Download or read book T cell mediated immune response in murine malaria differential effects of antigen specific Lyt T cell subsets in the recovery from Plasmodium yoelii infection in normal and T cell deficient mice written by Volker Brinkmann and published by . This book was released on 1984 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Revival Malaria 1989 written by Mary M. Stevenson and published by CRC Press. This book was released on 2017-11-22 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to analyze and determine how a host responds to a blood stage malaria infection. It focuses on strategies for anti-malarial vaccination, genetic control of host resistance to malaria, and the contribution of the host genetic background to resistance or susceptibility to malaria. This book is an important reference work for anyone who studies the field of microbiology, immunology, or parasitology.
Download or read book Malaria written by Mary M. Stevenson and published by CRC Press. This book was released on 1989-09-30 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to analyze and determine how a host responds to a blood stage malaria infection. It focuses on strategies for anti-malarial vaccination, genetic control of host resistance to malaria, and the contribution of the host genetic background to resistance or susceptibility to malaria. This book is an important reference work for anyone who studies the field of microbiology, immunology, or parasitology.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1985 with total page 1146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Immunology written by and published by . This book was released on 1990 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria written by Maria M. Mota and published by Springer. This book was released on 2017-01-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term. Malaria: Immune Response to Infection and Vaccination provides a comprehensive view on the immune response to malaria and to the different vaccines under development. The book offers the following: - Contributions by top research leaders in the field, - Comparisons of the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately, - Coverage of the immune responses to the different stages of malaria, which are frequently treated as separate fields of research.
Download or read book Methods in Immunotoxicology written by Gary R. Burleson and published by . This book was released on 1995 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Breaking the cycle attacking the malaria parasite in the liver written by Ute Frevert and published by Frontiers Media SA. This book was released on 2016-01-06 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.
Download or read book Malaria written by Julius P. Kreier and published by Academic Press. This book was released on 2014-05-12 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.
Download or read book A Comparative Genetic Approach to the Study of Host Resistance to Experimental Malaria written by Peter C. Sayles and published by . This book was released on 1990 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell mediated Immunity in Malaria written by Scientific Working Group on the Immunology of Malaria. Meeting and published by . This book was released on 1984 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Referativny Zhurnal written by and published by . This book was released on 1985 with total page 1054 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibody mediated Protection and Pathology in Malaria and Trypanosome Infections written by Hong Zhang and published by . This book was released on 2000 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria Immunity Cell Mediated Studies written by Robert M. Coleman and published by . This book was released on 1975 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors were able to effect recovery and immunity to virulent murine malaria by red cell transfusion at crisis, during which time erythropoiesis did not keep pace with the rate of red cell destruction. Utilizing these immune animals as a source of spleen cells the authors have demonstrated by in vitro techniques the presence of two cell-mediated cytotoxic effector systems (macrophages and lymphocytes) against erythrocyte targets from malaria infected animals. Although parasitized erythrocytes appeared to be the most likely targets for cell-mediated destruction, decreased survival of transfused normal erythrocytes in malaria infected rats was observed. It has been further noted that splenic lymphocytes become specifically sensitized to malaria antigens during the course of virulent murine malaria infection, and have the ability to inhibit the migration of peritoneal macrophages in vitro (Coleman, et al., 1975a).
Download or read book Malaria Immunology written by Peter Perlmann and published by S Karger Ag. This book was released on 2002-01-01 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Download or read book Immunology and Immunopathogenesis of Malaria written by and published by Springer Science & Business Media. This book was released on 2005-09-20 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines. This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.
Download or read book Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis written by Padma V. Devarajan and published by Springer Nature. This book was released on 2019-11-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
