Download or read book The Changing Faces of Glutathione a Cellular Protagonist written by Alfonso Pompella and published by Frontiers Media SA. This book was released on 2015-07-17 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Glutathione written by Leopold Flohe and published by CRC Press. This book was released on 2018-08-29 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery Chapter 11 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.
Download or read book Oxidative Stress in Cancer Biology and Therapy written by Douglas R. Spitz and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Download or read book Oxidants in Biology written by Giuseppe Valacchi and published by Springer Science & Business Media. This book was released on 2008-06-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.
Download or read book Antioxidant Enzyme written by Mohammed Amr El-Missiry and published by BoD – Books on Demand. This book was released on 2012-10-03 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals are constantly formed in living cells and removed by antioxidant defenses. Antioxidant enzymes are the main line of defense against free radicals in animal and plant cells. Uncontrolled generation ROS are involved in a number of human disease states, including diabetes and cancer due to disturbance in cellular and molecular processes including cell growth, differentiation and proliferation. When cells are exposed to oxidative stress a defense system endorses the expression and regulation of number of antioxidant enzymes as a defense mechanism to protect them from the damage induced by free radicals. Based on this fact, the book "Antioxidant Enzymes" was designed to overview the importance of the antioxidant enzymes in human and plant cells against toxic free radicals, their relationship with several pathophysiologic processes and their possible therapeutic application.
Download or read book Editor s Pick 2021 Highlights in Cell Death and Survival written by Craig Michael Walsh and published by Frontiers Media SA. This book was released on 2022-03-04 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Respiratory Disorders written by Nirmal K. Ganguly and published by Springer Science & Business Media. This book was released on 2014-03-31 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.
Download or read book Managing Plant Production Under Changing Environment written by Mirza Hasanuzzaman and published by Springer Nature. This book was released on 2022-02-22 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive edited volume collects the most recent information with up-to-date citations, on the decrease in plant productivity under climatic changes and its link with global food security. The book emphasis on the crop management practices and recent advancement in the techniques for mitigating the negative effects of climate induced biotic and abiotic stress. It brings together 19 chapters developed by eminent researchers in the area of plant and environmental sciences. Global climate change is increasingly becoming a concern for future of agriculture. High levels of inorganic and organic pollutants and climatic stress adversely affects the sensitive and complex equation of natural resources and ecosystem services. To meet the increased food demand, plant productivity needs to be enhanced, therefore this book fills in the gap and brings together information on the physiological and molecular approaches for improving crop productivity. The book is resourceful reading material for researchers, faculty members, graduate and post graduate students of plant science, agriculture, agronomy, soil science, botany, Molecular biology and environmental science.
Download or read book Novel Aspects of Diamond written by Nianjun Yang and published by Springer. This book was released on 2014-11-03 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on new research fields of diamond, from its growth to applications. It covers growth of atomically flat diamond films, properties and applications of diamond nanoparticles, diamond nanoparticles based electrodes and their applications for energy storage and conversion (supercapacitors, CO2 conversion etc.). Diamond for biomimetic interface, all electrochemical devices for in vivo detections and photo-electrochemical degradation of environmental hazards are highlighted.
Download or read book Studies on Hepatic Disorders written by Emanuele Albano and published by Springer. This book was released on 2015-05-28 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sections, each one thoroughly covering its topic and consisting of chapters written by recognized field leaders. Section One, covers basic principles including redox signaling, antioxidant defenses, nitric oxide, oxidative mechanisms in senescence and regeneration and the detection of oxidative stress. Section Two, explores Pathophysiology. It ranges from cell damage to fibrogenic response as broken out in chapters on hepatocellular injury, mitochondrial damage, unfolded protein response and autophagy, inflammation, ischemia-reperfusion injury and finally, fibrogenesis. Sections Three and Four cover specific diseases and cancer, respectively. Most of the chapters focus on diseases including acute failure, alcoholic disease, viral hepatitis, iron overload, autoimmune disease, Wilson’s disease and more, while the chapters on cancer round out the book.
Download or read book Nutrition and Oral Medicine written by Riva Touger-Decker and published by Springer Science & Business Media. This book was released on 2014-03-28 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition addresses the complex, multifaceted relationships between nutrition and oral health, explores proposed relationships between oral, systemic and nutritional well-being and provides insights into interprofessional, comprehensive care for individuals. Chapters focus on diet, nutrition and oral health promotion and disease prevention across the lifespan, oral and dental diseases and disorders, oral manifestations of systemic diseases, and discussions of the synergy between oral tissues and nutrients. Cutting edge research issues regarding the relationship of individual antioxidants, trace elements, polyphenols and other nutrient substrates and oral health/disease, nutrigenomics, screening for nutrition and oral risk and other areas are covered in detail. Editors and authors include experts in nutrition and oral health from around the world. This second edition is a invaluable resource for health professionals in the fields of nutrition and dentistry as well as other disciplines whose research, practice and education includes nutrition and oral medicine. It is an excellent resource for graduate level nutrition and dental students, dental and nutrition practitioners, educators and researchers as well as other health professionals.
