Download or read book Synthetic Receptors for Biomolecules written by Bradley D. Smith and published by Royal Society of Chemistry. This book was released on 2015-07-10 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic receptor molecules, molecules that mimic antibody recognition, are widely used for developing drug leads; drug delivery vehicles; imaging agents; sensing agents; capture agents and separation systems. Synthetic Receptors for Biomolecules covers the most effective synthetic receptors for each major class of biomolecules within the context of specific applications. The book starts with an introduction to the applications of synthetic receptors for biomolecules and their design and synthesis for biomolecule recognition. Dedicated chapters then cover synthetic receptors for the key biomolecules including inorganic cations; small organic and inorganic anions; carbohydrates; nucleosides/nucleotides; oligonucleotides; amino acids and peptides; protein surfaces as well as non-polar and polar lipids; Each chapter follows the same systematic format of (a) chemical structures and physical properties of the biomolecule, (b) biological recognition of the biomolecule, (c) synthetic receptors for the biomolecule, (d) future directions and challenges. Edited by a leader in the field, the book is written in an accessible style for readers new to supramolecular chemistry or for those looking for synthetic receptors.
Download or read book Functional Synthetic Receptors written by Thomas Schrader and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely overview of this rapidly-expanding topic, covering the most important classes of compounds and incorporating the latest literature. With its application-oriented approach, this book is the first to emphasize current and potential applications, extending to such fields as materials science, bioorganic chemistry, medicinal chemistry, and organic synthesis. In the biological context in particular, the book clarifies which receptor systems work well in water or better under physiological conditions. From the contents: * Amino Acid, Peptid and Protein Receptors * Carbohydrate Receptors * Ammonium, Amidinium and Guanidinium Receptors * Anion Receptors * Molecular Capsules and Self Assembly * Dynamic Combinatorial Libraries based on Molecular Recognition * Molecular Machines * Self-Replication Aimed at graduate students and specialists in the field, this is also of interest to pharmaceutical companies involved in drug design, as well as chemical companies with a polymer or nanotechnology group. In addition, analytical companies working on the advanced equipment covered here will find stimulating new applications.
Download or read book Designing Receptors for the Next Generation of Biosensors written by Sergey A. Piletsky and published by Springer Science & Business Media. This book was released on 2012-09-26 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite achievements in the application of enzymes, antibodies and biological receptors to diagnostics and sensing, the last two decades have also witnessed the emergence of a number of alternative technologies based on synthetic chemistry. This volume shows how synthetic receptors can be designed with characteristics that make them attractive alternatives to biological molecules in the sensory and diagnostics fields, with contributions from leading experts in the area. Subjects covered include synthetic receptors for a range of biomolecules, the use of antimicrobial peptides for the detection of pathogenic microorganisms, the development of molecularly imprinted polymer (MIP) nanoparticles, the in silico design of MIPs and MIP-based sensors, and two chapters examining the development of sensors from an industrial point of view. The particular focus of all chapters is on practical aspects, either in the development process or the applications of the synthesized materials. This book will serve as an important reference work for business leaders and technology experts in the sensors and diagnostics sector.
Download or read book Fluorescent Receptors for Biomolecules written by Chi-Linh Do-Thanh and published by . This book was released on 2011 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of synthetic receptors capable of high-affinity complexation of biologically relevant analytes in competitive solvent systems represents an ongoing challenge in molecular recognition. Anion recognition is particularly problematic, which is significant since numerous biological processes are regulated by anions, such as those resulting from phosphorylation. In this dissertation, we present the design and synthesis of a fluorescent sensor containing two cyclen groups that are preorganized to form a binding cleft for anion complexation. The receptor design includes a rigid acridine backbone, which is also exploited for fluorescence signal transduction. Furthermore, click chemistry is employed to facilitate receptor synthesis, and binding studies with various phosphorylated guest molecules are described. Additionally, the development of boronic acid-based carbohydrate receptors is presented. Carbohydrates play important roles in a large number of biochemical processes such as signal transduction and cell surface recognition events. The receptors will be used to study carbohydrate binding through Förster resonance energy transfer (FRET) and surface enhanced Raman spectroscopy (SERS). Another project involves the synthesis of aromatic compounds that can act as auxin herbicides. Auxins are plant hormones that play a major role in the regulation of plant growth and development. A modular synthetic strategy is employed to access a library of small molecules that will be tested for herbicidal activity on a variety of weeds. Finally, the work on the design and synthesis of molecular building blocks to generate covalently-bonded ordered organic frameworks is discussed.
