Download or read book Taming the Telomeres written by R. Shapiro and published by . This book was released on 2014-11-08 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book Club Reader Praise: "A spellbinding page turner."[Gold Award Winner, 2015 Readers' Favorite Int'l. Book Award Contest, Fiction Thriller]The only jet crash survivor has no idea the immense biological secrets she possesses, or even who she is. But intelligence agencies will kill over the secrets.A survivor. A soulmate. A secret.High school senior Amanda Michaels suffers amnesia with regard to everything before the jet crash. She loses her parents and her memory in the aftermath, but miraculously survives. While recovering, Amanda strikes up a whirlwind romance with a young hospital volunteer, but only recalls a haunting series of flashbacks of her near death experiences (NDE's). Meanwhile, her uncle, high profile DC trial attorney Andy Michaels, represents her and the families of numerous passengers against Hemispheres Airways. Spying. Covert Ops. Cover-up at the highest levels?As the major monetary settlements with Hemispheres are looming, both Amanda and her uncle Andy stumble onto evidence of possible sabotage of the jet and a link to her dad's classified biological research on cell chromosomal telomeres. Why was her dad's research so valuable? Once Amanda learns she may possess biological secrets that competing intelligence agencies will kill for, she has no idea who to trust, unwittingly caught up in a web of biological espionage. Amanda's personal roller coaster ride explores romance, heartbreak, depression, persistence and ultimate redemption. The fast paced story moves between Middleburg, Virginia horse farms, Washington, DC, New York city and points between. A series of stunning twists unwind along the path to the unforeseen climax.If you're a fan of Clancy, Connelly, or Grisham novels, "Taming" is a must read.

Download or read book Faceplant written by Richard N. Shapiro and published by Outskirts Press. This book was released on 2012-10-26 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most fascinating, jaw dropping, Facebook threads that have gone viral are collected in Faceplant: Facebooks True Tales and Epic Fails. The first Faceplant book covers dating, romance, job-related disasters and the ABC's of social networking.

Download or read book Telomeres written by Carole Saintome and published by John Wiley & Sons. This book was released on 2024-06-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres. The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here. Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.

Download or read book Taming The Rays written by Geoff Meggitt and published by Lulu.com. This book was released on 2017-12-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: A history of developments in the uses of radioactivity and ionising radiation in the last century and the measures used to protect people from harmful effects. The sources of radiation exposure covered include medical uses, nuclear power generation and natural ones, such as that from radon. The book traces the evolution of our understanding of the effects of radiation on the human body, particularly those leading to cancer and hereditable diseases. One of the key challenges for practitioners was constructing manageable frameworks for evaluating these effects so that there could be effective control and regulation. The book emphasises the international nature of these efforts and the need to change approaches as more data became available after the Second World War. For the second edition the opportunity has been taken to revise the citation system and make some correction but the major change is the addition of two new Chapters: one on nuclear criticality safety and the other on nuclear safety assessment.

Download or read book Subtelomeres written by Edward J Louis and published by Springer Science & Business Media. This book was released on 2013-12-18 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: New genes and diversity leading to adaptation and evolution are generated in special areas of genomes. One such area in all eukaryotic genomes and in those prokaryotes with linear chromosomes is the region near the ends of the chromosomes. These telomere-associated sequences or subtelomeres, have different properties than the rest of the genome and are one of the most exciting frontiers left in genomics. This book provides a broad introduction to the field of subtelomeres with detailed information from various fields and systems, covering yeasts and fungi, pathogens and parasites, plants, insects, humans and primates and bacteria with linear chromosomes. Advances in the field as well as continuing challenges are discussed throughout. The mosaic nature of this collection and the everchanging perspectives reflect the nature of subtelomeres themselves. Unlike the core of most genomes, which are conserved and stable over time, subtelomeres are dynamic and polymorphic, so much so that generally no two individuals look alike in these regions. The dynamic nature of the region and the ability to change the copy number, generate diversity and try novel combinations make it the evolutionary tinker’s toolbox. In many organisms the genes found in the region are involved in dealing with the environment. In yeasts, different gene families involved in sugar metabolism as well as clumping together are found in subtelomeres and differences in the region may be the reason why some strains are good for baking, others for brewing and why some are pathogenic. In fungal plant and animal pathogens, many of the genes involved in virulence are found here. In humans and primates there are a number of gene families that vary between ends, for example the diverse olfactory receptor genes. Even in bacterial linear chromosomes the region contains genes involved in adapting to their environments. Perhaps the ultimate use of these regions is in parasites where they rapidly adapt and escape from host immune systems through dynamic changes to the proteins exposed to the host’s defenses. Such dynamic, polymorphic structures are also found in plants and insects though it is not always clear what the function might be; in some cases they take on the role of end maintenance. The dynamic, polymorphic nature of subtelomeres, where many ends share segmental duplications, is an exciting area for study but also presents a difficult challenge from the technical perspective.

