Download or read book Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications written by Carmen Scholz and published by OUP USA. This book was released on 2014-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides detailed information on cutting-edge research in the field of polymer science for biomedical and pharmaceutical applications.

Download or read book Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications written by Carmen Scholz and published by . This book was released on 2013 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Polymers for Pharmaceutical and Biomedical Applications written by Vandana Patravale and published by Elsevier. This book was released on 2024-01-16 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters focusing on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are then highlighted, with chapters explaining in detail the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, tissue engineering, artificial organs, and dentistry. Throughout the book, the aim is to provide accessible, step-by-step coverage, supported by diagrams and case studies. Finally, safety and regulatory aspects are discussed. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting. Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers Guides the reader towards successful selection of polymer systems for specific target applications Addresses key challenges in this field that are supported by case studies and regulatory information

Download or read book Tailor Made and Functionalized Biopolymer Systems written by Hriday Bera and published by Woodhead Publishing. This book was released on 2021-07-28 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists. Provides a concise overview of tailor-made and functionalized biopolymer systems for biomedical applications Covers a range of modified biopolymers, biopolymeric composites and biopolymer-based systems in drug delivery, development of artificial organs, diagnostic applications, and more Describes characterization, synthesis and functionalization of biopolymers and biopolymers systems

Download or read book CVD Polymers written by Karen K. Gleason and published by John Wiley & Sons. This book was released on 2015-03-05 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method of CVD (chemical vapor deposition) is a versatile technique to fabricate high-quality thin films and structured surfaces in the nanometer regime from the vapor phase. Already widely used for the deposition of inorganic materials in the semiconductor industry, CVD has become the method of choice in many applications to process polymers as well. This highly scalable technique allows for synthesizing high-purity, defect-free films and for systematically tuning their chemical, mechanical and physical properties. In addition, vapor phase processing is critical for the deposition of insoluble materials including fluoropolymers, electrically conductive polymers, and highly crosslinked organic networks. Furthermore, CVD enables the coating of substrates which would otherwise dissolve or swell upon exposure to solvents. The scope of the book encompasses CVD polymerization processes which directly translate the chemical mechanisms of traditional polymer synthesis and organic synthesis in homogeneous liquids into heterogeneous processes for the modification of solid surfaces. The book is structured into four parts, complemented by an introductory overview of the diverse process strategies for CVD of polymeric materials. The first part on the fundamentals of CVD polymers is followed by a detailed coverage of the materials chemistry of CVD polymers, including the main synthesis mechanisms and the resultant classes of materials. The third part focuses on the applications of these materials such as membrane modification and device fabrication. The final part discusses the potential for scale-up and commercialization of CVD polymers.