Download or read book Artificial Receptors for Chemical Sensors written by Vladimir M. Mirsky and published by John Wiley & Sons. This book was released on 2010-12-20 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first to provide systematically organized information on all three important aspects of artificial receptor design, this book brings together knowledge on an exceptionally hot and multidisciplinary field of research. Strong emphasis is placed on the methodology for discovering artificial receptors, with both definitions for chemosensitivity as well as experimental setups supplied. There follows coverage of numerous classes of artificial receptors, including synthesis, immobilization on surfaces, and quantitative data on properties. The third part of the book focuses on receptor arrays for artificial nose and tongue applications and the whole is rounded off with an outlook and an appendix with all relevant quantitative data on artificial receptors.
Download or read book Cellular and Biomolecular Recognition written by Raz Jelinek and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.
Download or read book Advanced Synthetic Materials in Detection Science written by Subrayal M Reddy and published by Royal Society of Chemistry. This book was released on 2014-08-19 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a bid to develop synthetic molecules and materials that are capable of mimicking biological recognition and function, intensive research in the fields of synthetic receptor technologies, smart materials, synthetic biology and smart indicators has been under way for the past 20-30 years. The development of synthetic receptors continues to grow rapidly. Novel molecular architectures, with ever improving selective binding properties are constantly being described, and in some cases providing much-needed physical insights into the nature of non-covalent interactions and molecular recognition. Such receptor systems are finding increasingly esoteric applications and this book captures the key developments at the synthetic receptor/biology/detection science interface. The editor has extensive experience in applying smart materials and synthetic receptors to the development of biosensors. Reddy has developed smart, permselective and biocompatible molecularly imprinted polymers and membrane materials for the sensor/sample interface and the advancement of smart materials-based electrochemical, quartz crystal and optical sensors for medical, food and environmental applications. Chapters demonstrate how growing disciplines such as biomimetics, synthetic receptor technologies, pattern recognition and nanotechnology are being used to develop new smart materials for diagnostic sensor and biosensor applications. Postgraduate students and researchers in academia and industry will benefit from this resourceful handbook.
Download or read book Calix 4 arene and Its Application for the Recognition of Biomolecules written by Pinkeshkumar Sutariya and published by LAP Lambert Academic Publishing. This book was released on 2015-02-10 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on molecular recognition of amino compounds, such as biogenic amines, amino acids, peptides, proteins, and carbohydrate like essential substrates in biological processes, by synthetic receptors is an issue of great concern from both a supramolecular chemistry and analytical application point of view. Among naturally occurring amino acids tryptophan (L-Trp) is the most fluorescent, the indole ring of L-Trp have recently been the subject of much investigation due to the functional and structural prominence of such interactions in chemistry and biology. Recently, it was found that the reduced nutritional state of patients with chronic kidney disease could be attributed to the deficiency of histidine (L-His). L-His rich proteins are found to play many important roles in humans and their abnormal level could indicate a variety of diseases. Therefore, selective detection of L-His and L-Trp in biological fluids has become a significant objective and a number of methods have been developed for this purpose.