Download or read book Transposable Elements and Genome Evolution written by J. F. McDonald and published by Springer Science & Business Media. This book was released on 2000-07-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once considered merely `selfish' or `parasitic' DNA, transposable elements are today recognized as being of major biological significance. Not only are these elements a major source of mutation, they have contributed both directly and indirectly to the evolution of genome structure and function. On October 8-10, 1999, 100 molecular biologists and evolutionists representing 11 countries met on the campus of The University of Georgia in Athens for the inaugural Georgia Genetics Symposium. The topics of presentations ranged from how the elements themselves have evolved to the impact transposable elements have had on the evolution of their host genomes. The papers in this volume therefore represent state-of-the-art thinking, by leading world experts in the field, on the evolutionary significance of transposable elements.

Download or read book Ageless written by Andrew Steele and published by Anchor. This book was released on 2021-03-23 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.

Download or read book Fiber Fueled written by Will Bulsiewicz, MD and published by Penguin. This book was released on 2020-05-12 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times, USA Today, and Publisher's Weekly bestseller A bold new plant-based plan that challenges popular keto and paleo diets, from an award-winning gastroenterologist. The benefits of restrictive diets like paleo and keto have been touted for more than a decade, but as renowned gastroenterologist Dr. Will Bulsiewicz, or "Dr. B," illuminates in this groundbreaking book, the explosion of studies on the microbiome makes it abundantly clear that elimination diets are in fact hazardous to our health. What studies clearly now show--and what Dr. B preaches with his patients--is that gut health is the key to boosting our metabolism, balancing our hormones, and taming the inflammation that causes a host of diseases. And the scientifically proven way to fuel our guts is with dietary fiber from an abundant variety of colorful plants. Forget about the fiber your grandmother used to take--the cutting-edge science on fiber is incredibly exciting. As Dr. B explains, fiber energizes our gut microbes to create powerhouse postbiotics called short-chain fatty acids (SCFAs) that are essential to our health. SCFAs are scientifically proven to promote weight loss, repair leaky gut, strengthen the microbiome, optimize the immune system, reduce food sensitivities, lower cholesterol, reverse type 2 diabetes, improve brain function, and even prevent cancer. Restrictive fad diets starve the gut of the critical fiber we need, weaken the microbes, and make our system vulnerable. As a former junk-food junkie, Dr. B knows firsthand the power of fiber to dramatically transform our health. The good news is that our guts can be trained. Fiber-rich, real foods--with fruits, vegetables, whole grains, seeds, nuts, and legumes--start working quickly and maintain your long-term health, promote weight loss, and allow you to thrive and feel great from the inside out. With a 28-day jumpstart program with menus and more than 65 recipes, along with essential advice on food sensitivities, Fiber Fueled offers the blueprint to start turbocharging your gut for lifelong health today.

Download or read book Because of Khalid written by Carolyn Armstrong and published by Tiger Stripe Publishing. This book was released on 2020-04-08 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twelve-year-old Chris feels as if he is straddling two sides of a large trench. One foot is firmly planted back home in Chicago, where life is safe and familiar with friends and school. His other foot just landed on the unstable ground of the Serengeti. Chris’ parents have decided to move from Chicago to a remote part of western Africa to run a safari camp. Lonely days and fearful nights are his new norm, but then Chris meets Khalid, a young Maasai warrior, who shows Chris a different side of the Serengeti. From Khalid, this city kid learns about the land and animals integral to the Serengeti. And when his new home is threatened, Chris is drawn into a battle to save it.

