Download or read book System and Process Optimization for Biomedical Optical Imaging written by Yehe Liu and published by . This book was released on 2021 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optical imaging is widely used in the research community and medical diagnosis. However, many optical imaging techniques in the biomedical field are not optimized. Developing and improving these techniques is often a complex task involving sample preparation, instrument design, and data handling. As a summary of my Ph.D. research, this dissertation discusses the design optimization strategies for biomedical optical imaging applications. It is structured with an introduction discussing the general design consideration and the design process for biomedical optical imaging, followed by detailed discussions of four biomedical optical imaging applications developed during my Ph.D. program. The dissertation has six major chapters. The first chapter summarizes the general technology development processes for biomedical optical imaging applications, It introduces the three main elements of biomedical optical imaging, which include sample preparation, imaging systems, and data handling. Following the introduction, the second chapter discusses the Pocket MUSE project, a smartphone-based fluorescence microscope that costs less than $20 to build. Other highlights of the design include a small footprint, high imaging performance, versatile sample compatibility, and simple sample preparation methods. The third chapter describes the SLIME project, an OCT-based 3D microvascular mapping technique using an injectable scattering contrast agent, developed to study the coronary vascular abnormalities in a quail embryo animal model. This technique features a novel sample preparation strategy, where the PVA-borate cross-linking (slime) chemistry is used to stabilize a low-viscosity scattering contrast agent in situ. The fourth chapter introduces the LIMPID project, a simple optical clearing technique that makes tissues transparent in a single step. This sample preparation technique is designed to enhance the imaging depth for a broad range of optical imaging applications, enabling 3D optical imaging of millimeters-thick tissue samples. The fifth chapter describes the CompassLSM project, a simple yet high-performance light sheet microscope with sub-4-μm high optical sectioning capability in a multi-millimeter large FOV. The high imaging performance is achieved by synchronizing the focus of an axially swept light sheet to the rolling shutter of a CMOS camera. The final chapter provides a summary and conclusions about this dissertation.
Download or read book Biomedical Optical Imaging Technologies written by Rongguang Liang and published by Springer Science & Business Media. This book was released on 2012-09-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.
Download or read book Biomedical Optical Imaging written by James G. Fujimoto and published by Oxford University Press. This book was released on 2009-04-22 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
Download or read book Optical Imaging for Biomedical and Clinical Applications written by Ahmad Fadzil Mohamad Hani and published by CRC Press. This book was released on 2017-10-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging is a rapidly emerging imaging technique that has been successfjully translated into biomedical applications ranging from clinical diagnosis to molecular biology. This book includes an introductory section to explore various optical imaging devices and their functionality and roles for biomedical applications such as dermatology and ophthalmology. Recent developments as exemplified with the authors research are explored in detail. In depth discussion of other disease conditions and their diagnosis with optical imaging techniques are also covered.
Download or read book Optical Design for Biomedical Imaging written by Rongguang Liang and published by SPIE-International Society for Optical Engineering. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designing an efficient imaging system for biomedical optics requires a solid understanding of the special requirements of the optical systems for biomedical imaging and the optical components used in the systems. However, a lack of reference books on optical design (imaging and illumination) for biomedical imaging has led to some inefficient systems. This book fills the gap between biomedical optics and optical design by addressing the fundamentals of biomedical optics and optical engineering, and biomedical imaging systems. The first half provides a brief introduction to biomedical optics and then covers the fundamentals of optics, optical components, light sources, detectors, optical imaging system design, and illumination system design. This also includes important issues related to biomedical imaging, such as autofluorescence from optical materials. The second half of the text covers various biomedical imaging techniques and their optical systems, along with design examples.
Download or read book Fourier Ptychographic Imaging written by Guoan Zheng and published by Morgan & Claypool Publishers. This book was released on 2016-06-30 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book demonstrates the concept of Fourier ptychography, a new imaging technique that bypasses the resolution limit of the employed optics. In particular, it transforms the general challenge of high-throughput, high-resolution imaging from one that is coupled to the physical limitations of the optics to one that is solvable through computation. Demonstrated in a tutorial form and providing many MATLAB® simulation examples for the reader, it also discusses the experimental implementation and recent developments of Fourier ptychography. This book will be of interest to researchers and engineers learning simulation techniques for Fourier optics and the Fourier ptychography concept.
