Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Download or read book Boron Neutron Capture Therapy written by United States. Congress. Senate. Committee on Energy and Natural Resources and published by . This book was released on 1994 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Compounds Suitable for Neutron Capture Therapy for the Treatment of Cancer written by and published by . This book was released on 1988 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important aspect of boron neutron capture therapy (BNCT) is the determination of the biological distribution of the boron within an organism at some point in time after administration of a boron-containing species. To that end a variety of techniques have been developed and applied to the analysis of boron. These techniques include prompt gamma analysis, colorimetric techniques, and most recently, Inductively Coupled Plasma Atomic Emission spectroscopy (ICP-AES) techniques. The synthesis of new boron compounds for BNCT and understanding the mechanisms by which existing compounds achieve tumor localization is in. a very active stage of development internationally. Such research programs will undoubtedly contribute to improving the possibility for a new clinical trial of this binary therapeutic system in the United States. The papers presented in these proceedings present research into a wide variety of these techniques.
Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Download or read book Clinical Aspects of Neutron Capture Therapy written by R. Fairchild and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Download or read book Energy and Water Development Appropriations for Fiscal Year 1991 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Energy and Water Development and published by . This book was released on 1990 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Energy and Water Development Appropriations for Fiscal Year 1991 Department of the Army written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Energy and Water Development and published by . This book was released on 1990 with total page 1662 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumors of the Central Nervous System Volume 2 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2011-04-03 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.
Download or read book Energy Research Abstracts written by and published by . This book was released on 1993 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1968 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Radiation Detectors for Medical Applications written by Stefaan Tavernier and published by Springer Science & Business Media. This book was released on 2006-10-02 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of this book is the use of scintillating materials in the detection of ionising radiation for medical imaging. The text surveys the state of the art in radiation detectors for medical imaging, followed by an in-depth review of all aspects of the use of scintillating materials. Also included are detailed discussion of ways to improve the performance of existing scintillating materials and completely novel uses of scintillating materials.
Download or read book Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment written by Narayan S. Hosmane and published by World Scientific. This book was released on 2012 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
Download or read book Neutron Beam Design Development and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
Download or read book Government Research Directory written by Grant Eldridge and published by Gale Cengage. This book was released on 2001 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides more than 6,800 research facilities and programs of the U.S. and Canadian federal governments. Listings include e-mail and Web site addresses, and a wealth of descriptive information.
Download or read book Fiscal Year 1998 Budget Authorization Request Department of Energy DOE Office of Energy Research and DOE Management of Major System Acquisitions written by United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment and published by . This book was released on 1997 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The DOE FY 99 Budget Authorization Request H R 1806 to Provide for the Consolidation of the DOE Offices of Fossil Energy Renewable Energy and Energy Efficiency S 965 to Amend Title II of the Hydrogen Future Act of 1996 written by United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment and published by . This book was released on 1998 with total page 2068 pages. Available in PDF, EPUB and Kindle. Book excerpt:
