Download or read book The Cannabinoids Chemical Pharmacologic and Therapeutic Aspects written by Stig Agurell and published by Academic Press. This book was released on 2012-12-02 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects provides a comprehensive discussion of the various aspects of cannabis and its constituents. The book is organized into six sections. Section I covers the clinical aspects of cannabis including the health aspects, impact on memory function, and the characteristics and treatment of marijuana abusers. Section II on chemical aspects includes studies on the chemistry and structure-activity relationships of cannabinoids; smoking characteristics of marijuana cigarettes; and developments in cannabinoid analyses of body fluids. Section III on metabolic and pharmacokinetic aspects includes studies on the metabolism, disposition, and pharmacokinetics of delta-9-tetrahydrocannabinol (THC) in men and women; single dose kinetics of cannabidiol in man; and distribution and disposition of THC in different tissues of the rat. Section IV on reproductive aspects include studies on the effects of chronic administration of THC on the early embryonic development of mice; effects of cannabinoids on spermatogenesis in mice; and possible mechanism for the cellular effects of marijuana on male reproductive function. Section V on neuropharmacologic aspects includes studies on the discriminative stimulus properties of THC and the effects of cannabinoids on neurotransmitter receptors in the brain. Section VI on therapeutic aspects includes studies such as the possible anxiolytic effects of cannabidiol; tetrahydrocannabinol effects on extrapyramidal motor behaviors in Parkinson's disease; and the use of cannabinoids in glaucoma.
Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.
Download or read book Therapeutic Uses of Cannabis written by British Medical Association and published by CRC Press. This book was released on 1997-11-18 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Download or read book Marijuana and Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 1999-06-10 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.
Download or read book Cannabinoids as Therapeutics written by Raphael Mechoulam and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only a few years ago the endocannabinoid system was unknown. Today we are aware that endocannabinoids are involved in many of the functions of the mammalian body - in neuroprotection, appetite and suckling, pain, reproduction, anxiety, memory, bone formation etc. This volume presents an up-to-date picture of some of the major fields of endocannabinoid research. It summarizes the actions of the endocannabinoids on various physiological systems and opens new therapeutic windows to a large number of diseases. The first chapter, on the use of Cannabis in India, can be viewed as an expression of thanks to the herbal practitioners, who for centuries passed on the medical traditions associated with the drug. The chapter on chemistry is a short summary of active plant, synthetic and endogenous cannabinoids being investigated today, many of which are mentioned later in the book. Cannabidiol is an unusual cannabinoid - it does not bind to the known receptors and yet exerts a variety of effects. Hence a chapter is devoted to it. Further chapters deal with the endocannabinoid system and the endocannabinoids in a variety of conditions and physiological systems. The concluding chapter describes the research done on Sativex®, a standardized plant extract, shortly to be introduced in Canada as a drug for multiple sclerosis. The intended audience is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians interested in the effect of the endocannabinoid system in various physiological systems.
Download or read book The Therapeutic Potential of Marihuana written by Sidney Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific information about cannabis and its components has grown exponentially during the past decade. Certain of the findings have led to exploratory studies into the therapeutic utility of the drug. At the present time, a number of areas of usefulness have been investigated, with some showing greater promise than others. At what point should these data be collected and presented? Should it be early, after some initial impressions have been obtained? Or should it come later, following confirmatory studies by others? Both stages of development are represented in this volume. In a number of instances, the papers consist of hitherto unpublished material. It seemed worthwhile to bring together the investigators working in a wide variety of disciplines who had in common their research activities in the therapeutic aspects of the cannabinoids and related synthetic compounds. This was done at the Asilomar Conference Center in Pacific Grove, California during November, 1975. The papers presented and the ensuing discussion constitute the contents of this volume. It is the Editors' hope that the book will stimulate further involvement in the therapeutic studies. It should not be expected, nor is it anticipated that some cannabinoid will be available commercially in the near future. The nature of the approval process is such that years elapse between initial testing, however promising, and final approval for marketing. This is particularly true for a completely new chemical entity, and even more so for one with a checkered reputation.
