Download or read book Synthetic Studies on Selected Aromatic Polyketides written by Sutapa Ray and published by LAP Lambert Academic Publishing. This book was released on 2010-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled "Synthetic Studies on Selected Aromatic Polyketides" consists of three parts. Part A describes a direct synthetic method to 1,4- dihydroxyanthraquinones, an exploratory study towards anthracyclinones and a total synthesis of naturally occurring 1,4-dihydroxyanthraquinones ventinone A and ventinone B . Part B describes a total synthesis of an uncommon anthraquinone i.e. naturally occurring 9,10-dimethoxy-2-methyl-1,4- anthraquinone and Part C describes model studies towards the synthesis of chrymutasins and gilvocarcins that contain a benzo[d]naphtho[1,2-b] pyran-6-one as the core. The overall objective of the book is to give an idea of total synthesis of quinonoid natural products (e.g. anthracyclinones, anthraquinones) by exploitation of the Hauser annulation. The key reactions investigated here are Hauser annulation and carbonyl-ene reaction. The syntheses of few cyclopropaanthraquinones have also been given along with their chemistry.

Download or read book Synthetic and Biosynthetic Studies Toward Novel Aromatic Polyketides written by Taek Soon Lee and published by . This book was released on 2006 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards Aromatic Polyketide Derived Natural Products written by Peter Jaein Choi and published by . This book was released on 2011 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The first part of this thesis describes the successful synthesis of a series of 6,6- bisbenzannulated spiroketal analogues of the rubromycin family. The synthesis of spiroketals 183a-183e and spiroaminal 237 were successfully executed using a novel microwave-assisted DIHMA approach. Coupling of an aryl acetylene and an aryl aldehyde via acetylide anion addition resulted in the formation of an alkynol which was followed by oxidation to the desired ynone. Spirocyclisation using the DIHMA protocol afforded the desired bisbenzannulated spiroketals 183a-183e and spiroaminal 237 in good yields. Hydroxy-substituted 6,6- bisbenzannulated spiroketal 182 was successfully furnished by the reduction of ketosubstituted 6,6-bisbenzannulated spiroketal 183a with sodium borohydride. The second part of this research presents synthetic attempts to access the chiral 3-substituted phthalide containing natural products; aigialospirol (256) and herbaric acid (255). The synthesis of chiral vinylphthalide 406 proved challenging and was overcome by the use of a microwave-assisted chemoenzymatic resolution to install the C3 stereocenter of phthalide 406. Despite various attempts to functionalise vinylphthalide 406 towards the synthesis of aigialospirol, results were unsuccessful. With chiral vinylphthalide 406 in hand, the first synthesis and the structural assignment of ( -- )-herbaric acid (255) was accomplished. This was achieved via heteroatom-directed Wacker oxidation on vinylphthalide 406 to form aldehyde 460. Aldehyde 460 underwent smooth oxidation with Oxone® affording acid 488 which underwent facile methyl ester formation to facilitate purification, thus delivering enantioenriched lactone ester 489. Smooth demethylation with concomitant ester hydrolysis was effected by boron tribromide to give ( -- )-herbaric acid (255). The realisation of this entirely regioselective anti-Markovnikov addition of water during the Wacker oxidation provides a mild alternative to hydroboration/oxidation protocols that are traditionally used for terminal alkenes"--Abstract.

Download or read book Biosynthesis written by Finian J. Leeper and published by Springer. This book was released on 2003-07-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

Download or read book Synthetic Studies of Polyketide Related Compounds written by and published by . This book was released on 2004 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biosynthetic and Synthetic Studies on Polyketides written by David James Witter and published by . This book was released on 1994 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards Polyketide Derived Biologically Active Natural Products written by Amanda Heapy and published by . This book was released on 2009 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies on Polyketide Derived Natural Products and Intermediates written by Sarah Elaine Newberry and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies of Bioactive Polyketides written by Mina Razzak and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2022-05-17 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products. Hence, these new discoveries have created new avenues and applications for their use. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Download or read book Yeast Metabolic Engineering written by Valeria Mapelli and published by Humana Press. This book was released on 2014-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in industrial biotechnology applications. Beginning with an extensive section on molecular tools and technology for yeast engineering, this detailed volume is not limited to methods for Saccharomyces cerevisiae, but describes tools and protocols for engineering other yeasts of biotechnological interest, such as Pichia pastoris, Hansenula polymorpha and Zygosaccharomyces bailii. Tools and technologies for the investigation and determination of yeast metabolic features are described in detail as well as metabolic models and their application for yeast metabolic engineering, while a chapter describing patenting and regulations with a special glance at yeast biotechnology closes the volume. Written in the highly successful Methods in Molecular Biology series format, most chapters include an introduction to their respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Yeast Metabolic Engineering: Methods and Protocols aims to familiarize researchers with the current state of these vital and increasingly useful technologies.

Download or read book Essential and Non Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific progress, more and more, makes it possible to relate disease to irreg ularities on a molecular basis. Both, diagnosis and cure can be targeted to a well defined biological structure. Modern medical research aims at the investigation of the interaction of molecules and bio-macro-molecules, formerly the area of chemis try, biochemistry and pharmacology. This series was founded to provide a vehicle for the dissemination of results in a multidisciplinary area of contemporary research. It will publish extensive review articles at a high level, that will relate a particular subject to the scopes of medical chemistry. Thus, information and useful references will be spread among the schol ars. Table of Contents Toxicity and Carcinogenicity of Essential and Non-essential Metals M. Costa, A. J. Kraker and S. R. Patierno (USA) .......... 1 Secondary Metabolites with Antibiotic Activity from the Primary Metabolism of Aromatic Amino Acids R. G. Werner (FRG) . . . . . . . . . . . . . . . . . . . . . .. . . 47 . . . . Clinical Pharmacology of Benzodiazepines U. Klotz (FRG) .............. .

Download or read book Site Selective Catalysis written by Takeo Kawabata and published by Springer. This book was released on 2016-02-23 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Review articles for the individual volumes are invited by the volume editors.Readership: research chemists at universities or in industry, graduate students

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.