Download or read book The Antihistamines Their Clinical Application written by Samuel Maurice Feinberg and published by . This book was released on 1950 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book History of Allergy written by K.-C. Bergmann and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as 'the epidemic of the 21st century'. As described in ancient texts, allergies have been known for over 2,000 years, but the term 'allergy' was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Concluding with portrayals of allergy societies and collections, as well as being supplemented by two films, this book represents a veritable treasure trove of fascinating and richly illustrated information. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading.
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Download or read book Histamine in Inflammation written by Robin Thurmond and published by Springer Science & Business Media. This book was released on 2011-06-29 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Download or read book Essential Clinical Anesthesia written by Charles Vacanti and published by Cambridge University Press. This book was released on 2011-07-11 with total page 1191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.
Download or read book Management of Allergic and Nonallergic Rhinitis written by and published by . This book was released on 2002 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!
Download or read book Histamine Receptors as Drug Targets written by Ekaterini Tiligada and published by Humana. This book was released on 2017-03-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
Download or read book Pharmacology of Histamine Receptors written by C. R. Ganellin and published by Elsevier. This book was released on 2013-10-22 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.
Download or read book Histamine Receptors written by Patrizio Blandina and published by Springer. This book was released on 2016-11-07 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
Download or read book Middleton s Allergy written by and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. And this Expert Consult Edition offers online access to the complete contents of the 2-volume set, fully searchable, and much more. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important information quickly. links to useful online resources both for you and for your patients. Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge.
Download or read book Medical Pharmacology and Therapeutics E Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice
