Download or read book Technical Report on Toxicology and Carcinogenesis Studies of Formamide CAS No 75 12 7 in F344 N Rats and B6C3F1 Mice Gavage Studies written by R. D. Irwin and published by DIANE Publishing. This book was released on 2009-02 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. Groups of 50 animals received 20, 40, or 80 milligrams of formamide per kilogram body weight 5 days per week for 2 years; groups of animals receiving water alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The only effects observed in male and female rats were lower body weight in animals receiving the highest dose of formamide and a slight increase in bone marrow hyperplasia in male rats. The study concludes that exposure to formamide did not cause cancer in male or female rats, but it did produce hemangiosarcomas in the liver of male mice and may have been related to an increase in liver tumors in female mice. Increased incidence of bone marrow hyperplasia in male rats and testicular mineralization in male mice were also associated with formamide exposure. Illus.

Download or read book Understanding Toxicology written by Mercurio and published by Jones & Bartlett Publishers. This book was released on 2016-08-30 with total page 973 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter

Download or read book Technical Report Series written by and published by . This book was released on 2008 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Government Reports Announcements Index written by and published by . This book was released on 1993-03 with total page 1452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Government reports annual index written by and published by . This book was released on 199? with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toxicological Profile for Boron written by and published by . This book was released on 2010 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reporting for the Domestic Substances List written by Canada. Environment Canada and published by . This book was released on 1988 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Canadian Environmental Protection Act (CEPA) provides the legislative basis for addressing pollution problems on land, in water and through all layers of the atmosphere. It establishes a comprehensive framework to manage toxic substances through their life cycle, from development and manufacture, through transport, distribution, use and storage, to safe disposal as waste. This guide gives information on the CEPA, the domestic and non-domestic substances list and amendments to it; criteria for reporting; how to report; guidelines to substance reporting; confidentiality; and problem letters. The guide also includes relevant sections of CEPA and definitions of terms.

Download or read book Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 1999 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Download or read book Carcinogenesis Abstracts written by and published by . This book was released on 1976 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book IPCS International programme on chemical safety written by R. Cary and published by . This book was released on 1999 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise assessment of the risks to human health posed by exposure to azodicarbonamide, a chemical mainly used as a blowing agent in the rubber and plastics industries. The compound is used in the expansion of a wide range of polymers, including polyvinyl chloride polyolefins and natural and synthetic rubbers. Although no data on environmental levels are available, the report cites limited evidence suggesting rapid biodegradation in soil. Azodicarbonamide released to surface waters is expected to partition to the hydrosphere with no signification sorption to particulates. No data on exposure of the general population could be identified. Concerning kinetics and metabolism, limited animal studies of exposures via inhalation and ingestion indicate that substantial quantities remain unabsorbed and are rapidly eliminated in the faeces. Studies further suggest that most systemic exposure is to the breakdown product, biurea, and not to the parent compound. Toxicity studies conducted in experimental mammals demonstrate low acute toxicity and no irritation of skin, eye, or respiratory tract. Although azodicarbonamide was found to be a mutagen in bacterial systems, the report found no evidence that this effect would occur in vivo. No adequate studies of carcinogenicity and reproductive toxicity in animals or in humans could be identified. Case reports and epidemiological studies in humans have produced abundant evidence that azodicarbonamide can induce asthma, other respiratory symptoms, and skin sensitization in exposed workers. Adverse effects on other systems have not been studied.

Download or read book Patty s Industrial Hygiene VII Specialty Areas and Allied Professions written by Robert L. Harris and published by Wiley-Interscience. This book was released on 2000-03-27 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt: The standard reference in occupational health and safety for over 50 years, the new Patty's presents for the first time a separation of industrial hygiene and toxicology topics, offering complete reorganization of the material into four volumes of clearly defined topic areas.

Download or read book Taking an Exposure History written by Arthur L. Frank and published by . This book was released on 2001 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Target Organ and the Toxic Process written by Philip L. Chambers and published by Springer. This book was released on 1988-09-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toxicological Profile for Benzidine written by and published by . This book was released on 1995 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Riot Control Agents written by Eugene J. Olajos and published by CRC Press. This book was released on 2004-01-27 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proliferation and sophistication of riot control chemicals mean that all parties need to understand the responsible use and effects of such compounds. This book provides practical information on the history, chemistry, and biology of riot control agents and discusses their biological actions, risk assessment issues, and recent technical develop

Download or read book Proctor and Hughes Chemical Hazards of the Workplace written by Gloria J. Hathaway and published by John Wiley & Sons. This book was released on 2014-12-03 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The indispensable resource for health professionals on potentially unsafe chemicals--now fully updated Proctor and Hughes' Chemical Hazards of the Workplace, Fifth Edition provides a comprehensive reference text for health professionals who need toxicology data on chemicals that may be encountered in various work settings. Building on the success of the Fourth Edition-already a standard text-this new edition updates and revises the more than 600 entries of that text, and also adds monographs on new compounds. Introductory chapters cover toxicological concepts, clinical manifestations of exposure, the diagnosis of occupational disease, and industrial hygiene aspects of chemical exposures. The rest of the text consists of more than 625 alphabetically arranged entries on individual compounds, each of which includes: * Chemical formula * CAS number * 2003 ACGIH (American Conference of Government Industrial Hygienists) threshold limit value * Synonyms * Physical properties * Sources of exposure * Routes of exposure * Toxicological data The toxicological data includes both acute and chronic effects, especially as related to any known exposure levels. The data emphasizes human studies and cases over animal data whenever sufficient information is available, and addresses any known carcinogenic, mutagenic, fetotoxic, or other reproductive effects. Clinical information is presented in a succinct narrative form to aid in understanding. Easy to use, in-depth, and comprehensive, Proctor and Hughes' Chemical Hazards of the Workplace, Fifth Edition offers occupational health physicians, nurses, industrial hygienists, and other safety professionals an invaluable and up-to-date resource.