersuchung des Schicksals organischer Schadstoffe in Umwelt und Nahrungsketten heran. Dieses Buch zeigt, wie man exakte Werte von logK(OW) durch Experimente und Berechnungen erhält und anwendet und führt in verständlicher Weise in physikochemische Grundlagen ein.

Download or read book The Protein Folding Problem written by Donald B Wetlaufer and published by Routledge. This book was released on 2019-06-21 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins in living systems carry out a great variety of specific functions, each of which depends on the precise three-dimensional structure of a particular protein. Proteins are synthesized in the form of a flexible polypeptide chain that is capable of assuming a vast number of configurations; the transformation of this chain into a specific, relatively rigid three-dimensional structure is called folding--a remarkable process of self-organization. It is known that the amino acid sequences of some proteins have sufficient information to determine their three-dimensional structures. There are other proteins whose folding requires additional information beyond that found in the sequence of the mature protein. This book introduces the central problem of folding mechanisms as well as a number of other closely related issues. This book is neither a textbook nor a treatise. Rather, it is an attempt by several investigators to convey the excitement and challenges of those aspects of the folding problem in which they are actively engaged. The contributors give brief introductions to protein folding from the perspectives of molecular architecture, stability and dynamics, phage genetics, DNA exons, general physiology, and natural selection. They point out emerging new directions, including the suggestion of a class of diseases that result from protein folding defects.

Download or read book Membrane Protein Structure written by Stephen H White and published by Springer. This book was released on 2013-05-27 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of receptors, ion channels, and other membrane proteins require a solid understanding of the structural principles of these important biomolecules. Membrane protein structure is, however, a very challenging field. The structures of only three types of transmembrane proteins have been determined to moderate or high resolution during the last two decades, a period during which the amino acid sequences of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of structural models to serve as guides for studies of receptors, channels, and other membrane proteins has become crucially important. This book has been assembled in order to share the experiences and findings of expert researchers in protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemistry, whose work establishes the basis for the development of suitable model structures. The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature. The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches. The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists working on the function of membrane proteins such as receptors, ion channels, and transporters, as well as senior graduate students and independent investigators.

Download or read book Peptide Lipid Interactions written by Sidney A. Simon and published by Academic Press. This book was released on 2002-11-13 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Recent advances in voltage gated sodium channels their pharmacology and related diseases written by Mohamed Chahine and published by Frontiers E-books. This book was released on with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our pleasure to co-edit a Research Topic on voltage-gated sodium channels pharmacology and related diseases. We are in a process to inviting submissions of novel research article, state-of-the-art review papers and viewpoints on this topic. All the papers will follow a peer-review process according to the guidelines of Frontiers in Pharmacology. Voltage-gated sodium channel play a critical role in electrical signalling in many excitable cells such as neurons, skeletal muscle cells and cardiac myocytes. They are responsible for the initiation and the propagation of action potential, allowing integration of higher processes. They are formed by one alpha subunit that forms the pore of the channel and one or several regulatory subunits. Sodium channels are the target for local anaesthetics, antiarrhythmic drugs, and anticonvulsants. This class of ion channels is prime target to several toxins. Recently, a number of mutations in sodium channels that often results in alterations of rapid channel gating have been identified and linked to human diseases. Such channelopathies cause periodic paralysis, myotonia, long QT syndrome and other cardiac conductance disturbances, pain, hemiplegic migraine, and epilepsy. Sodium channels play also a negative role in malignant cellular proliferation, chronic pain, and other diseases. Considering these crucial physiological and pathological implications, it is not surprising that sodium channels have been and still are key targets for drug development. This Research Topic of Frontiers of Pharmacology of Ion Channels and Channelopathies will focus on this important class of ion channels how they operate, their pharmacology and their implication in diseases.

Download or read book Membrane Proteins Structures Interactions and Models written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 25th Jerusalem Symposium represents a most significant highlight in the development and history of these meetings. Living within the decimal system we have celebrated with much pleasure the lath and the 20th Jerusalem Symposia. With this one we experience a feeling of particular satisfaction because 25 years is different from, is more than, two decades and a half. It is a quarter of a century. It seems thus as if we have changed the dimension of our endeavour. In no way do we loose the sense of modesty with respect to the significance of these meetings. For the organizers, however, they do represent a continuity of efforts which we feel happy to have been able to carry out. At this occasion it seems useful to say a few words about the origin of the Jerusalem Symposia and to recall the name of a colleague who played an essential role in their creation and has been a most efficient and devoted co organizer of the seven first of them. This was Professor Ernst Bergmann, one of the most distinguished founders of Israeli Science and a world famous physico-organic chemist.