Download or read book NanoArmoring of Enzymes Rational Design of Polymer Wrapped Enzymes written by and published by Academic Press. This book was released on 2017-04-14 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoarmoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes, Volume 590 is the latest volume in the Methods in Enzymology series that focuses on nanoarmoring of enzymes and the rational design of polymer-wrapped enzymes. This new volume presents the most updated information on a variety of topics, including specific chapters on Encapsulating Proteins in Nanoparticles: Batch by Batch or One by One, Enzyme Adsorption on Nanoparticle Surfaces Probed by Highly Sensitive Second Harmonic Light Scattering, Armoring Enzymes by Metal–Organic Frameworks by the Coprecipitation Method, and Enzyme Armoring by an Organosilica Layer: Synthesis and Characterization of Hybrid Organic/Inorganic Nanobiocatalysts. Users will find this to be an all-encompassing resource on nanoarmoring in enzymes. Focuses on the nanoarmoring of enzymes Covers the rational design of polymer-wrapped enzymes Includes contributions from leading authorities working in enzymology Informs and updates on all the latest developments in the field of enzymology
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Receptor Endocytosis and Signalling in Health and Disease Part B written by and published by Elsevier. This book was released on 2023-02-20 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more. Provides information on the structure and function of nuclear receptors Discusses the basic pathways involved in receptor internalization, subcellular trafficking, metabolic degradation, and signaling Includes a wide range of neurological receptors and their roles
Download or read book The Interaction of Natural Products with Natural and Synthetic Receptors written by Benjamin Locke Miller and published by . This book was released on 1994 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Organic Receptors Used to Investigate Noncovalent Interactions in Biological Systems written by Stephen Leighton De Wall and published by . This book was released on 2000 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recognition Receptors in Biosensors written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.
Download or read book Chemical and Synthetic Biology Approaches to Understand Cellular Functions Part C written by and published by Academic Press. This book was released on 2020-02-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology
Download or read book Polym res Empreintes Mol culaires Comme R cepteurs Synth tiques Pour Des Glucuronates Et Leur Utilisation Pour Le Biod tection written by Nataliya Marchyk and published by . This book was released on 2012 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular recognition is a fundamental process in biological systems. The creation of synthetic receptors mimicking the biological processes is of high importance in practical application due to their higher stability to harsh environments, long on-shelf life and application flexibility comparing to natural counterparts. Molecularly imprinted polymers (MIP) readily meet these conditions. MIPs are tailor-made synthetic receptors that are able to specifically recognize a certain target molecule. Their synthesis is based on the presence of a molecular template that directs the self-assembly of functional monomers around. In an excess of cross-linking agent the monomers copolymerize, and subsequent removal of the template molecule generates three-dimensional binding sites in the material that are complementary to the template in size, shape and position of the functional groups. Due to complexity of composition and various influencing factors, the rational design should be employed in order to improve the performance of MIP systems. Core-shell nanoparticles provide a unique possibility to incorporate agents with optical or magnetic properties into the core, providing broader possibilities for MIPs application, such as in bioimaging and monitoring. The work of the thesis is focused on development of MIPs for the specific recognition of glucuronates in aqueous environment with outlook for applicability in biological systems. The rational design framework included molecular modelling, spectroscopic analysis and the design of experiments. Molecular modelling simulated intermolecular interactions and allowed to discover the most promising analyte-monomer combinations which could be verified in situ via spectroscopic (NMR) method. The design of experiments with multi-objective optimization allowed finding the composition of MIP with the best performance to glucuronate as well as to understand the effects of influencing factors, compounds concentrations in particular, onto the MIP performance. Förster resonance energy transfer (FRET) was applied in order to evaluate the recognition event of the target analyte in the MIP system. Bearing in mind the application in biological systems, a new approach for the synthesis of core-shell nanoparticles was proposed. The principle is based on one-pot synthesis by conventional emulsion polymerization of iniferter seeds which serve as cores for final particles. The up-converting particles (UCPs) possess unique optical properties to absorb the light at higher wavelength and emit it at lower wavelength. That makes them very promising in bioimaging, since the autofluorescence of biological samples can be decreased significantly. A novel strategy was proposed to synthesize composite core-shell nanoparticles where UCPs were employed as the second local light source to initiate the polymerization from the particles' surface.
Download or read book Cell Free Synthetic Biology written by Jian Li and published by Frontiers Media SA. This book was released on 2022-01-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