Download or read book Biomedical Optics written by Lihong V. Wang and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected].
Download or read book Biomedical Optical Phase Microscopy and Nanoscopy written by Natan T. Shaked and published by Academic Press. This book was released on 2012-12-31 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading optical phase microscopy experts, this book is a comprehensive reference to phase microscopy and nanoscopy techniques for biomedical applications, including differential interference contrast (DIC) microscopy, phase contrast microscopy, digital holographic microscopy, optical coherence tomography, tomographic phase microscopy, spectral-domain phase detection, and nanoparticle usage for phase nanoscopy The Editors show biomedical and optical engineers how to use phase microscopy for visualizing unstained specimens, and support the theoretical coverage with applied content and examples on designing systems and interpreting results in bio- and nanoscience applications. Provides a comprehensive overview of the principles and techniques of optical phase microscopy and nanoscopy with biomedical applications Tips/advice on building systems and working with advanced imaging biomedical techniques, including interpretation of phase images, and techniques for quantitative analysis based on phase microscopy Interdisciplinary approach that combines optical engineering, nanotechnology, biology and medical aspects of this topic. Each chapter includes practical implementations and worked examples
Download or read book Process Imaging For Automatic Control written by David M. Scott and published by CRC Press. This book was released on 2018-10-03 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: As industrial processes and their corresponding control models increase in complexity, the data provided by traditional point sensors is no longer adequate to ensure product quality and cost-effective operation. Process Imaging for Automatic Control demonstrates how in-process imaging technologies surpass the limitations of traditional monitoring systems by providing real-time multidimensional measurement and control data. Combined with suitable data extraction and control schemes, such systems can optimize the performance of a wide variety of industrial processes. Contributed by leading international experts, Process Imaging for Automatic Control offers authoritative, comprehensive coverage of this new area of process control technology, including: Basic goals of process modeling and their application to automatic control Direct imaging devices and applications, such as machine vision and spatial measurement of flow velocity, pressure, shear, pH, and temperature Various techniques, hardware implementations, and image reconstruction methods for process tomography Image enhancement and restoration State estimation methods State space control system models, control strategies, and implementation issues Five chapters devoted to case studies and advanced applications From theory to practical implementation, this book is the first to treat the entire range of imaging techniques and their application to process control. Supplying broad coverage with more than 270 illustrations and nearly 700 cited references, it presents an accessible introduction to this rapidly growing, interdisciplinary technology.
Download or read book Advanced Biophotonics written by Ruikang K. Wang and published by Taylor & Francis. This book was released on 2016-04-19 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and
Download or read book Advances in Optical Imaging for Clinical Medicine written by Nicusor Iftimia and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
Download or read book System Design and Optimization of Optical Coherence Tomography written by Avni Ceyhun Akcay and published by . This book was released on 2005 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finally, towards the optimization of OCT and OCM for use in clinical settings, we analyzed the detection electronics stage, which is a crucial component of the system that is designed to capture extremely weak interferometric signals in biomedical and biological imaging applications. We designed and tested detection electronics to achieve a compact and low-cost solution for portable imaging units and demonstrated that the design provided an equivalent performance to the commercial lock-in amplifier considering the system sensitivity obtained with both detection schemes.
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Download or read book Optical Compressive Imaging written by Adrian Stern and published by CRC Press. This book was released on 2016-11-17 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dedicated overview of optical compressive imaging addresses implementation aspects of the revolutionary theory of compressive sensing (CS) in the field of optical imaging and sensing. It overviews the technological opportunities and challenges involved in optical design and implementation, from basic theory to optical architectures and systems for compressive imaging in various spectral regimes, spectral and hyperspectral imaging, polarimetric sensing, three-dimensional imaging, super-resolution imaging, lens-free, on-chip microscopy, and phase sensing and retrieval. The reader will gain a complete introduction to theory, experiment, and practical use for reducing hardware, shortening image scanning time, and improving image resolution as well as other performance parameters. Optics practitioners and optical system designers, electrical and optical engineers, mathematicians, and signal processing professionals will all find the book a unique trove of information and practical guidance. Delivers the first book on compressed sensing dealing with system development for a wide variety of optical imaging and sensing applications. Covers the fundamentals of CS theory, including noise and algorithms, as well as basic design approaches for data acquisition in optics. Addresses the challenges of implementing compressed sensing theory in the context of different optical imaging designs, from 3D imaging to tomography and microscopy. Provides an essential resource for the design of new and improved devices with improved image quality and shorter acquisition times. Adrian Stern, PhD, is associate professor and head of the Electro-Optical Engineering Unit at Ben-Gurion University of the Negev, Israel. He is an elected Fellow of SPIE.
Download or read book Unconventional Optical Imaging for Biology written by Corinne Fournier and published by John Wiley & Sons. This book was released on 2024-05-21 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging of biological systems has undergone spectacular development in recent years, producing a quantity and a quality of information that, just twenty years ago, could only be dreamed of by physicists, biologists and physicians. Unconventional imaging systems provide access to physical quantities – phase, absorption, optical index, the polarization property of a wave or the chemical composition of an object – not accessible to conventional measurement systems. To achieve this, these systems use special optical setups and specific digital image processing to reconstruct physical quantities. This field is also known as computational imaging. This book presents various non-conventional imaging modalities developed for the biomedical field: wave front analysis imaging, digital holography/tomography, optical nanoscopy, endoscopy and singlesensor imaging. Experimental setups and reconstruction algorithms are presented for each modality.
Download or read book Scalable Computational Optical Imaging System Designs written by Ronan Kerviche and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational imaging and sensing leverages the joint-design of optics, detectors and processing to overcome the performance bottlenecks inherent to the traditional imaging paradigm. This novel imaging and sensing design paradigm essentially allows new trade-offs between the optics, detector and processing components of an imaging system and enables broader operational regimes beyond the reach of conventional imaging architectures, which are constrained by well-known Rayleigh, Strehl and Nyquist rules amongst others. In this dissertation, we focus on scalability aspects of these novel computational imaging architectures, their design and implementation, which have far-reaching impacts on the potential and feasibility of realizing task-specific performance gains relative to traditional imager designs. For the extended depth of field (EDoF) computational imager design, which employs a customized phase mask to achieve defocus immunity, we propose a joint-optimization framework to simultaneously optimize the parameters of the optical phase mask and the processing algorithm, with the system design goal of minimizing the noise and artifacts in the final processed image. Using an experimental prototype, we demonstrate that our optimized system design achieves higher fidelity output compared to other static designs from the literature, such as the Cubic and Trefoil phase masks. While traditional imagers rely on an isomorphic mapping between the scene and the optical measurements to form images, they do not exploit the inherent compressibility of natural images and thus are subject to Nyquist sampling. Compressive sensing exploits the inherent redundancy of natural images, basis of image compression algorithms like JPEG/JPEG2000, to make linear projection measurements with far fewer samples than Nyquist for the image forming task. Here, we present a block wise compressive imaging architecture which is scalable to high space-bandwidth products (i.e. large FOV and high resolution applications) and employs a parallelizable and non-iterative piecewise linear reconstruction algorithm capable of operating in real-time. Our compressive imager based on this scalable architecture design is not limited to the imaging task and can also be used for automatic target recognition (ATR) without an intermediate image reconstruction. To maximize the detection and classification performance of this compressive ATR sensor, we have developed a scalable statistical model of natural scenes, which enables the optimization of the compressive sensor projections with the Cauchy-Schwarz mutual information metric. We demonstrate the superior performance of this compressive ATR system using simulation and experiment. Finally, we investigate the fundamental resolution limit of imaging via the canonical incoherent quasi-monochromatic two point-sources separation problem. We extend recent results in the literature demonstrating, with Fisher information and estimator mean square error analysis, that a passive optical mode-sorting architecture with only two measurements can outperform traditional intensity-based imagers employing an ideal focal plane array in the sub-Rayleigh range, thus overcoming the Rayleigh resolution limit.
Download or read book Fundamentals of Biomedical Optics written by Caroline Boudoux and published by . This book was released on 2016-12-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Prof. Boudoux's book covers a comprehensive range of topics in biomedical optics and biophotonics. The organization of the material is well thought out, starting off with a toolbox of essential concepts that are general and yet detailed enough for a broad range of student backgrounds. The heart of the book covers the essential topics of tissue optics, as well as optical imaging system design concepts. With a well-balanced combination of engineering and physics, this text is an asset for students, and will be a valued long-term reference.