Download or read book Bottlebrush and Related Polymer Architectures for Biomedical Applications written by Hung VanThanh Nguyen and published by . This book was released on 2019 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1: Introduction to Bottlebrush Polymers as Carrier Platforms for Drug Delivery Biomedical Applications A brief intro to the current state of nanotechnology in drug delivery applications is provided, including the common myths and facts, design considerations, as well as important challenges towards successful translation to the clinic. In this context, the promises of bottlebrush polymers as a next-generation delivery platform, and the branched macromonomer approach is also discussed. Chapter 2: Scalable Synthesis of Multivalent Macromonomers for ROMP Here, we report the three-step convergent synthesis (two-step longest linear sequence) of a divalent exo-norbornene imide capable of efficient coupling with various nucleophiles and azides to produce diversely functionalized branched macromonomers optimized for ring-opening metathesis polymerization (ROMP). In addition, we describe an efficient iterative procedure for the synthesis of tri- and tetra-valent branched macromonomers. We demonstrate the use of these branched macromonomers for the synthesis of Janus bottlebrush block copolymers as well as for the generation of bottlebrush polymers with up to three conjugated small molecules per repeat unit. Chapter 3: Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors We report nitroxide-functionalized BASP organic radical contrast agents (ORCAs) that overcome the low contrast and poor in vivo stability associated with nitroxide-based MRI contrast agents. These features combine to provide for accumulation of a sufficient concentration of BASP-ORCA in murine subcutaneous tumors up to 20 h following systemic administration such that MRI contrast on par with metal-based agents is observed. Chapter 4: Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging We report a modular and scalable synthetic approach to nitroxide-based BASP-ORCAs with high nitroxide loadings, excellent stability in vivo, no acute toxicity, and highly desirable pharmacokinetic and biodistribution profiles for longitudinal detection of tumors by MRI. When injected intravenously into mice bearing subcutaneous plasmacytomas, BASP-ORCA3 affords distinct in vivo visualization of tumors on translationally relevant time scales while enabling efficient mapping of tumor necrosis, an important biomarker to predict therapeutic outcomes. Moreover, BASP-ORCA3 allows for detection of millimetric tumor implants in a disseminated murine model of advanced-stage human ovarian cancer that possess genetic, histological, and vascular characteristics that are similar to those seen in patients. Chapter 5: Brush-Arm Star Polymers as a Convergent Designer Platform for Theranostic Nanomaterials: Real Time Magnetic Resonance-Guided Drug Delivery Here, we report the conceptualization and execution of a novel theranostic platform system with heavy emphasis on the independence of its individual components: therapeutic payload, imaging moiety, stimuli trigger, and delivery platform. This would in turn allow for systematic variation of each player while minimizing disturbance towards the whole system. Specifically, we constructed a metal-free MRI-based brush-arm star polymer (BASP) bearing a doxorubicin (DOX) payload that is capable of generating changes in MRI contrast upon the release of the therapeutic payload. Moreover, via rational chemical design, we can specifically change not only the response trigger, but also the response rate under a specific stimulus. Chapter 6: Chiral Unimolecular-armed Bottlebrush as a Biological Probe Iterative exponential growth (IEG) is used to prepare a series of stereoisomeric norbomene-terminated macromonomers (MMs) with varying stereochemical sequence, length, and distance between sidechain groups. Ring-opening metathesis polymerization (ROMP) of these MMs along with a dye-labeled monomer provided stereoisomeric, fluorescent chiral unimolecular-arm bottlebrush polymers (CUBPs) that could be used as probes for understanding the role of chirality in biological systems, which were examined in both an in vitro and in vivo context. Intriguingly, via precise rational chemical modifications, these chirality-driven behaviors can be modulated, providing a proof-of-principle that the stereochemistry of BPs can be used to tailor their interactions with biological systems. Chapter 7: Polyoxazoline Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Nitroxide-Based Organic Radical Contrast Agents The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ROMP approach is described. Additionally, PEtOx-based BASPs with nitroxide radicals localized at the core-shell interface were also prepared, which displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials.

Download or read book Biocidal Polymers written by Narendra Pal Singh Chauhan and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-10-21 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocidal polymers are designed to inhibit or kill microorganisms such as bacteria, fungi and protozoans. This book summarizes recent findings in the synthesis, modification and characterization of various antimicrobial polymers ranging from plastics and elastomers to biomimetic and biodegradable polymers. Modifications with different antimicrobial agents as well as antimicrobial testing methods are described in a comprehensive manner.

Download or read book Antimicrobial Materials for Biomedical Applications written by Abraham J Domb and published by Royal Society of Chemistry. This book was released on 2019-07-31 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry. Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored. Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.

Download or read book Polymers in Medicine written by Emo Chiellini and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the collected papers presented at the Inter national Symposium on Polymers in Medicine, Biomedical and Pharma cological Applications, which was held at Porto Cervo, Italy, May 24-28, 1982. To the best of our knowledge, this symposium was the first to be organized in Italy entirely devoted to the several aspects of the use of synthetic and semisynthetic macromolecular materials in the field of biomedical and pharmacological applications. The inten~ tion of the Organizing Committee of the symposium was the promotion of a scientific and cultural initiative to gain the attention of various experts in line research of the potential of suitably de signed "man-made" polymeric materials in biomedical applications. With highly qualified and worldwide attendance, the above goal was fully satisfied. Indeed the opportunity of meeting to gether in a well conceived and discreet corner of the world, scien tists with different cultural backgrounds and objectives helped ex tend the meaning of the symposium far beyond the Italian borders and the perspectives of the National Research Council of Italy (CNR) , the major sponsor of the meeting.

Download or read book Handbook of Polyester Drug Delivery Systems written by M. N. V. Ravi Kumar and published by CRC Press. This book was released on 2017-03-27 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.

Download or read book Materials for Biomedical Engineering Nanomaterials based Drug Delivery written by Alina-Maria Holban and published by Elsevier. This book was released on 2019-03-20 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Nanomaterials-Based Drug Delivery highlights the progress made in the field of nanostructures bioactive materials and their impact on efficient drug delivery towards personalized medicine. Drug delivery is a well investigated and challenging bio-medical field, with promising perspectives in medicine and engineering. This book brings together the latest research findings regarding nanostructured materials and their potential in designing highly efficient and personalized drug delivery systems. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of nanostructures in drug delivery systems Includes novel opportunities and ideas for developing or improving technologies in composites by companies, biomedical industries, and in related sectors Features at least 50% of references from the last 2-3 years

Download or read book Advanced Polymers in Medicine written by Francesco Puoci and published by Springer. This book was released on 2014-12-02 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an up-to-date overview of the diverse medical applications of advanced polymers. The book opens by presenting important background information on polymer chemistry and physicochemical characterization of polymers. This serves as essential scientific support for the subsequent chapters, each of which is devoted to the applications of polymers in a particular medical specialty. The coverage is broad, encompassing orthopedics, ophthalmology, tissue engineering, surgery, dentistry, oncology, drug delivery, nephrology, wound dressing and healing, and cardiology. The development of polymers that enhance the biocompatibility of blood-contacting medical devices and the incorporation of polymers within biosensors are also addressed. This book is an excellent guide to the recent advances in polymeric biomaterials and bridges the gap between the research literature and standard textbooks on the applications of polymers in medicine.

Download or read book Materials for Biomedical Engineering written by Valentina Grumezescu and published by Elsevier. This book was released on 2019-03-25 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Inorganic Micro- and Nanostructures presents recent, specific insights in new progress, along with new perspectives for inorganic micro- and nano-particles. The main focus of this book is on biomedical applications of these materials and how their biological properties are linked to various synthesis methods and their source of raw materials. Recent information regarding optimized synthesis methods to obtain improved nano- and microparticles for biomedical use, as well as the most important biomedical applications of these materials, such as the diagnosis and therapy of cancer, are highlighted in detail. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of inorganic micro- and nanostructures in bioengineering Presents novel opportunities and ideas for developing or improving technologies in composites by companies, biomedical industries, and others Features at least 50% of its references from the last 2-3 years

Download or read book Pharmaceutical Applications of Polymers for Drug Delivery written by David Jones and published by iSmithers Rapra Publishing. This book was released on 2004 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.

Download or read book Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine written by Gilson Khang and published by CRC Press. This book was released on 2017-06-26 with total page 1480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.

Download or read book Introduction to Renewable Biomaterials written by Ali S. Ayoub and published by John Wiley & Sons. This book was released on 2017-09-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the entire evolutionary spectrum of biomass, from its genetic modification and harvesting, to conversion technologies, life cycle analysis, and its value to the current global economy This original textbook introduces readers to biomass—a renewable resource derived from forest, agriculture, and organic-based materials—which has attracted significant attention as a sustainable alternative to petrochemicals for large-scale production of fuels, materials, and chemicals. The current renaissance in the manipulation and uses of biomass has been so abrupt and focused, that very few educational textbooks actually cover these topics to any great extent. That’s why this interdisciplinary text is a welcome resource for those seeking a better understanding of this new discipline. It combines the underpinning science of biomass with technology applications and sustainability considerations to provide a broad focus to its readers. Introduction to Renewable Biomaterials: First Principles and Concepts consists of eight chapters on the following topics: fundamental biochemical & biotechnological principles; principles and methodologies controlling plant growth and silviculture; fundamental science and engineering considerations; critical considerations and strategies for harvesting; first principles of pretreatment; conversion technologies; characterization methods and techniques; and life cycle analysis. Each chapter includes a glossary of terms, two to three problem sets, and boxes to highlight novel discoveries and instruments. Chapters also offer questions for further consideration and suggestions for further reading. Developed from a successful USDA funded course, run by a partnership of three US universities: BioSUCEED - BioProducts Sustainability, a University Cooperative Center for Excellence in Education Covers the entire evolutionary spectrum of biomass, from genetic modification to life cycle analysis Presents the key chemistry, biology, technology, and sustainability aspects of biomaterials Edited by a highly regarded academic team, with extensive research and teaching experience in the field Introduction to Renewable Biomaterials: First Principles and Concepts is an ideal text for advanced academics and industry professionals involved with biomass and renewable resources, bioenergy, biorefining, biotechnology, materials science, sustainable chemistry, chemical engineering, crop science and technology, agriculture.

Download or read book Advances in Nanotechnology and the Environmental Sciences written by Alexander V. Vakhrushev and published by CRC Press. This book was released on 2019-09-25 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing a selection of new research on nanotechnological applications for environmental protection along with new advanced technologies in nanochemistry, this volume presents an interdisciplinary approach that brings together materials science, chemistry, and nanotechnology. Part I of the volume looks at environmental topics that include an exploration of the challenges of the global water crisis and new technology in nanofiltration and water purification. It provides an informative overview of green nanotechnology, green nanomaterials, and green chemistry. Some of the advanced technologies discussed in Part II include the application of quantum dots, a nanochemical approach to using ICT technology, and new research on polymer nanocomposites as a smart material along with its synthesis, preparation, and properties. Other important topics are included as well.