Download or read book Cannabis and Cannabinoids written by Ethan B Russo and published by Routledge. This book was released on 2013-09-05 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Study the latest research findings by international experts!This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world’s foremost researchers.Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana’s use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine.Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effectsCannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.
Download or read book Cannabinoids written by Vincenzo Di Marzo and published by John Wiley & Sons. This book was released on 2014-07-18 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cannabinoids ‘Cannabinoids’ is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors – protein molecules on the surface of cells – known as cannabinoid receptors. Over the past decades scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters covering their role in health and disease. The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area. An authoritative guide to the history, development and possible future of cannabinoid research. Includes contributions from leading international experts in the field. Clearly written, well organised and logically presented. Cannabinoids will prove invaluable to researchers, practitioners and students across a wide range of disciplines, needing an up-to-date guide to this significant area of research.
Download or read book The Handbook of Cannabis Therapeutics written by Ethan B. Russo and published by Routledge. This book was released on 2014-05-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the facts behind the pharmacology and pharmacokinetics of controversial cannabis therapeutics The Handbook of Cannabis Therapeutics: From Bench to Bedside sets aside the condemnation and hysteria of society’s view of cannabis to concentrate on the medically sound aspects of cannabis therapeutics. The world’s foremost experts provide a reasoned, thoroughly researched overview of the controversial subject of cannabis, from its history as a medicine through its latest therapeutic uses. The latest studies on the botany, history, biochemistry, pharmacology, toxicology, clinical use for various illnesses such as AIDS, epilepsy, and multiple sclerosis, and side effects of marijuana are all examined and discussed in depth. This comprehensive resource is a compendium of articles from the Journal of Cannabis Therapeuticswith additional contemporary commentary. It presents startling research that explores and supports the medicinal value of cannabis use and its derivatives as a valid therapeutic resource for pain and inflammation, for several illnesses less responsive to other therapies, and even for certain veterinary uses. Cannabinoids such as nabilone, THC, levonantradol, ajulemic acid, dexanabinal, and others are extensively described, with a review of new indications for cannabinoid pharmaceuticals. The book is carefully referenced to encourage your examination of previous studies and provides tables and figures to enhance understanding of information. The Handbook of Cannabis Therapeutics discusses: the uses of cannabis in Arabic, Greek, Roman, and early English medicines absorption rates pharmacokinetics pharmacodynamics separate extracts versus the use of cannabis in its entirety the therapeutic value of the endocannabinoid system cannabinoids and newborn feeding a comparison of smoking versus oral preparations clinical research data on eating cannabis therapeutic uses as appetite stimulant treatments in obstetrics and gynecology medicinal treatments used in Jamaica the use of cannabis in the treatment of multiple sclerosis the benefits versus the adverse side effects of cannabis use The Handbook of Cannabis Therapeutics is a reference work certain to become crucial to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public.
Download or read book Cannabinoids and Sleep written by Jaime M. Monti and published by Springer Nature. This book was released on 2021-02-03 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.
Download or read book Marijuana and the Cannabinoids written by Mahmoud A. ElSohly and published by Springer Science & Business Media. This book was released on 2007-11-15 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.
