Download or read book Cholinesterases and Anticholinesterase Agents written by George B. Koelle and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.
Download or read book Acetylcholinesterase Old Questions and New Developments written by Karl Tsim and published by Frontiers E-books. This book was released on with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acetylcholinesterase (AChE) is a primary regulator of cholinergic signaling within and out of the central nervous system. It has been studied extensively for several decades, yet many basic questions about its regulation, composition and functions remain open. Thus, neither the full impact of AChE’s activities on neuronal development, maintenance and functioning nor the reasons for why and how different AChE molecular forms are being synthesized and degraded are fully known yet, although recent evidence suggests the involvement of micro-RNA regulators in both of these aspects. The identification of the anchoring proteins, PRiMA and ColQ, stimulates studies on AChE’s assembly and its specific localization in the brain and muscle. Additionally, non-cholinergic function(s) of AChE has been proposed as relevant both for neuronal differentiation and cognitive functioning, whereas transgenic engineering, recombinant production and structure-function analyses of this enzyme’s variants with various inhibitors paved new avenues for the development of novel Alzheimer’s disease therapeutics, agricultural pesticides and prophylactics in anticipation of warfare agent exposure. The aims of this Research Topic is to provide a forum for experts in the field to critically discuss recent developments in AChE studies, initiate global critiques of the current views for resolving the fundamental questions in AChE research and promote the development of novel versions and uses of AChE-targeted agents. Topics of interest include but are not limited to: (i) post-transcriptional regulation of AChE; (ii) the non-cholinergic functions of AChE; and (iii) anti-AChE inhibitors and diseases.
Download or read book Ageing and Dementia written by Kurt Jellinger and published by Springer Science & Business Media. This book was released on 2002-08-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Download or read book Behavioral Pharmacology of the Cholinergic System written by Mohammed Shoaib and published by Springer Nature. This book was released on 2020-08-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475
Download or read book Cholinesterases and Cholinesterase Inhibitors written by Ezio Giacobini and published by CRC Press. This book was released on 2000-04-03 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the collaboration of the most distinguished scholars in this field Professor Giacobini has put together a publication which will convey present knowledge in the field of molecular biology and genetics, biochemistry, cell biology, pharmacology and toxicology as well of clinical applications (particularly in the field of Alzheimer's disease therapy) of cholinesterase inhibitors. In a concise but precise manner it condenses our present knowledge of these enzymes and their inhibitors and helps those who want to understand them as well as to utilize them for therapeutic purposes.
Download or read book Possible Long term Health Effects of Short term Exposure to Chemical Agents written by and published by National Academies. This book was released on 1982 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perspiration Research written by H. Yokozeki and published by Karger Medical and Scientific Publishers. This book was released on 2016-09-01 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into perspiration has developed dramatically during the last 15 years, continually improving our understanding of the pathogenesis of sweating disorders. It has become clear that, in addition to its temperature-regulating function, perspiration offers bactericidal protection as well. In this book, select authors further broaden our perspective on perspiration. Contributions cover a variety of new aspects, offering insight into the sweat glands' major role during the onset of disorders such as parapsoriasis, lichen planus, and lichen amyloidosis. They also highlight the importance of Malassezia - an allergen in sweat that exacerbates atopic dermatitis and cholinergic urticarial. Further roles of the sweat glands are discussed, including as storage of stem cells for replenishing epidermal cells in the case of thermal burns or as water retention sites for replenishing moisture in the stratum corneum. In addition, a novel analysis of the sweat glands' three-dimensional structures, using high-speed en-face optical coherence tomography (OCT), is introduced. Offering an in-depth overview of the latest knowledge in perspiration research, this book serves as an essential reference for all medical staff and researchers in the field.
Download or read book Alzheimer Disease written by Robert Becker and published by Springer Science & Business Media. This book was released on 1996-12-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the new potential treatments and research in the area of Alzheimer's disease. Special attention is given to international developments in all fields relevant to new drug development. Topics discussed include: progress in the international harmonization of drug development guidelines for dementia drugs; bioethics and law; development of rating instruments; behavioural treatments; and the activities of the Reagan Foundation. The text integrates basic and clinical research findings, and provides evaluation of new approaches to therapy by world leaders in the field. The potential benefit for Alzheimer patients and families resulting from these research programmes, from molecular biology to clinical pharmacology, is reviewed and evaluated.
Download or read book Butyrylcholinesterase written by Ezio Giacobini and published by CRC Press. This book was released on 2003-06-05 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two types of cholinesterases (ChEs) are found in the mammalian brain: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They are products of two different genes and exhibit different localizations and kinetic properties. Until recently, the function of BuChE and its role in the regulation of acetylcholine levels in the central nervous system have been largely unknown. There is now evidence that BuChE plays a vital role in the brain cholinergic system, and that it may have a key role in the development of Alzheimer's disease. Butyrylcholinesterase: Its Function and Inhibitors is for neurologists, psychiatrists, geriatricians and neuroscientists who want a full profile of BuChE.
Download or read book Alzheimer s Disease Cellular and Molecular Aspects of Amyloid beta written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2004-12-17 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Download or read book Quantitative Functional Brain Imaging with Positron Emission Tomography written by Richard E. Carson and published by Elsevier. This book was released on 1998-09-08 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. - Authored by international authorities in PET - Provides the latest up-to-date techniques and applications - Covers all fundamental disciplines of PET in one volume - A comprehensive resource for students, clinicians, and new PET researchers
Download or read book Cholinesterases written by Jean Massoulié and published by . This book was released on 1991 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the proceedings of the Third International Meeting on Cholinesterases, this volume provides a wealth of new information on current cholinesterase research and explores a number of avenues for future research. Important advances resulting from new concepts and methodologies such as monoclonal antibodies and molecular genetics, are covered. Among the topics covered in its 49 full papers and 140 poster papers are polymorphism and structure, cellular biology, gene structure and expression, agents, and noncholinergic roles of cholinesterases.
Download or read book Enzymes of the Cholinesterase Family written by A.S. Balasubramanian and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.
Download or read book Cholinergic Ligand Interactions written by D. J. Triggle and published by . This book was released on 1971 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholine ...
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2012-07-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.
