Download or read book Synthesis Spectral Studies and Cytotoxicity of Organotin IV Complexes with Hydrazone Ligands written by and published by . This book was released on 2012 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Structure Bioactivity of Organotin IV hydrazone Compounds written by M. A. Affan and published by . This book was released on 2012-02 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).

Download or read book Synthesis Characterization and Toxicity Study of Novel Organotin IV Complexes with Hydrazone written by and published by . This book was released on 2008 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the coordination chemistry of organotin (IV) with hydrazone and thiosemicarbarzone ligands. A comprehensive survey of the literature, focusing on works most pertinent and complementary to the synthesis, chemical reactivities, structures of organotin (IV) complexes and biological studies containing ONN, ONO, and ONS-donor us described extensively.

Download or read book Synthesis Spectral Characterization and Toxicity Activity of Organotin IV Complexes of Schiff Base Ligands written by and published by . This book was released on 2011 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dateline Bhopal written by Anees Chishti and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Characterization and Biological Activity of Organotin IV Complexes with Hydrazone Ligands written by and published by . This book was released on 2009 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis report four new chelating hydrazone ligands containing ONO- and ONN-donor atoms and their organotin (IV) complexes. Research works have been focused on the synthesis, spectroscopic characterization, structural elucidation and biological activities studies of these hydrazone ligands and their organotin (IV) complexes.

Download or read book Die bayerische Pressgesetzgebung nach dem Stande vom 1 Juli 1862 written by and published by . This book was released on 1862 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Spectral and EPR Studies of Oxovanadium IV Complexes Incorporating Tridentate ONO Donor Hydrazone Ligands written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Characterization and Anti cancer Properties of Organotin IV Cyanoximates written by Tiffany R. Maher and published by . This book was released on 2004 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Organotin IV Complexes with Hydrazone carbohydrazone Ligands written by and published by . This book was released on 2009 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Organotin IV Complexes written by Saira Shahzadi and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book includes the synthesis, characterization and X-ray analysis of organotin(IV) carboxylates and organotin(IV) thiocarboxylates. Various di- and triorganotin(IV) compounds have been synthesized with a stoichiometric amount of synthesized carboxylic acid and thiocarboxylic acid. The structural assignments were made on the basis of spectral techniques such as FT-IR, 1H, 13C, 119Sn NMR and mass spectrometry, which ascertain the tetrahedral environment around the tin atom in solution while penta or hexa coordination is found in the solid state. Biological activity tests of the synthesized carboxylates and thiocarboxylates were made against various medically important bacteria and fungi. Most of the compounds were found to show activity with a few exceptions. These compounds were also evaluated for their cytotoxicity using the brine-shrimp lethality bioassay method. Only few of the compounds were found to be nontoxic

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Download or read book Organotin Complexes of Heterocyclic 4 Cyclohexylthiosemicarbazones written by M. A. Salam and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eight new organotin(IV) complexes (3-10) with 2-acetylpyridine-N(4)-cyclohexylthiosemicarbazone [HPACT, (1)] and ten new organotin(IV) complexes (11-20) with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone [HBPCT, (2)] have been synthesized and characterized by various spectroscopic techniques and X-ray crystallography. In all the complexes (3-20), both ligands (1-2) are coordinated to the tin(IV) atom through the thiolato-S, azomethine-N and pyridine-N atoms, respectively. The X-ray study found that the all complexes are monomer and the central tin(IV) atom is six coordinated in a distorted octahedral geometry. The ligands (1-2) and their organotin(IV) complexes (3-20) were screened for their in vitro antibacterial and cytotoxicity. The screening results revealed that all these compounds have shown significant antibacterial and potential antitumor activity. Results of biological studies demonstrate that organotin(IV) derivatives are in general more active than the free ligands. In view of the diverse fields of applications, the results of wood decay resistance test showed that the novel organotin(IV) treated wood increased the duration of protection against biodegradation.

Download or read book Catalytic and Biological Screening of Organotin IV Carboxylates written by MUHAMMAD TARIQ and published by LAP Lambert Academic Publishing. This book was released on 2014-02 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Di- and tri-organotin(IV) carboxylates of the type R2SnL2 [R = CH3, n-C4H9, n-C8H17] and R3SnL [R = CH3, n-C4H9, C6H5, where L= oxygen donor ligand, have been synthesized and characterized by various analytical techniques such as elemental analysis, FT-IR, NMR (1H, 13C) and single crystal X-ray analysis. The synthesized complexes were screened for their catalytic activity in synthesis of biodiesel-an alternative fuel, and biological activities such as antibacterial, antifungal and cytotoxicity. The triorganotin(IV) complexes exhibited comparatively higher catalytic and biological activities than their diorganotin(IV) analogues. DNA interactions studies of the ligands and synthesized complexes were also investigated and the results showed that both ligands and complexes interact with DNA via intercalation as well as minor groove binding.

Download or read book Synthesis Structural Characterization and Spectroscopy Studies of New Oxovanadium IV V Complexes with Hydrazone Ligands written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

Download or read book Smith and Williams Introduction to the Principles of Drug Design and Action written by H. John Smith and published by CRC Press. This book was released on 2005-10-10 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio