Download or read book Synuclein and the Coelacanth written by James M. Gruschus and published by Academic Press. This book was released on 2021-01-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurodegenerative diseases have animal parallels such as Alzheimer's in chimpanzees, multiple sclerosis in macaques, Lou Gehrig's disease in dogs, but nothing like Parkinson's has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson's disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson's and actually halt the disease. - Proposes a new hypothesis on the origins of Parkinson's disease - Examines genetic risk factors, environmental toxins, and neuroanatomy of PD - Highlights new therapeutic treatment options in development for patients

Download or read book From Fossils to Mind written by and published by Elsevier. This book was released on 2023-02-23 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Fossils to Mind, Volume 275 in the Progress in Brain Research series, presents chapters on a variety of interesting topics, including What could our premammalian ancestors hear, see, smell, and touch? A review of ten years of research about cynodont paleoneurology, Endocasts of ornithopod dinosaurs: anatomy and comparison, Adaptationism and Structuralism in Brain Evolution Research, Genomic approaches for tracing the evolution of brain ageing and neurodegenerative diseases, Investigating the Coevolution of Language and Tools in the Brain: An ALE Meta-analysis of Neural Activation During Syntactic Processing and Tool Use, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Progress in Brain Research serials - Updated release includes the latest information on From Fossils and Mind

Download or read book Synucleins written by Andrei Surguchov and published by BoD – Books on Demand. This book was released on 2020-04-08 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation.

Download or read book Evolution of the Protein Synthesis Machinery and Its Regulation written by Greco Hernández and published by Springer. This book was released on 2016-08-10 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

Download or read book Dictyostelids written by Maria Romeralo and published by Springer. This book was released on 2013-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the genomic, cellular and biochemical levels with human cells, which has propelled the species Dictyostelium discoideum to become a model system for biology and medicine in many laboratories. This book covers the latest advances in our knowledge of these extraordinary organisms with topics spanning from their evolutionary history, ecology and diversity to the recent discoveries regarding their cellular and molecular biology.

Download or read book Cellular Osmolytes written by Laishram Rajendrakumar Singh and published by Springer. This book was released on 2024-10-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book presents the role of osmolytes in human health and diseases. Some of the chapters deal about the possibility of the use of osmolytes as diagnostic biomarkers and potential drug design for neurodegenerative and other human diseases. Other chapters also include reviews on the role of osmolytes in cancer, metastasis, infectious diseases, metabolic disorders, immunological disorders, and tissue regeneration. Importantly, the book also contain recent updates on the role of naturally occurring osmolytes in protein folding pathway, protein stability, and their underlying mechanisms. The book also covers the aspects that osmolytes could promote conformational alterations of transcription factors that favor metastatic behavior. Potential of the osmolytes in the various process of vaccine development, including enhancing the efficacy, production, and purification steps are also succintly described. Towards the end, the book also elucidates the use of specific molecules for the prevention of toxic gain of functions and restoration of function to disease-causing mutant protein. This book is an invaluable asset for the researchers especially working in osmolyte biology and scientists involved in basic and clinical research particularly neurodegeneration, diabetes, cancer, and metabolic disorders.

Download or read book Genetics Neurology Behavior and Diet in Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-08-11 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Download or read book Dendritic Spines written by Rafael Yuste and published by MIT Press. This book was released on 2010-09-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ramón y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the “spine problem,” searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research.

Download or read book Neurotransmitter Release written by Hugo J. Bellen and published by Oxford University Press, USA. This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.

Download or read book Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology written by Vladimir Uversky and published by Academic Press. This book was released on 2019-09-15 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Download or read book The Zebrafish in Biomedical Research written by Samuel Cartner and published by Academic Press. This book was released on 2019-11-22 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. - Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications - Includes the work of world-renowned authors - Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Download or read book Presynaptic Receptors and Neuronal Transporters written by S.Z. Langer and published by Elsevier. This book was released on 2013-10-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

Download or read book Convergence Analysis of Recurrent Neural Networks written by Zhang Yi and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the outstanding and pioneering research work of Hopfield on recurrent neural networks (RNNs) in the early 80s of the last century, neural networks have rekindled strong interests in scientists and researchers. Recent years have recorded a remarkable advance in research and development work on RNNs, both in theoretical research as weIl as actual applications. The field of RNNs is now transforming into a complete and independent subject. From theory to application, from software to hardware, new and exciting results are emerging day after day, reflecting the keen interest RNNs have instilled in everyone, from researchers to practitioners. RNNs contain feedback connections among the neurons, a phenomenon which has led rather naturally to RNNs being regarded as dynamical systems. RNNs can be described by continuous time differential systems, discrete time systems, or functional differential systems, and more generally, in terms of non linear systems. Thus, RNNs have to their disposal, a huge set of mathematical tools relating to dynamical system theory which has tumed out to be very useful in enabling a rigorous analysis of RNNs.

Download or read book Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C written by Vladimir N. Uversky and published by Elsevier. This book was released on 2021-10-19 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Download or read book Atlas of Chick Development written by Ruth Bellairs and published by Elsevier. This book was released on 2005-09-15 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This outstanding work is the only modern book devoted to the chick embryo and has been an essential resource for geneticists, molecular and developmental biologists, and other life scientists who use the chick embryo as their research model. This new enlarged and updated second edition is published in response to continuing demand. The text provides a detailed description of development, from fertilization to hatching, with emphasis on the earlier stages though also covering individual organ systems in detail. There are reviews of the more recent molecular research and a new section highlighting the important landmarks in the history of chick embryology which have had an impact on our understanding of developmental processes. The book is beautifully illustrated with 74 text-figures and over 500 photographs, including nearly 200 new scanning electron micrographs. - Updated and expanded text to accompany diagrams - More than 200 new labelled scanning electron micrographs showing individual tissues in great detail - Reviews of recent molecular research - Discusses the roles of genes such as Hox genes, BMPs, and sonic hedgehog during early development - New sections on genetical anomalies, techniques, and the poultry industry

Download or read book Why Fish Don t Exist written by Lulu Miller and published by Simon and Schuster. This book was released on 2021-04-06 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nineteenth-century scientist David Starr Jordan built one of the most important fish specimen collections ever seen, until the 1906 San Francisco earthquake shattered his life's work.

Download or read book Enzymatic Plastic Degradation written by and published by Academic Press. This book was released on 2021-02-10 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Plastic Degradation, Volume 648 in the Methods in Enzymology series, continues the legacy of this premier serial with chapters authored by leaders in the field. Chapters in this latest release include Evaluating plastic pollution and environmental degradation, Assessment methods for microplastic pollution in the oceans and fresh water, Exploring microbial consortia from various environments for plastic degradation, Characterization of filamentous fungi for attack on synthetic polymers via biological Fenton chemistry, Synthesis of radioactive-labeled nanoplastics for assaying the environmental (microbial) PS degradation, Exploring metagenome for plastic degrading enzymes, Cutinases from thermophilic bacteria (actinomycetes): from identification to functional and structural characterization, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Covers the latest research and technologies in enzymatic plastic degradation