Download or read book Synthesis of Carbon Phosphorus Bonds written by Robert Engel and published by CRC Press. This book was released on 2003-12-18 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Carbon-Phosphorus Bonds, Second Edition is a working guide for the laboratory, incorporating classical approaches with the recent developments of carbon-phosphorus (C-P) bond formation. These advances include the preparation of phosphoranes - specifically in the use of transient oxophosphoranes as intermediates in organophosphorus comp

Download or read book Synthesis of Carbon Phosphorus Bonds Second Edition written by Robert Engel and published by CRC Press. This book was released on 2003-12-18 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Carbon-Phosphorus Bonds, Second Edition is a working guide for the laboratory, incorporating classical approaches with the recent developments of carbon-phosphorus (C-P) bond formation. These advances include the preparation of phosphoranes - specifically in the use of transient oxophosphoranes as intermediates in organophosphorus compound synthesis ñ along with the new approaches towards the preparation of compounds with aromatic and vinylic C-P bonds. Synthesis of Carbon-Phosphorus Bonds, Second Edition serves as a useful tool in the laboratory. It offers detailed surveys of IUPAC nomenclature recommendations, common notation systems, and various experimental examples. These features help to make this text an effective source of critical and annotated references, as well as a a working guide for organic and phosphorus chemists specifically, or for any chemists working with C-P bonds.

Download or read book Carbon phosphorus Bond Formation written by Yamina Belabassi and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in this dissertation deals with the development of new methodologies for P-C bond formation as well as synthesizing biologically relevant organophosphorus compounds. A distinct emphasis is given to the important synthetic targets, the H-phosphinates. A review of relevant literature is provided in Chapter 1. Chapter 2 describes the synthesis and structural analyses, of triphenylmethyl-containing phosphorus compounds. For the first time, both phosphonothioic and boranophosphonic acids have been characterized by single X-ray diffractometry. The third chapter details the preparation and the reactivity of phosphine-borane complexes. Novel dialkoxyphosphine-borane complexes were introduced, both as general synthetic intermediates for the preparation of H-phosphinates or disubstituted phosphinic acids, and as boranophosphonate precursors. Related to this chemistry, silylation of an H-phosphinate intermediate can also be conducted and the resulting phosphonite protected with borane. This allows the temporary protection of the sensitive P-H group, so that manipulations of the alkyl chain might be conducted. In chapter 4, the palladium-catalyzed cross-coupling reaction of dialkylphosphites with aryl and heteroaryl halides is presented. An efficient, versatile and economically attractive alternative to the original Hirao cross-coupling by using only 1 mol% (or less) Pd(OAc)2/dppf is described. Moreover, first example of palladium-catalyzed P-C bond formation between activated aryl chlorides and a phosphite are herein reported. Chapter 5 focuses on the free-radical hydrophosphinylation of alkynes. The triethylborane-initiated radical addition of sodium hypophosphite to terminal alkyne affords the previously unknown 1,1-bis-H-phosphinates, precursors of the biologically relevant 1,1-bisphosphonates (e.g., treatment of bone diseases). Thus, the oxidative conversion of 1,1-bis-H-phosphinates to the corresponding bisphosphonates, as well as the synthesis of a series of bio-conjugates (steroids, carbohydrates, fluoroquinolones) was investigated. In the last chapter, the palladium-catalyzed hydrophosphinylation of hypophosphorous acid derivatives to terminal alkynes is reported. In an effort to improve the regioselectivity of the reaction, various terminal alkynes were tested, as well as the solvent and catalyst system.

Download or read book Carbon phosphorus and Oxygen phosphorus Bond Formation written by Henry C. Fisher and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The work in this dissertation deals with the continued development of new methodologies for P-C and P-O bond formation using alternative methods that avoid the use of PCl3. A review of the relevant literature that proceeds this work is presented in Chapter 1. Chapter 2 describes the study of the P(III) to P(V) tautomerization of phosphinylidene compounds and the structural influences that effect the thermodynamic and kinetic properties to favor the more reactive P(III) species. A collaboration using both computational and experimental methods, show that electron withdrawing groups such as phenyl stabilize the tautomerization of phosphinylidene compounds. The second part of this work highlights the influence of various catalysts on P(III) to P(V) tautomerization. Using computational chemistry as a screening tool, a variety of organic acids and bases were tested. The calculations and experimental results are in good agreement. Chapter 3 describes the work to develop the nickel-catalzyed hydrophosphinylation of unactivated alkenes, an extension of the work started with the nickel-catalyzed hydrophosphosphinylation of alkynes. The results show that nickel chloride is pre-activated to an active Ni(0) species and can be stabilized by the inexpensive bisphosphine ligand, ethylbis(diphenylphosphine), dppe. The reaction occurs at room temperature and works on a variety of different alkene substrates. Other manipulations used in tandem with the initial nickel hydrophosphinylation are highlighted, and show the reaction to be a versatile tool for making alkyl-H-phosphinate derivatives as precursors for further use. Chapter 4 details the development of manganese-promoted intermolecular and intramolecular additions of alkenes, alkynes and aryl compounds with H-phosphinates is described. The system utilizing catalytic Mn(OAc)2 either neat or in DMSO, is successful for a variety of different alkenes and two alkyne substrates. A more efficient and cost-effective system was recently developed for H-phosphinate arylations using catalytic Mn(OAc)2 and MnO2 as an oxidant, and further applied to alkene phosphonochlorination with LiCl. In Chapter 5, nickel-catalyzed oxidation of alkyl hypophosphites is utilized to prepare ubiquitous alkyl-H-phosphonates starting from hypophosphorous acid and avoiding the use of PCl3. The reaction can be considered a form of water splitting. The studies show that after the intitial esterification step, NiCl2 or Ni/SiO2 is enough to oxidize the first P-H bond to form the desired phosphonate. The reaction has been applied to the synthesis of the global herbicide glyphosate.

