Download or read book Synthetic Studies Towards Aromatic Polyketide Derived Natural Products written by Peter Jaein Choi and published by . This book was released on 2011 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The first part of this thesis describes the successful synthesis of a series of 6,6- bisbenzannulated spiroketal analogues of the rubromycin family. The synthesis of spiroketals 183a-183e and spiroaminal 237 were successfully executed using a novel microwave-assisted DIHMA approach. Coupling of an aryl acetylene and an aryl aldehyde via acetylide anion addition resulted in the formation of an alkynol which was followed by oxidation to the desired ynone. Spirocyclisation using the DIHMA protocol afforded the desired bisbenzannulated spiroketals 183a-183e and spiroaminal 237 in good yields. Hydroxy-substituted 6,6- bisbenzannulated spiroketal 182 was successfully furnished by the reduction of ketosubstituted 6,6-bisbenzannulated spiroketal 183a with sodium borohydride. The second part of this research presents synthetic attempts to access the chiral 3-substituted phthalide containing natural products; aigialospirol (256) and herbaric acid (255). The synthesis of chiral vinylphthalide 406 proved challenging and was overcome by the use of a microwave-assisted chemoenzymatic resolution to install the C3 stereocenter of phthalide 406. Despite various attempts to functionalise vinylphthalide 406 towards the synthesis of aigialospirol, results were unsuccessful. With chiral vinylphthalide 406 in hand, the first synthesis and the structural assignment of ( -- )-herbaric acid (255) was accomplished. This was achieved via heteroatom-directed Wacker oxidation on vinylphthalide 406 to form aldehyde 460. Aldehyde 460 underwent smooth oxidation with Oxone® affording acid 488 which underwent facile methyl ester formation to facilitate purification, thus delivering enantioenriched lactone ester 489. Smooth demethylation with concomitant ester hydrolysis was effected by boron tribromide to give ( -- )-herbaric acid (255). The realisation of this entirely regioselective anti-Markovnikov addition of water during the Wacker oxidation provides a mild alternative to hydroboration/oxidation protocols that are traditionally used for terminal alkenes"--Abstract.

Download or read book Synthetic Studies Towards Polyketide Derived Biologically Active Natural Products written by Amanda Heapy and published by . This book was released on 2009 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies Toward Novel Aromatic Polyketides written by Taek Soon Lee and published by . This book was released on 2006 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies on Polyketide Derived Natural Products and Intermediates written by Sarah Elaine Newberry and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies on Selected Aromatic Polyketides written by Sutapa Ray and published by LAP Lambert Academic Publishing. This book was released on 2010-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled "Synthetic Studies on Selected Aromatic Polyketides" consists of three parts. Part A describes a direct synthetic method to 1,4- dihydroxyanthraquinones, an exploratory study towards anthracyclinones and a total synthesis of naturally occurring 1,4-dihydroxyanthraquinones ventinone A and ventinone B . Part B describes a total synthesis of an uncommon anthraquinone i.e. naturally occurring 9,10-dimethoxy-2-methyl-1,4- anthraquinone and Part C describes model studies towards the synthesis of chrymutasins and gilvocarcins that contain a benzo[d]naphtho[1,2-b] pyran-6-one as the core. The overall objective of the book is to give an idea of total synthesis of quinonoid natural products (e.g. anthracyclinones, anthraquinones) by exploitation of the Hauser annulation. The key reactions investigated here are Hauser annulation and carbonyl-ene reaction. The syntheses of few cyclopropaanthraquinones have also been given along with their chemistry.

Download or read book Synthetic and Biosynthetic Studies on Polyketide Derived Natural Products written by and published by . This book was released on 2012 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Applied to Polyketide Natural Products written by Alexander Mandel and published by . This book was released on 2008 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyketide natural products are valuable components of the modern pharmacopea. These secondary metabolites have a diverse range of structures and activities. Studies of their biosynthesis and activity will help to provide access to better medicinal compounds. To this end, directly probing these mechanisms with derivatives of natural products is an important goal. Synthetic organic chemistry allows production of a greater variety of compounds than can be accessed by manipulation of isolated natural products. In some cases, these bioactive molecules are only obtainable in small quantities or at great expense. Herein, a modular synthesis of the Coenzyme A (10) precursors pantethine (35) and phosphopantetheine (14) is described. CoA is a cofactor that interacts with an estimated 4% of all enzymes known in nature, and it is central to the biosynthesis of polyketide antibiotics. Using d-pantolactone (50) to provide the key units, 53 and 63, pantetheine, phosphopantetheine, and derivatives were assembled through peptide couplings. Next, synthetic methods were applied toward the total synthesis of two related macrolide antibiotics, pladienolide B (70b) and FD-895 (71), in an attempt to elucidate their stereochemistries and to get a supply of each molecule for studies into the their stereochemistries and to get a supply of each molecule for studies into the molecule relies on a Stille coupling to connect the sidechain (133) to the 12-membered macrocyclic core (111), and an esterification / ring-closing metathesis sequence to furnish the ring from compounds 115 and 114. The sidechain of pladienolide B was completed and involved in model studies to demonstrate the overall retrosynthetic background. The core structure was proposed to arise from the chiral pool, but the strategy to combine the two units with the necessary stereochemistry met with failure under many different conditions. Due to complications in obtaining an authentic sample of pladienolide B (70b), and subsequent outside publication of a total synthesis incorporating many aspects of the work contained herein, FD-895 (71) was chosen as an alternative target. The same retrosynthetic breakdown was applied to FD-895.

Download or read book Studies Towards Total Synthesis of Polyketide Natural Products and Alkaloids written by Anastasia Hager and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies in Polyketide Total Synthesis written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation will describe the development of a practical and scalable crotylation reaction with application toward the total syntheses of two polyketide-derived natural products: Zincophorin and Dictyostatin.

Download or read book Synthetic Studies Towards Aromatic Natural Products written by N. G. J. Richards and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies on Polyketide Natural Products written by Sbu Z. Mbatha and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis of Biosynthetic Intermediates to Polyketide Derived Natural Products written by Paul Watts and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Download or read book Plant derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.

Download or read book Yeast Metabolic Engineering written by Valeria Mapelli and published by Humana Press. This book was released on 2014-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in industrial biotechnology applications. Beginning with an extensive section on molecular tools and technology for yeast engineering, this detailed volume is not limited to methods for Saccharomyces cerevisiae, but describes tools and protocols for engineering other yeasts of biotechnological interest, such as Pichia pastoris, Hansenula polymorpha and Zygosaccharomyces bailii. Tools and technologies for the investigation and determination of yeast metabolic features are described in detail as well as metabolic models and their application for yeast metabolic engineering, while a chapter describing patenting and regulations with a special glance at yeast biotechnology closes the volume. Written in the highly successful Methods in Molecular Biology series format, most chapters include an introduction to their respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Yeast Metabolic Engineering: Methods and Protocols aims to familiarize researchers with the current state of these vital and increasingly useful technologies.