Download or read book The Cell Surface and Neuronal Function written by Carl W. Cotman and published by North-Holland. This book was released on 1980 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neural Surface Antigens written by Jan Pruszak and published by Academic Press. This book was released on 2015-03-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functionalrole of surface molecules in neural development, stem cell research, and translational biomedical paradigms.With an emphasis on human and rodent model systems, this reference covers fundamentals of neural stemcell biology and flow cytometric methodology. Addressing cell biologists as well as clinicians working in theneurosciences, the book was conceived by an international panel of experts to cover a vast array of particularsurface antigen families and subtypes. It provides insight into the basic biology and functional mechanisms ofneural cell surface signaling molecules influencing mammalian development, regeneration, and treatments. Introduces early phase clinical trials of neural stem cells Outlines characterization of surface molecule expression and methods for isolation which open unprecedented opportunities for functional study, quantitation & diagnostics Highlights the role of stem cells in neural surface antigen and biomarker analysis and applications
Download or read book Neuroscience and Neurotechnology of Neuronal Cell Surface Molecules in Neural Circuits written by Masahito Yamagata and published by Frontiers Media SA. This book was released on 2021-08-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Download or read book Protein Trafficking in Neurons written by Andrew J. Bean and published by Elsevier. This book was released on 2006-10-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field
Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475
Download or read book Cell Surface Extensions Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Extensions: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cell Surface Extensions. The editors have built Cell Surface Extensions: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cell Surface Extensions in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cell Surface Extensions: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Neuronal Dynamics written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2014-07-24 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell surface Proteome and Signaling in Neural Circuit Wiring written by Jiefu Li and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the evolutionary transition from unicellular to multicellular organisms, single cells assemble into highly organized tissues and cooperatively carry out physiological functions. To act as an integrated system, individual cells communicate with each other extensively through signaling at the cellular interface. Cell-surface signaling thus controls almost every aspect of the development and physiology of multicellular organisms. Taking the nervous system as an example, cell-surface wiring molecules dictate the precise assembly of the neural network during development, while neurotransmitter receptors and ion channels mediate synaptic transmission and plasticity in adults. Delineating the cell-surface signaling is therefore crucial for understanding the organizing principles and operating mechanisms of multicellular systems. My dissertation research integrates method development and mechanistic interrogation to investigate cell-surface signaling in neural circuit assembly. My collaborators and I developed, for the first time to my knowledge, a method for quantitatively profiling cell-surface proteomes in intact tissues with cell-type and spatiotemporal specificities. Applying this method to Drosophila olfactory projection neurons (PNs), I captured cell-surface proteomes of developing and mature PNs and observed globally coordinated dynamics of PN surface proteins corresponding to the wiring and functional stages of the olfactory circuit, providing the first systemic view on how neuronal surface evolves in development. A proteome-instructed in vivo screen identified 20 new cell-surface molecules regulating neural circuit assembly, many of which belong to evolutionarily conserved protein families not previously linked to neural development. These discoveries highlight the power of this new method in uncovering new regulators of brain wiring. Notably, this method should be readily applicable for profiling proteins on the surface of other cell types, tissues, and organisms, far beyond the fly olfactory circuit. In a complementary set of studies on the Plexin B receptor, I developed a generalizable protein tagging approach that reveals cell-type-specific endogenous protein distribution in vivo. Combining this tagging approach and genetic analyses, we found that the Plexin B receptor uses multiple molecular strategies: temporally-regulated protein distribution, level-dependent signaling, and divergent engagement of signaling motifs, to sequentially instruct several distinct steps of axon targeting. These include axon-axon interaction, axon guidance, and synaptic partner selection. Our findings illustrate how a single molecule achieves multi-functionality while preserving its signal specificity in brain wiring. In summary, this dissertation combines quantitative multi-omic profiling and in vivo mechanistic interrogation to elucidate the systemic properties and molecular bases of cell-surface signaling underlying the precise wiring of neural circuits.
Download or read book Neuronal Cell Culture written by Shohreh Amini and published by Humana. This book was released on 2022-06-09 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume details the latest aspects of neural cells covering the practical and theoretical considerations of each techniques involved. Chapters guide readers through a general overview of the neuronal culturing principles, cell line models for neural cells, the isolation and propagation of primary cultures, stem cells, transfection and transduction of neural cultures, and other more advanced techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and easy to use, Neuronal Cell Culture: Methods and Protocols, Second Edition aims to be of interest to scientists at all levels studying cell culture models for neuroscientific studies.
Download or read book In Vitro Characterization of a Cell Surface Molecule Expressed by Certain Cells of Neuroectodermal and Mesenchymal Origin microform written by Bina Mittal and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1994 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Adhesive interactions between neurons and astroglia are likely to play an important role during central nervous system development. Using a monoclonal antibody (designated MAb 1A1) raised against purified neonatal rat astrocytes, I have characterized some of the in vitro functional and biochemical properties of a potentially novel cell surface molecule. By indirect immunofluorescence, the antibody labels subpopulations of astrocytes (flat type-1 astrocytes and Bergmann glia) and cells derived from the mesenchyme (leptomeninges and fibroblasts). The latter showed 1A1$ sp{+}$ immunoreactivity only when grown to confluency. Cell-cell contact and extracellular matrix molecules were found to play a role in the regulation of 1A1 antigen expression on leptomeninges. 1A1 Fab fragments inhibited the binding of neuron to astrocyte and astrocyte to astrocyte, but not of neuron to neuron in an in vitro adhesion assay, thus indicating that this surface antigen may function as a cell adhesion molecule on astrocytes. Addition of Fab fragments of MAb 1A1 also reduced leptomeningeal cell adhesion. Further functional antibody perturbation experiments indicated that this surface molecule mediates neurite outgrowth on astrocytes and neuronal migration on Bergmann glia via a heterophilic-binding mechanism. Both immunoprecipitation and immunocytochemical analysis showed the timing of 1A1 antigen expression in postnatal rat cerebellum to coincide with the developmental period of granule cell migration along Bergmann glia. On SDS-PAGE, the immunopurified 1A1 surface molecule migrated as a single molecular weight band of $ approx$135 kd and appeared to be poorly glycosylated. Based on its unique cell-type distribution, functional properties and biochemical analysis, this 135 kd glycoprotein is likely to be distinct from other known cell adhesion molecules expressed on astrocytes." --
Download or read book The Neuron written by Irwin B. Levitan and published by Oxford University Press, USA. This book was released on 2002 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Download or read book Molecular Basis of Olfaction written by and published by Academic Press. This book was released on 2015-01-23 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths. Comprehensive coverage of molecular processes in olfaction of vertebrates and insects Focus on the emerging field of insect olfaction Contributions by leading research groups in their fields, from a range of countries Discusses fundamental knowledge and also key applications being addressed by the research
Download or read book Cilia and Nervous System Development and Function written by Kerry L. Tucker and published by Springer Science & Business Media. This book was released on 2013-01-19 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