Download or read book New Reactions and Reagents for Phosphorus carbon Bond formation written by Michael B. Geeson and published by . This book was released on 2020 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 takes the format of an "Outlook", and sets forth the case for developing sustainable methods in the synthesis of phosphorus-containing compounds. Methods used by nature for phosphorus-carbon bond-formation, or in the chemistry of other elements such as silicon, are discussed as model processes for the future of phosphorus in chemical synthesis. Chapter 2 describes the discovery of [TBA][P(SiCl3)2], prepared from [TBA]3[P3O9]-.2H2O and trichlorosilane. The bis(trichlorosilyl)phosphide anion is used to prepare compounds that contain P–C, P–O, P–F, and P–H bonds in a method that bypasses white phosphorus (P4), the traditional route to organophosphorus compounds. Chapter 3 extends the phosphate precursors to [TBA][P(SiCl3)2] from trimetaphosphate to crystalline phosphoric acid. Balanced equations are developed for the formation of [TBA][P(SiCl3)2] from phosphate sources and the byproducts are identified as hexachlorodisiloxane and hydrogen gas. Extension of trichlorosilane reduction to bisulfate provides improved access the known trichlorosilylsulfide anion, [TBA][SSiCl3]. This anion was used as a thionation reagent to prepare thiobenzophenone and benzyl mercaptan from benzophenone and benzyl bromide, respectively. Chapter 4 describes the synthesis of neutral phosphine, HP(SiCl3)2, obtained by protonation of [TBA]1 with triflic acid. HP(SiCl3)2 is a highly efficient reagent for photochemical hydrophosphination of terminal alkenes. The phosphorus-silicon bonds in the hydrophosphination products can be functionalized to provide compounds of the general formulae: RPCl2, RPH2, [RP(R')3]Cl, RP(O)(H)(OH), and RP(O)(OH)2. Chapter 5 describes a method to prepare phosphiranes (three-membered rings that contain a phosphorus atom) from anthracene-based phosphinidene precursors and styrenic olefins. The phosphinidene transfer reaction requires an organoiron and fluoride catalyst. The resulting phosphirane is prepared in good yield (73%) with high stereoselectivity (>99%). Experimental investigations into the mechanism point toward the intermediacy of an iron-coordinated fluorophosphide species.

Download or read book Tailored Organic Inorganic Materials written by Ernesto Brunet and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the limitless ability to design new materials by layering clay materials within organic compounds. Assembly, properties, characterization, and current and potential applications are offered to inspire the development of novel materials. Coincides with the government's Materials Genome Initiative, to inspire the development of green, sustainable, robust materials that lead to efficient use of limited resources Contains a thorough introductory and chemical foundation before delving into techniques, characterization, and properties of these materials Applications in biocatalysis, drug delivery, and energy storage and recovery are discussed Presents a case for an often overlooked hybrid material: organic-clay materials

Download or read book Solvent free Organic Synthesis written by Koichi Tanaka and published by John Wiley & Sons. This book was released on 2009-03-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition of a best-selling handbook all the chapters have been completely revised and updated, while four completely new chapters have been added. In order to meet the needs of the practitioner, emphasis is placed on describing precisely the technology and know-how involved. Adopting a didactic and comprehensible approach, the book guides the reader through theory and applications, thus ensuring its warm welcome among the scientific community. An excellent, essential and exhaustive overview.

Download or read book Organophosphorus Chemistry written by György Keglevich and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-04-09 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organophosphorus Chemistry presents a groundbreaking resource in this branch of organic chemistry that demonstrates how phosphorus-containing compounds can be manipulated in a variety of organic reactions. The authors give an overview of the newest trends and synthesis strategies, introduce bioactive and environmentally friendly organophosphorus compounds and show their importance in mainstream organic chemistry.

Download or read book An Introduction to Biomaterials Second Edition written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2011-11-28 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property. Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new U.S. FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure. With nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data, this comprehensive introduction discusses 13 important classes of biomaterials, their fundamental and applied research, practical applications, performance properties, synthesis and testing, potential future applications, and commonly matched clinical applications. The authors include extensive references, to create a comprehensive, yet manageable didactic work that is an invaluable desk references and instructional text for undergraduates and working professionals alike.

Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Download or read book Reactivity of P H Group of Phosphorus Based Compounds written by Kolio D. Troev and published by Academic Press. This book was released on 2017-09-06 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactivity of P-H Group of Phosphorus Based Compounds bridges the gap between inorganic and organic phosphorus compounds, providing a basis to explore the myriad possibilities for synthesis of novel low and high molecular phosphorus-containing compounds. It covers well-documented reactions in detail, including: tautomerization, oxidation, reduction, alkylation, oxidation coupling, addition reaction to: carbon-carbon multiple bonds, Schiff base, isocyanates, nitriles, epoxides; addition to carbonyl group, Kabachnik- Fields reaction, cross-coupling reaction and more. In an accessible style complete with synthetic routes and figures, the resource then covers the reactivity of multiple P-H group members: phosphines, phosphine oxides, hypophosphorus acid, H-phosphinic acids and polys(alkylene H-phosphonate). This valuable coverage supports the advancement of research and applications in this area for scientists solving a scientific problem or starting a variety of new projects, such as a new reaction for the synthesis of biologically active compounds, new methods of polymer synthesis or a new methodology for polymer modification. Describes the diverse reactivity of the phosphorus-hydrogen group, perhaps the most powerful in organic chemistry Includes practical information for the synthesis of catalysts, biologically active substances, flame retardants, advance materials and polymer materials Offers a visually-accessible guide to important reactions by an internationally recognized chemist

Download or read book Handbook of Photosynthesis Second Edition written by Mohammad Pessarakli and published by CRC Press. This book was released on 1996-09-09 with total page 1058 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Details all of the photosynthetic factors and processes under both normal and stressful conditions--covering lower and higher plants as well as related biochemistry and plant molecular biology. Contains authoritative contributions from over 125 experts in the field from 28 countries, and includes almost 500 drawings, photographs, micrographs, tables, and equations--reinforcing and clarifying important text material."

Download or read book Catalyst Components for Coupling Reactions written by Gary A. Molander and published by John Wiley & Sons. This book was released on 2013-05-30 with total page 1749 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.

Download or read book Organophosphorus Chemistry written by Viktor Iaroshenko and published by John Wiley & Sons. This book was released on 2019-04-22 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap for an up-to-date reference that presents the field of organophosphorus chemistry in a comprehensive and clearly structured way, this one-stop source covers the chemistry, properties, and applications from life science and medicine. Divided into two parts, the first presents the chemistry of various phosphorus-containing compounds and their synthesis, including ylides, acids, and heterocycles. The second part then goes on to look at applications in life science and bioorganic chemistry. Last but not least, such important practical aspects as 31P-NMR and protecting strategies for these compounds are presented. For organic, bioinorganic, and medicinal chemists, as well as those working on organometallics, and for materials scientists. The book, a contributed work, features a team of renowned scientists from around the world whose expertise spans the many aspects of modern organophosphorus chemistry.

Download or read book Advances in Microwave Chemistry written by Bimal K Banik and published by CRC Press. This book was released on 2018-12-07 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microwave Chemistry discusses the novel bond formation methodologies, synergistic effects of microwaves with other entities, sample preparation including digestion, combustion, and extraction techniques, as well as selectivity in chemical processes. Recent updates are provided on microwave-assisted syntheses of pharmacologically significant aza-, oxo- and other heterocycles, including lactams, nucleosides, bile acids and sterols, the preparation of nanomaterials, composites, and absorber layer materials for thin film. This book also incorporates comparative discussions involving microwave irradiation with conventional methods in different aspects of organic, inorganic, medicinal, and green chemistry. Key Features: Provides a comparative discussion on microwave irradiation with conventional methods in different aspects of organic, inorganic, medicinal, and green chemistry Presents recent applications of microwave radiation in biocatalysis Offers a complete package correlating various aspects of microwaves in organic syntheses, the biological impact of products formed in reactions, pharmacological features, and environmental sustainability of the procedures Explains microwave-induced reactions on structurally complex bile acids and sterols Stands as a valuable and unique addition to the well-established book series, New Directions in Organic and Biological Chemistry

Download or read book Best Synthetic Methods written by Chris Timperley and published by Newnes. This book was released on 2014-12-01 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: Best Synthetic Methods: Organophosphorus (V) Chemistry provides systematic coverage of the most common classes of pentavalent organophosphorus compounds and reagents (including phosphonyl, phosphoryl, and organophosphates), and allows researchers an easy point of entry into this complex and economically important field. The book follows the Best Synthetic Methods format, containing practical methods, synthetic tips, and shortcuts. Where relevant, articles include toxicity data and historical context for the reactions. Typical analytical and spectroscopic data are also presented to enable scientists to identify key compound characteristics. The book is a valuable companion to research chemists in both academia and industry, summarizing the best practical methods (often originating in difficult-to-access, foreign-language primary literature) in one place. It is ideally suited for those working on industrial applications of these compounds, including insecticides, herbicides, flame retardants, and plasticizers. Includes a mixture of tried and tested, historical methods that are proven to work, alongside new methods to provide scientists with a quick, time-saving resource of reliable methods Includes tips and tricks to get reactions to work; important information often missing from other sources Includes key analytical data for compounds, so scientists have one handy resource to select, perform, and analyze the best reaction

Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively