EBookClubs

Read Books & Download eBooks Full Online

EBookClubs

Read Books & Download eBooks Full Online

Book The Role of Herpes Simplex Virus Type 1 Regulatory Protein Infected Cell Protein 27 ICP27 in Viral Gene Expression Regulation

Download or read book The Role of Herpes Simplex Virus Type 1 Regulatory Protein Infected Cell Protein 27 ICP27 in Viral Gene Expression Regulation written by Jenny Q. Dai-Ju and published by . This book was released on 2007 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The association of ICP27 with general transcription factors TFIID-TBP suggested that ICP27 interacts with the pre-initiation complex. ChIP assays further confirmed that ICP27 binds to the initiation complex at 5 h post-infection. These lines of evidence imply that ICP27 may have a role in viral gene transcription initiation.

Book Herpes Simplex Virus Type 1

Download or read book Herpes Simplex Virus Type 1 written by Kari Lynn Roberts and published by . This book was released on 2011 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus type 1 (HSV-1) replicates in the nucleus and buds through the nuclear membrane to access the cytosol and complete the maturation process. The HSV-1 protein pUL31, along with its binding partner, pUL34, has been previously shown to be required for nucleocapsids to successfully bud through the nuclear membrane. pUL31 is also required for efficient viral DNA synthesis and packaging. After the HSV-1 exits the nucleus, the capsid acquires several accessory proteins (tegument) and finally a mature envelope by budding into vesicles of the trans-Golgi network (TGN). These virion-laden vesicles traffic toward the cell periphery and through cortical actin until ultimately the virion is secreted upon fusion of the TGN vesicle with the plasma membrane. The data presented here reveals new roles for pUL31, as cells infected with a UL31-null virus were delayed for viral gene expression as well as activation of NF[kappa]B and c-Jun N-terminal kinase (JNK) in multiple cell lines. At least one representative from each kinetic class of viral genes was examined at various times post infection. The protein expression defects were not caused by a failure to enter cells, was not rescued by ICP27 expressed in trans and correlated with NF[kappa]B activation. The data shows that these defects were not observed in the absence of the pUL31 binding partner, pUL34, and that while most pUL31 is expressed at late times post infection, low levels are detectable as early as 2 hours post infection. Data presented in this work also demonstrates a role for the actin motor myosin Va in the secretion of HSV-1 virions. Expression of two isoforms of dominant negative myosin Va (DN-myoVa) decreased virion secretion by 5075% as well as significantly decreased surface expression of viral glycoproteins B, M and D. DN-myoVa colocalized with TGN markers and the conformation of native myosin Va in infected cells was altered by 4 hours post infection. These data suggest that myosin Va is involved in the egress of virion-laden TGN vesicles as they transit through cortical actin toward the plasma membrane.

Book Human Herpesviruses

    Human Herpesviruses

    Book Details:
  • Author : Ann Arvin
  • Publisher : Cambridge University Press
  • Release : 2007-08-16
  • ISBN : 1139461648
  • Pages : 1325 pages

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Book Chromatin and Coactivators in Herpes Simplex Virus Type 1 Gene Regulation

Download or read book Chromatin and Coactivators in Herpes Simplex Virus Type 1 Gene Regulation written by Sebla Bulent Kutluay and published by . This book was released on 2009 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Herpes Simplex Virus Immediate Early Proteins and Effects on Translation

Download or read book Herpes Simplex Virus Immediate Early Proteins and Effects on Translation written by Errin Claudine Fontaine and published by . This book was released on 2008 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus (HSV) gene regulation requires a complex network of viral and cellular protein interactions. HSV expresses its proteins in a temporal cascade in which immediate early (IE) proteins are required for the expression of early (E) proteins, and both IE and E, and viral DNA replication are required for the expression of late (L) proteins. The IE proteins of HSV are mainly involved in regulating viral gene expression, and this regulation is carried out in multiple steps. IE proteins ICP27 and ICP22 were initially shown to regulate gene expression at the level of transcription, however continued studies have shown their involvement in additional aspects of gene regulation. ICP27 is required for efficient viral DNA replication, and the expression of a subset of viral E and L genes. ICP27 associates with a variety of host cell proteins, and many functions of ICP27 are mediated through these interactions.

Book Identification of a Marek s Disease Virus Gene Homologous to ICP27 of Herpes Simplex Virus Type 1 and Investigation of MDV ICP27 Gene Regulatory Functions

Download or read book Identification of a Marek s Disease Virus Gene Homologous to ICP27 of Herpes Simplex Virus Type 1 and Investigation of MDV ICP27 Gene Regulatory Functions written by De-lin Ren and published by . This book was released on 1996 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The Herpesviruses

Download or read book The Herpesviruses written by Bernard Roizman and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book A Genetic and Biochemical Analysis of the Role of the Immediate Early Polypeptides ICP0 and ICP27 in the Regulation of the Herpes Simplex Virus Type 1 Gene Expression

Download or read book A Genetic and Biochemical Analysis of the Role of the Immediate Early Polypeptides ICP0 and ICP27 in the Regulation of the Herpes Simplex Virus Type 1 Gene Expression written by Rose Eleanor Sekulovich and published by . This book was released on 1988 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Studies on the Structure Function and Regulation of Expression of the Latency associated Transcript of Herpes Simplex Virus Type 1

Download or read book Studies on the Structure Function and Regulation of Expression of the Latency associated Transcript of Herpes Simplex Virus Type 1 written by Michael James Farrell and published by . This book was released on 1993 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: