Download or read book The Cerebellum Revisited written by Rodolfo Llinas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into three parts that correspond with the main groups of chapters delivered during the Cajal Centenary Meeting on The Neutron Doctrine. These chapters represent important aspects of the morphology, development, and function of the cerebellum and related structures. Clearly an exhaustive analysis of all aspects of the cerebellar system, as they relate to the legacy of Ramon y Cajal, would be impossible to contain in just one volume, given its far-reaching impact. Instead, we deliberately steered away from the traditional handbook approach that some of us have taken in the past and selected those aspects of cerebellar research currently under vigorous study that would also represent the widest scope of interest for neuroscientists in general and for cerebellar specialists in particular. In particular, we felt that as the discrete anatomy of the cerebellum is quite well known, only certain aspects of the structure should be discussed here. For example, the organization of the pontocerebellar pathways, we felt, would be particularly interesting given the enormity of the system in higher vertebrates. Also of interest is the distribution and development of the synaptology and neurotransmitter properties in this cortex. Indeed, from the point of view of cerebellar development, this may represent one of the clearest paradigms in the understanding of rules for neurogenesis for the central nervous system.
Download or read book The Cerebellum and Its Disorders written by Mario Manto and published by Cambridge University Press. This book was released on 2002 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive text on the cerebellum and its disorders for many years.
Download or read book The Neuronal Codes of the Cerebellum written by Detlef Heck and published by Academic Press. This book was released on 2015-10-07 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms. Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis. Compiles current knowledge about functioning of the cerebellum on a cellular basis and how information is encoded in the cerebellum Highlights findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes Contents include an introduction to the cerebellum and experimental/theoretical techniques, as well as the function of cerebral coding during disorder, learning, behavior generation, motor behavior, and more Bridges the gap for cerebellar researchers between single cell biophysics/anatomic studies and behavioral studies Incorporates various in vivo approaches with different behavioral paradigms in primates and rodents, modeling studies of coding, and in vitro approaches
Download or read book Cerebellum as a CNS Hub written by Hidehiro Mizusawa and published by Springer Nature. This book was released on 2021-11-10 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the 75th Fujihara Seminar held in December 2018 in Tokyo, Japan, this volume explores the latest research on the cerebellum. Contributors seek to examine the cerebellum's role as a unique hub for brain activity and discover new information about its purpose. The discussion is broad, ranging from evolutionary topics to therapeutic strategy and addresses both physiology and pathology. Subjects covered include anatomy, information processing, complex spikes, plasticity, modeling, and spinocerebellar ataxias. The volume is intended to set the stage for the future of cerebellar research and guide both basic and clinical researchers.
Download or read book Motor Learning and Synaptic Plasticity in the Cerebellum written by Paul J. Cordo and published by Cambridge University Press. This book was released on 1997-11-28 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is concerned with the involvement of the cerebellum in learning and remembering motor tasks. It is unique in discussing plasticity at both the cellular and at the behavioral level.
Download or read book Translational Medicine written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2018-07-16 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.
Download or read book The Cerebellum and Cognition written by and published by Academic Press. This book was released on 1997-10-02 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Comprehensive coverage of cerebellum in motor control and cognition New developments regarding the cerebellum and motor systems Therapeutic implications of cerebellar contributions to cognition Preeminent group of contributors
Download or read book Creating Coordination in the Cerebellum written by Chris I. De Zeeuw and published by Elsevier. This book was released on 2004-12-11 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Creating Coordination in the Cerebellum provides a multidisciplinary collection of chapters on the cerebellum with topics covering the entire spectrum from development and molecular neurobiology, cell physiology and plasticity to motor control, system physiology, functional imaging and pathology. The book not only presents novel discoveries obtained with recently developed technologies, but also gives new general concepts in global issues of cerebellar development and functions. By doing so it sets the standard for cerebellar research of the 21st century. * Provides a complete overview of current cerebellar research * Includes color illustrations * Contains contributions from renowned cerebellar scientists
Download or read book Development of the Cerebellum from Molecular Aspects to Diseases written by Hassan Marzban and published by Springer. This book was released on 2017-07-27 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.
Download or read book Neurobiology written by Franco Conti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how the brain works is undoubtedly the greatest challenge for human intelligence and one of the most ambitious goals of contemporary science. We are certainly far from this goal, but significant advancements in several fields of Neuroscience and Neurobiology are being obtained at an increasing pace. The NATO ASI School in Neurobiology, held in Erice May 2-12,1995, as the 23rd Course of the International School of Biophysics, provided an update on three basic topics: Biophysics and Molecular Biology ofIon Channels, Sensory Transduction, and Higher Order Functions. Current knowledge on these subjects was covered by formal lectures and critical discussions between lecturers and participants. This book collects original contributions from those scientists who attended the School. Many students presented their results in poster sessions, steering lively informal discussions. A selection of these contributions is also included. A major portion of the program of the School was devoted to a general overview of current trends of thought and experimental approaches in neurobiology, emphasising the importance of understanding molecular aspects of the elementary events underlying sensory transduction and processing in the nervous system, without indulging however in a pure reductionistic view of such complex phenomena. Recent studies of molecular biology and the electrophysiology of heterologously expressed ionic channels, have shed new light on the molecular mechanisms underlying ionic permeation of excitable membranes and its regulation by physical and chemical parameters.
Download or read book The Central Nervous System written by Per Brodal and published by Oxford University Press. This book was released on 2010-03-29 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Central Nervous System: Structure and Function, Fourth Edition continues the tradition of one of the most respected textbooks in clinical neuroscience by providing medical students the knowledge and understanding of neuroscience as a basis for clinical thinking. While remaining concise and easy to read, the text encourages reflection and critical thinking of established facts and scientific conjecture and will be of interest to medical, graduate, and undergraduate students alike. Prof Per Brodal provides clear descriptions of brain structures and relates them to their functional properties by incorporating data from molecular biology to clinical neurology. The numerous full color line drawings - based on the author's long experience of teaching undergraduate students and new to this edition - make it easier to understand complex structural and functional relationships. Thoroughly revised, this fourth edition goes further in integrating material from all fields of the neurosciences. Now divided into 8 Sections with a total of 34 Chapters, each chapter is introduced by a brief overview of what the student can expect to learn. New material has been incorporated in all chapters while maintaining the scope and coverage that has established The Central Nervous System: Structure and Function as the preeminent neuroscience textbook.
Download or read book The Self Organizing Brain From Growth Cones to Functional Networks written by M.A. Corner and published by Elsevier. This book was released on 1994-10-11 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concentrates on the organizational level of neurons and neuronal networks under the unifying theme "The Self-Organizing Brain - From Growth Cones to Functional Networks". Such a theme is attractive because it incorporates all phases in the emergence of complexity and (adaptive) organization, as well as involving processes that remain operative in the mature state. The order of the sections follows successive levels of organization from neuronal growth cones, neurite formation, neuronal morphology and signal processing to network development, network dynamics and, finally, to the formation of functional circuits.
Download or read book 20 Years of Computational Neuroscience written by James M Bower and published by Springer Science & Business Media. This book was released on 2013-07-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: When funding agencies and policy organizations consider the role of modeling and simulation in modern biology, the question is often posed, what has been accomplished ? This book will be organized around a symposium on the 20 year history of the CNS meetings, to be held as part of CNS 2010 in San Antonio Texas in July 2010. The book, like the symposium is intended to summarize progress made in Computational Neuroscience over the last 20 years while also considering current challenges in the field. As described in the table of contents, the chapter’s authors have been selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience. The proposed book will include several features that establish the history of the field. For each article, its author will select an article originally appearing in a CNS conference proceedings from 15 – 20 years ago. These short (less than 6 page) articles will provide illustrations of the state of the field 20 years ago. The new articles will describe what has been learned about the subject in the following 20 years, and pose specific challenges for the next 20 years. The second historical mechanism will be the reproduction of the first 12 years of posters from the CNS meeting. These posters in and of themselves have become famous in the field (they hang in the halls of the NIH in Bethesda Maryland) and were constructed as allegories for the state and development of computational neuroscience. The posters were designed by the book’s editor, who will, for the first time, provide a written description of each poster.