Download or read book Success Under Stress written by Sharon Melnick and published by AMACOM Div American Mgmt Assn. This book was released on 2013 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: From overflowing priority lists to power-hungry colleagues to nagging parental guilt, stress is the defining characteristic of most of our lives. Sharon Melnick provides a flexible array of stress-busting strategies to help you overcome the things that are weighing you down. You'll gain a veritable arsenal of "magic-bullet" solutions--hundreds of situation-specific, quick-acting tips for defusing stress and boosting productivity complete with quizzes, examples, exercises, and more to help you reach your professional goals.Success Under Stress eschews one-size-fits-all breathing exercises and visualization techniques and instead offers tangible advice to help you see opportunities rather than obstacles, get focused when overwhelmed, find energy when exhausted, stay calm when wired, and change the problem to prevent stress from returning. This practical book helps you gain control and exude calmness and confidence amidst everyday chaos by offering professional-level solutions appropriate to help you manage your big-time stressors.

Download or read book Industrial Pharmaceutical Biotechnology written by Heinrich Klefenz and published by Wiley-VCH. This book was released on 2002-04-22 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.

Download or read book Companion Animal Care and Welfare written by James Yeates and published by John Wiley & Sons. This book was released on 2019-02-04 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Companion Animal Care and Welfare: The UFAW Companion Animal Handbook presents a comprehensive, accessible and practical reference for all parties seeking information about the proper care of companion animals. Identifies the needs of companion animals, explains how we know these needs, and gives scientifically-backed advice on how to meet these needs Promotes the most humane treatment and best possible care of our companion animals Addresses controversial issues such as selective breeding, companion animal showing, the keeping of exotic species, and the international pet trade Covers the husbandry and care of all major companion animal species, including mammals, birds, fish, reptiles and amphibians

Download or read book Knowledge and Context in Tibetan Medicine written by and published by BRILL. This book was released on 2019-06-17 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge and Context in Tibetan Medicine is a collection of ten essays in which a team of international scholars describe and interpret Tibetan medical knowledge. With subjects ranging from the relationship between Tibetan and Greco-Arab conceptions of the bodily humors, to the rebranding of Tibetan precious pills for cross-cultural consumption in the People’s Republic of China, each chapter explores representations and transformations of medical concepts across different historical, cultural, and/or intellectual contexts. Taken together this volume offers new perspectives on both well-known Tibetan medical texts and previously unstudied sources, blazing new trails and expanding the scope of the academic study of Tibetan medicine. Contributors include: Henk W.A. Blezer, Yang Ga, Tony Chui, Katharina Sabernig, Tawni Tidwell, Tsering Samdrup, Carmen Simioli, William A. McGrath, Susannah Deane and Barbara Gerke

Download or read book Practical Flow Cytometry written by Howard M. Shapiro and published by John Wiley & Sons. This book was released on 2005-02-25 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the reviews of the 3rd Edition... "The standard reference for anyone interested in understandingflow cytometry technology." American Journal of Clinical Oncology "...one of the most valuable of its genre and...addressed to awide audience?written in such an attractive way, being bothinformative and stimulating." Trends in Cell Biology This reference explains the science and discusses the vastbiomedical applications of quantitative analytical cytology usinglaser-activated detection and cell sorting. Now in its fourthedition, this text has been expanded to provide full coverage ofthe broad spectrum of applications in molecular biology andbiotechnology today. New to this edition are chapters on automatedanalysis of array technologies, compensation, high-speed sorting,reporter molecules, and multiplex and apoptosis assays, along withfully updated and revised references and a list of suppliers.