Download or read book Metabolism and Side Effects of Cannabinoids written by Pharmacology University and published by Pharmacology University. This book was released on 2022-03-03 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the following ebook you will learn about biochemistry, metabolism, pharmacokinetics and side effects of cannabinoids. Cannabis is a plant species of the Cannabaceae family, which includes three strains: Cannabis indica, Cannabis sativa and Cannabis ruderalis. Thanks to its features, cannabis has been used in several fields throughout history. The first reference of its therapeutic use was in China, in the 4.000 B.C. in the most ancient pharmaceutical guide known: the Pen Ts’ao Ching, attributed to the emperor Shen Nung, where it was used against menstrual disorders, goute, malaria, constipation and muscular weakness; later, indications were extended to wound healing, against infectious processes, clearance of pus, treatment of rheumatism, and to decrease fever and anxiety. The growing interest in the biology, chemistry, pharmacology and toxicology of cannabis, has allowed the development of cannabinoid drugs, through the understanding of pharmacokinetics, its disposition in fluids and biological tissues, in order to understand the mechanism of action of cannabis and its therapeutic effects. Pharmacokinetics and metabolism of cannabinoids involve absorption through different routes of administration and drug prescriptions, distribution of their compounds throughout the body, metabolism by the liver and extrahepatic tissues, and elimination in feces, urine, sweat, oral fluids and hair, and excretion by different body fluids. Pharmacokinetic processes are dynamic, can change over time and can be affected by the frequency and magnitude of drug exposure. There is limited understanding of the expected side effects of cannabis use in a therapeutic context. Consequently, a significant amount of the data on this topic are derived from studies investigating the recreational use of cannabis, which implies caution in making conclusions regarding medicinal use. Specifically, the amount of cannabis used, methods of administration, and the existence of comorbidities differ significantly between recreational and medicinal cannabis-using populations. As a result, different side effects might be expected, but what has been documented to date refers to mild effects. At Pharmacology University we want you to understand the importance of cannabinoids through knowledge and education, understanding the biological, pharmacological, toxicological and medical implications so that through information you can connect with the world of cannabis and have a broad vision of this industry that has a very important potential and a promising future.
Download or read book Cannabinoids Pharmacology and Therapeutic Potential written by Eli Wright and published by States Academic Press. This book was released on 2021-11-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical compounds which are found in cannabis are termed as cannabinoids. The major cannabinoids are phytocannabinoid tetrahydrocannabinol and cannabidiol. The combination of cannabinoids which are produced by a cannabis plant constitute its cannabinoid profile. The pharmacology of cannabinoids studies the actions of cannabinoids on the human body. Cannabinoids have both medicinal and recreational uses. They are used to for the management of various diseases such as cancer and HIV/AIDS. In cancer patients, it is used to reduce the feeling of nausea and vomiting which is caused by chemotherapy. People suffering from HIV/AIDS sometimes use cannabinoids to increase appetite. Dronabinol and nabilone are two extracts of cannabis which are consumed in the form of pills to treat the side effects of AIDS and chemotherapy. Cannabinoids are also used in the management of neuropathic pain. This book outlines the therapeutic potential of cannabinoids in detail. It consists of contributions made by international experts. Those with an interest in this field would find this book helpful.
Download or read book Marijuana As Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2000-12-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
Download or read book Cannabis in Medical Practice written by Mary Lynn Mathre, R.N. and published by McFarland. This book was released on 2010-07-27 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because marijuana is a Schedule I drug under the Controlled Substances Act, the therapeutic benefits of cannabis are no longer mentioned in the formal education of health care professionals. Doctors who do learn of the drug's therapeutic value are often intimidated by its illegal status. Thus millions of patients afflicted with such illnesses as glaucoma, AIDS, cancer, multiple sclerosis, spinal cord injuries, seizure disorders and chronic pain are denied access to information about the drug's benefits and, in many cases, suffer needlessly. Straightforward and nonpoliticized information on the therapeutic uses of cannabis is provided here by medical, legal and scientific professionals. Legal issues, a worldwide history of therapeutic cannabis and a discussion of its pharmacology are covered. Specific medical uses are then examined, including its application for sufferers of cancer, AIDS, glaucoma, and seizure disorders, and its potential use in psychiatry. Dosages and administration of cannabis are explored, along with considerations on the use of the drug during pregnancy and the risks of addiction and dependency.
Download or read book Marijuana Chemistry Pharmacology Metabolism and Clinical Effects written by Raphael Mechoulam and published by . This book was released on 1973 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phytocannabinoids written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-01-24 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.
