Download or read book Synthesis of Polyketide Derived Natural Products and Putative Biosynthetic Intermediates written by Chengsen Cui and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Biosynthetic Intermediates to Polyketide Derived Natural Products written by Paul Watts and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Download or read book Polyketides written by American Chemical Society. Meeting and published by . This book was released on 2007 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of new discoveries in the field of polyketide research. It will benefit scientists and other sectors interested in the chemistry, molecular biology, and biotechnological aspects of this area of investigation.
Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
Download or read book Synthesis and Biosynthesis of Polyketide Natural Products written by Atahualpa Pinto and published by . This book was released on 2011 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Download or read book Structural Studies of Polyketide Synthase Biosynthetic Machinery written by Timothy Robert Valentic and published by . This book was released on 2016 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial, fungal, and plant secondary metabolic pathways afford a huge library of elaborate organic molecules known as natural products. Polyketides and nonribosomal peptides are natural products that are biosynthesized from multienzyme complexes known as polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), respectively. PKSs and NRPs utilize simple acyl-CoA or amino acid building blocks for the assembly of structurally diverse natural products. Because both polyketides and nonribosmal peptides exhibit a wide range of biological activities, they have been utilized as therapeutics and are important for drug discovery. The objective of this dissertation is to improve the structural understanding of how the biosynthetic machinery associated with polyketide and nonribosomal peptide biosynthesis generates such a large array of complex natural products. In type II PKS biosynthesis, aromatase/cyclases (ARO/CYCs) are responsible for the generation of set C7-C12 or C9-C14 ring patterns through the regiospecific cyclization of reactive poly-beta-ketone intermediates. In Chapter 2, the first co-crystal structures of WhIE bound to four distinct pantetheine linked polyketide chain mimics are discussed. This work provides the first snapshot of ARO/CYC binding modes which, until now, have remained hypothetical. Further, this is the first successful application of polyketide mimics to investigate the structures and functions of ARO/CYCs.Methyl-, ethyl-, and malonyl-CoA extender units are the most common building blocks employed by type I modular PKSs for natural product biogenesis. However, certain type I modular PKSs incorporate non-canonical long chain extender units to augment the structural diversity of a polyketide scaffold. Typically, crotonyl-CoA carboxylase/reductases (CCRs) are responsible for the generation of extravagant PKS extender units, whereas acyl-CoA carboxylases (ACCases) are responsible for the production of canonical short chain extender units. In Chapter 3, we discuss the structure and function of a novel ACCase ?- subunit, MccB from the stambomycin biosynthetic pathway that is capable of generating long chain extender units. The crystal structures of apo and hexanoyl-CoA bound MccB were solved, providing a structural basis for unusual ACCase-mediate extender formation during stambomycin biogenesis. Typically, in type I modular PKS biosynthesis, thioesterases (TEs) are responsible for product hydrolysis from the enzymatic assembly line. In some PKS/NRPS hybrid systems, however, a TE domain is absent and instead a terminal condensation domain (C domain) is required for product liberation from the enzymatic assembly line. The enacyloxin biosynthetic pathway is an example of a PKS/NRPS hybrid that utilizes a standalone NRPS condensation domain, bamb_5915, for product release through an intermolecular transesterification reaction between shikimate and a mature polyketide chain. The crystal structure and functional analysis of bamb_5915 is described in Chapter 4. In addition, bioinformatic analysis of PCP_5917 and other NRPS/PKS hybrid pathways is discussed. The information gleaned from these studies will aid in the generation of "mixed" PKS/NRPS natural products. Genome mining of environmental DNA is an emerging method that has led to the identification of novel PKS natural product pathways. The arixanthomycins are a group of recently discovered natural products that were identified through the heterologous expression of environmental DNA derived gene clusters in Streptomyces. Chapter 5 reports the crystal structure of ARX 21, a novel C-17 and C-19 reducing ketoreductase, and in vitro reconstitution of an unusual C9-C14 reducing ARO/CYC from the arixanthomycin pathway.
Download or read book Plant derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Download or read book Biochemistry and Molecular Biology of Plants written by Bob B. Buchanan and published by John Wiley & Sons. This book was released on 2015-08-31 with total page 1280 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 1000 original drawings and 500 photographs, this work offers complete coverage of cell biology, plant physiology and molecular biology.
Download or read book Phytocannabinoids written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-01-24 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.
Download or read book The Polyketide Metabolites written by David O'Hagan and published by Ellis Horwood. This book was released on 1991 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book The Science of Flavonoids written by Erich Grotewold and published by Springer Science & Business Media. This book was released on 2008 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book of its kind to provide an overview of the science of flavonoids in plants.
Download or read book S adenosylmethionine dependent Methyltransferases Structures And Functions written by Robert M Blumenthal and published by World Scientific. This book was released on 1999-07-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.
Download or read book Natural Product Biosynthesis by Microorganisms and Plants written by D. A. Hopwood and published by Academic Press. This book was released on 2012 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This volume of 'Methods in Enzymology' continues the legacy of this premier serial by containing quality chapters authored by leaders in the field.
Download or read book Biotechnology and Biology of Trichoderma written by Vijai G. Gupta and published by Newnes. This book was released on 2014-02-17 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology and Biology of Trichoderma serves as a comprehensive reference on the chemistry and biochemistry of one of the most important microbial agents, Trichoderma, and its use in an increased number of industrial bioprocesses for the synthesis of many biochemicals such as pharmaceuticals and biofuels. This book provides individuals working in the field of Trichoderma, especially biochemical engineers, biochemists and biotechnologists, important information on how these valuable fungi can contribute to the production of a wide range of products of commercial and ecological interest. Provides a detailed and comprehensive coverage of the chemistry, biochemistry and biotechnology of Trichoderma, fungi present in soil and plants Includes most important current and potential applications of Trichoderma in bioengineering, bioprocess technology including bioenergy & biofuels, biopharmaceuticals, secondary metabolites and protein engineering Includes the most recent research advancements made on Trichoderma applications in plant biotechnology and ecology and environment
