Download or read book 96 Electroweak Interactions and Unified Theories written by J. Thanh Van Tran and published by Atlantica Séguier Frontières. This book was released on 1996 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tau Pathology in Neurological Disorders written by Sonia Do Carmo and published by Frontiers Media SA. This book was released on 2021-11-12 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Download or read book Burma written by United States. Office of Geography and published by . This book was released on 1966 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The GTO Observing Program written by and published by . This book was released on 1985 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Twelfth General Catalogue of the Psi Upsilon Fraternity written by Psi Upsilon Fraternity and published by . This book was released on 1917 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Summary of Corrections written by and published by . This book was released on 1997 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalogue of the Psi Upsilon Fraternity written by Psi Upsilon Fraternity and published by . This book was released on 1917 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Circular of the Illinois Industrial University written by University of Illinois (Urbana-Champaign campus) and published by . This book was released on 1919 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The ATO Palm written by and published by . This book was released on 1897 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Water resources Investigations Report written by and published by . This book was released on 2000 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Astronomical Observations written by Royal Observatory, Greenwich and published by . This book was released on 1925 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1841-1914 include Rates of box and pocket chronometers on trial for purchase by the Board of Admiralty (varies slightly); 1888-1914 include Rates of chronometer watches on trial for purchase by the Board of Admiralty (varies slightly); 1838, 1845- include Reports of the Astronomer Royal to the Board of Visitors (these titles also issued separately).
Download or read book The Sigma Chi Quarterly written by and published by . This book was released on 1897 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers in Clinical Drug Research Dementia Volume 2 written by José Juan Antonio Ibarra Arias and published by Bentham Science Publishers. This book was released on 2021-11-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology. This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include: - Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions - Tau-targeted therapy in Alzheimer's disease - history and current state - Emerging nanotherapeutic strategies in Alzheimer's disease - Implication of dehydroepiandrosterone on dementia related to oxidative stress - Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.
Download or read book The Dementias 2 written by John Herbert Growdon and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Blue Books of Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and treatment of all forms of dementia, including Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and many others. Organized by the most common neurodegenerative diseases, it reflects new insights regarding commonalities among the neurodegenerative diseases, and clusters them according to their dominant molecular pathologic signatures, so you can best treat any dementia you see. Differentiate among various forms of dementia and provide the appropriate management strategy. Correlate neuroimaging with neuropsychological testing to form more accurate diagnoses. Administer the latest approved drugs to improve your patients' brain function. A new two-color design and full-color images throughout helps you access information more easily. New chapters and new authors help you incorporate the latest information and fresh perspectives into your practice.
Download or read book Crescent written by and published by . This book was released on 1917 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