Download or read book Contest written by Matthew Reilly and published by Pan Australia. This book was released on 2007-11-10 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thrilling international bestseller from Australia's favourite novelist, author of the Scarecrow series and Jack West Jr series with new novel Mr Einstein's Secretary out now. "Reilly hurls readers into an adrenaline-drenched thrill ride ... impossible to put down." Orlando Sentinel "Reilly ... can inspire awe. Speed demons, take note." Publishers Weekly The New York State Library. A silent sanctuary of knowledge; a 100-year-old labyrinth of towering bookcases, narrow aisles and spiralling staircases. For Doctor Stephen Swain and his eight-year-old daughter, Holly, it is the site of a nightmare. For one night, the State Library is to be the venue for a contest. A contest in which Stephen Swain is to compete - whether he likes it or not. The rules are simple: seven contestants will enter, only one will leave. With his daughter in his arms, Swain is plunged into a terrifying fight for survival. He can choose to run, to hide or to fight - but if he wants to live, he has to win. Because in a contest like this, unless you leave as the victor, you do not leave at all. Fans of Clive Cussler, Tom Clancy and Michael Crichton will love Matthew Reilly.

Download or read book Ageing Slowly Living Longer written by Vinod Nikhra, M D and published by . This book was released on 2020-09-11 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: WELCOME TO THE WORLD OF LONGEVITYThe world today is fast progressing and we live in the unprecedented times. There is a boom of advances in every field, from the art to the science and technology. This includes health science, too. The wonderful advances in the field of medical science make it possible to cure acute disorders and, thus, avoiding untimely demise. The chronic diseases like obesity, diabetes, high blood pressure, heart disease, etc. can be efficiently managed leading to virtual freedom from their complications. There is, in general, an appreciable increase in life expectancy and lifespan. The ideology apart, health is the prime instrument that lets us enjoy life. The preservation of health is the best formula for longevity. A healthy food, adequate physical activity and wholesome lifestyle keep the daily attrition-related damage at minimum and retard ageing. An optimal healthcare adds further. An individual's life course may appear unpredictable, but it is not. The genetic and environmental factors, both being of equal importance, and behavioral patterns can successfully predict the life expectancy. The longer life is not separate from ageing slowly. They are mutually related.The life is an eternal truth. We are because we live. We find people ageing; we ourselves age and grow older. The phenomenon of ageing is universal in the kingdom of living. With time, all living beings age. Yet, ageing is an enigma. We do not understand it. We do not exactly know, what makes us age and grow old, finally losing vitality of life? Living a healthy and long life is a common dream. All of us nourish the dream; all of us wish to realize it. But various disorders and infirmities annihilate the dream. Falling prey to them, we lose our health and fitness, and pass through an abridged life. There have been immense developments in scientific research, including medical science. There has evolved a whole novel understanding of the biology of ageing. A vast body of knowledge can explain the changes that take place with ageing at molecular and cellular level. At the same time, the progress in healthcare and technology makes it possible to slow ageing. The science has progressed and there are futuristic visions of achieving significant longevity. There are possibilities of being able to reverse the ageing process. The eternal dream of immortality, is on the verge of becoming a reality. This book aims to provide answers to the questions related to ageing. It aims to explain ageing and charts out a program for slowing ageing. It also gives a peep into the futuristic visions of longevity and suggests scientific ways for a long life. Simultaneously, it is designed to educate you for fitness and to lead a healthy life. As you read through the book, you will find long-held views interspersed with shattering myths, and scientific facts intermingled with results from research and studies, which are still not out of the lab doors. It may seem at times, but the book is not a fiction. Neither, it is a concocted dream. The book is based on current state of scientific knowledge and gerontological research. I intend to share with you the current state of knowledge relating to ageing and gerontology. There are, to share with you, the facts and visions more eloquent than imaginations, and amazing thoughts amounting to the reality-pregnant-early-morning dreams. You will notice few things as you read through the book. Using certain words has been avoided. You will only rarely find the words like aged, old, etc. The words like elderly have been used very sparingly. This has been done purposely and is well in line with the central thought of the book, which is to come out of our age-old prejudices against the old age. So, I request you to read on. After all, theme of the book ageing slowly and living longer, as indicated by the title chosen, is of the prime concern to all of us. Your partner in healthy long life, Dr Vinod Nikhra, M.D.

Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.