Download or read book Drug Discovery and Development E Book written by Raymond G Hill and published by Elsevier Health Sciences. This book was released on 2012-07-20 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. - The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ? non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ? Visiting Industrial Professor of Pharmacology in the University of Bristol ? Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ? Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ? President and Chair of the Council of the British Pharmacological Society ? member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: - Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. - New topic - DMPK Optimization Strategy in drug discovery. - New chapter on Scaffolds: Small globular proteins as antibody substitutes. - Totally updated chapters on Intellectual Property and Marketing - 50 new illustrations in full colour Features - Accessible, general guide to pharmaceutical research and development. - Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. - Written by a strong team of scientists with long experience in the pharmaceutical industry. - Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: '... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. - Highly Commended in the medicine category of the BMA 2006 medical book competition - Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Download or read book Technology in Transition A D 300 650 written by Luke Lavan and published by BRILL. This book was released on 2008-03-31 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first general work to be published on technology in Late Antiquity. It seeks to survey aspects of the technology of the period and to respond to questions about technological continuity, stagnation and decline. The book opens with a comprehensive bibliographic essay that provides an overview of relevant literature. The main section then explores technologies in agriculture, production (metal, ceramics and glass), engineering and building. Papers draw on both archaeological and textual sources, and on analogies with medieval and early modern technologies. Reference is made not only to the periods which preceded it, but to the transition to the Early Middle Ages and to the technological heritage of Late Antiquity to the Islamic world. Several papers focus on Italy, whilst others consider North Africa, Asia Minor, and the Near-East.

Download or read book Technological Learning in the Transition to a Low Carbon Energy System written by Martin Junginger and published by Academic Press. This book was released on 2019-11-22 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological Learning in the Transition to a Low-Carbon Energy System: Conceptual Issues, Empirical Findings, and Use in Energy Modeling quantifies key trends and drivers of energy technologies deployed in the energy transition. It uses the experience curve tool to show how future cost reductions and cumulative deployment of these technologies may shape the future mix of the electricity, heat and transport sectors. The book explores experience curves in detail, including possible pitfalls, and demonstrates how to quantify the 'quality' of experience curves. It discusses how this tool is implemented in models and addresses methodological challenges and solutions. For each technology, current market trends, past cost reductions and underlying drivers, available experience curves, and future prospects are considered. Electricity, heat and transport sector models are explored in-depth to show how the future deployment of these technologies--and their associated costs--determine whether ambitious decarbonization climate targets can be reached - and at what costs. The book also addresses lessons and recommendations for policymakers, industry and academics, including key technologies requiring further policy support, and what scientific knowledge gaps remain for future research. Provides a comprehensive overview of trends and drivers for major energy technologies expected to play a role in the energy transition Delivers data on cost trends, helping readers gain insights on how competitive energy technologies may become, and why Reviews the use of learning curves in environmental impacts for lifecycle assessments and energy modeling Features social learning for cost modeling and technology diffusion, including where consumer preferences play a major role

Download or read book Accelerating Technology Transition written by National Research Council and published by National Academies Press. This book was released on 2004-11-15 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accelerating the transition of new technologies into systems and products will be crucial to the Department of Defenses development of a lighter, more flexible fighting force. Current long transition times-ten years or more is now typical-are attributed to the complexity of the process. To help meet these challenges, the Department of Defense asked the National Research Council to examine lessons learned from rapid technology applications by integrated design and manufacturing groups. This report presents the results of that study, which was based on a workshop held to explore these successful cases. Three key areas emerged: creating a culture for innovation and rapid technology transition; methodologies and approaches; and enabling tools and databases.

Download or read book Information Technology Research Innovation and E Government written by National Research Council and published by National Academies Press. This book was released on 2002-06-03 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Governments have done much to leverage information technology to deploy e-government services, but much work remains before the vision of e-government can be fully realized. Information Technology Research, Innovation, and E-government examines the emerging visions for e-government, the technologies required to implement them, and approaches that can be taken to accelerate innovation and the transition of innovative information technologies from the laboratory to operational government systems. In many cases, government can follow the private sector in designing and implementing IT-based services. But there are a number of areas where government requirements differ from those in the commercial world, and in these areas government will need to act on its role as a "demand leader." Although researchers and government agencies may appear to by unlikely allies in this endeavor, both groups have a shared interest in innovation and meeting future needs. E-government innovation will require addressing a broad array of issues, including organization and policy as well as engineering practice and technology research and development, and each of these issues is considered in the book.

