Download or read book Tachykinins written by Peter Holzer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Download or read book The Tachykinin Receptors written by Stephen H. Buck and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors, including neuropeptide/peptide and G-protein-linked receptors in general. It covers the physiology, pharmacology, biochemistry, and molecular biology of these receptors from both clinical and basic research points of view. Topics treated by the distinguished contributors include the characterization of tachykinin receptors, the mechanisms of tachykinin receptor action, a reflection on future prospects, and a historical consideration of tachykinin research.
Download or read book Tachykinins written by Peter Holzer and published by Springer Science & Business Media. This book was released on 2004-06-17 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.
Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography
Download or read book New Insights to Neuroimmune Biology written by Istvan Berczi and published by Elsevier. This book was released on 2010-05-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Insights to Neuroimmune Biology investigates the mechanisms that and functions of the Neuroimmune Regulatory Supersystem. Covering molecular regulation of cytokines in brain astrocytes, immunoregulation by the sympathetic nervous system, circadian regulation of immune reactions, antigen recognition by the CNS, the modulation of the immune response by head injury, neurogenic inflammation, the role of tachykinins in asthma and allergic disease, defence and defeat reactions, cytokines, behavior and affective disorders, increased activity of type 1 helper T cell functions after reward stimulation.This book has relevance to the entire scientific community in Biology, Medicine and Veterinary medicine as it discusses molecular, cellular, organic and systemic aspects as well as the physological, pathophysiological and behavioral mechnisms which are involved in Neuroimmiune Biology.
Download or read book Tachykinins and Calcitonin Gene related Peptide in Relation to Peripheral Functions of Capsaicin sensitive Sensory Neurons written by Xiao-Ying Hua and published by . This book was released on 1986 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asthma written by Peter J. Barnes and published by Elsevier. This book was released on 1998-04-20 with total page 973 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field. - Comprehensive coverage of both basic science and clinical aspects of asthma - Extensively referenced throughout
Download or read book Sensory Nerves Containing Tachykinins and CGRP in the Lower Airways written by Claes-Roland Martling and published by . This book was released on 1987 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurogenic Inflammation written by Pierangelo Geppetti and published by CRC Press. This book was released on 1996-03-22 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.
Download or read book Neuropeptides written by Fleur L. Strand and published by MIT Press. This book was released on 1999 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.
Download or read book Neurogenic Inflammation in Health and Disease written by and published by Newnes. This book was released on 2008-11-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. - Neurogenic inflammation in historical perspective - Cardiac protection by nociceptive afferents - Molecular mechanisms of nociception - Sensory mechanisms in migraine pathophysiology - Vagal signaling of visceral inflammation - Neurogenic mechanisms in arthritis - Therapeutic implications of vanilloid-type compounds
Download or read book New Drugs for Asthma Allergy and COPD written by Trevor T. Hansel and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!
Download or read book Asthma Treatment written by D. Olivieri and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the 19-29 May 1991 the NATO ASI Course PAsthma Treatment: A P Multidisciplinary Approach was held in Erice, on the rocky North West Coast of Sicily, facing the ancient Phoenician shore of the African Continent. Sixty NATO sponsored participants arriving from many different European Countries - Nato members and non - attended the course. Qualified researchers from Europe and the United States held extensive lectures, short meetings and small informal group discussions. Erice is a magical place which draws together people from different backgrounds and cultures under her Mediterrean charm, recreating the ancient Greek openair discussion atmosphere. And so, during the 10 days gathering, the extensive willingness of the senior investigators and the laudable enthusiasm of the younger participants was stimulated. All of the most recent findings in the biology and the pharmacology of Asthma were discussed, initially behind closed doors, to be unhurriedly continued along the alley ways of the "Cittadella della Scienza" , in Erice's small restaurants, and on her deserted beaches. The texts collected here are testimony to the high quality of the investigators contributions as well as their far reaching interests. I think that a Director of such a Course would be adequatly satisfied by merely considering the enthusiasm and high level involvement of every participant. He could not have been more satisfied after having considered the proceedings summerizing the scientific content of the meeting.
Download or read book Pathophysiology of the Enteric Nervous System written by Robin Spiller and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.
Download or read book The Immune Neuroendocrine Circuitry written by I. Berczi and published by Elsevier. This book was released on 2003-08-14 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarises the current understanding of the Nervous -, Endocrine and Immune systems with emphasis on shared mediators and receptors and functional interaction. In addition to the fundamental physiological and pathophysiological mechanisms, which are presented in detail, some clinically relevant subjects are also presented, such as inflammation, asthma and allergy, autoimmune disease, immunodeficiency and the acute phase response. • A comprehensive presentation of neuroimmune biology • Introduces the subject matter to the uninformed reader • Contains basic information, theoretical considerations and up-to-date clinical chapters • The clinical chapters will be helpful to practising physicians
Download or read book Contemporary Issues in Chronic Pain Management written by Winston C.V. Parris and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROFESSOR SIR KENNETH L. STUART Pain control has become one ofmedicine's most rapidly growing disciplines, and Iwelcome the opportunity to write this foreword to abook that Iam sure will make its own unique contribution to advancing this discipline. My pleasure in writing it is heightened by my pride in the fact that its editor was at one time an undergraduate student of mine at the University of the West Indies in Jamaica. One of the uncertainties teachers always face is that they can never predict how their charges will turn out. This uncertainty has been happily resolved. Dr. Parris' professional career has been marked by the same dedication and commitment that characterized his undergraduate days and that clearly has been brought to the preparation of this scholarly and practical work. Pain reliefhas been until recently acomparatively neglected field. Its neglect was determined not so much by lack ofprofessional awareness ofits import ance but mainly because so little could be done about it in the past.
