Download or read book Bioinformatics of Genome Regulation and Structure II written by Nikolay Kolchanov and published by Springer Science & Business Media. This book was released on 2006-06-15 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years in development of biology were marked with accumulation of unprecedentedly huge arrays of experimental data. The information was amassed with exclusively high rates due to the advent of highly efficient experimental technologies that provided for high throughput genomic sequencing; of functional genomics technologies allowing investigation of expression dynamics of large groups of genes using expression DNA chips; of proteomics methods giving the possibility to analyze protein compositions of cells, tissues, and organs, assess the dynamics of the cell proteome, and reconstruct the networks of protein-protein interactions; and of metabolomics, in particular, high resolution mass spectrometry study of cell metabolites, and distribution of metabolic fluxes in the cells with a concurrent investigation of the dynamics of thousands metabolites in an individual cell. Analysis, comprehension, and use of the tremendous volumes of experimental data reflecting the intricate processes underlying the functioning of molecular genetic systems are unfeasible in principle without the systems approach and involvement of the state-of-the-art information and computer technologies and efficient mathematical methods for data analysis and simulation of biological systems and processes. The need in solving these problems initiated the birth of a new science— postgenomic bioinformatics or systems biology in silico.
Download or read book Handbook of Toxicogenomics written by Jürgen Borlak and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Download or read book Advances in Protein Chemistry and Structural Biology written by and published by Academic Press. This book was released on 2014-03-11 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. - Describes advances in application of powerful techniques in a wide bioscience area - Chapters are written by authorities in their field - Targeted to a wide audience of researchers, specialists, and students - The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 2003 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1822 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computer Networks and Inventive Communication Technologies written by S. Smys and published by Springer Nature. This book was released on 2021-06-02 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of peer-reviewed best selected research papers presented at 3rd International Conference on Computer Networks and Inventive Communication Technologies (ICCNCT 2020). The book covers new results in theory, methodology, and applications of computer networks and data communications. It includes original papers on computer networks, network protocols and wireless networks, data communication technologies, and network security. The proceedings of this conference is a valuable resource, dealing with both the important core and the specialized issues in the areas of next generation wireless network design, control, and management, as well as in the areas of protection, assurance, and trust in information security practice. It is a reference for researchers, instructors, students, scientists, engineers, managers, and industry practitioners for advance work in the area.
Download or read book Biological Networks and Pathway Analysis written by Tatiana V. Tatarinova and published by Humana Press. This book was released on 2017-08-29 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, expert practitioners present a compilation of methods of functional data analysis (often referred to as “systems biology”) and its applications in drug discovery, medicine, and basic disease research. It covers such important issues as the elucidation of protein, compound and gene interactions, as well as analytical tools, including networks, interactome and ontologies, and clinical applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology series, this work provides detailed description and hands-on implementation advice. Reputable, comprehensive, and cutting-edge, Biological Networks and Pathway Analysis presents both “wet lab” experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.
Download or read book Neurofibromatosis Type 1 written by Meena Upadhyaya and published by Springer Science & Business Media. This book was released on 2013-01-29 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Download or read book The Yeasts written by Cletus Kurtzman and published by Elsevier. This book was released on 2011-05-09 with total page 2362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Yeasts: A Taxonomic Study is a three-volume book that covers the taxonomic aspect of yeasts. The main goal of this book is to provide important information about the identification of yeasts. It also discusses the growth tests that can be used to identify different species of yeasts, and it examines how the more important species of yeasts provide information for the selection of species needed for biotechnology. • Volume 1 discusses the identification, classification and importance of yeasts in the field of biotechnology. • Volume 2 focuses on the identification and classification of ascomycetous yeasts. • Volume 3 deals with the identification and classification of basidiomycetous yeasts, along with the genus Prototheca. - High-quality photomicrographs and line drawings - Detailed phylogenetic trees - Up-to-date, clearly presented yeast taxonomy and systematic, easy-to-use reference sequence accession numbers to allow for correct identification
Download or read book Applications of RNA Seq in Biology and Medicine written by Irina Vlasova-St. Louis and published by BoD – Books on Demand. This book was released on 2021-10-13 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book evaluates and comprehensively summarizes the scientific findings that have been achieved through RNA-sequencing (RNA-Seq) technology. RNA-Seq transcriptome profiling of healthy and diseased tissues allows FOR understanding the alterations in cellular phenotypes through the expression of differentially spliced RNA isoforms. Assessment of gene expression by RNA-Seq provides new insight into host response to pathogens, drugs, allergens, and other environmental triggers. RNA-Seq allows us to accurately capture all subtypes of RNA molecules, in any sequenced organism or single-cell type, under different experimental conditions. Merging genomics and transcriptomic profiling provides novel information underlying causative DNA mutations. Combining RNA-Seq with immunoprecipitation and cross-linking techniques is a clever multi-omics strategy assessing transcriptional, post-transcriptional and post-translational levels of gene expression regulation.
Download or read book Encyclopedia of Optimization written by Christodoulos A. Floudas and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 4646 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the Encyclopedia of Optimization is to introduce the reader to a complete set of topics that show the spectrum of research, the richness of ideas, and the breadth of applications that has come from this field. The second edition builds on the success of the former edition with more than 150 completely new entries, designed to ensure that the reference addresses recent areas where optimization theories and techniques have advanced. Particularly heavy attention resulted in health science and transportation, with entries such as "Algorithms for Genomics", "Optimization and Radiotherapy Treatment Design", and "Crew Scheduling".
Download or read book Computational Systems Biology of Cancer written by Emmanuel Barillot and published by CRC Press. This book was released on 2012-08-25 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.
Download or read book Thermophiles written by Frank Robb and published by CRC Press. This book was released on 2007-12-13 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: We might think of them as living on the very edge of existence. Referred to as extremophiles, these microorganisms exhibit the most radical capacity for adaptation in those harsh environments that are just barely conducive to the existence of cellular life. Unlocking the mechanisms and understanding the evolutionary development that allows these si
Download or read book Antioxidant Defense in Plants written by Tariq Aftab and published by Springer Nature. This book was released on 2022-05-04 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book highlights the molecular basis of various enzymatic and non-enzymatic antioxidants, defense mechanisms and adaptation strategies employed by plants to avoid the stressful conditions. Special focus is given to gene expression, omics and other latest technologies such as CRISPR-Cas mediated genome editing applications for defense related studies in plants. Environmental stresses such as drought, salinity or floods etc. induce the generation of reactive oxygen species (ROS) which causes severe damage to cell membrane integrity by accelerating lipid peroxidation. To counteract the detrimental effect of ROS, plants are inherited with an intricate and vibrant antioxidant defense system, comprised of enzymatic (catalase, peroxidase, superoxide dismutase, glutathione reductase, glutathione S-transferase, guaiacol peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase etc.), and non-enzymatic (glutathione, ascorbate, α-tocopherol, carotenoids, flavonoids etc.) antioxidants, which scavenge and/or reduce excess ROS and improve plant tolerance to various stresses. Stress tolerance in most crop plants is positively correlated with an efficient antioxidant system. Therefore, studying the efficiency of antioxidant defense systems in plants is necessary for facilitating the plant’s nature of adaptation against challenging environments. This book is of interest to teachers, researchers and academic experts. Also, the book serves as additional reading material for undergraduate and graduate students of biotechnology and molecular biology of plants.
Download or read book The Practical Bioinformatician written by Limsoon Wong and published by World Scientific. This book was released on 2004 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics: - Overview of modern molecular biology and a broad spectrum of techniques from computer science -- data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. - In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. - Incisive discussion of computational prediction of secondary structure of RNA sequences. - Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. - Overview of methods for discovering protein-protein interactions. - Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. - Case studies on analysis of phylogenies, functional annotation of proteins, construction of purposebuilt integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery. - Written in a practical, in-depth tutorial style - Covers a broad range of bioinformatics topics and of techniques used in bioinformatics - Comprehensive overviews of the development of various approaches in a number of selectedtopics - In-depth exposition of a number of important topics - Contributions by prominent researchers: Vladimir Bajic, Ming Li, Kenta Nakai, Limsoon Wong, Cathy Wu, etc. - Extensive, integrated references to background liter
Download or read book Thermophilic Microorganisms and Life at High Temperatures written by T.D. Brock and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 1965 through 1975, I conducted an extensive field and laboratory research project on thermophilic microorganisms. The field work was based primarily in Yellowstone National Park, using a field laboratory we set up in the city of W. Yellowstone, Montana. The laboratory work was carried out from 1965 through 1971 at Indiana University, Bloomington, and subsequently at the University of Wisconsin, Madison. Although this research project began small, it quickly ramified in a wide variety of directions. The major thrust was an attempt to understand the ecology and evolutionary relationships of thermophilic microorganisms, but research also was done on biochemical, physiologic, and taxonomic aspects of thermophiles. Four new genera of thermophilic microorganisms have been discovered during the course of this 10-year period, three in my laboratory. In addition, a large amount of new information has been obtained on some thermophilic microorganisms that previously had been known. In later years, a considerable amount of work was done on Yellowstone algal bacterial mats as models for Precambrian stromatolites. In the broadest sense, the work could be considered geomicrobiological, or biogeochemi cal, and despite the extensive laboratory research carried out, the work was always firmly rooted in an attempt to understand thermophilic microorga nisms in their natural environments. Indeed, one of the prime motivations for initiating this work was a view that extreme environments would provide useful models for studying the ecology of microorganisms. As a result of this 10-year research project, I published over 100 papers.