Download or read book Drug Discovery and Development written by H. P. Rang and published by Churchill Livingstone. This book was released on 2006 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful.

Download or read book Translation in Transition written by Arnt Lykke Jakobsen and published by John Benjamins Publishing Company. This book was released on 2017-09-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translation practice and workflows have witnessed significant changes during the last decade. New market demands to handle digital content as well as technological advances are leading this transition. The development and integration of machine translation systems have given post-editing practices a reason to be in the context of professional translation services. Translators may still work from a source text, but more often than not they are presented with already translated text involving different degrees of translation automation. This scenario radically changes the cognitive demands of translation. Technological development has inevitably influenced the translation research agenda as well. It has provided new means of penetrating deeper into the cognitive processes that make translation possible and has endorsed new concepts and theories to understand the translation process. Computational analysis of eye movements and keystroke behaviour provides us with new insights into translational reading, processes of literality, effects of directionality, similarities between inter- and intralingual translation, as well as the effects of post-editing on cognitive processes and on the quality of the final outcome. All of these themes are explored in-depth in the articles in this volume which presents new and valuable insights to anyone interested in what is currently happening in empirical, process-oriented translation research.

Download or read book Population Technology and Lifestyle written by Robert J. A. Goodland and published by . This book was released on 1992 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three of the factors that most directly affect the potential for sustainability - population, technology, and lifestyle - are discussed and analyzed in-depth. In addition, the authors examine global patterns of income distribution and the pressing need for greater equality between the northern and southern hemispheres. The authors, all leading scholars in their fields, argue that traditional means of economic growth which rely on an ever-increasing use of energy and natural materials cannot be sustained. They advocate an imaginative pursuit of economic ends that are less resource intensive and allow for increases in quality of life without corresponding decreases in environmental quality.

Download or read book HDTV and the Transition to Digital Broadcasting written by Philip J. Cianci and published by Taylor & Francis. This book was released on 2012-07-26 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: HDTV and the Transition to Digital Broadcasting bridges the gap between non-technical personnel (management and creative) and technical by giving you a working knowledge of digital television technology, a clear understanding of the challenges of HDTV and digital broadcasting, and a scope of the ramifications of HDTV in the consumer space. Topics include methodologies and issues in HD production and distribution, as well as HDTV's impact on the future of the media business. This book contains sidebars and system diagrams that illustrate examples of broadcaster implementation of HD and HD equipment. Additionally, future trends including the integration of broadcast engineering and IT, control and descriptive metadata, DTV interactivity and personalization are explored.

Download or read book Distance and E learning in Transition written by András Szücs and published by Wiley-ISTE. This book was released on 2009-08-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rushed development of information and communication technologies and their impact on the world of learning in the last decade have profoundly changed the paradigms, scenarios and values at all levels of education. The professionalization of tools and practices, in addition to the consolidation of academic and practical knowledge, has been a major continuing issue throughout these years. The annual conferences of the largest European professional community in distance and e-learning have been setting the landmarks in this process. The selection from this unique knowledge pool demonstrates the deepening and consolidation of knowledge and experience. This book presents the developments in the field of open, distance and e-learning, through new technologies, methodologies and tools, which have profoundly changed the paradigms, scenarios and values at all levels of education over the last decade.

Download or read book Digital Memory Studies written by Andrew Hoskins and published by Routledge. This book was released on 2017-09-27 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Digital media, networks and archives reimagine and revitalize individual, social and cultural memory but they also ensnare it, bringing it under new forms of control. Understanding these paradoxical conditions of remembering and forgetting through today’s technologies needs bold interdisciplinary interventions. Digital Memory Studies seizes this challenge and pioneers an agenda that interrogates concepts, theories and histories of media and memory studies, to map a holistic vision for the study of the digital remaking of memory. Through the lenses of connectivity, archaeology, economy, and archive, contributors illuminate the uses and abuses of the digital past via an array of media and topics, including television, videogames and social media, and memory institutions, network politics and the digital afterlife.