Download or read book Structure Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites written by Sergey M. Korogod and published by Frontiers Media SA. This book was released on 2018-10-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Activity of the multi-functional networked neurons depends on their intrinsic states and bears both cell- and network-defined features. Firing patterns of a neuron are conventionally attributed to spatial-temporal organization of inputs received from the network-mates via synapses, in vast majority dendritic. This attribution reflects widespread views of the within-cell job sharing, such that the main function of the dendrites is to receive signals and deliver them to the axo-somatic trigger zone, which actually generates the output pattern. However, these views are now revisited due to finding of active, non-linear properties of the dendritic membrane practically in neurons of practically all explored types. Like soma and axon, the dendrites with active membrane are able to generate self-maintained, propagating depolarizations and thus share intrinsic pattern-forming role with the trigger zone. Unlike the trigger zone, the dendrites have complex geometry, which is subject to developmental, activity-dependent, or neurodegenerative changes. Structural features of the arborization inevitably impact on electrical states and cooperative behavior of its constituting parts at different levels of organization, from sub-trees and branches to voltage- and ligand-gated ion channels populating the dendritic membrane. More than two decades of experimental and computer simulation studies have brought numerous phenomenological demonstrations of influence of the dendritic structure on neuronal firing patterns. A necessary step forward is to comprehend these findings and build a firm theoretical basis, including quantitative relationships between geometrical and electrical characteristics determining intrinsic activity of neurons. The articles in this eBook represent progress achieved in a broad circle of laboratories studied various aspects of structure and function of the neuronal dendrites. The authors elucidate new details of dendritic mechanisms underlying intrinsic activity patterns in neurons and highlight important questions that remain open in this important domain of cellular and computational neuroscience.
Download or read book Human and Machine Perception written by Virginio Cantoni and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following are th€:" proceedings of the Second International Workshop on Human and Machine Perception held in Trabia, Italy, on July 21~25, 1996, under the auspices of two Institutions: the Cybernetic and Biophysics Group (GNCB) of the Italian National Research Council (CNR) and the 'Centro Interdipartimentale di Tecnologie della Conoscenza' ofPalenno University. A broad spectrum of topics are covered in this series, ranging from computer perception to psychology and physiology of perception (visual, auditory, tactile, etc.). The theme of this workshop was: "Human and Machine Perception: Information Fusion". The goal of information and sensory data fusion is to integrate internal knowledge with complementary and/or redundant information from many sensors to achieve (and maintain) a better knowledge of the environment. The mechanism behind the integration of information is one of the most difficult challenges in understanding human and robot perception. The workshop consisted of a pilot phase of eight leCtures introducing perception sensorialities in nature and artificial systems, and of five subsequent modules each consisting of two lectures (dealing with solutions in nature and machines respectively) and a panel discussion.
Download or read book The Synaptic Organization of the Brain written by Gordon M. Shepherd and published by Oxford University Press. This book was released on 2004 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.
Download or read book Cerebellar Functions written by J. Bloedel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few semesters a group of neurologists, neurophysiologists, and brain theorists in various departments of Tlibingen University have gathered periodically in an effort to review ideas and evidence on cerebel lar functions. At times, general solutions seemed close, when credit was given to various theoretical proposals advanced since the early days of cer ebellar physiology, however, it became clear in every case that a large part of the available facts refused to submit to the general ideas. As believers in the power of scientific discussion, we felt that the time was ripe for posing the problem of the cerebellum once more to a well articulated group of specialists that would include proponents of every disparate point of view. The sponsorship of the Max Planck Society and of the Deutsche Forschungsgemeinschaft, to whom we express our profound gratitude, made it possible to organize an international meeting in Septem ber, 1983. The aim of making new, even extravagant ideas palatable to each other was well accomplished by the participants. We trust that some of the ensuing excitement has been carried over into the printed version.
