Download or read book The Death Gene written by George J. Brewer and published by Xlibris Corporation. This book was released on 2002-04-29 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: As most everyone who reads the newspapers these days will be aware, DNA technology and cloning genes (isolating and obtaining the DNA for a specific gene) is on the cutting edge of science. Almost every week a new gene is cloned, its DNA sequence determined, and its function discovered. Discoveries of genes that cause specific diseases, even some cancers (such as breast cancer), are being made on a regular basis. The gene that is discovered in the present story is, at present, fictional. It is a gene that promotes the aging process, and therefore, it promotes death. The flip side of the gene is that if its action is turned off by a new drug, as it is in the story, it stops aging and allows an unlimited life-span. Neither the discovery of such a gene, or its manipulation by a drug, are at all far-fetched. In fact, it can be anticipated that such a gene probably will be discovered sooner or later. This is a story about what happens when such a gene, and a way to turn it off, are discovered. Story Line It all started with something seemingly trivial, the interruption of the usual behavior of the pet mice in Dr. Al Grogans laboratory. A world-class physician-scientist in his mid-fifties, Grogan has been spending long evenings in his lab and office trying to solve a riddle. Why had one of his discoveries, a promising new long-acting contraceptive called DNA-C129, quit working? The unusual squeaks and sounds of protest from the mice interrupted Grogans concentration. The reason the mice are disturbed is obvious. Maria, Grogans new lab assistant, an attractive lady in her late thirties, has disturbed the mice by peering closely at them. Initially disgruntled at the interruption, Grogan nevertheless demonstrates to Maria a trick he had taught the mice. Maria asks about the age of the mice and Grogan says theyre maybe four years old, since they were part of the original DNA-C129 experiments. Maria, who has had considerable experience studying mouse aging, contradicts her boss, saying that mice of this strain simply dont live that long. In human terms, they would be the equivalent of two-hundred years old! Grogan, who now realizes he isnt very well-informed about mouse life-span, tells Maria he was probably mistaken about the age of the mice. But he knows they are really about four years old, and his mind starts churning excitedly about some of the possible effects of DNA-C129, and about the reason it may have stopped working. With this new clue, things begin to snap into place in Grogans mind. DNA-C129 had quit working when he had lost his junior partner, a younger man named Bowdler, who had been carrying out the actual experiments under Grogans general supervision. Bowdler had been killed in an auto accident. Grogan now realizes that DNA-C129 has antiaging properties, and probably owes its long-lasting effects to Bowdler doing an outlaw experiment, namely using an illegal vector (the viral-like particle that delivers the therapy DNA), one that had not been authorized by Grogan. The keys to DNA-C129 effects, including its antiaging effects, no doubt lay not only in its own innate properties, but in the vector Bowdler had used. With Bowdlers death, and with Grogan now using the standard vector, DNA-C129 had lost its properties in Grogans experiments. During the next four months the Grogan lab becomes a beehive of activity as Grogan sets out to test these ideas. As the work goes on, a romance develops between Grogan and Maria. However, Grogan is very secretive about the purpose of the experiments, even with Maria. He works for a modest-sized biotech company, in Madison, Wisconsin, called DNA Unlimited, and he doesnt trust management. He codes all the results, and mixes up the experiments in such a manner that no single technician has a complete picture of the studies and the results. During this time Grogan places regular calls to a former student, and current best friend, Kirk Starge
Download or read book The Death Gene written by Malcolm Rose and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Creative Gene written by Hideo Kojima and published by VIZ Media LLC. This book was released on 2021-10-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since he was a child, Metal Gear Solid and Death Stranding creator Hideo Kojima was a voracious consumer of movies, music, and books. They ignited his passion for stories and storytelling, and the results can be seen in his groundbreaking, iconic video games. Now the head of independent studio Kojima Productions, Kojima’s enthusiasm for entertainment media has never waned. This collection of essays explores some of the inspirations behind one of the titans of the video game industry, and offers an exclusive insight into one of the brightest minds in pop culture. -- VIZ Media
Download or read book Epigenetics written by Joel D. Wallach and published by SelectBooks, Inc.. This book was released on 2014-05 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHAT IS EPIGENETICS? Epigenetics is an emerging field of science that studies alterations in gene expression caused by factors other than changes in the DNA sequence. Epigenetics: The Death of the Genetic Theory of Disease Transmission is the result of decades of research and its findings that could be as critical to our understanding of human health as Pasteur’s research in bacteriology. Dr. Joel “Doc” Wallach has dedicated his life work to identifying connections between certain nutritional deficiencies and a range of maladies, formerly thought to be hereditary, including Cystic Fibrosis and Muscular Dystrophy. This nexus between nutrition and so-called genetic disease has been observed in both humans and primates, and it is the central theme of Epigenetics. To bring us Epigenetics, Wallach has teamed with noted scholars Dr. Ma Lan and Dr. Gerhard N. Schrauzer. Their collective expertise gives this book its far reaching perspective. Epigenetics is of vital importance to anyone who wants real knowledge about how the human body functions, and it provides a path for better health. Epigentics dispels the dogma and misinformation propagated by medical institutions and doctors resistant to change. Epigenetics is the beginning of a new era of well-being on this planet.
Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
Download or read book Population Biology and Evolution written by K. Wöhrmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers presented at a symposium on popula tion biology sponsored by the Deutsche Forschungsgemeinschaft. It was . held at the guest house of the University of Ttibingen at Oberjoch on May 15-19, 1983. Prior to this conference a small group of European biologists had met in Berlin (June 1981) and Pavia (September 1982) to discuss re search problems on the borderline between population genetics and evolutionary ecology. From the contributions and discussions at these meetings it became evident that the unification of approaches to evolutionary problems in population genetics and evolutionary ecology has not yet been suc cessful and requires further efforts. It was the consensus that a larger symposium with international participation would be helpful to con front and discuss the different approaches to population biology in order to assess "where we are now" and "where we should be going. " As a result an organizational committee was formed (F. Christiansen, S. Jayakar, V. Loeschcke, W. Scharloo, and K. W6hrmann) to iden tify topics that seemed, at least to them, to be fruitful in tackling problems in population biology. Consequently, a number of colleagues were asked to participate in the meeting. We have divided this book into chapters corresponding to the eight topics chosen. The volume begins with the relation between genotype and phenotype and is followed by a chapter on quantitative genetics and selection in natural populations.
Download or read book The Family Gene written by Joselin Linder and published by HarperCollins. This book was released on 2017-03-14 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.
Download or read book The Sports Gene written by David Epstein and published by Penguin. This book was released on 2014-04-29 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestseller – with a new afterword about early specialization in youth sports – from the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.
Download or read book Gene Therapy of Cancer written by Stanton L. Gerson and published by Elsevier. This book was released on 2002-04-04 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Provides in-depth description of targeted systems and treatment strategies Explains the underlying cancer biology necessary for understanding a given therapeutic approach Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses Presents translational focus with emphasis on requirements for clinical implementation Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference
Download or read book The Gene written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2016-05-17 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Download or read book Gene written by Stel Pavlou and published by Simon and Schuster. This book was released on 2010-03-04 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detective James North is called upon to deal with a young, mentally unstable man holding a child hostage at New York's Metropolitan Museum of Art. When he arrives, he is disturbed to discover that - although the bad guy is a complete stranger - he's been asking for North by name. The hostage situation goes wrong, and North finds himself injected with a substance that causes hallucinatory nightmares and flashes of memory that are not his own. He begins to hunt through New York for his attacker, a man he feels inexplicably compelled to kill - a man called Gene. As he does so, North unlocks the secret of his past, a past that stretches back over 3000 years. GENE is the story of forgotten Greek warrior Cyclades who fought and died in the Trojan Wars, and was fated by the gods to be reincarnated seven times. Locked in a cycle of battle with the Babylonian Magi Athanatos, Cyclades must once again strive to defeat him and thwart his quest to achieve immortality. Cyclades and Athanatos. North and Gene. But in this incarnation, neither man knows which is which, or why each of them has the instinctive need to kill the other.
Download or read book The Last Chapter written by Gene Amole and published by Big Earth Publishing. This book was released on 2002 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Denver's beloved columnist Gene Amole stunned readers of the Rocky Mountain News in October 2001 when he announced in his column that he was dying. He passed away six months later, just shy of his 79th birthday. This book presents Amole's powerful, poignant, and first-person account of his last days.
Download or read book The Biology of Death written by André Klarsfeld and published by Cornell University Press. This book was released on 2004 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we die? Do all living creatures share this fate? Is the body's slow degradation with the passage of time unavoidable, or can the secrets of longevity be unlocked? Over the past two decades, scientists studying the workings of genes and cells have uncovered some of the clues necessary to solve these mysteries. In this fascinating and accessible book, two neurobiologists share the often-surprising findings from that research, including the possibility that aging and natural death may not be forever a certainty for most living beings. André Klarsfeld and Frédéric Revah discuss in detail the latest scientific findings and views on death and longevity. They challenge many popular assumptions, such as the idea that the death of individual organisms serves to rejuvenate species or that death and sexual reproduction are necessarily linked. Finally, they describe current experimental approaches to postpone natural death in lower organisms as well as in mammals. Are all organisms that survive until late in life condemned to a "natural" death, as a consequence of aging, even if they live in a well-protected, supportive environment? The variability of the adult life span--from a few hours for some insects to more than a millennium for the sequoia and thirteen times that for certain wild berry bushes--challenges the notion that death is unavoidable. Evolutionary theory helps explain why and how some species have achieved biological mechanisms that seemingly allow them to resist time. Death cannot be understood without looking into cells--the essential building blocks of life. Intriguingly, at the level of cells, death is not always an accident; it is often programmed as an indispensable aspect of life, which benefits the organism as a whole.
Download or read book Evolution by Gene Duplication written by Susumu Ohno and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.
Download or read book Race with the Devil written by Susan VanHecke and published by Macmillan. This book was released on 2000-08-19 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Famous for his classic hit 'Be-Bop-A-Lula,' Gene Vincent was one of the most influential rock 'n' roll artists of all time. This is the first American biography written of this rock pioneer and the most comprehensive account of his career and turbulent personal life. Adored by British and European fans, Gene Vincent moved to the UK in 1959 where his leather-clad, street-tough persona met with instant acclaim. The survivor of the crash that killed Eddie Cochran, his closest friend, he was to die himself at just 36, a victim of torment and tragedy. Illustrated.
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Download or read book Genetic Twists of Fate written by Stanley Fields and published by MIT Press. This book was released on 2013-02-08 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