Download or read book Information Technology and Socialist Construction written by Daniel E. Saros and published by Routledge. This book was released on 2014-05-09 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The failure of command central planning in the twentieth century has led to a general disillusionment within the socialist movement worldwide. Some alternatives to capitalism have been proposed since the end of the Cold War, but none has offered an alternative form of economic calculation. This book explains how modern information technology may be used to implement a new method of economic calculation that could bring an end to capitalism and make socialism possible. In this book, the author critically examines a number of socialist proposals that have been put forward since the end of the Cold War. It is shown that although these proposals have many merits, their inability effectively to incorporate the benefits of information technology into their models has limited their ability to solve the problem of socialist construction. The final section of the book proposes an entirely new model of socialist development, based on a "needs profile" that makes it possible to convert the needs of large numbers of people into data that can be used as a guide for resource allocation. This analysis makes it possible to rethink and carefully specify the conditions necessary for the abolition of capital and consequently the requirements for socialist revolution and, ultimately, communist society. Information Technology and Socialist Construction will be of interest to students and scholars of political economy, the history of economic thought, labour economics and industrial economics.

Download or read book Technology and Transition written by Abdelkader Djeflat and published by Routledge. This book was released on 2014-01-14 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Maghreb countries had a promising start in economic growth after independence. For the most part they thrived on industrialisation by import substitution; but unfortunately this strategy left them with macroeconomic and structural imbalances which together have effectively constrained their ability to compete in the world economic system and to catch up with the rapidly changing global techno-economic circumstances. Issues relating to aspects of technology transfer to the Maghreb, strategies for technological and resource development and the integration of education and R&D systems with the productive systems of the economies in the region are discussed along with relevant cases from Mexico, China, South Korea, India and Bangladesh.

Download or read book Accelerating Technology Transition written by National Research Council and published by National Academies Press. This book was released on 2004-10-15 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accelerating the transition of new technologies into systems and products will be crucial to the Department of Defenses development of a lighter, more flexible fighting force. Current long transition times-ten years or more is now typical-are attributed to the complexity of the process. To help meet these challenges, the Department of Defense asked the National Research Council to examine lessons learned from rapid technology applications by integrated design and manufacturing groups. This report presents the results of that study, which was based on a workshop held to explore these successful cases. Three key areas emerged: creating a culture for innovation and rapid technology transition; methodologies and approaches; and enabling tools and databases.

Download or read book Rethinking Media Change written by David Thorburn and published by MIT Press. This book was released on 2004-09-17 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essays in Rethinking Media Change center on a variety of media forms at moments of disruption and cultural transformation. The editors' introduction sketches an aesthetics of media transition—patterns of development and social dispersion that operate across eras, media forms, and cultures. The book includes case studies of such earlier media as the book, the phonograph, early cinema, and television. It also examines contemporary digital forms, exploring their promise and strangeness. A final section probes aspects of visual culture in such environments as the evolving museum, movie spectaculars, and "the virtual window." The contributors reject apocalyptic scenarios of media revolution, demonstrating instead that media transition is always a mix of tradition and innovation, an accretive process in which emerging and established systems interact, shift, and collude with one another.

Download or read book Disabled Students in Education written by David Moore and published by . This book was released on 2012 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book reports on research projects aimed at improving the educational prospects of disabled people, through its discussion of three main themes--technology, transition and inclusivity"--Provided by publisher.

Download or read book System Innovation and the Transition to Sustainability written by Boelie Elzen and published by Edward Elgar Publishing. This book was released on 2004-01-01 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern societies face several structural problems such as transport congestion and greenhouse gas emissions due to the widespread use of fossil fuels. To address these important societal problems and achieve sustainability in the broad sense, major transformations are required, but this poses an enormous challenge given the complexity of the processes involved. Such transformations are called 'transitions' or 'system innovations' and involve changes in a variety of elements, including technology, regulation, user practices and markets, cultural meaning and infrastructure. This book considers two main questions: how do system innovations or transitions come about and how can they be influenced by different actors, in particular by governments. The authors identify the theories which can be used to conceptualise the dynamics of system innovations and discuss the weaknesses in these theories. They also look at the lessons which can be learned from historical examples of transitions, and highlight the instruments and policy tools which can be used to stimulate future system innovations towards sustainability. The expert contributors address these questions using insights from a variety of different disciplines including innovation studies, evolutionary economics, the sociology of technology, environmental analysis and governance studies. The book concludes with an extensive summary of the results and practical suggestions for future research. This important new volume offers an interdisciplinary assessment of how and why system innovations occur. It will engage and inform academics and researchers interested in transitions towards sustainability, and will also be highly relevant for policymakers concerned with environmental issues, structural change and radical innovation.