Download or read book The Unconsoled written by Kazuo Ishiguro and published by Vintage. This book was released on 2012-09-05 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the universally acclaimed author of The Remains of the Day comes a mesmerizing novel of completely unexpected mood and matter--a seamless, fictional universe, both wholly unrecognizable and familiar. When the public, day-to-day reality of a renowned pianist takes on a life of its own, he finds himself traversing landscapes that are by turns eerie, comical, and strangely malleable.

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Download or read book Every Tool s a Hammer written by Adam Savage and published by Atria Books. This book was released on 2020-10-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and break­ing, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the fric­tion in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.

Download or read book Building a Second Brain written by Tiago Forte and published by Simon and Schuster. This book was released on 2022-06-14 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Building a second brain is getting things done for the digital age. It's a ... productivity method for consuming, synthesizing, and remembering the vast amount of information we take in, allowing us to become more effective and creative and harness the unprecedented amount of technology we have at our disposal"--

Download or read book Maritime Economics written by Alan Branch and published by Routledge. This book was released on 2013-04-15 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition Maritime Economics provides a valuable introduction to the organisation and workings of the global shipping industry. The author outlines the economic theory as well as many of the operational practicalities involved. Extensively revised for the new edition, the book has many clear illustrations and tables. Topics covered include: * an overview of international trade * Maritime Law * economic organisation and principles * financing ships and shipping companies * market research and forecasting.

Download or read book The Math Gene written by Keith Devlin and published by Basic Books. This book was released on 2001-05-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: If people are endowed with a "number instinct" similar to the "language instinct" -- as recent research suggests -- then why can't everyone do math? In The Math Gene, mathematician and popular writer Keith Devlin attacks both sides of this question. Devlin offers a breathtakingly new theory of language development that describes how language evolved in two stages and how its main purpose was not communication. Devlin goes on to show that the ability to think mathematically arose out of the same symbol-manipulating ability that was so crucial to the very first emergence of true language. Why, then, can't we do math as well as we speak? The answer, says Devlin, is that we can and do -- we just don't recognize when we're using mathematical reasoning.

Download or read book Feedback Control of Dynamic Systems Int written by J. David Powell and published by Pearson Academic Computing. This book was released on 2012-06 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the material that every engineer, and most scientists and prospective managers, needs to know about feedback control, including concepts like stability, tracking, and robustness. Each chapter presents the fundamentals along with comprehensive, worked-out examples, all within a real-world context.

Download or read book Deus Irae written by Philip K. Dick and published by Houghton Mifflin Harcourt. This book was released on 2013 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this collaboration with Roger Zelazny, an armless and legless painter must undertake a pilgrimage through a nuclear war-ravaged America in a search for the God of Wrath, whose picture he has been commissioned to paint.

Download or read book Tropic of Kansas written by Christopher Brown and published by HarperCollins. This book was released on 2017-07-11 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Timely, dark, and ultimately hopeful: it might not ‘make America great again,’ but then again, it just might.”—Cory Doctorow, New York Times bestselling and award winning author of Homeland Acclaimed short story writer and editor of the World Fantasy Award-nominee Three Messages and a Warning eerily envisions an American society unraveling and our borders closed off—from the other side—in this haunting and provocative novel that combines Max Barry’s Jennifer Government, Philip K. Dick’s classic Man in the High Castle, and China Mieville’s The City & the City The United States of America is no more. Broken into warring territories, its center has become a wasteland DMZ known as “the Tropic of Kansas.” Though this gaping geographic hole has no clear boundaries, everyone knows it's out there—that once-bountiful part of the heartland, broken by greed and exploitation, where neglect now breeds unrest. Two travelers appear in this arid American wilderness: Sig, the fugitive orphan of political dissidents, and his foster sister Tania, a government investigator whose search for Sig leads her into her own past—and towards an unexpected future. Sig promised those he loves that he would make it to the revolutionary redoubt of occupied New Orleans. But first he must survive the wild edgelands of a barren mid-America policed by citizen militias and autonomous drones, where one wrong move can mean capture . . . or death. One step behind, undercover in the underground, is Tania. Her infiltration of clandestine networks made of old technology and new politics soon transforms her into the hunted one, and gives her a shot at being the agent of real change—if she is willing to give up the explosive government secrets she has sworn to protect. As brother and sister traverse these vast and dangerous badlands, their paths will eventually intersect on the front lines of a revolution whose fuse they are about to light. “Futurist as provocateur! The world is sheer batshit genius . . . a truly hallucinatorily envisioned environment.”—William Gibson, New York Times bestselling and award-winning author

Download or read book Atoms Molecules and Photons written by Wolfgang Demtröder and published by Springer. This book was released on 2019-02-09 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to Atomic and Molecular Physics explains how our present model of atoms and molecules has been developed over the last two centuries both by many experimental discoveries and, from the theoretical side, by the introduction of quantum physics to the adequate description of micro-particles. It illustrates the wave model of particles by many examples and shows the limits of classical description. The interaction of electromagnetic radiation with atoms and molecules and its potential for spectroscopy is outlined in more detail and in particular lasers as modern spectroscopic tools are discussed more thoroughly. Many examples and problems with solutions are offered to encourage readers to actively engage in applying and adapting the fundamental physics presented in this textbook to specific situations. Completely revised third edition with new sections covering all actual developments, like photonics, ultrashort lasers, ultraprecise frequency combs, free electron lasers, cooling and trapping of atoms, quantum optics and quantum information.

