Download or read book Thalidomide Catastrophe written by Martin Johnson and published by Onwards and Upwards. This book was released on 2018-05-14 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: "e;This momentous book is the first comprehensive history of thalidomide...It demonstrates how many thousands of victims could have been spared very late in the day if Chemie Grunenthal had taken any notice of the early alarms: ... [It] carries conviction by its scientific rigour, and the clarity of the writing. Fifty years after the deaths and sufferings, the thalidomide tragedy is marked by ... the odour of corruption and cover up."e; - Sir Harold Evans, former editor of The Sunday Times and The Times

Download or read book Dark Remedy written by Trent Stephens and published by Basic Books. This book was released on 2009-04-27 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this riveting medical detective story, Trent Stephens and Rock Brynner recount the history of thalidomide, from the epidemic of birth defects in the 1960's to the present day, as scientists work to create and test an alternative drug that captures thalidomide's curative properties without its cruel side effects. A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.

Download or read book Animals and Medicine written by Jack Botting and published by Open Book Publishers. This book was released on 2015-05-04 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.

Download or read book Thalidomide and the Power of the Drug Companies written by Henning Sjöström and published by . This book was released on 1972 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Silent Shock written by Michael Magazanik and published by Text Publishing. This book was released on 2015-05-22 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The baby started to come out. Head first, everything OK. But then I saw that there were no arms. And then no legs. The little girl had only a torso and a head. Lyn Rowe was born in Melbourne in 1962, seven months after her mother Wendy was given a new wonder drug for morning sickness called thalidomide. For fifty years the Rowe family cared for Lyn. Decades of exhausting, round-the-clock work. But then in 2011 Lyn Rowe launched a legal claim against the thalidomide companies. Against the odds, she won a multi-million-dollar settlement. Former journalist Michael Magazanik is one of the lawyers who ran Lyn’s case. In Silent Shock he exposes a fifty-year cover up concerning history’s most notorious drug, and details not only the damning case against manufacturers Grünenthal—whose enthusiastic promotion of their lucrative drug in the face of mounting evidence beggars belief—but also the moving story of the Rowe family. Spanning Australia, the United States, the United Kingdom, Japan, Canada, Sweden and, of course, Germany, Silent Shock is an epic account of corporate wrongdoing against a backdrop of heroic personal struggle and sacrifice. Michael Magazanik has worked as a journalist for the Age, the Australian and ABC-TV, and is now a lawyer with Slater & Gordon. He lives in Melbourne with his partner and three children. ‘Magazanik exposes myths and concealments on a grand scale... A compelling read. Highly recommended.’ BookMooch ‘Magazanik—a lawyer on the Rowes’ legal team and a former journalist—has woven an extraordinary story...Magazanik has moulded [the Rowes'] story into a modern Australian myth, the battlers who took on the pharmaceuticals and won.' Age/Sydney Morning Herald ‘A harrowing read of the damage wrought by this infamous drug.’ WA Today ‘A frightening account of secrets in the pharmaceutical industry and the inspiring story of a family and their legal team that just wouldn't give up.’ Law Society Journal ‘Silent Shock is an ambitious, important book...Magazanik does an excellent job.’ Australian Book Review

Download or read book Suffer the Children written by and published by Viking Adult. This book was released on 1979 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thalidomide, was hailed as a "wonder drug" that provided a "safe, sound sleep". Thalidomide was a sedative that was found to be effective when given to pregnant women to combat many of the symptoms associated with morning sickness. The drug was tested on animals. When given to pregnant women, thalidomide was a catastrophic drug with tragic side effects. It caused startling birth malformations, and death to babies. Birth defects included: deafness, blindness, disfigurement, cleft palate, and phocomelia (short limbs). The FDA did not approve thalidomide in the United States. Around the world, in the late 1960's and into the early 1970's, the victims of the drug thalidomide and their families entered into class action legal suits against the various drug companies who manufactured and/or distributed the drug. This book tells the story of thalidomide in Great Britain and how the parents overcame the formidable obstacles placed in their way to secure a just settlement for their children.

Download or read book Paediatric Clinical Pharmacology written by Evelyne Jacqz-Aigrain and published by CRC Press. This book was released on 2021-02-25 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.

Download or read book Frankie written by James Essinger and published by Blue Sparrow Books. This book was released on 2018-11-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ten million thalidomide pills had already been produced for distribution in the United States when it was first submitted to the FDA for approval. The morning sickness wonder drug had been approved for sale in Germany, Canada, and the UK, and the drug's distributors assumed that it would be no different in the United States. The answer they received was unexpected and firm: it needed more testing. It later came to light that thalidomide was causing severe birth defects throughout the world, and that Frances Kelsey, the FDA pharmacologist who had denied the drug's approval, was in fact a hero. Her courageous and unwavering integrity proved to be decisive in preventing one of the greatest pharmaceutical disasters of the twentieth century.Now, in this first ever biography, the fascinating and unlikely hero is portrayed in full detail. Read about the quiet, matter-of-fact woman who stood up to a major pharmaceutical company, did her job in the face of enormous pressure, and when presented with the highest civic honors, credited her whole team with the accomplishment. It's an incredible story of integrity in the moment of truth, of the power of humble courage, and of hundreds of thousands of lives saved by an ordinary woman."

Download or read book The Lomidine Files written by Guillaume Lachenal and published by JHU Press. This book was released on 2017-10-02 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultimately, it illuminates public health not only as a showcase of colonial humanism and a tool of control but as an arena of mediocrity, powerlessness, and stupidity.

Download or read book Teratogenicity Testing written by Paul C. Barrow and published by Humana Press. This book was released on 2012-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.

Download or read book Problems of Birth Defects written by T.V.N. Persaud and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surprisingly, the beginning of a modern approach This collection of articles and commentaries is an to the problems of birth defects is relatively recent integration of information from many disciplines, and dates from Gregg's classical report in 1941 that and presents a comprehensive survey of both recent mothers who contracted rubella during the first tri and previously reported work related to the major mester of pregnancy gave birth to infants with severe aspects of birth defects. In particular, an attempt multiple anomalies. For the first time, an environ has been made to provide a critical assessment of mental agent was found to be teratogenic in man current concepts and to identify areas in need of and was documented in a thoroughly convincing further investigation. manner. Since then, many important discoveries The scope of this volume and space limitations and significant developments have been made, par precluded discussion of and reference to all papers ticularly in the areas of environmental teratogenesis, of relevance or importance: a work of the present hereditary mechanisms, and prenatal diagnosis. nature must necessarily be selective. Some good In recent years, there has been an impressive papers have been left out or given relatively little surge of interest in the causes and prevention of consideration. It is my hope that the list of Further birth defects. Undoubtedly this resulted not only References will be consulted and should compensate from the thalidomide tragedy, but also from the for this lack of completeness.

Download or read book An Introduction to Toxicology written by Philip C. Burcham and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text. ​

Download or read book Pharmageddon written by David Healy and published by Univ of California Press. This book was released on 2013-04 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This searing indictment, David Healy’s most comprehensive and forceful argument against the pharmaceuticalization of medicine, tackles problems in health care that are leading to a growing number of deaths and disabilities. Healy, who was the first to draw attention to the now well-publicized suicide-inducing side effects of many anti-depressants, attributes our current state of affairs to three key factors: product rather than process patents on drugs, the classification of certain drugs as prescription-only, and industry-controlled drug trials. These developments have tied the survival of pharmaceutical companies to the development of blockbuster drugs, so that they must overhype benefits and deny real hazards. Healy further explains why these trends have basically ended the possibility of universal health care in the United States and elsewhere around the world. He concludes with suggestions for reform of our currently corrupted evidence-based medical system.

Download or read book Women and Health Research written by Anna C. Mastroianni and published by . This book was released on 1994 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Trials of Psychedelic Therapy written by Matthew Oram and published by JHU Press. This book was released on 2018-10-01 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise—and fall—of research into the therapeutic potential of LSD. After LSD arrived in the United States in 1949, the drug's therapeutic promise quickly captured the interests of psychiatrists. In the decade that followed, modern psychopharmacology was born and research into the drug's perceptual and psychological effects boomed. By the early 1960s, psychiatrists focused on a particularly promising treatment known as psychedelic therapy: a single, carefully guided, high-dose LSD session coupled with brief but intensive psychotherapy. Researchers reported an astounding 50 percent success rate in treating chronic alcoholism, as well as substantial improvement in patients suffering from a range of other disorders. Yet despite this success, LSD officially remained an experimental drug only. Research into its effects, psychological and otherwise, dwindled before coming to a close in the 1970s. In The Trials of Psychedelic Therapy, Matthew Oram traces the early promise and eventual demise of LSD psychotherapy in the United States. While the common perception is that LSD's prohibition terminated legitimate research, Oram draws on files from the Food and Drug Administration and the personal papers of LSD researchers to reveal that the most significant issue was not the drug's illegality, but the persistent question of its efficacy. The landmark Kefauver-Harris Drug Amendments of 1962 installed strict standards for efficacy evaluation, which LSD researchers struggled to meet due to the unorthodox nature of their treatment. Exploring the complex interactions between clinical science, regulation, and therapeutics in American medicine, The Trials of Psychedelic Therapy explains how an age of empirical research and limited government oversight gave way to sophisticated controlled clinical trials and complex federal regulations. Analyzing the debates around how to understand and evaluate treatment efficacy, this book will appeal to anyone with an interest in LSD and psychedelics, as well as mental health professionals, regulators, and scholars of the history of psychiatry, psychotherapy, drug regulation, and pharmaceutical research and development.

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Download or read book Birth Defects in India written by Anita Kar and published by Springer Nature. This book was released on 2021-07-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the epidemiology of birth defects and their public health and social implications in India. As neglected childhood disorders, birth defects remain invisible in global maternal and child health dialogues. Birth defects services are emerging in India. This book approaches birth defects from a public health perspective, identifying the core functions of a birth defects service. Keeping in mind the complex task of providing multidisciplinary services for children with disabilities and complex medical conditions, the book examines the basic public health activities that have been put in place to address these conditions in India. The book describes birth defects surveillance and the challenges of acquiring accurate and timely data on birth defects against the background of India’s mixed health system. It discusses opportunities for prevention of birth defects and describes the structure and function of an emergent genetic service. It explores issues related to an integrated service for children with special healthcare needs, such as screening, early intervention, and rehabilitation. Furthermore, it describes the impact of these conditions on caregivers, including birth defects stigma. This book not only addresses a knowledge gap in the field of public health in India, but also explores the broader issues of services for children with disabilities and disabling conditions in low and low-middle income settings where access to health care is not universal. Given the depth and breadth of its coverage, the book offers an essential resource for birth defects researchers, researchers in the field of maternal and child health, public health/ global health, disability researchers, and researchers from the fields of rehabilitation sciences, nursing and anthropology. This book will be a valuable read for social medicine/community medicine departments, global health courses, and public health schools in India and other low middle-income countries.