Download or read book Industrial Pharmaceutical Biotechnology written by Heinrich Klefenz and published by Wiley-VCH. This book was released on 2002-04-22 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.

Download or read book Elemental Speciation in Human Health Risk Assessment written by P. Apostoli and published by World Health Organization. This book was released on 2006 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Definitions of species and speciation - - Strructural aspects of speciation - - Analytical techniques and methodology - - Bioaccessibility and bioavailability - - Toxicokinetics and biological monitoring - - Molecular and cellular mechanisms of metal toxicity - - Health effects - - Conclusions and recommendations.

Download or read book Immunology for Surgeons written by Andrew P. Zbar and published by Springer Science & Business Media. This book was released on 2002-02-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the complex workings of the immune system is essential for all surgeons. Immune responses play a crucial part in the way human body reacts to infection and trauma. Immunology for Surgeons contains a high-level discussion of this difficult clinical area. The text looks at tumor immunobiology and immunotherapy as well as the worldwide results of various clinical trials. The topics discussed focus on relevant immunological and molecular biological trends for future treatment of complex surgical disease. The main objective of the text is to render a difficult area accessible for the postgraduate surgical trainee and established surgeon who is interested in immunology.

Download or read book Cutaneous Drug Eruptions written by John C. Hall and published by Springer. This book was released on 2015-08-21 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The burden of cutaneous drug reactions is significant, in both outpatient and inpatient settings, and can result in morbidity and even mortality. This book is unique in its approach to this problem. This text is divided into basic principles, common drug reactions, skin conditions mimicked by drug reactions, drug reactions to the skin appendages, life-threatening drug reactions, less common drug reactions, and special groupings of drug reactions. For the clinician, the skin can only morphologically react in to many limited ways. This is also true for the pathologist. Combining these two forever linked specialties is a synergistic paradigm that greatly enhances diagnosis, and ultimately therapy, for these pernicious conditions. Drug reactions in the skin remain a common complication of therapy. True incidences of drug reactions are not available. For general discussion, the rule of 3% can be applied with reasonable assuredness. Approximately 3% of all hospitalized patients develop an adverse cutaneous drug reaction. Approximately 3% of these reactions are considered severe. Outpatient data is even more obscure, but at least 3% of dermatology clinic outpatient visits are due to a drug reaction. Cutaneous drug reactions compromise approximately 3% of all drug reactions. Even more challenging is the fact that the most vulnerable populations to drug reactions are increasing and include the elderly patients on prolonged drug therapy, and patients that use multiple drugs at the same time.

Download or read book Lewis Acids and Selectivity in Organic Synthesis written by M. Santelli and published by CRC Press. This book was released on 1995-11-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lewis acids provide inexpensive access to elaborated molecules obtained with high selectivities (regio-, stereo-, and enantioselectivity). Lewis Acids and Selectivity in Organic Synthesis is the first book to deal with these new and promising roles of Lewis acids. The book begins with general considerations on Lewis acids and a description of Lewis acid-carbonyl complexes, which are involved in most of the reactions described: ene reactions, allylsilane and allyltin addition to carbonyl compounds, addition of nucleophiles to acetals, conjugated addition of allylsilanes and allyltins to unsaturated carbonyl compounds (Sakurai reaction), and Diels-Alder reaction. Subsequent chapters examine these issue in detail, with special attention given to the way Lewis acids induce diastereo- and enantioselectivity. The extensive use of schemes (approximately 1000) ensures rapid visual uptake of the information. Lewis Acids and Selectivity in Organic Synthesis serves as a valuable source of information for all who face the challenge of selectivity in organic synthesis.

Download or read book Essentials of Cancer Genomic Computational Approaches and Precision Medicine written by Nosheen Masood and published by Springer Nature. This book was released on 2020-03-20 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Download or read book Nontraditional Careers for Chemists written by Lisa M. Balbes and published by . This book was released on 2007 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Chemistry background prepares you for much more than just a laboratory career. The broad science education, analytical thinking, research methods, and other skills learned are of value to a wide variety of types of employers, and essential for a plethora of types of positions. Those who are interested in chemistry tend to have some similar personality traits and characteristics. By understanding your own personal values and interests, you can make informed decisions about what career paths to explore, and identify positions that match your needs. By expanding your options for not only what you will do, but also the environment in which you will do it, you can vastly increase the available employment opportunities, and increase the likelihood of finding enjoyable and lucrative employment. Each chapter in this book provides background information on a nontraditional field, including typical tasks, education or training requirements, and personal characteristics that make for a successful career in that field. Each chapter also contains detailed profiles of several chemists working in that field. The reader gets a true sense of what these people do on a daily basis, what in their background prepared them to move into this field, and what skills, personality, and knowledge are required to make a success of a career in this new field. Advice for people interested in moving into the field, and predictions for the future of that career, are also included from each person profiled. Career fields profiled include communication, chemical information, patents, sales and marketing, business development, regulatory affairs, public policy, safety, human resources, computers, and several others. Taken together, the career descriptions and real case histories provide a complete picture of each nontraditional career path, as well as valuable advice about how career transitions can be planned and successfully achieved by any chemist.

Download or read book 2011 Nurse s Drug Handbook written by Jones & Bartlett Learning, and published by Jones & Bartlett Publishers. This book was released on 2010-06-29 with total page 1266 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new and updated version of this best-selling resource! Jones and Bartlett Publisher’s 2011 Nurse’s Drug Handbook is the most up-to-date, practical, and easy-to-use nursing drug reference! It provides: * Accurate, timely facts on hundreds of drugs from abacavir sulfate to Zyvox * Concise, consistently formatted drug entries organized alphabetically * No-nonsense writing style that speaks your language in terms you use everyday * Index of all generic, trade, and alternate drug names for quick reference It has all the vital information you need at your fingertips: * Chemical and therapeutic classes, FDA pregnancy risk category and controlled substance schedule * Indications and dosages, as well as route, onset, peak, and duration information * Incompatibilities, contraindications; interactions with drugs, food, and activities; and adverse reactions * Nursing considerations, including key patient-teaching points * Vital features include mechanism-of-action illustrations showing how drugs at the cellular, tissue, or organ levels and dosage adjustments help individualize care for elderly patients, patients with renal impairment, and others with special needs * Warnings and precautions that keep you informed and alert

Download or read book Preclinical Development Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2008-03-21 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Download or read book NanoBioTechnology written by Oded Shoseyov and published by Springer Science & Business Media. This book was released on 2008-02-07 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: NanoBiotechnology is a groundbreaking text investigating the recent advances and future direction of nanobiotechnology. It will assist scientists and students in learning the fundamentals and cutting-edge nature of this new and emerging science. Focusing on materials and building blocks for nanotechnology, leading scientists from around the world share their knowledge and expertise in this authoritative volume.

Download or read book Pharmaceutical Biotechnology written by Daan J. A. Crommelin and published by CRC Press. This book was released on 2002-11-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

Download or read book Medicinal Inorganic Chemistry written by Jonathan L. Sessler and published by . This book was released on 2005 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Download or read book Targets in Heterocyclic Systems written by and published by . This book was released on 1997 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Materials Science and Applied Chemistry written by Valdis Kokars and published by Trans Tech Publications Ltd. This book was released on 2018-02-05 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: 58th International Conference of Materials Science and Applied Chemistry (MSAC 2017) Selected, peer reviewed papers from the 58th International Conference of Materials Science and Applied Chemistry - MSAC 2017, October 20, 2017, Riga, Latvia

Download or read book Stereoselective Synthesis written by Gary A. Molander and published by Thieme Chemistry. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonyl and imino groups are two of the most integral functional groups employed in organic synthesis. Specific topics discussed: reduction, alkylation, alkenylation, and arylation of these groups, as well as asymmetric aldol, Mannich, and Morita-Bayliss-Hillman reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)

Download or read book Sulfonamides written by Debayan Sarkar and published by Nova Science Publishers. This book was released on 2021 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book presents comprehensive accounts of the chemistry revolving around the sulphonamides. Sulfonamides are widely present in various drugs as a functional group and are a manmade synthetic drug. Hence, their extended research is a prerequisite for every practitioner of organic chemistry. Chapter 1 introduces the synthesis, reactivity, acidity, and pharmaceutical properties of the sulphonamides. It highlights the synthesis of biologically active sulphonamides, the study of their biological activity by QSAR method, and their medical applications. Chapter 2 deals with the classification of sulphonamides (i.e. acyclic and cyclic) and their structural activity relationship. It also describes the application of sulphonamides in pharmaceuticals as antimicrobial, anti-diabetic, anti-viral, anti-cancer, anti-inflammatory and anti-malarial agents. Chapter 3 reviews the synthetic attempts towards sulphonamide synthesis by employing the fixation of sulphur-dioxides. These approaches have been categorized into three parts: a) transition metal-catalyzed, b) employing Lewis acid, c) photocatalytic. Chapter 4 discusses the use of sulphonamides as potent organocatalysts, briefly describing how the mono- and C2-symmetric bis-sulfonamides act as efficient bifunctional and multifunctional organocatalysts in the enantioselective Michael addition of carbonyl compounds to alpha, beta-unsaturated compounds. Chapter 5 details the oxidative sulphonamidation of alkenes and dienes, which also direct the routes to the synthesis of numerous heterocycles and linear compounds. Special emphasis is given to the comparison of reactivity of triflamides, arenesulfonamides, and the deprotection of sulfonamides. Chapter 6 describes the therapeutic properties of sulphonamides, which are significantly increased by the presence of the metal ions and ligands. This complex generation provides the opportunity to exploit the unique properties of metal centers, such as multiple oxidation states, redox properties, a wide variety of coordination numbers, symmetries and structural patterns, which offer highly adaptable platforms for drug design. Chapter 7 provides an overview of the clinical applications of sulphonamides on the toxicity and pharmacokinetic aspects of various sulpha-drugs. The mechanism involved in the development of sulfonamide resistance is briefly discussed. Thus, this book summarizes important attempts undertaken by chemists and biologists worldwide in the area of sulphonamides. Most importantly, the book also correlates the structural activity relationship and the related biological activity of the sulphonamides, attracting both novice and experienced chemists across the globe"--

Download or read book The Basic Science of Oncology written by Ian Tannock and published by McGraw Hill Professional. This book was released on 2005 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.