Download or read book Mechanism of Plant Hormone Signaling under Stress 2 Volume Set written by Girdhar K. Pandey and published by John Wiley & Sons. This book was released on 2017-04-24 with total page 1114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant hormone signaling plays an important role in many physiological and developmental processes including stress response. With the advent of new post-genomic molecular techniques, the potential for increasing our understanding of the impact of hormone signaling on gene expression and adaptive processes has never been higher. Unlocking the molecular underpinnings of these processes shows great promise for the development of new plant biotechnologies and improved crop varieties. The topics included in this book emphasize on genomics and functional genomics aspects, to understand the global and whole genome level changes upon particular stress conditions. With the functional genomics tools, the mechanism of phytohormone signaling and their target genes can be defined in a more systematic manner. The integrated analysis of phytohormone signaling under single or multiple stress conditions may prove exceptional to design stress tolerant crop plants in the field conditions. Bringing together the latest advances, as well as the work being done to apply these findings to plant and crop science, Mechanism of Plant Hormone Signaling Under Stress will prove extremely useful to plant and stress biologists, plant biotechnology researchers, as well as students and teachers.
Download or read book Traumatic Brain Injury written by Farid Sadaka and published by BoD – Books on Demand. This book was released on 2014-02-19 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury is a major source of death and severe disability worldwide. This book provides an excellent and detailed overview of the management of patients with traumatic brain injury, in a stepwise approach, from the intensive care unit, through to discharge from the hospital, rehabilitation, recovery and assimilation in family and society. This book also discusses mechanisms of pathophysiology pertaining to traumatic brain injury and provides grounds for future research in traumatic brain injury, especially pertaining to pathophysiology, imaging, neuroprognostication, rehabilitation, recovery, and outcomes.
Download or read book Environmental Exposures and Human Health Challenges written by Papadopoulou, Paraskevi and published by IGI Global. This book was released on 2019-03-15 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental health is an area with significant developments and noteworthy challenges that expand into various disciplines: medicine and public health, sociology and communications, technology, policymaking, and legislation. Due to the massive amount of health-related issues, additional literature involving environmental health is required to improve the wellbeing of citizens worldwide. Environmental Exposures and Human Health Challenges provides interdisciplinary insights into concepts and theories related to environmental exposures and human health impacts via the air, water, soil, heavy metal exposure, and other chemical toxins. The book also addresses inequalities and environmental injustices in relation to environmental exposures and health impacts. Covering topics such as health policies, pollution effects, and heavy metal exposure, this publication is designed for public health professionals, preventive medicine specialists, clinicians, data scientists, environmentalists, academicians, practitioners, researchers, and students.
Download or read book Yeasts in Biotechnology written by Thalita Peixoto Basso and published by BoD – Books on Demand. This book was released on 2019-08-07 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a broad understanding of several ways in which yeasts can be applied to the biotechnology industry. The seven chapters are grouped into three sections (apart from the "Introduction" section). The Animal Nutrition section comprises two chapters dealing with the utilization of yeast as a probiotic for animal nutrition. The Food Industry section addresses the utilization of yeast in food products. Finally, the Industrial Bioproducts section deals with the development of new yeast platforms as cell factories for biochemical production.
Download or read book Cosmetic Science and Technology Theoretical Principles and Applications written by Kazutami Sakamoto and published by Elsevier. This book was released on 2017-03-03 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetic Science and Technology: Theoretical Principles and Applications covers the fundamental aspects of cosmetic science that are necessary to understand material development, formulation, and the dermatological effects that result from the use of these products. The book fulfills this role by offering a comprehensive view of cosmetic science and technology, including environmental and dermatological concerns. As the cosmetics field quickly applies cutting-edge research to high value commercial products that have a large impact in our lives and on the world's economy, this book is an indispensable source of information that is ideal for experienced researchers and scientists, as well as non-scientists who want to learn more about this topic on an introductory level. Covers the science, preparation, function, and interaction of cosmetic products with skin Addresses safety and environmental concerns related to cosmetics and their use Provides a graphical summary with short introductory explanation for each topic Relates product type performance to its main components Describes manufacturing methods of oral care cosmetics and body cosmetics in a systematic manner
