Download or read book The Chemistry and Mechanics of Human Aging written by Joseph M. Brown (Mechanical engineer) and published by . This book was released on 2008-03-13 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the root cause of human aging at the molecular level. A mechanism producing aging is proposed and research is suggested for a cure. The mechanism consists of chemical forces producing torsional elastic strains at each division in the human genetic material which in turn produces a different chemical constituency of cells and this is manifested as aging.

Download or read book Human Aging written by Calogero Caruso and published by Academic Press. This book was released on 2021-05-11 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. - Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging - Offers the ability to access cross-sectional knowledge more easily - Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Download or read book Time of Our Lives The Science of Human Aging written by Tom Kirkwood Professor of Biological Gerontology University of Manchester and published by Oxford University Press, USA. This book was released on 1999-06-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: As recent articles about "the graying of America" suggest, a demographic revolution is well underway. The number of people living into extreme old age is increasing dramatically. By the year 2050 one in five of the world's population, including the developing countries, will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood unfolds some of the deepest mysteries of medical science while demolishing some of the most persistent misconceptions. He overturns the almost universally held belief that aging is either necessary or inevitable--it isn't--and debunks the idea that there exists a "death gene" that evolved to inhibit population growth. Instead, Kirkwood shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. Expanding his thesis of the "disposable soma," developed over twenty years of research, Kirkwood makes sense of the evolution of aging, explains how aging occurs, and answers fundamental questions like why women live longer than men. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.

Download or read book Lifespan written by David A. Sinclair and published by Atria Books. This book was released on 2019-09-10 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Download or read book The Future of Aging written by and published by Springer Science & Business Media. This book was released on 2010-07-28 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Download or read book The Chemical Age written by Frank A. von Hippel and published by University of Chicago Press. This book was released on 2020-09-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This sweeping history reveals how the use of chemicals has saved lives, destroyed species, and radically changed our planet: “Remarkable . . . highly recommended.” —Choice In The Chemical Age, ecologist Frank A. von Hippel explores humanity’s long and uneasy coexistence with pests, and how the battles to exterminate them have shaped our modern world. He also tells the captivating story of the scientists who waged war on famine and disease with chemistry. Beginning with the potato blight tragedy of the 1840s, which led scientists on an urgent mission to prevent famine using pesticides, von Hippel traces the history of pesticide use to the 1960s, when Rachel Carson’s Silent Spring revealed that those same chemicals were insidiously damaging our health and driving species toward extinction. Telling the story in vivid detail, von Hippel showcases the thrills—and complex consequences—of scientific discovery. He describes the creation of chemicals used to kill pests—and people. And, finally, he shows how scientists turned those wartime chemicals on the landscape at a massive scale, prompting the vital environmental movement that continues today.

Download or read book The Biology of Human Aging written by John K. Hampton and published by McGraw-Hill Science, Engineering & Mathematics. This book was released on 1997 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting up-to-date information about the biology of human ageing, this second edition of the text includes background biological material, numerous illustrations and end-of-chapter review questions.

Download or read book Oxidative Stress in Aging written by Satomi Miwa and published by Springer Science & Business Media. This book was released on 2008-06-17 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human aging is a complex phenomenon. This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.

Download or read book Long lived Proteins in Human Aging and Disease written by Roger J. W. Truscott and published by John Wiley & Sons. This book was released on 2021-01-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Download or read book Aging its Chemistry written by Albert Arnold Clarence Dietz and published by . This book was released on 1980 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Cellular and Metabolic Fundamentals of Human Aging written by Evandro Fei Fang and published by Academic Press. This book was released on 2022-10-23 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. - Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer's disease - Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging - Highlights recurring themes and key principles shared across the hallmarks of aging - Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging

Download or read book Exploring the Mechanisms of Human Aging written by Jeffrey Bland and published by . This book was released on 1977 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Aging Body written by Susan Krauss Whitbourne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to provide information that will be useful to people in a variety of disciplines who wish to learn more about normal aging processes in the human body. Although gerontologists in the biological sciences are making great strides in research on human aging and documenting this work in mono graphs, texts, and review chapters, this information is generally not easily acces sible nor is it comprehensible to nonprofessionals in these fields. This book is intended to provide a summary of this work, along with its implications for psy chological functioning of the aging individual. The majority of the book is devoted to describing the results of research on the physiological changes in the human body with aging and to seeking explana tions for these age effects. This description has been approached in such a way as to make it readable for the nonspecialist, but also to focus on research issues that will be useful reading for those who are currently working in these parti cular areas. In addition, throughout the book, I have tried to develop some themes regarding physiological and psychological adaptation during adulthood.

Download or read book Human Biological Aging written by Glenda E. Bilder and published by John Wiley & Sons. This book was released on 2016-04-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehension of the theories of aging requires rudimentary knowledge of oxidation and reduction reactions, protein function, cell organelles, mitosis, acquired immunity, and evolution, among other basic biological concepts. Without these fundamentals, students of biological aging struggle to learn the essentials of biological aging and how to appreciate the research advances in the field. Human Biological Aging: From Macromolecules To Organ-Systems is an introduction to human aging from the level of macromolecules to organ systems. Age changes in proteins, DNA, polysaccharides and lipids are discussed relative to known age-related alterations in structure and function produced by free radicals and oxidants. At the cellular level, age-dependent mechanisms that diminish organelle function are described. Cellular phenomena of replicative senescence apoptosis, autophagy and neuroplasticity are detailed as to their contribution to compromised cellular functions. Authored by a leader in the field, Human Biological Aging: From Macromolecules To Organ-Systems is an invaluable introduction for those studying human aging.

Download or read book Biomarkers of Human Aging written by Alexey Moskalev and published by . This book was released on 2019 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Download or read book Biochemistry of Aging written by Amin Elsersawi and published by AuthorHouse. This book was released on 2010 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a good introduction to the biology and chemistry of aging. It emphasizes on cellular aging, and covers different areas and theories which deal with the mechanism of aging.

Download or read book The Maillard Reaction written by Merlin C. Thomas and published by Royal Society of Chemistry. This book was released on 2010 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September 2009, a meeting was held in Palm Cove, Australia, which brought together the world experts in the Maillard or 'browning' reaction. This reaction causes the browning of foods when they are heated and in chocolate, caramel and beer, this reaction is appetizing, contributing to aroma, taste and texture. But when these products accumulate in the body, this same process contributes to disease and ageing. The book is the proceedings of that meeting, held in response to a growing recognition of the role reactive carbonyl compounds play in food technology, nutrition and tissue ageing in biology and medicine. Reactive carbonyls now touch every aspect of food science, biology and medicine. Efforts to counteract the damage caused by these products are gaining acceptance as a basis for novel therapeutic approaches, and the fields of food technology, ageing and preventive medicine are experiencing an upsurge of interest in strategies to minimize the unwanted effects of the Maillard reaction. The meeting also fostered a balanced approach to understanding both the advantageous and deleterious properties of carbonyl compounds and their end products in food science, technology and medicine. The major audience of this book is the large body of scientists and worldwide industries with an interest in the Maillard reaction in foods and biology and medicine, with both basic and applied researchers and industry representatives from diverse fields, who have interests in: * Chemistry of the Maillard Reaction * Biology and the Maillard Reaction * Enzymology, Receptors and Signal Transduction * Bioinformatics and Systems Biology * Physiology, Disease and Therapeutics * Food Science and Nutrition and the Maillard Reaction