Download or read book The Dysautonomia Project written by Msm Kelly Freeman and published by Bardolf. This book was released on 2015-10-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Dysautonomia Project" is a much needed tool for physicians, patients, or caregivers looking to arm themselves with the power of knowledge. It combines current publications from leaders in the field of autonomic disorders with explanations for doctors and patients about the signs and symptoms, which will aid in reducing the six-year lead time to diagnosis.

Download or read book Medical Terminology in a Flash written by Sharon Eagle and published by F A Davis Company. This book was released on 2006 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides students with a foundation of knowledge they can build on as they pursue a career in healthcare. This work is written in a user-friendly style.

Download or read book Mathematicians in Love written by Rudy Rucker and published by Macmillan. This book was released on 2008-07-08 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: A riveting new science fiction novel from the writer who twice won the Philip K. Dick Award for best SF novel.Bela and Paul, two wild young mathematicians, are friends and roommates, and in love with the same woman, who happens to be Alma, Bela's girlfriend. They fight it out by changing reality using cutting edge math, to change who gets the girl. The contemporary world they live in is not quite this one, but much like Berkeley, California, and the two graduate students are trying to finish their degrees and get jobs. It doesn't help that their unpredictable advisor Roland is a mad mathematical genius who has figured out a way to predict isolated and specific bits of the future that can cause a lot of trouble. . .and he's starting to see monsters in mirrors. Bela and Paul start to mess around with reality, and when that happens, all heaven and hell break loose. Those monsters of Roland's were really there, but who are they? This novel is a romantic comedy with a whole corkscrew of SF twists. At the publisher's request, this title is being sold without Digital Rights Management software (DRM) applied.

Download or read book The Lathe Of Heaven written by Ursula K. Le Guin and published by Simon and Schuster. This book was released on 2022-07-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a new introduction by Kelly Link, the Locus Award-winning science fiction novel by legendary author Ursula K. Le Guin, set in a world where one man’s dreams rewrite the future. During a time racked by war and environmental catastrophe, George Orr discovers his dreams alter reality. George is compelled to receive treatment from Dr. William Haber, an ambitious sleep psychiatrist who quickly grasps the immense power George holds. After becoming adept at manipulating George’s dreams to reshape the world, Haber seeks the same power for himself. George—with some surprising help—must resist Haber’s attempts, which threaten to destroy reality itself. A classic of the science fiction genre, The Lathe of Heaven is prescient in its exploration of the moral risks when overwhelming power is coupled with techno-utopianism.

Download or read book Medical Surgical Nursing Single Volume Text and Elsevier Adaptive Learning Package written by Sharon L. Lewis and published by Elsevier. This book was released on 2014-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corresponding chapter-by-chapter to Medical-Surgical Nursing, 9e, Elsevier Adaptive Learning combines the power of brain science with sophisticated, patented Cerego algorithms to help you learn faster and remember longer. It's fun; it's engaging; and it's constantly tracking your performance and adapting to deliver content precisely when it's needed to ensure core information is transformed into lasting knowledge. Please refer to the individual product pages for the duration of access to these products. An individual study schedule reduces cognitive workload and helps you become a more effective learner by automatically guiding the learning and review process. The mobile app offers a seamless learning experience between your smartphone and the web with your memory profile maintained and managed in the cloud. UNIQUE! Your memory strength is profiled at the course, chapter, and item level to identify personal learning and forgetting patterns. UNIQUE! Material is re-presented just before you would naturally forget it to counteract memory decay. A personalized learning pathway is established based on your learning profile, memory map, and time required to demonstrate information mastery. The comprehensive student dashboard allows you to view your personal learning progress.

Download or read book Rule of Capture written by Christopher Brown and published by HarperCollins. This book was released on 2019-08-13 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This one is fresh, intelligent, and emotional with a plot that envisions an alternate reality hard to dismiss as unreal. It’s a legal thriller, with a big twist, stirring and imaginative, brimming with skullduggery, that will have you asking: is this possible?”-- New York Times bestselling author Steve Berry Better Call Saul meets Ben Winter's The Last Policeman in this first volume in an explosive legal thriller series set in the world of Tropic of Kansas—a finalist for the 2018 Campbell Award for best science fiction novel of the year. Defeated in a devastating war with China and ravaged by climate change, America is on the brink of a bloody civil war. Seizing power after a controversial election, the ruling regime has begun cracking down on dissidents fighting the nation’s slide toward dictatorship. For Donny Kimoe, chaos is good for business. He’s a lawyer who makes his living defending enemies of the state. His newest client, young filmmaker Xelina Rocafuerte, witnessed the murder of an opposition leader and is now accused of terrorism. To save her from the only sentence worse than death, Donny has to extract justice from a system that has abandoned the rule of law. That means breaking the rules—and risking the same fate as his clients. When Donny bungles Xelina’s initial hearing, he has only days to save the young woman from being transferred to a detention camp from which no one returns. His only chance of winning is to find the truth—a search that begins with the opposition leader’s death and leads to a dark conspiracy reaching the highest echelons of power. Now, Donny isn’t just fighting for his client’s life—he’s battling for his own. But as the trial in the top secret court begins, Xelina’s friends set into motion a revolutionary response that could destroy the case. And when another case unexpectedly collides with Xelina’s, Donny uncovers even more devastating secrets, knowledge that will force him to choose between saving one client . . . or the future of the entire country.

Download or read book Silva s Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.